Valocordin indications for use. What Valocordin helps from: indications for use, composition, mechanism of action and adverse reactions. For herpesvirus outbreaks

Instruction

Quantitative and qualitative composition

1 ml (=20 drops) contains:

Active ingredients:

Phenobarbital - 18.4 mg

Ethyl bromisovalerianate - 18.4 mg

Excipients: mint oil, hop oil, ethanol 96%, purified water

The medicinal product contains 56% (v/v) ethyl alcohol.

Description

Clear, colorless solution, aromatic smell, bitter taste.

Pharmacological properties

Combination drug containing phenobarbital and ethyl bromisovaleriant. The drug has a sedative or hypnotic effect depending on the dose.

Indications for use

As part of complex therapy as a symptomatic remedy for functional disorders of the nervous system (neurasthenia and sleep disorders).

The drug is intended for short-term use due to the risk of addiction and dependence.

Contraindications

Hypersensitivity to bromine or any component of the drug;

Renal and / or liver failure;

Porfiria;

Alcoholism, epilepsy, traumatic brain injury and other brain diseases with a decrease in the seizure threshold;

Pregnancy, lactation;

Children's age up to 18 years.

Side effect:

From the nervous system: drowsiness, decreased concentration, slow reactions, impaired coordination of movements, dizziness, headache, nervousness, agitation, anxiety, confusion, increased motor activity, ataxia, depression of the central nervous system, sleep disturbances, insomnia, nightmares, mental disorders, hallucinations .

From the respiratory system: hypoventilation, apnea.

From the digestive system: nausea, vomiting, constipation, with prolonged use - a violation of liver function.

From the side of the hematopoietic organs: agranulocytosis, megaloblastic anemia, thrombocytopenia.

From the side of the cardiovascular system: bradycardia, low blood pressure, fainting.

From the musculoskeletal system: with prolonged use of drugs containing phenobarbital, there is a risk of impaired osteogenesis. There have been reports of reduced bone mineral density, the development of osteopenia and osteoporosis, fractures in patients who have been taking phenobarbital for a long time.

Others: blurred vision, allergic reactions (angioedema, skin rash, ecofoliative dermatitis), fever, liver damage.

With prolonged use - drug dependence.

With prolonged use of large doses, the development of chronic bromine poisoning is possible, the manifestations of which are: depressive mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements.

After prolonged use, megaloblastic anemia may develop.

With the use of drugs containing phenobarbital, there have been reports of the development of life-threatening skin reactions (Stevens-Johnson syndrome and toxic epidermal necrolysis).

In the event of adverse reactions, including those not listed in this leaflet, you should stop taking the drug and consult a doctor.

Interaction with othersmedicines

Medicines containing valproic acid increase the effect of barbiturates. Phenobarbital induces liver enzymes and therefore may accelerate the metabolism of certain drugs that are metabolized by these enzymes (for example, coumarin derivatives, antibacterials and sulfonamides).

When taken simultaneously with coumarin derivatives, lamotrigine, thyroid hormones, doxycycline, chloramphenicol, antifungal drugs (azole type), griseofulvin, glucocorticoids or oral contraceptives with Valocordin®, adverse reactions and interactions may occur due to the phenobarbital contained in the preparation.

Women taking phenobarbital should be offered non-hormonal methods of contraception.

The toxicity of pharmaceutical preparations containing methotrexate is increasing.

The effect of phenobarbital on the metabolism of phenytoin is unpredictable, the concentrations of phenytoin and phenobarbital in the blood should be monitored if these drugs are prescribed simultaneously.

Sodium valproate and valproic acid inhibit the metabolism of phenobarbital.

Interactions associated with the presence of ethyl alcohol in the composition: it is necessary to avoid co-administration of drugs that cause a disulfiram-like reaction (feeling of heat, redness of the skin, vomiting, tachycardia) when taken together with alcohol (disulfiram, cefamandol, cefoperazone, latamoxef, chloramphenicol, chlorpropamide, glibenclamide, glipizide, tolbutamide, griseofulvin, nitro-5-imidazole derivatives (metronidazole, ornidazole, tinidazole), ketoconazole, procarbazine).

It is necessary to avoid the simultaneous use of other drugs containing ethyl alcohol.

If you are taking other medicines at the same time, you should consult your doctor.

Doses and duration of administration are set by the doctor individually.

Valocordin® is administered orally before meals 3 times a day, 15-20 drops, previously dissolved in a small amount of water. If sleep is disturbed, the dose can be increased to 30 drops.

The drug is intended for episodic short-term use due to the risk of addiction and dependence.

Overdose

Symptoms of chronic overdose: depression of the central nervous system, nystagmus, ataxia, lowering blood pressure, blood count disorders, agitation, chronic bromine intoxication (depression, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements).

With the development of symptoms of an overdose, it is necessary to stop using the drug and consult a doctor.

Acute overdose of barbiturates manifested in the inhibition of the function of the central nervous system and the respiratory system: Cheyne-Stokes respiration, areflexia, oliguria, tachycardia, arterial hypotension, hypothermia and coma. Shock (apnea, circulatory collapse, respiratory arrest and death) may develop.

With the development of symptoms of acute overdose, it is necessary to maintain the vital functions of the body and conduct detoxification therapy, resuscitation may be required.

Precautionary measures

The drug contains 56% (v/v) ethyl alcohol, the content of ethyl alcohol in the maximum single dose (30 drops) is 663 mg.

The drug should not be taken by patients with alcoholism, pregnant and breastfeeding women, children under 18 years of age, high-risk patients such as patients with liver disease and epilepsy.

The simultaneous use of alcoholic beverages with Valocordin® should be avoided. Simultaneous alcohol intake increases the toxicity of phenobarbital.

It should be avoided prescribing the drug to patients with depressive disorders, suicidal tendencies, people with drug addiction.

Elderly and debilitated patients may respond to phenobarbital by developing marked agitation, depression, and confusion.

With prolonged use, accumulation of bromine in the body and the development of intoxication are possible. Phenobarbital can cause the development of addiction, mental and physical dependence. When addiction (tolerance) to phenobarbital develops, the dose required to maintain the same level of effect increases. Abrupt discontinuation of phenobarbital after long-term use in a dependent individual may lead to withdrawal symptoms.

In case of signs of intoxication, addiction (tolerance) or dependence, the patient should immediately consult a doctor. Signs of chronic intoxication include confusion, decreased criticism, irritability, insomnia, and somatic complaints. Caution should be exercised when prescribing phenobarbital to patients with acute or chronic pain because paradoxical arousal may develop and important clinical symptoms may be masked.

There have been reports of the development of life-threatening skin reactions (Stevens-Johnson syndrome and toxic epidermal necrolysis) with the use of drugs containing phenobarbital. Very often, a life-threatening skin rash is accompanied by flu-like symptoms. If symptoms of skin reactions appear, the drug should be stopped immediately and consult a doctor. In such cases, the patient should never resume taking Valocordin® again.

Use in children

The drug is contraindicated in children and adolescents under the age of 18 years.

Application during during pregnancy and lactation

The drug Valocordin® is contraindicated in pregnant women who are breastfeeding.

Influence on the ability to drive a car and work with mechanisms

The drug contains ethyl alcohol, phenobarbital and ethyl bromisovalerianate, therefore, patients taking Valocordin® are contraindicated in driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Release formska

Drops for oral administration of 20 ml and 50 ml in brown glass bottles with a dropper. Each dropper bottle, along with instructions for use, is placed in a cardboard box.

Storage conditions

Store in a place protected from light at a temperature not exceeding 25°C.

Keep out of the reach of children.

Shelf life

Do not use after the expiry date stated on the packaging.

Terms of dispensing from pharmacies

Without a doctor's prescription.

Manufacturer

Crevel Meuselbach GmbH

Crevelstrasse 2

53783 Eitorf, Germany

In this article, you can read the instructions for using the drug Valocordin. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Valocordin in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Valocordin in the presence of existing structural analogues. Use for the treatment of neurosis, insomnia, tachycardia in adults, children, as well as during pregnancy and lactation. The composition and interaction of the drug with alcohol.

Valocordin- a combined medicinal product, the therapeutic effect of which is due to the pharmacological properties of the components that make up its composition. Phenobarbital has a sedative and vasodilatory effect, and also has a mild hypnotic effect. It helps to reduce the excitation of the central nervous system and facilitates the onset of natural sleep. Ethylbromisovalerianate has a sedative, hypnotic and antispasmodic effect. Peppermint oil has reflex vasodilating and antispasmodic activity.

Compound

Phenobarbital + Alpha-bromisovaleric acid ethyl ester + excipients (Valocordin).

Doxylamine succinate + excipients (Valocordin Doxylamine).

Indications

• functional disorders of the cardiovascular system (including cardialgia, sinus tachycardia);
• neurosis, accompanied by irritability, anxiety, fear;
• insomnia (difficulty falling asleep);
• states of excitation, accompanied by pronounced vegetative reactions.

Release forms

Drops for oral administration.

Effervescent tablets 15 mg (Doxylamine).

Instructions for use and dosage

Drops

Valocordin is taken orally, before meals, with a small amount of liquid.

How many drops are needed to achieve a therapeutic effect? The dosage is set individually. Adults are usually prescribed 15-20 drops 3 times a day. In case of disturbed falling asleep, the dose can be increased to 30 drops.

The duration of the drug is set individually by the doctor.

Effervescent tablets

Taken inside. Adults with insomnia, sleep disorders - 15-25 mg 15-30 minutes before bedtime. With allergic reactions - in doses up to 25 mg every 4-6 hours.

Children aged 6-12 years - 6.25-12.5 mg if necessary - every 4-6 hours.

The maximum daily dose for adults is 150 mg.

Side effect

• drowsiness;
• mild dizziness;
• depressed mood;
• apathy;
• rhinitis;
• conjunctivitis;
• hemorrhagic diathesis;
• impaired coordination of movements.

Contraindications

• severe impairment of kidney and / or liver function;
• pregnancy,
• lactation period;
• hypersensitivity to any of the components of the drug.

Use during pregnancy and lactation

During pregnancy, Valocordin is contraindicated. If necessary, the appointment of the drug during lactation should decide on the termination of breastfeeding.

Use in children

Children are prescribed at the rate of 1 drop per year of the child's life and depending on the clinical picture of the disease.

special instructions

The drug contains 55 vol% ethanol (alcohol) and phenobarbital, so Valocordin, even when used correctly, can weaken the ability of patients to respond quickly in certain situations, such as when they are outside or when servicing cars. This is especially pronounced with the simultaneous intake of alcohol.

With prolonged use of the drug, the formation of drug dependence is possible; possible accumulation of bromine in the body and the development of poisoning them.

AT traditional medicine Valocardin is used to cauterize herpetic vesicles and eliminate the unpleasant symptoms of herpes.

drug interaction

With the simultaneous use of Valocordin with sedatives, an increase in the effect is noted.

Simultaneous use with neuroleptics and tranquilizers enhances, and with CNS stimulants - weakens the effect of each of the components of the drug.

Alcohol enhances the effects of Valocordin and may increase its toxicity.

The presence of phenobarbital in the composition of Valocordin can induce liver enzymes, and this makes it undesirable for its simultaneous use with drugs that are metabolized in the liver, since their concentration and, accordingly, the effectiveness will decrease as a result of a more accelerated metabolism (indirect anticoagulants, antibiotics, sulfonamides).

Phenobarbital weakens the effect of coumarin derivatives, glucocorticosteroids (GCS), griseofulvin, oral contraceptives (oral contraceptives).

Analogues of the drug Valocordin

Structural analogues for the active substance:

• Corvaldin.

Analogues by pharmacological group (Sedatives):

• Adonis bromine;
• Balm Muscovy;
• Barboval;
• Bellataminal;
• Bromenval;
• Valemidin;
• Valeodicramen;
• Valerian;
• Valoserdin;
• Glycine;
• Doppelgerz Vitalotonic;
• Doppelhertz Melissa;
• St. John's wort;
• Karniland;
• Kliofit;
• Klosterfrau Melisana;
• Corvalol;
• Corvalol MFF;
• Cravaleon;
• Landyshevo-valerian drops;
• Landyshevo-valerian drops with adonizide and sodium bromide;
• Landyshevo-motherwort drops;
• Lotusonic;
• Negrustin;
• Novo Passit;
• Passifit;
• Persen;
• Pesren forte;
• Motherwort;
• Sanason Lek;
• Sedative collection No. 2;
• Sedoflor;
• Sleepex;
• Songa Knight;
• Calming collection No. 2;
• Calming collection No. 3;
• Calm down;
• Fito Novo Sed;
• Phytorelax;
• Fitosedan No. 2;
• Fitosedan No. 3;
• Hops infructescence;
• Hop extract liquid.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

Sedative drug

Active ingredients

Release form, composition and packaging

◊ Drops for oral administration in the form of a clear, colorless liquid with an aromatic odor.

Excipients: mint oil - 1.29 mg, hop oil - 0.18 mg, ethanol 96% - 469.75 mg, purified water - 411.97 mg.

20 ml - dark glass dropper bottles (1) - packs of cardboard.
50 ml - dark glass dropper bottles (1) - packs of cardboard.

pharmachologic effect

Valocordin is a combined drug, the therapeutic effect of which is due to the pharmacological properties of the components that make up its composition.

Phenobarbital has a sedative and mild hypnotic effect. It helps to reduce the excitation of the central nervous system and facilitates the onset of natural sleep.

Ethyl bromoisovalerianate has a sedative, hypnotic and antispasmodic effect.

Indications

Contraindications

• hypersensitivity to any of the components of the drug;
• severe impairment of kidney and / or liver function;
• lactation period;
• children's age up to 18 years.

Carefully

Liver disease, alcoholism, traumatic brain injury, brain disease, tk. the preparation contains ethanol.

Dosage

Valocordin is taken orally, before meals, with a small amount of liquid. The dose is set individually.

Adults usually prescribed 15-20 drops 3 times / day.

At disturbed falling asleep the dose can be increased to 30 drops.

The duration of the drug is set individually by the doctor.

Side effects

Valocordin is generally well tolerated even with prolonged use.

In some cases: during the daytime, drowsiness and lightness may be observed.

With prolonged use of high doses it is possible to develop chronic bromine poisoning, the manifestations of which are: depressive mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements.

Rarely, with hypersensitivity: skin reactions.

If you experience any side (unusual) effects that are not reflected in the instructions, you must report them to your doctor.

Overdose

Symptoms: with mild and moderate intoxication, drowsiness, dizziness, psychomotor disturbances are observed. In severe cases - coma, decreased blood pressure, respiratory failure, tachycardia, vascular collapse, decreased peripheral reflexes.

Treatment: gastric lavage, activated charcoal. You should urgently call a doctor.

drug interaction

With the simultaneous use of the drug Valocordin with sedatives, an increase in the effect is noted.

Simultaneous use with neuroleptics and tranquilizers enhances, and with CNS stimulants - weakens the effect of each of the components of the drug.

Alcohol enhances the effects of Valocordin and may increase its toxicity.

The presence of phenobarbital in the Valocordin preparation can induce liver enzymes, and this makes it undesirable to use it simultaneously with drugs that are metabolized in the liver, since their concentration, and therefore effectiveness, will decrease as a result of a more accelerated metabolism (indirect, antibiotics, sulfonamides, etc. ).

Phenobarbital weakens the effect of coumarin derivatives, corticosteroids, griseofulvin, oral contraceptives.

special instructions

The drug contains 55 vol% ethanol (the absolute content of ethanol in the maximum single dose (30 drops) is 0.469 g) and phenobarbital, so Valocordin, even when used correctly, can weaken the ability of patients to respond quickly in certain situations, such as, for example, when being outdoors or when servicing cars. This is especially pronounced with the simultaneous intake of alcohol.

With prolonged use of the drug, the formation of drug dependence is possible; possible accumulation of bromine in the body and the development of them.

Content

People who live in modern world It is very difficult to avoid stressful situations. Many women and men experience irritability, suffer from neuroses. As a result, the general condition worsens, lethargy, insomnia, spasms, tachycardia appear, fatigue and blood pressure increase. It is important to monitor your health and use special sedatives in a timely manner. One of them is Valocordin - a sedative that is prescribed for disorders of the nervous system and the presence of cardiovascular diseases.

Composition of Valocordin

The drug is available in two dosage forms. Valocordin drops look like a clear liquid with a strong aromatic odor. They can be purchased in glass dropper bottles of 20 and 50 ml, packed in carton boxes. More depressant produced in the form of regular and soluble tablets (10 pieces per blister).

The composition of Valocordin is as follows:

Valocordin action

Drops and tablets are a combined medicine, the therapeutic effect of which is based on the pharmacological properties of the constituent elements. Valocordin contains ethyl bromisovalerianate (ethyl ester of α-bromisovaleric acid) and phenobarbital. These components have a hypnotic or sedative effect on the body, depending on the dosage. Phenobarbital refers to derivatives of barbituric acid, the substance inhibits the inhibitory system of the reticular formation. Sedative and antispasmodic effect gives ethyl bromisovalerianate.

Phenobarbital is absorbed very actively in the stomach. Further, 35% of the substance is bound by blood plasma proteins, and the rest is filtered in the kidneys. Reabsorption (reabsorption of fluid) occurs at a low pH level. Approximately 30% of phenobarbital is excreted unchanged from the body with urine, the rest of the substance is oxidized by the liver. If Valocordin is used for a long time, then the active component accumulates in the plasma, and the induction of liver enzymes also occurs. The procedure for the oxidation of phenobarbital is activated.

Indications for use

There are a number of conditions and diseases for which a sedative is prescribed. Instructions for the use of Valocordin include the following indications:

• insomnia, sleep disturbance;
• headache (migraine);
• flatulence (complex therapy);
• sudden attacks of angina pectoris (chest pain);
• neuroses;
• pain in the region of the heart (for example, cardialgia) caused by spasm of the coronary vessels;
• psycho-emotional overexcitation, which is provoked by a stressful situation;
• spasms of the gallbladder and intestines (if there is no obstruction of these organs);
• hypertension of the first stage (frequent and persistent increase in blood pressure).

How to take Valocordin

According to the instructions, drops or tablets are taken orally. The dosage and duration of the medication is prescribed by the doctor on an individual basis. Approximate average dosage of drops:

• high blood pressure, nervousness: 15-20 drops two to three times a day before meals with a small amount of water;
• tachycardia, pain in the heart area: twice a day, 30-40 drops, drink sweet tea or water;
• children from 14 to 18 years old 1-2 times a day, 3-8 drops.

Sometimes Valocordin is prescribed in tablets. The dosage of this dosage form is as follows:

• single dose: 15-25 mg per day;
• for the treatment of allergy symptoms: 25 mg every 4-6 hours (no more than 150 mg per day);
• children from 6 to 12 years: 6.25-12.5 mg every 6 hours.

special instructions

To avoid the manifestation of adverse reactions and not aggravate well-being, it is necessary to study the special instructions for the use of Valocordin. The main features that you should know when using the medication:

The drops contain 55% ethyl alcohol (ethanol).

When a person who has been taking phenobarbital for a long time abruptly stops the course of treatment, he may develop a withdrawal syndrome (accompanied by convulsions, delirium, and a fatal outcome is likely).

The substance phenobarbital can be addictive. Physical and psychological dependence can manifest itself with prolonged use of drops or tablets in a large dosage. If the body quickly becomes addicted to the active ingredient, then the dose for effective therapy is increased.

Patients with acute or chronic pain should take phenobarbital with caution. This is due to an increased risk of paradoxical arousal and masking of serious clinical signs.

Chronic poisoning with a sedative drug can cause irritability, sleep disturbance, confusion, and somatic problems. Symptoms of an overdose are similar to those of a chronic form of alcoholism.

Valocordin during pregnancy

The drug should not be taken during pregnancy. Phenobarbital, which is contained in Valocordin, can cause a delay in fetal development, and ethanol can provoke the development of congenital malformations, anomalies, and even serious damage to the internal organs of the embryo. During lactation (breastfeeding), the use of a sedative medication is also contraindicated. Its active elements are able to penetrate into breast milk, and with it enter the body of a newborn. As a result, severe poisoning and depression of the central nervous system (CNS) develops.

drug interaction

The instructions for use describe the interaction of the drug with other drugs. During therapy, the following points should be considered:

1. If you use drops simultaneously with other sedative medications, antipsychotics and tranquilizers, then the effect of phenobarbital is significantly enhanced.
2. The active ingredient can reduce the effectiveness of oral contraceptives, griseofulvin and coumarin derivatives, and glucocorticosteroids.
3. If you use antipsychotics and tranquilizers with CNS stimulants, then the effect of phenobarbital is reduced.
4. Alcohol can enhance the medicinal effect of Valocordin by increasing the level of toxicity of the drops.
5. Doctors do not recommend drinking phenobarbital with drugs that are metabolized in the liver. Some of the components of the sedative can accelerate hepatic metabolism and increase the concentration of the constituent substances of Valocordin.

Side effects

In most cases, Valocordin is normally tolerated by the human body. If the dosage of the drug is not observed, personal intolerance to the drug and other reasons, side effects may occur:

1. Respiratory system: apnea (stopping respiratory movements), hypoventilation (lack of oxygen for tissues and organs).
2. Digestive system: attacks of nausea, vomiting, constipation.
3. Nervous system: mental disorders, agitation, anxiety, confusion, insomnia or drowsiness, ataxia (loss of coordination), hallucinations, nervousness, depression of the central nervous system.
4. Cardiovascular system: decreased blood pressure, bradycardia (slow heart rate), dizziness, fainting.
5. The development of anemia (decrease in hemoglobin concentration) with prolonged use of Valocordin. For the same reason, chronic bromine poisoning can occur with the following symptoms: apathy, hemorrhagic diathesis, impaired coordination of movements, rhinitis, depression, conjunctivitis.

Overdose

If you take Valocordin for a long period of time and do not follow the permitted dosage, then health problems may arise. The main symptoms of an overdose:

• weakness;
• bradycardia (sudden slowing of the heart rate);
• apathy;
• difficulty breathing, lack of oxygen;
• psychomotor disorders;
• intoxication of the body;
• dizziness, fainting;
• vascular collapse, impaired reflexes;
• a sharp drop in blood pressure.

Contraindications

In some cases, therapy with Valocordin is prohibited. Contraindications described in the instructions for the drug:

• age category up to 14 years;
• acute myocardial infarction;
• liver and kidney failure;
• brain diseases;
• traumatic brain injury;
• individual intolerance to the remedy;
• alcoholism;
• pregnancy, breastfeeding;
• cardiogenic shock.

Terms of sale and storage

You can buy a sedative at any pharmacy without a prescription. It is necessary to store drops or tablets out of the reach of children, at a temperature not exceeding 15º C. The shelf life of the sedative is 5 years.

Analogues

When a patient cannot be treated with Valocordin for a number of reasons, the doctor prescribes analog drugs. Often it is replaced by such drugs:

Valecard - drops with a sedative effect. They are prescribed for neurosis, functional lesions of the cardiovascular system, states of strong nervous excitement.

The drug Barboval, when used correctly, has an antispasmodic, sedative, hypotensive effect. The solution effectively relaxes the muscles and eliminates flatulence (bloating).

Another analogue of Valocordin is Corvalol tablets and drops. This drug gives a pronounced antispasmodic and sedative effect.

Corvaldin is a solution that restores normal sleep, calms the nervous system, relieves spasms.

Corvaltab tablets fight well with insomnia, help reduce the excitability of the central nervous system, and have a sedative effect.

Corvalcaps are capsules that are prescribed for tachycardia, minor spasms of the coronary vessels, neurosis with high irritability, vegetative dystonia, and insomnia.

Valocordin price

Buy medicinal product it is possible in almost every pharmacy in Moscow and the region. It is also ordered in the online store at an affordable price (promotions, discounts apply). The approximate cost of funds is presented in the table.

Name:

Valocordin (Valocordin)

Pharmacological
action:

Pharmacodynamics. Valocordin is a combination drug containing phenobarbital and ethyl bromoisovalerianate (ethyl ester of α-bromoisovaleric acid). Depending on the dose, both of these substances have a sedative, hypnotic effect, and in high doses - a narcotic effect. Like other derivatives of barbituric acid, phenobarbital inhibits the inhibitory system of the reticular formation. Ethyl bromisovalerianate has both antispasmodic and sedative effects. At the concentration contained in Valocordin, ethyl bromisovalerianate acts as a synergist of phenobarbital (rapid manifestation of the effect).

Pharmacokinetics. Phenobarbital is absorbed quickly (directly in the stomach). About 35% binds to plasma proteins, the part that is not bound to proteins is filtered in the kidneys.
Reabsorption occurs at low pH levels. Back diffusion does not occur due to the alkalinity of the urine. About 30% of phenobarbital is excreted unchanged in the urine, and only a small part is oxidized in the liver.
With prolonged use, there is an accumulation of the active substance in the blood plasma, as well as the induction of liver enzymes. As a result of this induction, the process of oxidation of phenobarbital and other drugs is accelerated.
Bromine from ethyl bromisovalerianate is excreted very slowly from the body. If the drug is used for a long time, it accumulates in the central nervous system, which leads to chronic bromine intoxication.

Indications for
application:

Functional disorders of the cardiovascular system (including cardialgia, sinus tachycardia);
- neurosis, accompanied by irritability, anxiety, fear;
- insomnia (difficulty falling asleep);
- states of excitation, accompanied by pronounced vegetative reactions.

Mode of application:

Valocordin is taken orally, before meals, with a small amount of liquid. The dosage is set individually.
Adults usually prescribed 15-20 drops 3 times / day. In case of disturbed falling asleep, the dose can be increased to 30 drops.
children prescribed at the rate of 1 drop per year of a child's life and depending on the clinical picture of the disease.
The duration of the drug is set individually by the doctor.

Side effects:

Valocordin is generally well tolerated even with prolonged use.
In some cases, drowsiness and slight dizziness may occur during the daytime.
With prolonged use of large doses, the development of chronic bromine poisoning is possible, the manifestations of which are: depressive mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements.
If you experience any side (unusual) effects that are not reflected in the instructions, you must report them to your doctor.

Contraindications:

Severe impairment of kidney and / or liver function;
- pregnancy,
- lactation period;
- hypersensitivity to any of the components of the drug.

The drug contains 55 vol% ethanol and phenobarbital, therefore Valocordin®, even when used correctly, may impair the ability of patients to respond quickly in certain situations, such as when being outdoors or while servicing cars.
This is especially pronounced with the simultaneous intake of alcohol.
With prolonged use of the drug, the formation of drug dependence is possible; possible accumulation of bromine in the body and the development of poisoning them.

Interaction
other medicinal
by other means:

When using the drug with other drugs that depress the central nervous system, a mutual enhancement of the action (sedative-hypnotic effect) is possible, which may be accompanied by respiratory depression. Alcohol enhances the effect of the drug and may increase its toxicity.
Medicines containing valproic acid increase the effect of barbiturates.
Phenobarbital induces liver enzymes and, accordingly, can accelerate the metabolism of certain drugs that are metabolized by liver enzymes (for example, coumarin derivatives, antibiotics and sulfonamides). Phenobarbital enhances the effect of analgesics, anesthetics, anesthetics, neuroleptics, tranquilizers; reduces the effect of paracetamol, indirect anticoagulants, metronidazole, tricyclic antidepressants, salicylates, digitoxin.

Possible effect on blood concentrations of phenytoin, as well as carbamazepine and clonazepam. MAO inhibitors prolong the effect of phenobarbital. Rifampicin may reduce the effect of phenobarbital. When used with gold preparations, the risk of kidney damage increases. With prolonged simultaneous use with NSAIDs, there is a risk of gastric ulcers and bleeding.
The simultaneous use of drugs containing phenobarbital with zidovudine increases the toxicity of both drugs. Undesirable interaction Valocordin(contains phenobarbital) with lamotrigine, thyroid hormones, doxycycline, chloramphenicol, antifungal drugs (azole group), griseofulvin, corticosteroids, oral contraceptives due to the possible weakening of the effect of these drugs.
Increases the toxicity of methotrexate.

Pregnancy:

Contraindicated. If necessary, the appointment of the drug during lactation should decide on the termination of breastfeeding.

Overdose:

Symptoms. Acute (mild to moderate) barbiturate poisoning: dizziness, fatigue, deep sleep from which the patient cannot be awakened.
Hypersensitivity reactions may occur: angioedema, urticaria, itching, rash.
Acute severe poisoning: deep coma accompanied by tissue hypoxia, shallow breathing, first accelerated and then slowed down, increased heart rate, arrhythmia, hypotension, bradycardia, vascular collapse, decrease or loss of reflexes, nystagmus, headache, nausea, weakness, impaired cardiac activity , decrease in body temperature, decrease in heart rate, decrease in diuresis.
If timely medical care is not provided, death is possible as a result of vascular insufficiency, respiratory paralysis or pulmonary edema.
Long-term use of drugs containing bromine can lead to bromine poisoning, which is characterized by such symptoms: confusion, ataxia, apathy, depressed mood, conjunctivitis, colds, acne or purpura.

Treatment. Cases of acute poisoning with Valocordin should be treated in the same way as poisoning with other hypnotics and barbiturates, depending on the severity of the symptoms of poisoning. The patient must be admitted to the intensive care unit. Respiration and circulation require stabilization. Respiratory failure requires artificial respiration, shock is stopped by the introduction of plasma and plasma substitutes. If a lot of time has passed after taking the drug, it is necessary to wash the stomach (10 g of activated carbon powder and sodium sulfate are injected into the stomach). In order to quickly remove barbiturate from the body, forced diuresis with alkalis, as well as hemodialysis and / or hemoperfusion, can be performed.
Treatment of bromine poisoning: the removal of bromine ions from the body can be accelerated by the introduction of a significant amount of table salt solution with the simultaneous administration of saluretic agents.
If hypersensitivity reactions occur, prescribe desensitizing drugs.

Release form:

Drops Valocordin for oral administration, in dropper bottles of 20 and 50 ml.
Drops Valokrdin-Doxylamine drops 25 mg / ml: 20 or 50 ml in a vial.

Storage conditions:

Store in original packaging at a temperature not exceeding 25 °C.
Shelf life- 5 years.
Conditions for dispensing from pharmacies - dispensed without a prescription.

1 ml Valocordin drops for oral administration contains:
- ethyl ester of bromisovaleric acid - 2%;
- phenobarbital -2%;
- peppermint oil - 0.14%;
- hop oils -0.02%;
- a mixture of ethyl alcohol - 96%;
- distilled water - up to 10%.