Dimephosphone - reviews. Dimephosphon - reviews, instructions, application Reviews of Dimephosphon

Dimephosphone is a drug that normalizes the acid-base balance in the blood. The composition of dimephosphone includes the active component dimethyloxobutylphosphonyl dimethylate and the auxiliary substance - purified water. Dimephosphone has an antioxidant, anti-inflammatory, membrane-stabilizing and anti-acidotic pharmacological effect, reduces pulmonary and heart failure, normalizes the metabolism and blood flow of brain tissues, improves the regulation of blood circulation, including the brain. The antiacidotic effect of the drug is realized through the intensification of the pulmonary and renal mechanism for regulating the acid-base balance, enhancing tissue metabolism and intraorgan blood flow, reducing the content of pyruvic and lactic acid in the brain tissue.

Dimephosphone normalizes cell membranes, improves the functions of the brain stem and the functions of its cerebral hemispheres, reduces the depth of impaired consciousness, restores the wakefulness-sleep cycle, as well as reflexes with arcs closing through the stem sections, reduces the severity of auditory, visual, cerebellar, pyramidal and vestibular disorders. The antioxidant effect of dimephosphone is produced by increasing the activity of antioxidant enzymes in the brain tissues and preventing the activation of lipid peroxidation. The drug can enhance energy processes in the brain both directly, due to its direct effect on mitochondria, and indirectly, due to stimulation of the pituitary-thyroid system, increasing the consumption of thyroid hormones by tissues, which occurs accompanied by the activation of catabolic and energy processes in cellular mitochondria.

Dimephosphon exhibits the qualities of some neurotransmitters, reduces pulmonary and heart failure, restores the resistance of peripheral venous and arterial vessels. It helps to improve the regulation of cerebral circulation in the absence of pronounced vasodilating effects, but it has a positive effect on the metabolism of brain tissues during their ischemia, and normalizes venous outflow. Dimephosphone increases resistance to ischemia from nerve cells, reduces edema, improves microcirculation, which, in general, confirms the effectiveness of the use of this drug in clinical practice for various types of cerebrovascular insufficiency. When used topically, dimephosphone enhances the protective functions of the mucous membranes and skin, has an antiseptic and anti-inflammatory effect.

After a single dose of the drug, dimephosphone dimethyloxobutylphosphonyl dimethylate is quite completely absorbed into the bloodstream, easily penetrates and distributes through tissues and organs, reaches a maximum concentration in the blood plasma within an hour, and after three hours - in the spleen, heart and brain. After seventy-two hours, only a trace concentration of the drug remains in the body. It is excreted from the body mainly with urine.

The drug dimephosphone is produced in the form of a solution for internal and external use with a content of fifteen grams of the active ingredient, in orange glass bottles of one hundred milliliters. One bottle in a cardboard box. The shelf life of dimephosphone is three years, the drug is available by prescription.

Indications for use

Orally, as part of complex therapy

• in chronic non-specific lung diseases with signs of pulmonary heart and respiratory failure;
• with chronic and acute circulatory disorders in the brain;
• with the consequences of hemorrhagic and ischemic strokes;
• with craniocerebral injuries;
• during planned neurosurgical operations;
• with migraine;
• in chronic cerebrovascular insufficiency due to hypertension and atherosclerosis;
• with vegetative-vascular dystonia of the parasympathetic type;
• with multiple sclerosis;
• with osteochondrosis;
• with Meniere's disease;
• with pollinosis;
• with atopic bronchial asthma;
• with acidosis;
• in diseases of the respiratory system.

• with infectious-inflammatory-allergic diseases and damage to the mucous membranes and wounds (the areas of the seams and the exit of the Ilizarov wires, wounds, erysipelas);
• in the complex treatment of skin diseases in dermatology (acne, rosacea, oily seborrhea);
• in the prevention of radiation mucositis.

Contraindications for use

• with epilepsy;
• with chronic renal failure of the second and third degree;
• in children and adolescents up to eighteen years of age (there is no complete clinical data on the benefits or harms of the drug for this category of patients): the consequences of hemorrhagic and ischemic stroke, chronic and acute circulatory disorders in the brain, craniocerebral injuries, Meniere's disease, migraine, chronic cerebrovascular insufficiency due to hypertension and atherosclerosis, in chronic nonspecific lung diseases with signs of pulmonary heart and respiratory failure, multiple sclerosis, osteochondrosis, planned neurosurgical operations;
• in children under twelve years of age with vegetative-vascular dystonia of the parasympathetic type.

Side effects

The drug dimephosphone, when taken orally, can cause drowsiness, dyspepsia and impaired concentration (symptoms disappear by the third or fourth day of taking the medicine).

Reviews about Dimephosphon

Here are some characteristic reviews of Dimephosphone:

• Olya. I am taking dimephosphon after having radiation therapy on my throat. The puffiness subsided, the pains disappeared, I can drink and eat. Helps. Only expensive medicine.

• Victor. At me at a chicken pox the cerebral circulation is broken. Began to drink dimephosphone. It helps me feel better.

"Reviews!"

Dimephosphone is an antiacidemic agent that normalizes blood flow and metabolism of brain tissues and acid-base balance in acidosis of various etiologies, reduces pulmonary and heart failure, and improves the regulation of blood circulation, including cerebral. When applied topically, the drug has an antiseptic effect.

Release form and composition

Dosage forms of Dimephosphone - 15% solution for oral and external use, as well as a concentrate for preparing a solution for injection.

The active substance of the drug is dimethyloxobutylphosphonyl dimethylate. In 100 ml of solution it contains 15 grams. Purified water is used as an auxiliary component.

1 ml of concentrate contains 1 gram of dimethyloxobutylphosphonyl dimethylate.

Dimephosphone solution is sold in 100 ml glass bottles, concentrate - in 1 ml ampoules.

Indications for use

According to the instructions for Dimephosphone, the drug is used for:

• Acidosis caused by diabetes mellitus, SARS, chronic lung diseases, pneumonia;
• Acidosis in the postoperative period;
• Pollinosis in children;
• Myelopathy and radiculopathy;
• Bronchospastic variant of bronchial obstruction, including chronic bronchitis, bronchial asthma, incl. atopic bronchial asthma in children;
• Dyscirculatory encephalopathy, incl. developed against the background of arterial hypertension;
• Subcompensated hypertension in the pulmonary circulation;
• Atopic dermatitis;
• Rickets-like diseases in children;
• Mucositis developed as a result of radiation therapy for malignant neoplasms;
• Transient ischemic attacks, ischemic and hemorrhagic stroke (at the initial stages of the disease; with complications after a previous stroke);
• Syndrome and Meniere's disease;
• Vegetative lability;
• Infected wounds and trophic ulcers;
• Hereditary entero-oxaluric syndrome;
• Traumatic brain injuries (concussion and bruise of the brain);
• Neurosurgical surgical injuries of the brain and spinal cord;
• Diseases of the ENT organs;
• dental diseases;
• Infectious and inflammatory diseases of the skin and mucous membranes, including acne, erysipelas, as well as purulent-inflammatory complications at the exit points of the spokes of the Ilizarov apparatus.

Contraindications

The use of Dimephosphone is contraindicated in:

• Hypersensitivity to dimethyloxobutylphosphonyl dimethylate;
• epilepsy;
• Chronic renal failure II and III stages.

Method of application and dosage

According to the instructions for Dimephosphon, the dosage of a 15% oral solution is determined at the rate of 30-50 mg per kilogram of weight. Take the drug, depending on the doctor's prescription, from 1 to 4 times a day. The solution has a bitter taste, so children can be given to drink it with sweet tea, milk or fruit juice.

Duration of Dimephosphon use:

• With Meniere's syndrome and disorders of cerebral circulation - 1-4 weeks;
• With autonomic dysfunction, atopic bronchial asthma in children, acidosis and respiratory diseases - 2-4 weeks;
• With craniocerebral injuries - from 3 to 8 weeks;
• When carrying out planned neurosurgical interventions - 5 days before surgery and 10-14 after;
• With hay fever for the prevention of exacerbation - starting 3 weeks before the expected seasonal deterioration and throughout the entire flowering period of the allergen plant.

External use of Dimephosphone:

• In infectious-inflammatory-allergic diseases of the mucous membranes and skin - in the form of lotions, turundas and dressings with a 15% solution daily for 3-14 days;
• In order to prevent the development of radiation mucositis, gauze wipes soaked in a solution are placed in the projection of radiation beams approximately 20 minutes before the dose is exposed;
• In case of acne, the solution should wipe the skin 3-4 times a day, and in the evening make additional lotions;
• With erysipelas - lubricate the affected areas three times a day.

A solution for intravenous infusion is prepared from Dimephosphone concentrate:

• For jet administration, the contents of 1-2 ampoules are diluted, respectively, in 10 or 20 ml of sterile injection water or 0.9% sodium chloride solution;
• For drip administration, the contents of 1-2 ampoules are diluted in 200-400 ml of 0.9% NaCl solution.

Enter the drug 1-4 times a day. Treatment usually lasts 7 to 10 days.

Side effects

In the vast majority of cases, Dimephosphone, according to patient reviews, is well tolerated.

When ingested, diarrhea, heartburn, nausea, and vomiting are sometimes noted.

At the beginning of treatment, some patients experience increased drowsiness and a deterioration in the ability to concentrate.

special instructions

When applied to mucous membranes, Dimephosphone can cause irritation, in which case the solution can be diluted with water (twice).

The drug can cause drowsiness and impair the ability to concentrate, especially at the beginning of treatment, therefore, in the first days of using Dimephosphon, it is recommended to refrain from potentially hazardous activities and driving a car.

Analogues

Dimephosphone has no structural analogues. In this or that case, the doctor may prescribe one of the following drugs: Actinogyal, Homeovox, Carmolis, Kokkulin, Laprot, Ronidaza, Ingafitol, Lidaza, Longidaza, Mucosa compositum, Pulsatilla compositum, Strumel T, Ceruloplasmin, Cystamin, Ubiquinone compositum, Schwef-Hel , Mardil Selen, Neovasculgen.

Terms and conditions of storage

Dimephosphon belongs to a group of drugs sold in pharmacies by prescription.

Store the medicinal product, according to the instructions, in a dark place at temperatures up to 25 ºС. Shelf life - 3 years.

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Antiacidemic agent, normalizes the acid-base state in acidosis of various etiologies - by activating the metabolic mechanisms of its regulation (especially renal and pulmonary), enhancing intraorganic blood flow and tissue metabolism. It has a cerebrovasodilating, nootropic, antidepressant, antiedematous, antiischemic, stress-protective, mnemotropic and antiamnestic, antiallergic, membrane stabilizing, immunomodulatory, antihypoxant, antimutagenic and radioprotective action, inhibits platelet aggregation, stimulates tissue regeneration.

Dose-dependently reduces the intensity of lipid peroxidation, inhibits spontaneous and ADP-induced aggregation, increases the antioxidant activity of platelets and reduces the content of lipid peroxidation products in them.

Improves cerebral circulation, normalizes the tone of cerebral vessels and blood supply to the brain, improves venous outflow. Neurotropic activity and cerebroprotective properties are due to the effect on the mechanisms of neurometabolic protection of the brain (normalizes carbohydrate and energy metabolism, prevents the activation of lipid peroxidation, increases the activity of antioxidant enzymes in the brain tissue).

In traumatic brain injury, it has a beneficial effect on its metabolism and electrical activity; eliminates vasomotor cephalgia; reduces oxygen consumption by brain tissues, cardiac and respiratory failure of central origin, promotes regression of focal hemispheric and stem symptoms. Eliminates allergic inflammation, in particular, with the development of a leukotriene-dependent reaction of intolerance to sulfites, reduces the severity of manifestations of atopic bronchial asthma and atopic dermatitis. In combination with vitamins, pancreatic enzymes and cholestyramine in children with hereditary entero-oxaluric syndrome, it slows down the progression of the disease and increases life expectancy.

When applied topically, it has an antiseptic effect, increases the protective functions of the skin and mucous membranes.

Dimephosphone is an antiacidemic drug that normalizes the acid-base state (ACS) in acidosis of various etiologies.

Release form and composition

The medicine is produced in the form of:

• 15% solution for oral administration, 100 ml of which contains 15 mg of dimethyloxobutylphosphonyl dimethylate and distilled water (up to 100 ml);
• concentrate for the preparation of a solution intended for intravenous injection and external use, 1 gram of which contains 1 g of the active substance.

Indications for use

According to the instructions for Dimephosphon, the drug is intended for the treatment of:

• pollinosis (hay fever) in children;
• rickets-like diseases in children;
• infected wounds and trophic ulcers;
• acidosis that developed in the period after surgery.

Dimephosphone is also used for:

• transient ischemic attacks;
• dyscirculatory encephalopathy (including if it developed against the background of arterial hypertension);
• neurological diseases of the spinal cord, radiculopathy;
• craniocerebral injuries (in case of a concussion or bruise of the brain);
• atopic dermatitis;
• diseases of the skin and mucous membranes of an infectious and inflammatory nature, as well as with purulent-inflammatory complications at the exit points of the spokes of the Ilizarov apparatus;
• dental and ENT diseases;
• erythematous and erosive-ulcerative lesions of the mucosa of the digestive tract, due to radiation therapy in malignant tumors.

In addition, Dimephosphone is prescribed to patients with:

• diabetes mellitus;
• acute respiratory viral infections;
• chronic lung diseases;
• subcompensated hypertension in the pulmonary circulation;
• Meniere's disease or syndrome;
• with an unstable autonomic nervous system;
• entero-oxaluric syndrome.

• who have had a hemorrhagic or ischemic stroke (both for the purpose of treating the initial manifestations of the pathology, and to eliminate the consequences of a stroke suffered earlier);
• who have undergone neurosurgical surgery on the brain or spinal cord.

Contraindications

The use of Dimephosphon, according to the instructions, is contraindicated:

• with hypersensitivity to dimethyloxobutylphosphonyl dimethylate or any auxiliary component;
• patients with renal insufficiency of the second and third degree;
• with epilepsy.

Method of application and dosage

The dosage of a 15% solution of Dimephosphone is calculated depending on the weight of the patient. As a rule, the drug is prescribed at the rate of 30-50 mg per kilogram of body weight. The frequency of receptions is from 1 to 4 times a day. Due to the fact that the drug has a bitter taste, children are advised to drink it with a sweet liquid (juice or tea) or milk.

The duration of treatment with Dimephosphone depends on the diagnosis:

• In conditions accompanied by disorders of cerebral circulation, as well as in Meniere's syndrome, the drug is taken for 7-28 days;
• With TBI, the solution is drunk for 3-8 weeks;
• For planned neurosurgical interventions, the following treatment regimen is recommended: 5 days before surgery and 10-14 days in the postoperative period;
• With acidosis, diseases of the respiratory tract, atopic bronchial asthma in children, treatment is continued for 2-4 weeks;
• In order to prevent exacerbation of hay fever, it is recommended to undergo a three-week course of treatment before the expected seasonal worsening, as well as continue taking the drug throughout the entire flowering period of the allergen plant.

As an external agent, the solution is used in the form of applications, lotions, turundas and dressings. Indications for the use of Dimephosphon are infectious, inflammatory and allergic diseases of the skin and mucous membranes. The course of treatment lasts from 3 days to 2 weeks, depending on the severity of the symptoms.

To prevent mucositis, which often occurs during radiation therapy, it is recommended to apply a gauze bandage moistened with a solution to the area of ​​​​the projection of radiation beams twenty minutes before the exposure of the dose.

For intravenous injections, Dimephosphone concentrate is used, from which a solution is prepared. Enter it:

• jet, previously diluting the contents of 1-2 ampoules, respectively, in 10 or 20 ml of water for injection or isotonic NaCl solution;
• drip, diluting the solution with 0.2-0.4 l of isotonic sodium chloride solution.

The frequency of injections is 1-4 times a day, the course of treatment lasts from 1 week to 10 days.

Side effects

According to patient reviews, in most cases, Dimephosphone is well tolerated and has no side effects. Rarely, diarrhea, nausea, heartburn, and vomiting occur.

At the beginning of treatment, drowsiness may occur, which disappears on its own within a few days.

In individual cases - in the presence of hypersensitivity or intolerance to one or another component of Dimephosphon - the development of allergic reactions is possible.

special instructions

Since one of the side effects of the drug is drowsiness, in the first days of treatment it is recommended to refrain from driving and performing potentially hazardous activities that require speed of reactions and increased concentration.

With simultaneous use, Dimephosphone potentiates the antiplatelet effect of acetylsalicylic acid.

Analogues

Dimephosphon has no structural analogues. The following drugs are produced with a similar mechanism of action: Actinogal, Arnigel, Berberis-Homaccord, Galium-hel, Gepar compositum, Homeovox, Homeostres, Carmolis, Kokkulin, Coenzyme compositum, Laprot, Lidaza, Longidaza, Mardil Selenium, Neovasculgen, Pulsatilla compositum, Ronidase, Strumel T, Ubiquinone compositum, Ceruloplasmin, Cystamin, Garlic tincture, Garlic extract, Schwef-Hell.

Terms and conditions of storage

Dimephosphone is a drug of list B. It should be stored in a cool place, protected from sunlight. Subject to these recommendations, the shelf life of a 15% solution is 1.5 years, a concentrate - 2 years.

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Dimephosphone is a synthetic drug that normalizes the acid-base environment caused mainly by acute respiratory and infectious diseases.

Widely used in pediatrics.

pharmachologic effect

Antiacidemic agent. It is used in the treatment of acute respiratory and other infectious diseases, diabetes mellitus, rickets-like diseases that cause acid-base balance disorders. Dimephosphon has antiseptic, immunomodulatory, antiischemic, membrane stabilizing, antiamnestic, antidepressant, antiallergic, antiedematous and stress-protective effects.

When applied externally, it has an antiseptic effect, increasing the protective functions of the skin and mucous membranes. With traumatic brain injuries, it has a beneficial effect on tissue metabolism and electrical activity.

The active substance of Dimephosphone is dimethyloxobutylphosphonyl dimethylate.

Release form

Dimephosphone is produced as a solution (colorless transparent liquid) for internal and external use. 100 ml of the solution contains 15 mg of dimethyloxobutylphosphonyl dimethylate and the excipient is water. In orange glass bottles of 100 ml.

Indications for use

The drug is effective in the treatment of a wide range of diseases.

According to the instructions, Dimephosphone is used as part of complex therapy for:

• acidosis;
• Acute and chronic disorders of cerebral circulation;
• Respiratory diseases and respiratory failure in infectious and inflammatory diseases (influenza, SARS, pneumonia, tuberculosis);
• Traumatic brain injuries;
• Osteochondrosis;
• Vegetative-vascular dystonia of the parasympathetic type;
• multiple sclerosis;
• Migraine;
• Meniere's disease;
• Planned neurosurgical operations;
• Atopic bronchial asthma;
• Consequences of ischemic and hemorrhagic strokes;
• Pollinose.

Outwardly Dimephosphone is used to treat:

• Trophic ulcers;
• Traumatic disorders of the skin and soft tissues;
• Erysipelas;
• Burns.

Dimephosphone is also used as a prophylaxis of purulent-inflammatory complications in traumatology at the exit points of the spokes of the Ilizarov apparatus.

Contraindications

According to the instructions, Dimephosphone is contraindicated in epilepsy, increased convulsive readiness and renal failure of 2-3 degrees.

The drug is also not used for hypersensitivity to the active substance.

Application instruction of Dimefosfon

Dimephosphone can be used orally, topically, or as an intravenous injection. The dose of the drug is calculated the same for children and adults based on body weight.

When taken orally as a solution - 30-50 mg per 5 kg of body weight. Apply after meals, usually with water.

The drug is taken 1-4 times a day. The duration of treatment depends on the disease:

• With acidosis, respiratory diseases, disorders of cerebral circulation and bronchial asthma, children are prescribed from one to four weeks. According to reviews after Dimephosphon, improvement in children occurs quite quickly;
• When carrying out neurosurgical operations, the drug is used for 5 days before the operation and 10-14 after it;
• With craniocerebral injuries, the course is longer, usually from 3 weeks to 2 months;
• To prevent exacerbation of hay fever, Dimephosphone is used for children and adults before the expected exacerbation and does not stop taking throughout the entire period of pollination of plants.

According to the instructions, Dimephosphone is used externally in the form of lotions, dressings or turundas for skin diseases of allergic and infectious-inflammatory origin or for inflammation of the mucous membranes. The drug is used until the disappearance of clinical manifestations.

Dimephosphone is used intravenously 1-4 times a day for 7-10 days:

• Jet. The contents of 1-2 ampoules are diluted with water for injection or 0.9% sodium chloride solution (10-20 ml);
• Drip. The contents of 1-2 ampoules are diluted with 0.9% sodium chloride solution (200-400 ml).

According to reviews, Dimephosphone at the beginning of treatment can cause drowsiness and indigestion. During this period, you need to drive vehicles with caution. With an overdose, the side effects increase. In this case, activated charcoal, symptomatic therapy and gastric lavage are used.

Storage conditions

Dimephosphone is available by prescription. Shelf life - 3 years.

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