Antiviral drugs that cause infertility. Can taking Kagocel cause infertility? Instant cold powders

According to recent scientific research, scientists claim that the female factor in the development of infertility accounts for only 40% of cases. A man's guilt in childlessness reaches 30%, while for males one of the defining triggers of this condition is medications. Many of their components adversely affect spermatogenesis or are spermatic. As a result, the seminal fluid loses its properties, and the sperm loses its activity, which makes fertilization of the egg impossible. For women, there are also pills that cause infertility, but in the vast majority of cases we will be talking about contraceptives.

What drugs cause infertility in men?

Impaired fertility in representatives of the stronger sex occurs due to the use of drugs that have an effect on such organs and systems.

1. Endocrine, which ensures the course of all metabolic processes in the body, including the regulation of dopamine levels, the production of sex hormones - prolactin, testosterone, follicle-stimulating hormone, as well as serotonin and endorphins.
2. The central and peripheral nervous system, especially drugs that inhibit their functioning.
3. Circulatory system.

Medications of various groups lead to depression of sexual function. These can be cytostatics, anabolic steroids, anti-tuberculosis drugs (and they affect the ability to conceive in representatives of both sexes). Taking into account the dosage and course of treatment, the reproductive cells can be suppressed permanently or temporarily, which will prevent the woman from becoming pregnant.

In most cases, the abolition of the egg, which is harmful to the fertilization of the egg, is enough to return fertility to normal levels. It is important to understand that conceiving a child is possible only if both sexual partners are in full health. Female and male infertility go hand in hand and are very close, since they require treatment of both partners.

These drugs most often provoke male infertility.

Antidepressants

These medications impair or reduce erections, contributing to the development of erectile dysfunction. Also, while taking them, painful ejaculation is noted. This is due to blockade of the cholinergic system, which leads to a decrease in the sensitivity of alpha-adrenergic receptors. The same effects are observed when taking certain bromides or barbiturates.

Cytostatics

Cytostatic drugs act in several directions at once. First of all, they inhibit the division and reproduction of cells, including sex cells - sperm. Cytostatics also interfere with sperm meiosis, which entails the development of gene mutations, due to which mature sperm receive a “defective” genome that carries information with the presence of hereditary pathologies. Or they lose the opportunity to fertilize female reproductive cells.

Hormonal drugs

Estrogens themselves inhibit male libido and potency. Taking thyroid hormones also has similar properties, especially if we are talking about a serious disorder or change in hormonal levels. Here it is also important to monitor the correct use of medications, since if the patient takes 5 tablets per day, even in the smallest dosage, other thyroid diseases may develop, for example, instead of hypothyroidism, thyrotoxicosis will develop, which is also characterized by a pronounced decrease in fertility.

Glucocorticoids

The use of tablets or injections of glucocorticosteroids adversely affects the reproductive system due to interference with metabolic processes. They trigger prolactin production with renewed vigor, which entails a decrease in libido and erectile dysfunction. To control the two groups of drugs listed above, it is necessary to regularly conduct blood tests for hormones.

Blood pressure medications

Medicines with antihypertensive activity. They cause a decrease in potency in more than 1% of people who regularly take them. Moreover, this situation occurs not only in people who take old drugs, but also in patients who use relatively new, modern antihypertensive pills.

Psychotropic substances

Scientific experiments have proven their effect on sperm motility, and asthenozoospermia has sometimes been observed.

Anabolic drugs

The risk group includes men who actively work out in the gym to build muscle mass. The use of these substances leads to disruption of the hypothalamic-pituitary system, which controls all processes within the body, so sexual function also suffers. Irreversible processes often develop, and testicular atrophy occurs.

Antiandrogens

Inhibits the activity of male sex hormones. These also include the aldosterone inhibitor veroshpiron or spironaloctone, cimetidine. In addition to their main effects, they lead to the appearance of gynecomastia and cause disruption of sperm formation.

Antiviral

Reduce sperm activity. One of the most controversial drugs today is Kagocel, discussions about which are ongoing not only among andrologists, but also reproductive specialists and gynecologists.

Other means

Toxic substances, including cannabinoids, ethyl alcohol, which is part of any alcoholic drink, nicotine, which is part of all cigarettes. These substances can sometimes be used for medical purposes. But with excessive abuse, persistent and pronounced depression of fertility develops.

Drugs cause infertility in women

Special attention is paid to drugs that cause infertility in the fairer sex. This is due to the fact that infertility therapy for women is a very difficult process. If a girl has been taking steroid drugs for a long time, the recovery period of her reproductive system will take a long period of time.

First of all, when diagnosing infertility, a woman needs to take care of her regular menstrual cycle. A gynecologist will help with this issue. Cycle disruption can be preceded by various trigger factors that need to be quickly eliminated, and then treated for this condition. The most common treatment option for infertility in women due to an irregular menstrual cycle is taking gonadotropin or clomiphene.

Bromocriptine is used to treat infertility due to increased blood prolactin concentrations. It restores ovulation, the formation of an egg and its release into the uterus by reducing this hormone.

According to doctors, the best prevention of childlessness for girls is timely treatment of borne diseases, including pathologies of the uterus and endometriosis. You should also regularly visit a female gynecologist. Strict avoidance of products harmful to the body - alcoholic beverages, smoking, narcotic drugs - is necessary. The correct selection of contraceptives - oral contraceptives, hormonal contraceptive pills - is considered important.

Barrier methods will eliminate diseases of the ovaries and uterus, which also contributes to the safety of a possible subsequent pregnancy. It is important to understand that abortions and any sexually transmitted diseases provoke problems with pregnancy in the vast majority of cases. And the drugs that are used to treat infertility against the background of such pathological processes have a harmful effect on other organs and systems.

Doctors say that all modern medications that have a contraceptive effect are highly effective and do not affect reproductive function after their discontinuation. Contraceptive drugs, which can lead to infertility, are a thing of the past. They are divided into several groups.

1. Monophasic, containing equal amounts of estrogen and gestagen. These include Regulon, Silhouette and others.
2. Biphasic ones contain the same amount of estrogen, but the concentration of progestogen differs in periods 1 and 2. The products of this group are Femoston, Neo-Eunomin.
3. There are also triphasic contraceptive medications. Their hormone dosage changes three times, depending on the current menstrual cycle. Representatives of this group are Tri-Regol, Triziston.
4. Microdosed birth control pills are better suited for young girls - Jess, Mercilon.
5. Doctors advise low-dose medications to be taken by those who have already given birth - Yarina, Diana.
6. Highly dosed - Non-Ovlon, Triqualor. These are pills with a high content of hormones. These are medications for the treatment of hormonal dysfunctions in women.

It is important to understand that contraceptives promote conception after they are discontinued and hormonal levels stabilize. In order to eliminate this problem, it is best to contact a gynecologist and follow all his recommendations and instructions. It is important to understand that normalization of the endocrine system does not occur immediately; you need to wait some time until the organs recover after taking the drugs.

Until recently, if a married couple did not have a child in the next year or two after the wedding, no one doubted that the woman was to blame. As a rule, men believed that if they had no problems with erection and ejaculation, then they were completely healthy.

They began to examine the woman, treat her, and send her to sanatoriums, but often without success. True, it was the sanatoriums that sometimes “helped” - by risking a change of partner, she was convinced that everything was fine with her women’s health. Currently, gynecologists do not begin to examine a woman for infertility until her husband is examined. In Russia, the cause of half of the cases of infertility among married couples is a failure in the reproductive system of the man.

Male infertility comes in two forms:

• secretory form;
• obstructive (lat. obturatio - clogging).

At secretory there is a disruption in the formation of sperm in the testicles. At obstructive– an obstacle arises on the way of sperm to the urethra.

The main causes of male infertility include the following:

Hormonal disorders

They can be identified by taking a blood test. If it turns out that the level of follicle-stimulating hormone in the blood is increased, it means that too few sperm are produced in the testicles or they are not produced at all.

Impairment of the vas deferens (obturation)

This defect can be either congenital or acquired. For example, patency may be impaired after certain infectious diseases that cause inflammatory processes in the genitals. In particular, these are gonorrhea, syphilis, chlamydia, ureaplasmosis, etc. In the place where there was inflammation, scars form, preventing the advancement of sperm. If the inflammation was unilateral, the number of sperm in the semen decreases; if it was bilateral, they are absent altogether.

Low sperm motility

The reason for this may be diseases of the accessory sex glands, for example the prostate. To determine male fertility (from the Latin fertilis - fertile, prolific, that is, the ability to produce offspring), men are asked to take a spermogram. A spermogram is an analysis that can be used to evaluate the quality, quantity of sperm, the concentration of male reproductive cells in the entire volume of ejaculate (what comes out after ejaculation) and in 1 ml, as well as sperm motility.

Immune factor

It is associated with 10–20% of cases of male infertility. To identify it, a MAR test of sperm is done to check for the presence of autoantibodies to one’s own sperm, that is, an increased amount of antisperm antibodies in the sperm.

Ejaculation disorder

Ejaculation disorder, when sperm does not come out of the urethra or very little comes out. It can be either congenital or a consequence of certain diseases (diabetes mellitus), or operations (on the prostate gland). Some medications (for example, to lower blood pressure) also have this side effect.

Injuries and diseases of the testicles (testicles)

Male reproductive cells (sperm) and male sex hormones (in particular, testosterone) are formed in the testicles (testicles), so most pathologies are associated with disruption of their functioning.

Cryptorchidism

For example, with cryptorchidism, a congenital disease that occurs in 2–5% of newborn boys, the testicles do not descend into the scrotum at birth. This interferes with the normal maturation of sperm and leads to infertility. Cryptorchidism requires surgical intervention.

Azoospermia

Testicular diseases can also cause a complete absence of male germ cells in sperm (azoospermia). For example, a childhood disease such as mumps, contracted after puberty, can lead to the destruction of sperm-producing cells.

Varicocele

The cause of infertility can also be dilation of the veins of the scrotum - varicocele. Due to stagnation of blood and increased temperature inside the testicles, sperm lose activity.

Effect of drugs and chemicals

For example, the production of male germ cells can be suppressed by the antimicrobial drug metronidazole. Some drugs used to treat stomach ulcers reduce the production of the male hormone testosterone. Even some cold medications can affect sperm quality. Men who work in chemical production, constantly dealing with varnishes, paints, etc., may also have problems with fertility.

Wrong lifestyle

A sedentary lifestyle, sedentary work, excessive amounts of alcohol and smoking addiction, constant stress and lack of sleep, insufficient amounts of protein and vitamins in food - all this affects the quality and quantity of sperm. It is also believed that those who like a bath or steam room that is too hot may also have a disruption in the production of male reproductive cells due to increased temperature in the scrotum area. Correctly diagnosed and timely treatment of male infertility in most cases gives a positive result.

Today you can increasingly hear that doctors prescribe Kagocel for colds. It is Russian, it is not registered in the USA, and there is no information about Kagocel in the World Health Organization. Among other things, the effectiveness of the drug has not yet been established, which raises some vague doubts. With all this, not every person knows what causes infertility, and why this happens, we will learn from this article. Kagocel belongs to the group of interferons; it is designed to stimulate the production of its own interferon in the body. The annual sales volume of this medicine amounts to more than 2.5 billion rubles.

According to reliable information, it became known that the manufacturer Rosnan invests about 1.2 billion rubles in this product annually. Kagocel contains gossypol, there is a lot of interesting information about it, but there are reliable facts that are confirmed by scientists and that’s the point. Chinese scientists found that men who consumed food with cottonseed oil experienced such an unpleasant pathology as infertility.

Not everyone knows that back in 1929, gossypol was used in contraceptives, which were extremely popular because they were considered more effective than other contraceptives. This discovery led the Chinese to create a whole study on the effectiveness of using gossypol. But in 1986, due to frequent side effects, scientists had to abandon the idea of ​​using it.

It was found that 20% of men experienced irreversible infertility from using this medication. In nineteen ninety-eight, WHO ordered the suspension of any research concerning him. It was found that it not only causes an adverse reaction, but is also highly toxic. Therefore, no other manufacturer considered it as a contraceptive.

The composition of Kagocel contains 20% gossypol, of which only 3% is combined. No studies have been conducted, it is allowed to take 10 mg per day. The instructions for use of Kagocel clearly state that this product should not be used by children under six years of age.

Oddly enough, it is actively promoted by many doctors and pediatricians, despite its huge list of side effects.

1. Be sure to read the active ingredient included in the composition.
2. Look for a description on the English site.
3. See the instructions for use in which cases it is prescribed.
4. Read reviews on the Internet about this medicine, for which diseases it is more effective.
5. Buy only from an official seller, as fakes are very common.

Kagocel was created at the research institute, and around 2000 the first tests were carried out. And in two thousand and three, Kagocel was officially registered under the original name, which you all know. In 2005, Kagocel began to be produced as a full-fledged medicine. In 2013, Kagocel was already sold everywhere and gained popularity among other drugs in this segment.

I would like to note that the drug was tested only once. This trial involved approximately 1,000 people and was a placebo-controlled study of the drug's effectiveness. However, these studies were not carried out in accordance with established standards. Among other things, these studies were criticized for violating the law regarding examinations of military personnel. There is no information about the drug on the official website dedicated to clinical trials. Therefore, each patient must decide for himself whether he needs it or not. We emphasize that all clinical trials were published exclusively in Russian literature. It has never been used abroad, and the World Health Organization has no information about this medicine.

The drug stimulates the production of interferon and provides an antiviral effect. To date, no research has been conducted. Therefore, it is impossible to talk about effectiveness; you can only rely on reviews on the Internet about this drug.

The manufacturer assures everyone that Kagocel causes the so-called interferon production. When consumed orally, the medicine reaches its effectiveness after two days. After a day, the medicine accumulates to a large extent in the liver and is excreted naturally. Small concentrations are found in the heart, as well as in the brain and blood.

With daily consumption of the drug orally, the substance accumulates in all these organs in greater concentration. The medicine is usually eliminated from the body naturally through the intestines a week after use.

When prescribed in therapeutic dosages, the drug is non-toxic and does not have any mutagenic properties. The effectiveness of the drug was noticed during therapy from the fourth day of the disease. According to doctors, it is taken from any day of infection. It is most often prescribed for severe influenza illness.

1. Suppression of spermatogenesis.
2. Infertility in men.
3. Headache.
4. Nausea.
5. Vomiting and diarrhea (overdose).

According to the manufacturer, the medicine is not toxic and does not pose any danger to humans.

Gossypol undergoes a chemical change before use, so it does not pose a danger. The manufacturer states that the medication is classified as low-toxic and does not cause pathological changes. It should be said that the manufacturer agrees with the possibility of gossypol, but this happens extremely rarely.

The instructions for use state that the medicine is well absorbed from the stomach, and its bioavailability is approximately 20%. After a day, it is completely distributed throughout the human body. But at the same time, absolutely nothing is written about him in motorball. Note that 80% of the medication is excreted by the intestines, and 20% is excreted by the kidneys.

In animal experiments, no negative effects on sperm were found. However, when the substance was administered to rats, it resulted in the formation of a cyst in the tail area. Therefore, there is no point in discussing the safety of the drug; each person must determine for himself whether he needs it or not, because on the Internet there are two opinions on this matter: some say that the drug helps with infectious diseases.

Today, the medicine is actively promoted by all medical institutions for patients aged three to six years and adults. However, there are no clinical safety trials.

Because the effects of this medication have not been monitored by the manufacturer, it is generally recommended with caution for adolescents and young children.

For viral diseases, we recommend purchasing similar antiviral medications with good reviews.

1. Lactose deficiency.
2. Age category.
3. Lactose intolerance.
4. Pregnancy.
5. Breastfeeding period.
6. Allergy.

On the official medical forum there is information that this medication reduces potency with long-term use. It is typically prescribed during treatment for herpes zoster and as an antiviral agent.

Every year, about five hundred million people become infected with influenza, and about five hundred thousand patients die. In the first three months of the severe epidemic, more than ten thousand people worldwide died. This is truly a scary statistic, because the attention of all researchers over ten years led to the production of drugs against influenza. Since 2007, more than twenty drugs against this virus have been registered in Russia. I wonder why this happens? Some of the remedies immediately receive permission to purchase without a prescription, others begin to be actively advertised on television, but nowhere do they talk about the composition of the medicine and what it was previously used for. We decided to give a description of the most widely advertised medicines of today for the influenza virus.

The manufacturer is Valenta, the active substance is pentanedioic acid. The manufacturer claims that it is antiviral. In 2008, Ingavirin was registered as a treatment for influenza. It should be noted that the main substance Ingavirin was still part of Dicarbamine on April 12, 2010, which was prescribed to cancer patients. And if you compare these two drugs, they are completely different in action.

Ingavirin's instructions indicate that it scans all cells and destroys only infected ones. However However, in studies on the activity of Ingavirin, it was found that its concentration is not capable of destroying viruses. So what is Ingavirin? And how is it different from Dicarbamine? Nothing is completely clear, so before using it you need to think about how it was initially used to treat cancer patients, and now it has become antiviral.

Anaferon. The active substance is antibodies to human interferon gamma. Appeared on the medicine market back in 2002, Anaferon is an immunomodulatory drug, available for both children and adults, although the difference between them is minimal, this is a kind of commercial move.

Walking into a pharmacy recently, I was amazed at how many cold medications were on the shelves. It seemed to me that five years ago there was no such abundance. And for sure: knowledgeable people told me that such a number of medications for flu and colds appeared not so long ago, after the 2009 influenza pandemic. They also told me that some drugs are known only on the Russian market, which immediately aroused my suspicion. And I decided to conduct my own mini-investigation.

One of the widely advertised drugs, Kagocel, “became famous” in 2009, when Tatyana Golikova could not find it in the pharmacy. But then for some reason everyone latched on to Arbidol, which was also not on sale, and they happily forgot about Kagocel, and then it appeared as if nothing had happened: untainted and beyond suspicion. Although knowing the history of its appearance and composition, it was necessary to immediately ban it from sale.

It was like this. Soviet virologist Felix Ershov, at the head of a group of scientists, was sent to America: to learn and see how things are in medicine in the West. Scientists spent a whole year in the USA and returned with the following decision: it is necessary to treat colds and flu with interferon (in the States there was just interest in its inducers). Together with Vladimir Nesterenko (head of the immunology department of the Research Institute of Epidemiology and Microbiology), Kagocel was invented. Here are the words of Nesterenko himself, which I found on the Internet: “We took cellulose, this is a polymer from cotton, took another certain substance obtained from cotton, combined it with cellulose and got a polymer. It’s called kagocel.” Both Nesterenko and Ershov kept silent about the fact that the new drug causes male infertility. But this can also be found on the Internet. For example, in the same Wikipedia.

Ergoferon is not included in Wikipedia, but if you type this name into Google, the first site will tell us the following: “Homeopathic antiviral remedy Ergoferon - it will help during the cold season.”

Plus, the price is a little surprising. For example, Anaferon (20 tablets) costs approximately 200 rubles. This high cost is usually due to expensive ingredients. One of the main components of Anaferon is lactose, and it costs about 100 rubles per bag weighing... 25 kilograms.

Let's scour the Internet further. We find this: “The production technology includes immunization of rabbits with recombinant human interferon gamma, after which the desired antibodies are isolated from the rabbit’s blood serum on an adsorption column.” Knowing the composition of the drug, it can be calculated that “only about four molecules are required for the entire annual production of anaferon! From one rabbit you can extract antibodies for the next couple of million years of production."

What conclusion can be drawn from everything written? There are a lot of drugs in Russia, but often among them there are some local drugs that have never been heard of abroad. This, unfortunately, happens not only in medicine. I would advise taking medications that are known not only here. You can also read research materials on this topic. There are decent medicines, you just need to not be lazy and find them, and not grab anything. How do you think?

There are a great many of this “illness”:

Causes of infertility in women

The list of factors influencing the reproductive function of the female body is also not short.

• Congenital disorders in the structure of the genitourinary system. For example, an underdeveloped (“infantile”) uterus, absence of uterine tubes or ovaries, bends of the uterus and its bifurcation.
• Abnormal hormonal levels. Improper production of hormones disrupts the menstrual cycle, causes a lack of ovulation, promotes the development of neoplasms, and leads to the formation of multiple ovarian cysts.
• Lesions of the cervix, defects of the cervical canal mucosa. They can be erosive in nature and contribute to the development of inflammatory processes. Also here, a common reason that provokes difficulties with childbearing are polyps, endometrial growth, and tumors.
• Psychological reasons. Facing constant stressful situations, unpreparedness to take responsibility for the baby, and fear of pregnancy often become the only obstacles to conception. If medical examinations have shown a healthy picture of the development of the body, it is important for a woman to pay attention to the psychological factor.

After a thorough medical examination, including ultrasound, fluoroscopy, laboratory tests (for hormones, infections, a detailed blood picture), the doctor prescribes treatment. At the same time, it is important not only to correctly use fertility drugs for women, but also to try to organize a relatively calm daily routine and a healthy diet.

Types of medications used for infertility

According to the ailments they affect, medications are divided into the following types:

1. antibiotics;
2. hormonal drugs;
3. medications that affect blood viscosity and its composition;
4. anti-inflammatory;
5. antiviral;
6. medications that affect the immune system.

When drugs are prescribed for infertility, much attention is paid to the health of the hormonal system, since hormones are the leading cause of the inability to fertilize an egg or bear a child.

Men and women are equally prescribed hormonal medications for infertility. They affect the endocrine system, allowing you to normalize hormonal levels and eliminate the cause of infertility.

If a woman has no or irregular ovulation, medications containing clomiphene citrate are most often prescribed. The effectiveness of this substance in medicines has been verified by a quarter-century history of use. Such drugs belong to the category of antiestrogens and increase the production of hormones that stimulate egg maturation. Ovulation most often occurs in the first cycle after using Clomid or Serophene.

After ovulation occurs, the drug is used for no longer than six months. If ineffective, another treatment is prescribed, most often in the form of injections.

An injectable fertility drug may contain the following hormones:

1. human gonadotropin (for example, Pregnil);
2. follicle-stimulating hormone FSH (Fortinex);
3. GnRH agonists (also prescribed for endometriosis, benign uterine tumors and other diseases);
4. GnRH antagonists (for infertility, they are prescribed with stimulators of egg maturation; more often they are used in antitumor therapy);
5. human menopausal gonadotropin - “Menotropin” (used for anovulation, poor functionality of the corpus luteum, to stimulate superovulation - during).

It must be said that hormonal drugs for the treatment of male infertility often do not constitute a separate category. For various problems, these may be the same medications as for women. Thus, “Menotropin” in men is used to stimulate the process of spermatogenesis with weak or absent sperm motility. Antiestrogens (for example, Tamoxifen) help increase the level of testosterone and gonadotropic hormones.

Non-hormonal drugs for the treatment of infertility in men

Some drugs for male infertility have an immunocorrective function. There are malfunctions in the body when antibodies to sperm begin to be produced in the testicles; as a result, spermatogenesis is significantly impaired. This can occur due to inflammatory or infectious processes in the genitourinary system, as a result of surgery or injury.

In such cases, treatment is first prescribed to eliminate the primary factors that caused the antisperm effect. Next, treatment is carried out with enzymes, and, if necessary, hormonal agents are added.

Antibiotics, antiviral, immunostimulating drugs used in the treatment of sexually transmitted infections are also a kind of drugs for the treatment of male infertility. After all, infections often lead to multiple complications that affect reproductive function.

In any case, timely treatment and a responsible approach to it can completely eliminate the causes of most diseases that cause infertility.