Instructions for use of dimephosphone, price, reviews, analogues. Means "Dimephosphon". Instructions for use and description Externally, Dimephosphone is used to treat

Are you here: Nervous

An anti-acidemic agent that normalizes the acid-base state during acidosis of various etiologies - by activating the metabolic mechanisms of its regulation (especially renal and pulmonary), increasing intraorgan blood flow and tissue metabolism. It has cerebrovasodilating, nootropic, antidepressant, decongestant, anti-ischemic, stress-protective, mnemotropic and antiamnestic, antiallergic, membrane-stabilizing, immunomodulatory, antihypoxic, antimutagenic and radioprotective effects, suppresses platelet aggregation, stimulates tissue regeneration.

Dose-dependently reduces the intensity of lipid peroxidation, inhibits spontaneous and ADP-induced aggregation, increases the antioxidant activity of platelets and reduces the content of lipid peroxidation products in them.

Improves cerebral circulation, normalizes the tone of cerebral vessels and blood supply to the brain, improves venous outflow. Neurotropic activity and cerebroprotective properties are due to the impact on the mechanisms of neurometabolic protection of the brain (normalizes carbohydrate and energy metabolism, prevents the activation of lipid peroxidation, increases the activity of antioxidant enzymes in brain tissue).

In case of traumatic brain injury, it has a beneficial effect on its metabolism and electrical activity; eliminates vasomotor cephalgia; reduces oxygen consumption by brain tissue, cardiac and respiratory failure of central origin, promotes regression of focal hemispheric and brainstem symptoms. Eliminates allergic inflammation, in particular, with the development of a leukotriene-dependent reaction of sulfite intolerance, reduces the severity of manifestations of atopic bronchial asthma and atopic dermatitis. In combination with vitamins, pancreatic enzymes and cholestyramine in children with hereditary entero-oxaluric syndrome, it slows down the progression of the disease and increases life expectancy.

When applied topically, it has an antiseptic effect and increases the protective functions of the skin and mucous membranes.

Description and instructions for the drug Dimephosphone

Dimephosphone is a medicine that leads to normalization of the acid-base balance in the patient’s blood. This effect is achieved through the action of a substance called dimethyloxobutylphosphonyl dimethylate. This compound enhances metabolic processes, “pumping” blood through internal organs, and dilates blood vessels that ensure blood delivery to the brain. Dimephosphone has anti-stress, anti-allergic, regenerative and many other effects. The kidneys and lungs, under the influence of the medicine, reduce the acidity of the blood flowing through them. Dimephosphone also has antiseptic properties. They can also be used for external local treatment, treating areas of the skin that need to be disinfected.

Dimephosphone is used for:

- inside –

Surgical and traumatic brain lesions;
Infectious lesions accompanied by difficulty breathing, including ARVI, pneumonia and so on;
Recovery after resuscitation;

- externally –

Burns;
Erysipelas;
Trophic ulcers;
Ranah;
Traumatic disorders of the skin and soft tissues.

Dimephosphone is produced in the form of a solution that you can drink and treat the skin with, according to indications. This medicine should be taken orally after meals. It is washed down with water. The instructions for the drug Dimephosphon show how to select its dosage for patients of different age groups. If this drug is used externally, then it can be used to impregnate the dressing material, which is adjacent and directly placed into the wound. In addition, you can treat with Dimephosphone surfaces that remain open and are not covered by a bandage.

Dimephosphone is contraindicated for:

Epilepsy;
Severe and moderate kidney dysfunction;
Drug intolerance.

Side effects and overdose of Dimephosphone

Taking Dimephosphone orally can cause digestive disorders in the patient. In addition, the nervous system may develop fatigue and drowsiness.

Reviews of Dimephosphone

It’s not very often that you come across reviews of Dimephosphone. Typically, mentions of this drug are questions about its use. Mothers of children whose kidney health suffers are especially often worried about the possibility and necessity of using Dimephosphone:

We found sediment in the bladder. A diagnosis of “hidden” was made. However, urine tests are good. As a result, Dimephosphon was prescribed. Well, there are no problems with canephron - it is herbal and has helped many. But I still can’t figure out the second drug: there are few reviews, I haven’t found any about its use in children, the indications for its use are very severe, and they don’t contain our diagnosis!

I have some kind of inflammatory process going on in my genitourinary system. So far the tests have yielded nothing. I drink, which are periodically prescribed. I noticed that if you reduce the acidity of your urine, your condition improves. I found the drug Dimephosphone on the Internet, but I don’t know how to use it correctly.

Obviously, such issues need to be resolved with your doctor. If a specialist cannot or does not want to give comprehensive explanations about the prescribed medication, this is a reason to look for another doctor. In absentia, it cannot be recommended to use Dimephosphon internally, since it has too broad an effect on the state of the nervous, respiratory, and urinary systems.

Rate Dimephosphone!

Helped me 296

Didn't help me 43

General impression: (236)

The drug "Dimephosphon", the price of which is within 300 rubles, belongs to the membrane-stabilizing, immunomodulating, anti-inflammatory drugs. The drug has radioprotective and antihypoxic activity. The medication exhibits an antioxidant effect and dose-dependently reduces the severity of lipid peroxidation. By activating metabolic mechanisms, the acid-base state is normalized, tissue metabolism and intraorgan blood flow are enhanced. The drug "Dimephosphon" (reviews from experts confirm this) has some neuropharmacological properties.

Thus, the drug has a nootropic, anti-amnestic and antidepressant effect, and is distinguished by anti-ischemic, mnemotropic, stress-protective effects. Thanks to the action of the drug "Dimephosphon" (the instructions for use contain such data), cerebral circulation and venous outflow are improved, blood supply to the brain and tone in the cerebral vessels are normalized. Neurotropic effects and cerebroprotective activity are determined by the effect on the neurometabolic system of the brain. Energy and carbohydrate metabolism are normalized, the activity of antioxidant enzymes in brain tissue increases, and the development of lipid peroxidation is prevented. The maximum level in the blood is observed 2-3 hours after taking the medicine.

Means "Dimephosphon". Instructions for use. Indications

The medicine is prescribed for disorders of cerebral circulation associated with hypertension, atherosclerosis, spinal pathologies, and vasomotor dystonia. Indications include, in particular, radiculopathy, myelopathy, discirculatory encephalopathy, consequences of previous and ischemic strokes, and transient ischemic attacks. The instructions for use recommend the drug "Dimephosphon" for TBI, surgical injuries of the spinal cord and brain of a neurosurgical nature, disease and Meniere's syndrome.

The medicine is prescribed for chronic and acute pathologies in the respiratory tract, accompanied by pulmonary subcompensated hypertension, acidosis in pneumonia, bronchospastic variant of bronchial obstruction (pulmonary tuberculosis, bronchial asthma, chronic bronchitis). Indications include atopic dermatitis, pathologies in the ENT organs, rickets-like diseases in children, trophic ulcers, infected wounds, acute respiratory viral lesions, entero-oxaluric syndrome of a hereditary nature.

Medicine "Dimephosphon". Instructions for use

The drug is prescribed intravenously. The contents of 1-2 ampoules are diluted in 10-20 ml of water (sterile) for injection or 0.9% sodium chloride solution. For drip administration, the drug is dissolved in 200-400 ml of sodium chloride 0.9%. Injections are carried out 1-4 times a day for seven or ten days. Oral medication is recommended at a dose of 30-50 mg/kg no more than four times a day. The duration of therapy against the background of children, pathologies in the respiratory system and acidosis, with autonomic dysfunction, and circulatory disorders is from one to four weeks, for TBI - from three weeks to two months.

Dimephosphone is a synthetic drug that normalizes the acid-base environment, mainly caused by acute respiratory and infectious diseases.

Widely used in pediatrics.

pharmachologic effect

Antiacidemic agent. It is used in the treatment of acute respiratory and other infectious diseases, diabetes mellitus, rickets-like diseases that cause acid-base imbalance. Dimephosphone has antiseptic, immunomodulatory, anti-ischemic, membrane-stabilizing, anti-amnestic, antidepressant, anti-allergic, decongestant and stress-protective effects.

When used externally, it has an antiseptic effect, increasing the protective functions of the skin and mucous membranes. In case of traumatic brain injury, it has a beneficial effect on tissue metabolism and electrical activity.

The active ingredient of Dimephosphone is dimethyloxobutylphosphonyl dimethylate.

Release form

Dimephosphone is produced in the form of a solution (colorless transparent liquid) for internal and external use. 100 ml of solution contains 15 mg of dimethyloxobutylphosphonyl dimethylate and an excipient - water. In orange glass bottles of 100 ml.

Indications for use

The drug is effective in treating a wide range of diseases.

According to the instructions, Dimephosphone is used as part of complex therapy for:

Acidosis;
Acute and chronic cerebrovascular accidents;
Diseases of the respiratory system and respiratory failure due to infectious and inflammatory diseases (influenza, ARVI, pneumonia, tuberculosis);
Traumatic brain injuries;
Osteochondrosis;
Vegetative-vascular dystonia of the parasympathetic type;
Multiple sclerosis;
Migraine;
Meniere's disease;
Planned neurosurgical operations;
Atopic bronchial asthma;
Consequences of ischemic and hemorrhagic strokes;
Pollinosis.

Externally, Dimephosphone is used to treat:

Trophic ulcers;
Traumatic disorders of the skin and soft tissues;
Erysipelas;
Burns.

Dimephosphon is also used as a prevention of purulent-inflammatory complications in traumatology at the exit sites of the Ilizarov apparatus wires.

Contraindications

According to the instructions, Dimephosphone is contraindicated for epilepsy, increased convulsive readiness and grade 2-3 renal failure.

The drug is also not used in case of hypersensitivity to the active substance.

Instructions for use of Dimephosphone

Dimephosphone can be used orally, topically, or as an intravenous injection. The dose of the drug is calculated the same for children and adults based on body weight.

When taken orally in the form of a solution - 30-50 mg per 5 kg of body weight. Use after meals, usually with water.

The drug is taken 1-4 times a day. The duration of treatment depends on the disease:

For acidosis, respiratory diseases, cerebrovascular accidents and bronchial asthma, children are prescribed from one to four weeks. According to reviews, after Dimephosphone, improvement in children occurs quite quickly;
When performing neurosurgical operations, the drug is used for 5 days before surgery and 10-14 after it;
For traumatic brain injuries, the course is longer, usually from 3 weeks to 2 months;
To prevent exacerbation of hay fever, Dimephosphone is used for children and adults before the expected exacerbation and does not stop taking it throughout the entire period of plant dusting.

Externally, Dimephosphon is used according to the instructions in the form of lotions, bandages or turundas for skin diseases of allergic and infectious-inflammatory origin or for inflammation of the mucous membranes. The drug is used until clinical manifestations disappear.

Intravenous Dimephosphone is used 1-4 times a day for 7-10 days:

Jet. The contents of 1-2 ampoules are diluted with water for injection or 0.9% sodium chloride solution (10-20 ml);
Drip. The contents of 1-2 ampoules are diluted with 0.9% sodium chloride solution (200-400 ml).

According to reviews, Dimephosphone may cause drowsiness and indigestion at the beginning of treatment. During this period, you need to drive with caution. With an overdose, the side effects increase. In this case, activated charcoal, symptomatic therapy and gastric lavage are used.

Storage conditions

Dimephosphone is available by prescription. Shelf life – 3 years.

Sincerely,

Dimephosphone is an anti-acidemic drug that normalizes the acid-base state (ABS) in acidosis of various etiologies.

Release form and composition

The medicine is available in the form:

15% oral solution, 100 ml of which contains 15 mg of dimethyloxobutylphosphonyl dimethylate and distilled water (up to 100 ml);
concentrate for the preparation of a solution intended for intravenous injection and external use, 1 gram of which contains 1 g of active substance.

Indications for use

According to the instructions for Dimephosphone, the drug is intended for the treatment of:

hay fever (hay fever) in children;
rickets-like diseases in children;
infected wounds and trophic ulcers;
acidosis that developed in the period after surgery.

Dimephosphone is also used for:

transient ischemic attacks;
dyscirculatory encephalopathy (including if it developed against the background of arterial hypertension);
neurological diseases of the spinal cord, radiculopathy;
traumatic brain injuries (in case of concussion or bruise of the brain);
atopic dermatitis;
diseases of the skin and mucous membranes of an infectious and inflammatory nature, as well as with purulent-inflammatory complications at the exit sites of the Ilizarov apparatus wires;
dental and ENT diseases;
erythematous and erosive-ulcerative lesions of the mucous membrane of the digestive tract caused by radiation therapy for malignant tumors.

In addition, Dimephosphone is prescribed to patients with:

diabetes mellitus;
acute respiratory viral infections;
chronic lung diseases;
subcompensated hypertension in the pulmonary circulation;
Meniere's disease or syndrome;
with an unstable autonomic nervous system;
entero-oxaluric syndrome.

those who have suffered a hemorrhagic or ischemic stroke (both for the purpose of treating the initial manifestations of the pathology, and to eliminate the consequences of a stroke suffered earlier);
who have undergone neurosurgical surgery on the brain or spinal cord.

Contraindications

The use of Dimephosphone, according to the instructions, is contraindicated:

with hypersensitivity to dimethyloxobutylphosphonyl dimethylate or any auxiliary component;
patients with second and third degree renal failure;
for epilepsy.

Directions for use and dosage

The dosage of 15% Dimephosphone solution is calculated depending on the patient’s weight. As a rule, the drug is prescribed at the rate of 30-50 mg per kilogram of body weight. The frequency of doses is from 1 to 4 times a day. Due to the fact that the drug has a bitter taste, children are advised to take it with a sweet liquid (juice or tea) or milk.

The duration of treatment with Dimephosphon depends on the diagnosis:

For conditions accompanied by cerebrovascular accidents, as well as Meniere's syndrome, the drug is taken for 7-28 days;
For TBI, drink the solution for 3-8 weeks;
For planned neurosurgical interventions, the following treatment regimen is recommended: 5 days before surgery and 10-14 days in the postoperative period;
For acidosis, respiratory tract diseases, atopic bronchial asthma in children, treatment is continued for 2-4 weeks;
In order to prevent exacerbation of hay fever, it is recommended to undergo a three-week course of treatment before the expected seasonal deterioration, and also to continue taking the drug throughout the entire period of flowering of the allergen plant.

As an external agent, the solution is used in the form of applications, lotions, turundas and dressings. Indications for the use of Dimephosphone are infectious, inflammatory and allergic diseases of the skin and mucous membranes. The course of treatment lasts from 3 days to 2 weeks depending on the severity of symptoms.

To prevent mucositis, which often occurs during radiation therapy, it is recommended to apply a gauze bandage moistened with a solution to the area of projection of the radiation beams twenty minutes before dose exposure.

For intravenous injections, Dimephosphone concentrate is used, from which a solution is prepared. Enter it:

in a stream, after diluting the contents of 1-2 ampoules, respectively, in 10 or 20 ml of water for injection or isotonic NaCl solution;
drip, diluting the solution with 0.2-0.4 liters of isotonic sodium chloride solution.

The frequency of injections is 1-4 times a day, the course of treatment lasts from 1 week to 10 days.

Side effects

According to patient reviews, in most cases Dimephosphone is well tolerated and has no side effects. In rare cases, diarrhea, nausea, heartburn and vomiting may occur.

At the beginning of treatment, drowsiness may occur, which goes away on its own within a few days.

In individual cases - in the presence of hypersensitivity or intolerance to one or another component of Dimephosphone - allergic reactions may develop.

special instructions

Since one of the side effects of the drug is drowsiness, in the first days of treatment it is recommended to refrain from driving and performing potentially dangerous activities that require quick reactions and increased concentration.

With simultaneous use, Dimephosphone potentiates the antiplatelet effect of acetylsalicylic acid.

Analogs

Dimephosphone has no structural analogues. The following drugs are produced with a similar mechanism of action: Actinogial, Arnigel, Berberis-Gomaccord, Galium-hel, Gepar compositum, Homeovox, Homeostres, Carmolis, Kokkulin, Coenzyme compositum, Laprot, Lidaza, Longidaza, Mardil Selenium, Neovasculgen, Pulsatilla compositum, Ronidase, Strumel T, Ubiquinone compositum, Ceruloplasmin, Cystamine, Garlic tincture, Garlic extract, Schwef-Hell.

Terms and conditions of storage

Dimephosphone is a Schedule B drug. It should be stored in a cool place, protected from sunlight. If these recommendations are followed, the shelf life of a 15% solution is 1.5 years, of a concentrate – 2 years.