Vitamin magnesium B6 composition. Magnesium B6: instructions for use and what it is for, price, reviews, analogues. Side effects of Magne B6

Deficiency of vitamins and minerals in the body can cause various disorders. One of the most important components is magnesium. He takes part in maintaining the work internal organs especially the heart and blood vessels. To compensate for the lack of this element, it is recommended to take the drug "Magnesium B6".

Magnesium is an important element that is extremely necessary for every person. It is involved in the processes that constantly occur in the body, namely:

1. Protein production.
2. Removal of compounds that send the body.
3. Stabilization of cell growth.
4. Normalization of functioning nervous system.
5. Maintain normal blood cholesterol levels.
6. Prevention of violations in the work of the myocardium.

Magnesium also helps in preventing the development of urolithiasis.

What causes magnesium deficiency?

Often people are faced with the fact that in their body there is a lack of magnesium. As a result, various violations may occur. The reasons for the deficiency may be the following:

• Genetic failures that cause a decrease in the amount of magnesium in the blood.
• Improper nutrition, in which the balance of vitamins and minerals is not observed.
• Pathological processes arising in the work of the endocrine organs.
• Increased excretion of magnesium from the body.
• Violation of the absorption of the component in the digestive organs.
• Increased body's need for magnesium.

To detect a lack of magnesium, it is enough to undergo a laboratory blood test.

Indications for use

"Magnesium B6" is allowed to be taken only if indicated and strictly in agreement with the attending doctor. A specialist may recommend taking the drug in the presence of the following conditions:

1. Impaired functioning of the heart vascular system.
2. Increased blood pressure.
3. Arrhythmia.
4. Atherosclerotic vascular disease.
5. Heart failure.
6. Ischemia of the heart muscle.
7. Pathological processes in the nervous system.
8. Increased blood clotting.
9. Cholesterolemia.
10. Sleep disorders.
11. Nervous tic.
12. Depression.
13. Vegetative dystonia.
14. Excessive irritability.

Only a doctor decides on the advisability of using magnesium. It is not worth prescribing this medication on your own.

Instructions for use and dosage

"Magnesium B6" is available in the form of tablets and solution. They have different application rules. Tablets must be taken by swallowing with plenty of water. You can do this during meals or after a meal.

The dosage of the drug is determined for each patient individually. The number of pills can reach 8 pieces per day for adolescents over 12 years old and adults, 5 pieces for children from 6 to 12 years old. The duration of treatment is also set individually. AT medicinal purposes the medication is usually taken for a month.

"Magnesium B6" in the form of a solution is supplied in ampoules. Each contains 100 mg of the active ingredient. In this dosage form, dosages are also selected depending on age. Up to 12 years, take about 1-4 ampoules per day, over 12 years - 2-4 ampoules per day. If the baby weighs less than 10 years, the use of the drug is prohibited.

The solution is taken orally. To do this, dilute the medication with 100 ml of water. You need to drink the remedy immediately, otherwise the remedy will lose its medicinal properties.

Can pregnant women take it?

When carrying a child, magnesium is useful both for the body of the expectant mother and for the full development of the fetus. Therefore, the drug "Magnesium B6" is recommended for pregnant women in order to prevent the occurrence of hypoxia in the baby.

But the expectant mother does not have to take magnesium in the form of tablets or solution. To ensure a sufficient amount of the element, the diet should be reviewed. You need to eat more foods containing this component. These include buckwheat, oatmeal, legumes, dried fruits.

Use in children

"Magnesium B6" for children is used in the following cases:

• Increased nervous excitability.
• Unfounded fears.
• Sleep disorders.
• Nervous exhaustion.
• neurotic reactions.
• High anxiety.

Such symptoms can be caused by magnesium deficiency in the body. But this is far from always the case, so you first need to send the child for examination and identify the exact cause of the ailment. Only the result of the diagnosis will determine whether Magnesium B6 is needed for children or not.

Side effects

The concentration of magnesium in the blood should be normal. Its decrease, as well as its increase, can cause negative consequences. Therefore, it is important to take the drug strictly in the dosage prescribed by the doctor.

Side effects from the use of "Magnesium B6" are extremely rare. These include the following manifestations:

• Allergic reaction.
• Nausea.
• Vomit.
• Increased gas formation.
• Chair disorder.
• Pain in the abdomen.

If you experience these symptoms, you should inform your doctor. If necessary, the specialist will prescribe another remedy or adjust the dosage.

Contraindications

"Magnesium B6" has a number of limitations for use. These include the following:

1. Individual intolerance to the components of the drug.
2. Kidney failure.
3. Phenylketonuria.
4. Syndrome of glucose-galactose malabsorption.

If you need to take pills, then there is a contraindication - the age is less than 6 years. The solution is forbidden to use for babies under one year old.

Overdose

It is quite difficult to accidentally overdose on magnesium. But if this happens, the following consequences are possible:

• Nausea, vomiting.
• Excessive drop in blood pressure.
• Decreased speed of reflexes.
• Respiratory failure.
• Anuria.

Exceeding the concentration of magnesium in the body can even cause cardiac arrest.

special instructions

It is necessary to take "Magnesium B6" taking into account special instructions. These include the following:

1. People with diabetes should take the drug in the form of tablets with extreme caution, since its shell contains sucrose.
2. During therapy, you should not take laxatives, drink alcohol, play sports intensively, because these factors contribute to a decrease in magnesium in the blood, and treatment may be ineffective.
3. The drug solution contains sulfite. This substance can cause an allergic reaction or make it worse.

The doctor should inform the patient about the available features of the use of magnesium.

drug interaction

"Magnesium B6" is not combined with all medicines. It is not recommended to take it together with Levodopa. Otherwise, the effectiveness of the last medication will decrease. If both drugs cannot be dispensed with, then a third drug will also need to be included in the therapy, which will help prevent a decrease in effectiveness.

Also, magnesium should never be taken in conjunction with calcium preparations. This will cause magnesium to be absorbed very slowly. Therefore, it is first necessary to make up for its deficiency, and then start taking calcium.

You should not drink "Magnesium B6" and antibiotics that belong to the tetracycline group at the same time, otherwise the effectiveness of antibiotic therapy will be reduced. It is also not recommended to take the magnesium component with sorbents at the same time. Between doses you need a break of 3 hours.

Medicines with magnesium

There are several popular drugs that contain magnesium. These include the following:

1. "Magne B6 forte". The cost is around 450 rubles. It does not contain any additional elements, only magnesium and vitamin B6.
2. "Evalar Magnesium B6". The average price is 250 rubles. Unlike the previous medication, this remedy has a complex of useful substances, the main of which are magnesium and B6.
3. Magne-B6 Antistress. It costs about 400 rubles. Also includes several active ingredients, in particular magnesium and vitamin B6.
4. "Doppelgerz Active". Prices for this drug - 230 rubles. This tool also contains a set of useful elements.

Which drug to choose, the doctor decides. You cannot choose your own medication.

One tablet contains

active substances: magnesium lactate dihydrate 470 mg (equivalent to 48 mg magnesium), pyridoxine hydrochloride 5 mg

excipients: sucrose, heavy kaolin, acacia gum, carbomer 35000 mPa.s, talc, magnesium stearate

shell composition: acacia gum, sucrose, titanium dioxide (E 171), carnauba wax, talc.

Description

Tablets, coated white, smooth, shiny, oval

Pharmacotherapeutic group

Mineral Supplements. Other minerals. Magnesium preparations. Combination of various magnesium salts

ATX code A12CC30

Pharmacological properties

Pharmacokinetics

Malabsorption of magnesium salts in the gastrointestinal tract affects, inter alia, a passive mechanism in which salt solubility is a determining factor. The absorption of magnesium salts from the gastrointestinal tract does not exceed 50%. They can be excreted from the body, mainly in the urine.

Pharmacodynamics
Magnesium is predominantly an intracellular cation. It reduces the excitability of neurons and neuromuscular conduction and takes part in many enzymatic processes. Magnesium is an indispensable component of the body, half of the amount of magnesium in the body is in the bone tissue.

Clinical Findings: Serum Magnesium Levels

Between 12 and 17 mg/l (1 – 1.4 mEq/l or 0.5 – 0.7 mmol/l) indicates a mild magnesium deficiency

Below 12 mg/l (1 mEq/l or 0.5 mmol/l) indicates severe magnesium deficiency

Magnesium deficiency can be:

Primary, due to congenital pathology of metabolism (chronic congenital hypomagnesemia)

Secondary, due to inadequate intake (prolonged malnutrition, alcoholism, exclusively parenteral nutrition), gastrointestinal absorption disorders (chronic diarrhea, gastrointestinal fistulas, hypoparathyroidism) or excessive losses at the renal level (tubular defect, severe polyuria, diuretic abuse, chronic pyelonephritis , primary hyperaldosteronism, treatment with cisplatin).

Also, magnesium deficiency can be with an increase in the need for magnesium (with increased physical and mental stress, stress, pregnancy, use of diuretics).

Pyridoxine (vitamin B6) as a coenzyme is involved in many metabolic processes of the body, in the regulation of the function of the nervous system. Promotes faster absorption of magnesium in the intestinal tract, penetration and maintenance of its level inside the cell.

Indications for use

Established magnesium deficiency, isolated or associated.

A combination of the following symptoms may indicate a magnesium deficiency:

Nervousness, irritability, mild anxiety, transient fatigue, minor sleep disturbances

Signs of anxiety such as gastrointestinal cramps or palpitations (without any underlying heart disease)

Muscle cramps, tingling sensation in the muscles

Dosage and administration

Dosage

For adults and children over 6 years of age only.

Adults: 6-8 tablets per day, divided into 2-3 doses with meals.

Children: 10 - 30 mg / kg / day (0.4 - 1.2 mmol / kg / day), that is, children over 6 years old (weighing about 20 kg) 4 - 6 tablets per day, divided into 2 -3 doses during meals.

Treatment should be stopped as soon as the magnesium level in the blood returns to normal.

Method of administration

For ingestion. The tablets should be swallowed whole with a large glass of water.

Side effects

abdominal pain

Skin reactions

allergic reactions

Contraindications

Hypersensitivity to one of the components of the drug

Severe renal failure (creatinine clearance less than 30 ml/min)

Simultaneous administration with levodopa

Drug Interactions

Contraindicated combinations

Co-administration with levodopa should be avoided, the activity of levodopa is inhibited if the administration of this drug is not combined with the administration of peripheral dopa decarboxylase inhibitors. Any pyridoxine-containing drugs should be avoided unless peripheral dopa decarboxylase inhibitors are prescribed concomitantly with levodopa.

Phosphate or calcium salts

These foods inhibit the absorption of magnesium in the small intestine.

Combinations to consider

Orally administered tetracyclines

An interval of at least two hours between oral tetracycline and magnesium should be observed, since magnesium reduces the gastrointestinal absorption of tetracyclines.

special instructions

Warnings

Treatment of patients with severe deficiency should begin with intravenous administration of the drug. It is also recommended for patients suffering from malabsorption. Correction of magnesium deficiency is recommended before treatment of hypocalcemia.

Since this preparation contains sucrose, it is contraindicated in patients with fructose intolerance, with malabsorption of glucose and galactose, or with a deficiency of sucrase and isomaltase.

Precautionary measures

This drug is for adults and children over 6 years of age.

There are dosage forms more suitable for children under 6 years of age. In moderate renal insufficiency, precautions should be taken to prevent the risk associated with hypermagnesemia.

Pregnancy and lactation

If necessary, magnesium can be used at any stage of pregnancy as prescribed by a doctor.

Each component, magnesium or vitamin B6, is individually considered compatible with lactation. Given the limited data available, the maximum recommended dose of vitamin B6 during lactation is 20 mg/day.

Features of influence medicinal product on the ability to manage vehicle or potentially dangerous mechanisms

Medicines from any group should be used only on the advice of a doctor. Complaints about the ineffectiveness or harmful effects of drugs often arise due to their improper use. For example, magnesium B6: instructions for use of these tablets prescribe an average of 4 per day. But the doctor may suspect a magnesium deficiency in the patient or take into account the fact of pregnancy. In this case, the dose must be doubled to be effective. The doctor will recommend to stop taking the pills if there are contraindications and will advise an adequate replacement.

What is magnesium B6, why is it needed

The drug, designed to compensate for the lack of magnesium in the body, consists of two active ingredients - magnesium and pyridoxine (vitamin B6), supplemented with stabilizing components. Available in the form of tablets and solution for oral administration.

Why does the body need magnesium?

Mg is an important substance for the body, more than a third of metabolic processes can not do without its participation. The stock of magnesium in the body is 20-30 g, the main depot is bones and teeth, one percent is in the blood, the rest is distributed in muscles and other tissues.

Magnesium levels have the greatest effect on the heart muscle. Without it, the immune system suffers:

• impaired production of antibodies;
• disturbed heart rhythm, blood pressure;
• stress vulnerability increases and the disorder of the nervous system begins;
• increased risk of developing diabetes and its complications;
• calcium is not absorbed, therefore, the state of the skeletal system suffers, dental health worsens;
• protein synthesis and many metabolic processes are disturbed.

What are the benefits of vitamin B6

He takes part in many vital processes:

• normalizes blood lipid balance, cholesterol levels, reducing the risk of stroke, heart attack, atherosclerosis;
• regulates blood pressure;
• improves the contractility of the heart muscle;
• necessary for the processes of protein metabolism and the creation of red blood cells;
• improves memory, brain function;
• contributes to the prevention of oncological pathology;
• stimulates the immune system, increases the production of antibodies;
• improves hair health.

Indications for the use of the drug

The inclusion of these two components in the composition of the drug is due not only to their beneficial effects on the heart, blood vessels and nervous system, but also to the mutual reinforcing effect.

The intake of magnesium B6 is indicated for the following conditions:

• cardiovascular disorders;
• hypertension;
• heart failure;
• arrhythmias;
• cholesterolemia;
• increased blood clotting.
• pathology of the nervous system;
• sleep disorders;
• irritability;
• depressive states;
• nervous tics;

Magnesium B6: what is needed during pregnancy

During pregnancy, the need for magnesium increases threefold. If a woman usually needs 300 mg of magnesium per day, then the pregnancy period already requires 925 mg, and the lactation period and 1250 mg.

Doctors recommend saturating the body of the expectant mother with magnesium even before pregnancy, at the planning stage. Women are explained which ones they should eat more. And they prescribe the drug magnesium B6 to strengthen the nervous and vascular systems of the mother, to prepare them for a period of increased stress.

The intake of magnesium B6 during the period of bearing a child provides:

• decrease in excitation in the nervous system;
• prevention of convulsive phenomena in the muscles, tics, painful spasms;
• prevention of spontaneous abortions, as it helps to reduce the tone of the uterus;
• reducing the risk of malformations of the nervous and vascular system in a child, due to the properties of pyridoxine.

The use of any drugs during pregnancy, including magnesium B6, must be agreed with the doctor.

Magnesium B6: instructions for use (tablets and ampoules)

The drug is indicated for use in adults and children. Dosage and duration of administration is determined by the attending physician. Usually the drug is well tolerated, but taking magnesium B6 can cause side effects in the form of

• nausea, vomiting;
• increased gas formation in the intestines;
• diarrhea or constipation;
• allergic reactions;
• stomach ache;
• paresthesia, numbness, neuropathic phenomena.

Similar effects may accompany long-term use of the drug at a high dosage.

Dose, duration of administration are determined by the degree of magnesium deficiency, according to laboratory studies. Since magnesium slowly accumulates in the body, the course of treatment is usually at least a month or two.

How to take magnesium B6 tablets

The daily dose of tablets, which averages 6-10 for adults and 4-6 for children, is divided into several doses per day.

Take with food.

The tablets are swallowed whole, without chewing.

Wash down with a glass of water, other liquid is not recommended.

How to take magnesium B6 in ampoules

It is worth remembering that the ampoules contain 100 mg of magnesium, and take this into account when dosing. This form of the drug is convenient to use in children and debilitated bedridden patients, in people with impaired solid food intake.

Children from one to six years old individually calculate the dose - 10-30 mg of magnesium per 1 kg of body weight. Usually it is 1-4 ampoules per day. For babies weighing less than 10 kg, the drug is not prescribed.

Children 6-12 years old use magnesium B6 ampoules 1-3 times a day.

After the age of twelve, the daily dose may be 2-4 ampoules.

Having broken the tip of the ampoule, its contents are poured into a glass and mixed with 100 ml of water. Apply immediately, the solution is not subject to storage.

When you can not take magnesium B6 - contraindications

The main contraindications are:

• kidney failure;
• simultaneous reception with Levodopa;
• phenylketonuria;
• intolerance to components;
• less than a year old.
• the drug in the form of tablets is not given to children under six years of age;
• patients with glucose-galactose malabsorption syndrome;
• with fructose intolerance;
• with a lack of enzymes that break down sugars.

Magnesium B6 - analogues

Medicinal preparations having a similar composition and effect:

• Magnelis B6 (Russia);
• Magnefar and Magvit B6 (Poland);
• Beresh plus (Hungary);
• Magnikum (Ukraine);
• Magnesium B6 Evalar;
• Magnesium plus B6.

Replacement can take place only after the approval of the attending physician.

Vitamin Magnesium B 6 supports the normal functioning of blood vessels and the heart, has a positive effect on the condition of the kidneys, liver and nervous system. The combination with Pyridoxine (B 6) also helps with neurological and cardiovascular pathologies, improves metabolic processes, has a positive effect on the immune system and is involved in the relief of depression. But drinking drugs with magnesium and B 6 is not always useful. Therefore, before taking dietary supplements, you should read the instructions.

When to Take Vitamin Supplements

Indications for the use of vitamin Magnesium B 6 are pathologies caused by a lack of micronutrient intake with food. The instructions indicate that Magne B 6 must be drunk for the treatment or prevention of the following conditions:

• magnesium deficiency due to an unbalanced diet;
• hypertension;
• arrhythmia;
• myocardial ischemia;
• heart failure;
• atherosclerosis;
• high blood clotting;
• pain and spasm in the muscles;
• sleep disorder;
• hyperexcitability and irritability;
• great physical or mental stress;
• frequent stress;
• increased fatigue;
• depressive disorders;
• chronic fatigue syndrome;
• vegetative dystonia.

Pregnant drugs with Magne B 6 are prescribed to maintain such processes:

• prevention of fetal hypoxia, miscarriage;
• reducing the severity of toxicosis;
• normalization of the emotional background.

A bioadditive is also useful for intensive sports, when there is a loss of salts.

Important! Before using the drug, you should consult with your doctor. If the reason for the deterioration of well-being is not magnesium deficiency, then the use of a dietary supplement will not help, and sometimes even harm health.

Absolute and relative contraindications

The instructions say that taking the drug is prohibited if the patient has a history of:

• severe renal failure;
• intolerance to pyridoxine or a magnesium element, as well as inactive components that make up the vitamin supplement;
• enzymatic deficiency of sucrase-isomaltase;
• phenylketonuria;
• age up to one year.

Doctors also advise:

1. With moderate renal insufficiency, Magne B 6 is recommended to be taken under the supervision of a therapist, since impaired renal filtration increases the risk of developing hypermagnesemia.
2. When taking tablets with Magnesium B 6 for diabetes, you need to consider that the drug shell contains sucrose, and this can increase blood glucose.
3. The use of magnesium tablets in tablets is contraindicated until the age of six. Children under 6 years of age are given a magnesium-vitamin solution.
4. In case of intolerance to components from group C, doctors practice prescribing Magnesium preparations without B 6 .

What is produced Magnesium B 6

For oral administration, the pharmacological industry produces 2 forms of Magne B 6:

1. Pills. Magnesium intake in this form is indicated for adults and children over 6 years of age. The composition includes 48 mg of magnesium and 5 mg of B 6 .
2. Syrup. The liquid form is convenient to give to babies from the age of one year. The solution for oral administration is packaged in 10 ml ampoules, with a concentration of magnesium 10 mg / ml and vitamin 1 mg / ml. Liquid is easy to dose. The drug in the form of a syrup is also recommended for people who have impaired swallowing function.

Important! Both editions are well received.

Pharmacies will offer several options for preparations containing Magne B 6: Magnicum, Magvit, Magnesium B 6 Evalar, Magne B 6, etc.

How and how much to drink Magne B 6

In the annotation to the bioadditive, standard therapeutic daily doses are given.

Tablet remedy:

• adults and children over 12 years old - 6-8 pcs.;
• pregnancy and lactation - 4-6 pieces;
• 6-12 years - 2-5 tablets.

The daily amount of funds is divided into 2-3 servings. It should be taken after meals with plenty of water.

Dosing suspension according to age:

• 1-6 years old, weighing 10 kg or more - 1-4 mg (10-30 mg per 1 kg of body weight);
• 7-12 - 1-3 mg;
• children after 12 and adults - 2-4 mg.

Application principle:

The product should be diluted in 100 ml of warm water and consumed after meals. It is impossible to store the finished drug - the liquid loses its medicinal properties over time.

The duration of the course is 1-2 months.

Important! Despite the fact that the annotation attached to the drug indicates how to drink, the dosage and duration of the therapeutic course should be determined by the doctor.

Adverse reactions

Magne B 6 is well tolerated by patients and almost does not cause deterioration in well-being. In rare cases, the following conditions may occur:

• skin rash;
• dyspeptic disorders;
• numbness of hands and feet;
• muscle weakness.

When adverse reactions you need to stop drinking the remedy and visit a doctor. He himself will tell you whether there is a need to continue taking Magne B 6 or whether you need to stop the drug.

Is there an overdose

Magnesium and pyridoxine are well excreted in the urine. If the kidneys are healthy, then the excess drugs are removed from the body.

In people with impaired renal function, high doses of magnesium can also accumulate in tissues and cause acute or chronic overdose.

acute form

It happens when a once taken portion exceeds several times the daily norm. Overdose symptoms:

• vomit;
• lowering blood pressure;
• lethargy;
• violation (stopping) of breathing or heart function;
• oliguria and anuria;
• allergic rashes.

There is no antidote for magnesium. In life-threatening conditions, infusion therapy is carried out and drugs are used to restore the functioning of vital systems.

Young children are more likely to suffer from acute overdose. They take beautiful pills in a sweet shell for sweets.

Chronic overdose

It often occurs in adults when the drug is used without medical prescription. Prolonged self-poisoning with a magnesium agent can cause:

• sensory disturbance (feeling of numbness or tingling of the skin);
• hand tremor;
• lack of coordination.

Symptoms are not life threatening and gradually disappear after the abolition of the dietary supplement.

Important! In case of impaired renal function, the dosage of vitamin Magnesium B 6 must be strictly observed. The use of a large amount of the drug can provoke magnesium intoxication.

Expiration date and storage rules

The duration of storage depends on the form of release:

• tablets - 2 years;
• ampoules with suspension - 3 years.

After this period, the active components are destroyed, and the product can not be used.

To preserve the medicinal qualities of the drug, it must be stored at a temperature of + 5-25ᵒ C in a dark place, inaccessible to small children.

Drug compatibility

Before drinking Magnesium B 6 along with drugs, you need to study how they affect each other:

1. Calcium. Slows down the absorption of magnesium. If it is necessary to eliminate magnesium and calcium deficiency, then the Magne B 6 course is first prescribed. Then the calcium deficiency is replenished.
2. Antibiotics from the tetracycline group. When taken simultaneously with magnesium, the effectiveness of antibiotic therapy decreases. The interval between the use of the antibiotic and Magne B 6 should be at least 3 hours.
3. Vitamin C. good compatibility. Both substances are absorbed.
4. Sorbents. These substances interfere with the absorption of the vitamin and magnesium component.

Magnesium without B 6

With intolerance to B vitamins, the doctor may prescribe magnesium supplements without pyridoxine, but the effectiveness of therapy will be lower. This therapy provides:

• bioavailability of magnesium;
• the entry of an element from the intestine into the tissues;
• uptake of substances by cells.

Helpful advice. Magnesium without B 6 is poorly absorbed and its deficiency is replenished more slowly. If there is a history of intolerance to drug forms of B vitamins, then in order to increase the effectiveness of magnesium treatment, it will be necessary to include foods rich in pyridoxine in the menu.

Therapeutic and preventive intake of Magne B 6 normalizes the activity of the nervous system, reduces the risk of cardiovascular pathologies, and prevents miscarriage in pregnant women. But despite the fact that the lack of an element negatively affects health, it is impossible to drink drugs without medical prescription. Otherwise, uncontrolled intake can provoke the development of magnesium intoxication or cause side effects.

If you have already taken funds with Magnesium B 6, then leave your feedback. Tell us why you drank the supplement and what therapeutic effect you got.

Pharmacodynamics. Under physiological conditions, magnesium is a cation, which is mainly found inside cells. Magnesium reduces the excitability of neurons and neuromuscular transfer, takes part in many enzymatic processes.
Pyridoxine, a coenzyme factor, is involved in most metabolic processes.
Pharmacokinetics. Magnesium is present in the body at an average concentration of 17 mmol / kg, 99% of it is located inside the cells. Subjected to selective absorption in the mucous membrane of the small intestine, approximately 40-50% of the accepted amount.
Almost 2/3 of intracellular magnesium is present in bone tissue, and 1/3 in smooth or striated muscles and in erythrocytes.
Magnesium is primarily excreted through the kidneys. In the kidneys, 70% of magnesium undergoes glomerular filtration, after which 95-97% of it is reabsorbed in the renal tubules. Magnesium present in the urine, on average, is 1/3 of the microelement ingested with food.
In the body, pyridoxine undergoes oxidation to pyridoxal or is in the form of pyridoxamine. As a result of subsequent phosphorylation, pyridoxal phosphate is formed. This form of pyridoxine is the active metabolite.

Indications for the use of Magne-B6

The drug in solution is recommended for adults, children and infants weighing 10 kg (at the age of approximately 1 year);
in the form of tablets - for adults and children over the age of 6 years with symptoms associated with magnesium deficiency:

• psycho-emotional lability, transient fatigue, sleep disturbance;
• feeling anxious, having symptoms such as gastrointestinal cramps or tachycardia;
• convulsions, paresthesia.

The use of Magne-B6

Adults are prescribed orally 6-8 tablets or the contents of 3-4 ampoules per day in 2-3 doses with meals. Children in the form of tablets are prescribed with meals at the rate of 10-30 mg / kg per day (0.4-1.2 mmol / kg per day), which for children over the age of 6 years with a body weight of approximately 20 kg corresponds to 4- 6 tablets or in the form of a solution for oral administration to children and infants weighing 10 kg, 1-4 ampoules per day in 2-3 divided doses. The contents of the ampoule are diluted in 1/2 cup of water.
Magne B6 Premium: the recommended dose for adults and children over 12 years of age is 3-4 tablets per day, divided into 2-3 doses.
The recommended dose for children 6-12 years old (weighing about 20 kg) is 2-4 tablets per day in 2-3 doses.
The duration of treatment is 1 month. If after 1 month of treatment there is no improvement in the condition, the drug is canceled.

Contraindications to the use of Magne-B6

Hypersensitivity to the drug, severe renal failure (creatinine clearance below 30 ml / min), age up to 6 years for the drug in the form of tablets. breastfeeding period. Fructose intolerance, glucose or galactose malabsorption syndrome, sucrase-isomaltase deficiency (due to the content of sucrose in the preparation).

Side effects of Magne-B6

Possible allergic reactions, including anaphylactic reactions and bronchospasm, rash on the skin, diarrhea, abdominal pain.

Special instructions for the use of Magne-B6

In moderate renal failure, the drug should be used with caution to avoid the risk of developing hypermagnesemia.
The ampoules contain sodium metabisulfite, which can lead to the development of allergic reactions, including anaphylactic ones, or increase the severity of their course, especially in patients at risk.
Magne B6 Premium contains lactose. Due to the presence of lactose in the tablets, the drug is contraindicated in congenital galactosemia, glucose-galactose absorption disorder or lactase deficiency.
With moderate renal insufficiency, the drug should be prescribed with caution, due to the risk of hypermagnesemia.
Serum magnesium levels:
12-17 mg / l (1-1.4 mEq / l or 0.5-0.7 mmol / l) - moderate magnesium deficiency;
below 12 mg / l (1 mEq / l or 0.5 mmol / l) - severe magnesium deficiency.
Magnesium deficiency can be:
primary - due to a congenital anomaly of magnesium metabolism (chronic congenital hypomagnesemia);
secondary - due to inadequate intake (severe malnutrition, alcoholism, only parenteral nutrition); due to impaired gastrointestinal absorption (chronic diarrhea, gastrointestinal fistula, hypoparathyroidism); due to loss at the renal level (tubular pathology, significant polyuria, diuretic abuse, chronic pyelonephritis, primary hyperaldosteronism, cisplatin treatment).
Use during pregnancy breastfeeding.
The drug can be used during pregnancy, if necessary, despite the fact that experimental data on animals are insufficient, limited clinical data show positive results from the use of the drug.
Due to the fact that magnesium penetrates into breast milk, it is not recommended to use the drug during breastfeeding.
Influence on the ability to drive a car and perform work requiring increased attention. Does not affect.

Magne-B6 drug interactions

not recommended combinations: should not be administered simultaneously with preparations of phosphates or calcium salts (inhibit the absorption of magnesium in the digestive tract);
combinations requiring caution when using:
use oral tetracyclines with caution, since magnesium reduces the absorption of tetracyclines in the stomach and intestines. With simultaneous use with oral tetracyclines, the administration of Magne-B6 should be delayed by at least 2 hours.

Overdose of the drug Magne-B6, symptoms and treatment

Generally, oral overdose of magnesium does not cause toxic reactions in normal renal function. In renal failure, toxic effects caused by magnesium poisoning may occur. Symptoms magnesium poisoning: decreased blood pressure, nausea, vomiting, CNS depression, slow reflexes, ECG changes, respiratory depression, coma, cardiac arrest and respiratory paralysis, anuria.
Treatment: rehydration, forced diuresis. In case of renal insufficiency, if necessary, hemodialysis or peritoneal dialysis is performed.

Storage conditions for Magne-B6

In a dry, dark place with room temperature(not higher than 25 °C).

List of pharmacies where you can buy Magne-B6:

• St. Petersburg