Streptocide group. Streptocide (tablets): instructions for use. The ability to influence the reaction rate when driving vehicles or other mechanisms

Streptocide is an antimicrobial drug belonging to the group of chemotherapeutic drugs with a bacteriostatic effect against streptococci, gonococci, meningococci, Escherichia coli, pneumococci and other bacteria.

In this article we will look at why doctors prescribe Streptocide, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Streptocide can be read in the comments.

Composition and release form

The drug is available in the following dosage forms:

• Suspension 5% containing streptocide 5 g, thymol 0.5 g, distilled water 69.75 g, and emulsifier 20 g;
• White tablets containing 300 and 500 mg of streptocide, in packs of ten pieces;
• Streptocidal ointment 5% and 10% on a vaseline basis, in tubes of 25, 30 or 50 g;
• Liniment 5%, which contains streptocide 5 g, animal fat 3.1 g, lime water 57.9 g, fish oil 34 g, in cans of 25 or 30 g.

What does Streptocide help with?

According to the instructions, Streptocide is indicated for:

• epidemic cerebrospinal meningitis;
• sore throat and various coccal infections;
• chronic and acute gonorrhea;
• wound infections;
• colitis;
• pyelite;
• colibacillary cystitis.

Treatment with Streptocide is especially effective for infections caused by beta-hemolytic streptococcus (puerperal sepsis, erysipelas, streptococcal pneumonia, etc.).

pharmachologic effect

In accordance with the instructions of Streptocide, the drug has a bacteriostatic effect. This drug is active against gram-negative and gram-positive cocci, chlamydia, nocardia, gram-negative rods, as well as protozoa. An alkaline environment promotes the activation of streptocide.

Treatment with Streptocide is not effective in the presence of anaerobes, enterococci, and Pseudomonas aeruginosa.

Instructions for use

The powder is used externally, applied directly to the infected areas, dressings are done once every 1-2 days. Maximum doses:

• children over 3 years old: once/daily – 0.3 g;
• adult patients: single dose – 5 g, daily – 15 g.

Streptocid tablets:

• Orally for adults – 500 mg-1 g 5-6 times a day; children under 1 year – 50-100 mg, from 2 to 5 years – 200-300 mg, from 6 to 12 years – 300-500 mg per dose.

The ointment is used topically and externally to lubricate the affected surface or apply gauze napkins with ointment to the affected areas; dressings are done once every 1-2 days.

Contraindications

Diseases of the hematopoietic system, kidneys, Graves' disease (thyroid disease), hypersensitivity to sulfonamides.

Side effects

After using streptocide, side effects such as severe headache, slight dizziness, gag reflex, nausea and vomiting cannot be ruled out. Some patients experienced a severe allergic reaction, as well as impaired cardiovascular function, manifested in the form of tachycardia.

In case of overdose of the drug, it is necessary to perform gastric lavage with a 2% solution of sodium bicarbonate and activated carbon, as well as other enterosorbents. In case of overdose, nausea, vomiting, headache, dizziness, tachycardia, paresthesia, cholestasis, diarrhea, renal shock, hematuria, cyanosis are possible.

Analogues

According to the active substance, structural analogues of streptocide are such drugs as: Streptonitol, Osartsid, Sulfanilamide. In addition, the following streptocide preparations are produced: soluble streptocide in the form of a white powder. This analogue of the drug, due to its good dissolution in water, can be used not only internally, but also intramuscularly, intravenously or subcutaneously.

Sunoref ointment, which contains streptocide, eucalyptus oil, sulfadimezin, camphor, ephedrine hydrochloride, norsulfazole. The ointment is used topically to treat acute and chronic rhinitis.

Pills.

Basic physical and chemical properties: white tablets with a flat surface, scored and chamfered.

Pharmacological group

Antibacterial agents for systemic use. Short-acting sulfonamides.

ATX code J01E B06.

Pharmacological properties

Pharmacological.

Streptocide disrupts the creation of so-called “germ factors” in microorganisms - folic, dehydrofolic acids, and other compounds that have PABA (PABA) in their molecule. Due to the similarity of the structures of PABA and Streptocide, sulfanilamide, as a competitive acid antagonist, is included in the metabolic chain of microorganisms and disrupts metabolic processes in it, which leads to a bacteriostatic effect. Streptocide is a short-acting sulfonamide that exhibits a bacteriostatic effect against streptococci, meningococci, pneumococci, gonococci, E. coli, pathogens of toxoplasmosis and malaria. Does not affect anaerobic microorganisms.

Pharmacokinetics.

When taken orally, it is quickly absorbed - the maximum concentration of streptocide in the blood is determined after 1-2 hours (within 4:00 it appears in the cerebrospinal fluid); a decrease in the maximum concentration in the blood by 50% occurs in less than 8:00. Approximately 95% is excreted by the kidneys.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug: infectious diseases of the skin and mucous membranes (wounds, ulcers, bedsores), enterocolitis, pyelitis, cystitis.

Contraindications

Sensitivity to sulfonamides, sulfones or other components of the drug; a history of severe toxic-allergic reactions to sulfonamides; inhibition of hematopoiesis in the bone marrow; uncompensated heart failure; diseases of the hematopoietic system; anemia leukopenia Graves' disease; kidney and liver diseases (nephrosis, nephritis, liver failure, severe renal failure, acute hepatitis) hyperthyroidism, congenital deficiency of glucose-6-phosphate dehydrogenase; azotemia; porphyria.

Interaction with other drugs and other types of interactions

When used simultaneously

¾ with non-steroidal anti-inflammatory drugs, sulfonylurea derivatives, anticoagulants, vitamin K antagonists - the effect of these drugs is enhanced;

¾ with folic acid, bactericidal antibiotics (including penicillins, cephalosporins) - the effectiveness of sulfonamides is reduced;

¾ with bactericidal antibiotics, oral contraceptives - the effect of these drugs is reduced;

¾ with PAS and barbiturates - the activity of sulfonamides increases;

¾ with erythromycin, lincomycin, tetracycline - antibacterial activity is mutually enhanced, the spectrum of action is expanded;

¾ rifampicin, streptomycin, monomycin, kanamycin, gentamicin, oxyquinoline derivatives (nitroxoline) - the antibacterial effect of the drugs does not change;

¾ with nalidixic acid (nevigramon) - sometimes antagonism is observed;

¾ with chloramphenicol, nitrofurans - the total effect is reduced;

¾ with drugs containing PABA esters (novocaine, anestesin, dicaine) - the antibacterial activity of sulfonamides is inactivated.

Sulfonamides should not be prescribed simultaneously with hexamethylenetetramine (urotropine), with hypoglycemic drugs (sulfonylurea derivatives), with definin, neodicoumarin and other indirect anticoagulants.

Streptocide may enhance the effect of methotrexate due to its displacement from protein binding and/or weakening of its metabolism.

When used simultaneously with other drugs that cause bone marrow suppression, hemolysis, hepatotoxicity, the risk of developing toxic effects.

Phenylbutazone (butadione), salicylates and indomethacin can displace sulfonamides from binding to plasma proteins, thereby increasing their concentration in the blood. When used with para-aminosalicylic acid and barbiturates, the activity of sulfonamides increases; with chloramphenicol - the risk of developing agranulocytosis increases; with preparations containing para-aminobenzoic acid esters (novocaine, anesthesin, dicaine), the antibacterial activity of sulfonamides is inactivated.

Features of application

When treating with the drug, it is necessary to systematically monitor renal function and peripheral blood parameters, blood glucose levels.

During long-term treatment with the drug, it is necessary to periodically conduct blood tests (biochemical and general blood tests). Prescribing the drug in insufficient doses or early discontinuation of the drug may increase the resistance of microorganisms to sulfonamides.

Sulfonamides should not be used to treat infections caused by group A beta-hemolytic streptococcus, since they do not eradicate it and, as a result, cannot prevent complications such as rheumatism and glomerulonephritis.

The drug should be prescribed with caution to patients with chronic heart failure, liver disease and impaired renal function. Streptocide should be prescribed with caution to patients with severe allergic diseases or bronchial asthma, with blood diseases. If signs of a hypersensitivity reaction appear, the drug should be discontinued. In case of renal failure, accumulation of sulfonamide and its metabolites in the body is possible, which can lead to the development of a toxic effect.

Sulfonamides, including streptocide, should be used with caution in patients with diabetes mellitus, since sulfonamides can affect blood sugar levels. High doses of sulfonamides have a hypoglycemic effect.

Since sulfonamides are bacteriostatic and not bactericidal drugs, a full course of therapy is necessary to prevent relapse of infection and the development of resistant forms of microorganisms.

Given the similarity of chemical structure, sulfonamides should not be used in people with hypersensitivity to furosemide, thiazide diuretics, carbonic anhydrase inhibitors and sulfonylureas.

Patients need to consume sufficient fluids to prevent crystalluria and the development of urolithiasis.

Elderly people have an increased risk of developing severe adverse reactions from the skin, suppression of hematopoiesis, thrombocytopenic purpura (the latter - especially when combined with thiazide diuretics). Prescribing the drug to patients over 65 years of age should be avoided due to the increased risk of severe adverse reactions.

During treatment, it is necessary to follow the dosage regimen, apply the recommended dose at intervals of 24 hours, and do not skip doses of the drug. If a dose is missed, DO NOT double the next dose.

If the signs of the disease do not begin to disappear or, on the contrary, the health condition worsens and adverse events occur, it is necessary to stop using the drug and consult a doctor regarding further use of the drug.

Use during pregnancy or breastfeeding

The drug is contraindicated during pregnancy and breastfeeding. If it is necessary to use the drug during breastfeeding, breastfeeding should be stopped.

The ability to influence the reaction rate when driving vehicles or other mechanisms

Until the patient’s individual reaction to the drug is clarified, you should refrain from driving vehicles or operating machinery, given that during treatment with streptocide, the following adverse reactions from the nervous system may occur: dizziness, convulsions, ataxia, drowsiness, depression, psychosis.

Directions for use and doses

Take orally during or after meals with 150-200 ml of water. A single dose for adults and children over 12 years of age is 600 mg-1.2 g, the daily dose is 3-6 g. The daily dose is divided into 5 doses. Maximum doses for adults: single - 2 g, daily - 7 g.

A single dose for children aged 3 to 6 years - 300 mg, from 6 to 12 years - 300 mg-600 mg. The frequency of administration for children is 4-6 times a day.

The maximum daily dose for children is 900 mg-2.4 g.

The duration of treatment is determined by the doctor individually depending on the severity and course of the disease, the localization of the process, and the effectiveness of therapy.

Children

The drug is used for children under 3 years of age.

Overdose

Side effects may increase.

In case of an overdose, anorexia (lack of appetite), nausea, vomiting, colicky pain, headache, drowsiness, dizziness, and fainting may occur. With long-term use, fever, hematuria, crystalluria, cyanosis, tachycardia, paresthesia, diarrhea, cholestasis, renal failure with anuria, toxic hepatitis, leukopenia, agranulocytosis are possible.

Treatment. In case of overdose, it is recommended to consult a doctor. Treatment is symptomatic. To provide medical assistance, rinse the stomach with a 2% sodium bicarbonate solution and take a suspension of activated carbon or other enterosorbents. Drinking plenty of fluids, forced diuresis, and hemodialysis are indicated.

Streptocide belongs to the antibacterial agents of the sulfonamide series. Sulfonamides in the history of medicine became one of the first broad-spectrum antibacterial agents. Streptocide for angina was previously used everywhere, including in pediatric practice. In recent years, streptocide for the throat has been prescribed in Russian medicine only in powder form, topically. This is due to the high toxicity to the body that Streptocid tablets have: the instructions for use warn of the possible occurrence of this undesirable effect when using the drug.

The principle of action of "Streptocide"

The spectrum of action of this antibiotic is wide. It affects the following pathogenic microorganisms:

• actinomycetes, which cause inflammatory diseases of the mouth, upper respiratory tract and gastrointestinal tract;
• gram-positive/gram-negative cocci;
• E. coli;
• Shigella, which causes dysentery;
• clostridia leading to gas gangrene of tissues;
• Vibrio cholerae;
• plague stick;
• diphtheria bacillus;
• the anthrax bacillus, which causes a dangerous disease - anthrax;
• chlamydia, often the cause of trachoma, ornithosis, inguinal lymphogranuloma;
• protozoan microorganisms are the causative agents of toxoplasmosis and malaria.

This universal activity of the active substance against pathogens is the reason for the spread that “Streptocide” tablets received at one time; their use is especially effective when affected by pneumococci, meningococci, gonococci, as well as pathogens of bacterial dysentery.

The principle of the selective action of streptocide on microorganisms is based on its ability to interfere with the synthesis of dihydrofolic acid, which pathogens need for the reproduction of nucleic acids. These acids play an important role in the storage and transmission of genetic data in all living organisms. But in humans, dihydrofolic acid is not synthesized; tissues utilize the finished substance.

Pharmacokinetics

“Streptocide” refers to short-acting sulfonamides - the half-life is about 8 hours. The active substance is quickly absorbed into the gastrointestinal tract, partially binds to blood proteins and is distributed in all tissues, including passing through the barrier between the circulatory and nervous systems, as well as through the placenta . After 4 hours it is detected in the cerebrospinal fluid. Accumulates in the serous cavities of the human body (thoracic, abdominal, pelvic cavities). In the liver, acetylation of sulfonamide occurs, the resulting chemical compounds no longer have an antibacterial effect. They are less soluble than the original substance, so they can cause crystalluria - the accumulation of excess salts in the body that are not excreted. The largest part of sulfonamides and their metabolites is excreted by the kidneys by filtration (up to 95%). A small amount of them is through the intestines, sweat and salivary glands.

The maximum concentration of streptocide in the blood is observed 2-3 hours after its administration. A decrease in concentration by 50% occurs after 6-8 hours. Since streptocide has been used in domestic medicine for many years, in recent decades there has been an increase in the resistance of pathogenic microorganisms to this drug - in Russia this level has reached 60% of cases. Therefore, and also due to the high toxicity of the drug, “Streptocid” in tablets is not used orally. For the treatment of infectious diseases, it is recommended to prescribe other antibiotics.

"Streptocide" tablets: instructions for use

One tablet of the drug contains the following substances:

• sulfonamide (300 mg);
• potato starch as a filler base;
• Calcium stearate is an emulsifier.

Indications for use of the drug are the following:

• bacterial diseases, with preliminary determination of the level of resistance of microorganisms;
• infectious diseases of the skin and mucous membranes, accompanied by suppuration, the formation of ulcers, bedsores;
• infectious inflammation of the large and small intestines;
• inflammation of the renal pelvis caused by the presence of pathogenic microorganisms in the kidneys;
• inflammation of the bladder mucosa associated with infection of the urinary system.

Single dosage is:

• for adults - 2-4 pcs.;
• children 3-5 years old - 1 piece;
• children 6-12 years old - 1-2 pcs.

The daily dose for adult patients is divided into 5 doses, the total number of tablets should not exceed 20 pieces.

The following factors are contraindications for the use of this drug:

• individual intolerance to sulfonamide antibacterial drugs;
• diseases of the circulatory system: decreased number of leukocytes (leukopenia), anemia and others;
• severe and acute diseases of the liver and kidneys: inflammatory diseases of these organs associated with pathological changes in tissue, failure, hepatitis;
• hyperthyroidism syndrome;
• hypersensitivity to drugs with a similar chemical composition: furosemide, thiazide-based diuretics (hydrochlorothiazide, cyclopenthiazide and others), diuretic carbonic anhydrase inhibitors (diacarb) and sulfonylurea derivatives;
• increased content of nitrogenous compounds in the blood;
• congenital diseases associated with a violation of the structure of hemoglobin (porphyria);
• deficiency of glucose-6-phosphate dehydrogenase;
• children under 3 years of age;
• pregnancy period.

When breastfeeding while taking the drug, feeding the baby must be stopped, as the active substance passes into mother's milk.

The following symptoms may appear as side effects:

• disorders of the gastrointestinal tract: vomiting, diarrhea, bile stagnation;
• disorders associated with the central nervous system: dizziness, headache, blurred vision, sensitivity disorder, numbness, tachycardia, muscle motility disorders;
• inflammation of the peripheral nervous system, manifested in decreased sensitivity and paralysis;
• disorders in the hematopoietic system: an increase in the number of eosinophils, a decrease in platelets, leukocytes, which results in increased bleeding;
• allergies in the form of skin rashes and dermatitis;
• toxic kidney damage;
• inflammation of the arterial wall of blood vessels (periarteritis nodosa).

During the period of treatment with Streptocide, you need to drink a fairly large amount of drink.

"Streptocide" ointment: instructions for use

10% ointment "Streptocid" contains the following substances:

• 100 mg of sulfonamide per 1 g;
• mineral oil to obtain a viscous consistency;
• white paraffin as a filler.

The ointment is used to treat purulent-inflammatory lesions of the skin accompanied by bacterial infection: various wounds, cracks, ulcerative necrotic lesions, pustular diseases (boils, impetigo and others), erysipelas. It is applied directly to the affected area in a thin layer. The duration of treatment depends on the severity of the disease and is determined by the doctor.

Contraindications for the use of ointment are:

• individual intolerance to the drug;
• acute renal failure;
• porphyria;
• pregnancy and breastfeeding;
• children's age, since there are no data on clinical trials in this age group.

It should also be taken into account that a short course or untimely application of ointment to damaged areas can lead to pathogenic microorganisms developing resistance to sulfanilamide. As a result, the drug will not have the desired therapeutic effect in treating a bacterial infection. If local allergic reactions occur, stop using the drug.

• caffeine-containing products;
• “Novocaine”, as it reduces the effectiveness of “Streptocide”;
• "Adrenalin";
• "Phenobarbital";
• cardiac glycosides;
• medications containing hydrochloric acid (Acidin-pepsin, Panzinorm, Pepsidil and others).

Streptocide for sore throat

“Streptocide” for the throat can be used in two forms - powders and tablets. In both cases, these drugs are used in the treatment of sore throat only locally, including “Streptotsid” - tablets; the instructions for use do not contain such information, but in everyday practice they have long been used for rinsing. In order to cure a sore throat, one tablet is dissolved in a glass of warm boiled water and gargled. Due to the toxicity of the drug, it is not recommended to dissolve tablets.

Streptocide powder can be used to treat purulent sore throat and infectious diseases of the pharynx. To do this, dust the throat, tonsils and other affected areas of the mucous membranes. For children, this drug in powder form is also prescribed for aphthous stomatitis, in which many painful ulcers form on the oral mucosa. The powder is left on the affected areas for 10-15 minutes, during which time you should not eat or drink. After storing the drug, the throat is rinsed with an aqueous solution of any antiseptic. This procedure is repeated 3-5 times a day, depending on the severity of the lesion.

Streptocide powder is also actively used to treat postoperative and traumatic wounds and inflamed areas of the skin. Before topical use of the drug, it is necessary to check whether there is an allergic reaction to it.

The drug Streptocid is considered as an antimicrobial agent intended for topical use. The composition is produced in the form of a powder, packaged in heat-sealed bags. The active component is sulfonamide - the component is a proven antibacterial agent.

Dosage form

Streptocide is a powder intended for external use.

Description and composition

Streptocide is presented in the form of a white crystalline powder. The granules do not have a uniform shape. The composition contains the active component sulfanilamide. The product is packaged in laminated bags for ease of use. A cardboard box contains 3 sachets of powder. The drug is accompanied by instructions for use.

Pharmacological group

Streptocide can be characterized as a broad-spectrum antibacterial drug. Sulfanilamide is the main representative of the initial chemotherapeutic agents. The mechanism of influence of the composition is explained by a competitive antagonist with PABA and competitive destruction of the enzyme. This course leads to a disruption in the production of dihydrofolic and tetrahydrofolic acid. Against this background, there is a decrease in the intensity of nucleic acid production. The active substance is capable of destroying gram-positive and gram-negative pathogenic microorganisms.

Indications for use

The drug is indicated for use in infectious and inflammatory diseases provoked by pathogenic microorganisms that are not resistant to the active substance. The drug can be used in the treatment of erysipelas, enterocolitis and infectious pathologies affecting the mucous membranes and skin.

for adults

When used externally, it is used to prevent secondary infection of the wound surface.

for children

The drug can be used in pediatric practice for children over 2 years of age. The composition is well tolerated and rarely provokes adverse reactions from various organs and systems.

The drug for external use can be used during pregnancy in the 2nd and 3rd trimester as prescribed by a doctor. It is worth noting that the composition should not be used on mucous membranes. Streptocide can only be used on limited areas of the skin.

Contraindications

The drug in powder form for external use can be used in the 1st-3rd trimester of pregnancy and during lactation, subject to the rules of extreme caution.

The only contraindication to the use of the composition is the increased sensitivity of the patient’s body to the active substance. In some cases, when used externally, contact allergies may occur.

Applications and dosages

The drug in powder form is intended exclusively for external use on injured areas of the skin.

for adults

The drug is actively used by patients in this age category. The product can be used for cuts and abrasions. The composition is sprinkled on the affected area and covered with a gauze bandage.

for children

The drug in external form can be used in pediatric practice. The drug is used according to the scheme specified for adult patients.

for pregnant women and during lactation

The drug can be used during pregnancy and breastfeeding only in external form. The drug can be applied to limited areas of the skin. When treating large areas with deep lesions, there is a risk of penetration of the active substance into the bloodstream.

Side effects

Adverse reactions with the use of a composition intended for external use are extremely rare. In some cases, a hypersensitivity reaction may occur in patients with a predisposition to allergic reactions. In such cases, a rash may appear on the patient’s skin, accompanied by itchy skin. If such a reaction occurs, it is necessary to decide on stopping therapy. Continued use may cause severe allergies.

Interaction with other drugs

There are no data on drug interactions.

special instructions

Before you start using the composition, you must test for an allergic reaction. To do this, the composition is applied to a limited area of ​​the skin and wait for the appearance of allergy symptoms for 15 minutes; if there is no reaction, the product can be used.

Overdose

When used externally, the active substance of the drug composition is not absorbed into the systemic bloodstream. The likelihood of an overdose against this background is minimized. An overdose is likely only when treating large areas of the skin with deep lesions. Under such conditions, the composition can be absorbed into the systemic circulation and cause side effects.

Storage conditions

The drug Streptocide in powder form for external use should be stored at a temperature of no more than 25 degrees in a dry place, protected from children’s access. It is important to maintain optimal humidity conditions; when in contact with high humidity, the product loses its structure and loses its effectiveness. The composition should be stored in its original packaging, which should be opened immediately before use.

The medicine is sold to the population through a network of pharmacies on free supply. A doctor's prescription is not required.

Analogues

The drug Streptocide is an antibacterial drug. The composition in powder form is used to treat the skin after injuries accompanied by a violation of the integrity of the dermis layer. The composition allows you to prevent possible infection and infection. Streptocide accelerates regeneration processes and reduces the likelihood of complications during the recovery period. The medicinal composition has no direct analogues for the active substance. The optimal substitute is a product that has a number of advantages compared to the outdated product.

The drug is produced by pharmacological companies in the form of powder and ointment for external use. Both dosage forms contain 2 antibiotics that have the ability to destroy various pathogens. The product contains neomycin and bacitracin. The composition is often used for various skin diseases. The advantage of this product is its safety. actively used during pregnancy and breastfeeding. The drug can be used in pediatrics to treat various disorders in children. The active components begin their action immediately after application to the injured area. Despite a certain list of advantages, the composition has its drawback - high cost.

Price

The cost of Streptocid powder is on average 55 rubles. Prices range from 10 to 139 rubles.

Streptocide (sulfonamide) is an antibacterial drug, the first representative of the sulfonamide series of drugs.

The drug is active against streptococci, pneumococci, gonococci and other bacteria. With the accidental discovery of penicillin in 1929, the era of antibiotics began in medicine. Streptocide was one of the first to be discovered.

Used in the treatment of infectious and inflammatory diseases caused by bacteria sensitive to the drug. Side effects of Streptocide include dyspepsia (nausea, vomiting, diarrhea), disorders of the hematopoietic system, and dermatological allergic reactions.

Clinical and pharmacological group

Broad-spectrum antibacterial agent.

Terms of sale from pharmacies

Can buy without a doctor's prescription.

Price

How much does Streptocide cost in pharmacies? The average price is 65 rubles.

Composition and release form

You can find ointment and powder in pharmacies. Such varieties of the drug as Streptocide white and Streptocide soluble liniment are also known. Streptocide tablets have not been produced or sold in Russia since 2008.

The active substance is sulfonamide. Streptocid ointment also contains soft white paraffin as an additional component. The powder contains 0.5 mg of sulfonamide.

pharmachologic effect

The substance has an antimicrobial effect and is active against gram-positive and negative cocci. Applying the powder to damaged skin accelerates wound healing and helps erosions epithelialize faster. The mechanism of action is based on the connection of compounds with para-aminobenzoic acid, which is necessary for the life of bacteria.

Due to their similarity to this acid, sulfonamides penetrate into the protoplasm of bacteria, replace the substrate, and block the enzyme system. A disruption of metabolic processes occurs, microbes stop growing and multiplying due to the lack of folic acid. Sulfanilamide is active and quickly absorbed from the gastrointestinal tract. It reaches its maximum concentration after a couple of hours, being found in the blood.

Four hours after administration, Streptocide is detected in cerebrospinal fluid, saliva, gastric juice, bile, and urine. Part of the molecule, under the action of enzymes, becomes acetoform, which reduces the antimicrobial activity of the product. This form is found in 10-20% concentration in the blood, in urine - up to 50%. Within eight hours, 50% of the drug is excreted by the kidneys.

Indications for use

The drug is used in the treatment of the following infectious and inflammatory diseases that are caused by microorganisms sensitive to the action of the drug:

• impetigo;
• carbuncles;
• pyelitis;
• enterocolitis;
• boils;
• infectious diseases of the mucous membranes and skin.

This remedy is also used in complex therapy of infected burns (I–II stage), purulent wounds and other purulent-inflammatory processes of the skin.

Streptocide tablets are prescribed for infectious diseases of the skin, ENT organs, respiratory and urinary tract, and wound infections.

Contraindications

Severe renal failure, blood diseases, glucose-6-phosphate dehydrogenase deficiency, nephrosis, nephritis, acute porphyria, thyrotoxicosis, I and II trimesters of pregnancy, lactation, hypersensitivity to sulfonamides.

Prescription during pregnancy and lactation

Contraindications to the drug indicate that Streptocide should not be taken during pregnancy and lactation. The active substance of the drug quickly passes through the placental barrier and is found in the fetal blood. In addition, it can cause toxic effects.

When breastfeeding, the drug can cause kernicterus in infants.

Dosage and method of administration

As indicated in the instructions for use, Streptocide powder can be applied externally to the damaged surface of the skin or blown into deep wounds. Also mixed with Sulfathiazole, Benzylpenicillin and Ephedrine, Streptocide is used for nasal respiration in case of acute runny nose.

The powder is applied to the damaged surface of the skin using the powdering method, that is, first a little powder is poured onto gauze, after which the surface of the wound is “powdered” with this gauze. You can also gently pour the powder directly from the bag onto the surface of the wound. But you should try to evenly distribute the powder over the surface of the wound. After applying the powder to the damaged surface, you can cover it on top with a gauze cloth, bandage it, or leave it uncovered. For a single application to the wound, take 2–5 g of powder, depending on the size of the damage.

The powder can be applied to the wound surface 3 to 4 times a day. In this case, the frequency of application of the powder is determined by the course of the infectious-inflammatory process. For example, if the wound is wet, with copious discharge, then its surface is sprinkled with powder often, up to 4 times a day. If the wound is dry, then it can be treated with Streptocide powder only 1 - 2 times a day. In such a situation, it is recommended to apply Streptocide powder once a day if the wound is then covered with a bandage, and 2 times a day if the wound is left open.

If the wound is deep, then Streptocide powder is blown directly into it. In this case, for one injection, take 5–15 g of powder, depending on the size of the wound. After the powder is injected, the wound is usually covered with a bandage. The powder is injected 1-4 times a day, depending on the intensity of discharge from the wound, following the rule: the more the wound gets wet, the more often the powder needs to be injected into it. The powder is applied to the wounds until they begin to heal or until the release of pus or inflammatory fluid from the wound surface stops.

Streptocide for acne

One of the effective remedies in the fight against acne is Streptocide. It is a good antiseptic and destroys pathogenic microflora. Streptocide ointment is most often used to treat skin rashes. The drug in powder form is more suitable for making lotions and masks. Before using the ointment, you need to wash your face and wipe it with calendula tincture.

Then apply ointment to each pimple (do this twice a day for 2 weeks). You can also use tablets: crush 20 pieces into powder and mix with aloe juice to the consistency of sour cream, add a couple of drops of iodine. Apply this mixture to pimples at night and wash off in the morning with plain water. If the use of Streptocide does not help, then you should consult a doctor so that he can identify the cause of acne (this could be a hormonal surge, clogged pores, or disruption of the gastrointestinal tract).

Side effect

When using the product, allergic reactions are possible, in addition, the following side effects are observed: headache, paresthesia, nausea, dyspepsia, agranulocytosis, cyanosis, dizziness, tachycardia, vomiting, leukopenia, crystalluria.

Tablets can also cause diarrhea, and in rare cases, nephrotoxic reactions, thrombocytopenia, hypoprothrombinemia, eosinophilia, visual impairment, peripheral neuritis, hypothyroidism, ataxia.

Overdose

Symptoms of overdose are as follows: headache, vomiting, nausea, cyanosis, dizziness.

In case of overdose, symptomatic therapy is necessary.

special instructions

When treating patients with pathologies of kidney function, Streptocide is used with caution. The volume of fluid consumed during the treatment period should be increased.

Interaction with other drugs

When treating with a drug or an analogue of Streptocide, it is necessary to take into account that novocaine and other drugs with a similar chemical structure containing a para-aminobenzoic acid residue may exhibit an antisulfonamide effect.