Cinnarizine group of drugs. Cinnarizine is the best remedy for migraines and dizziness. Instructions for use of cinnarizine

Cinnarizine is a drug that blocks the so-called. “slow” calcium channels, mainly in cerebral vessels. The drug inhibits the process of calcium entry into cells, reduces their concentration in plasmalemma depots, has a relaxing effect on the smooth muscle frame of small arteries, and potentiates the vasodilating effect of carbon dioxide. By directly acting on the smooth muscles of blood vessels, it reduces their sensitivity to biogenic vasoconstrictor compounds (catecholamines). It exhibits a vasodilating effect (especially in relation to cerebral vessels), with virtually no effect on blood pressure. Exhibits antihistamine properties, reducing the reactivity of the vestibular apparatus and sympathetic tone. Cinnarizine is effective in patients with latent cerebrovascular insufficiency, nascent atherosclerosis of cerebral vessels, chronic vascular diseases and signs of post-stroke focal lesions. In patients with peripheral vascular lesions, cinnarizine improves blood supply to affected organs and tissues (including the heart) and enhances post-ischemic vasodilation. The drug increases the elasticity of erythrocyte membranes, their deformability, improves the rheological characteristics of blood, and increases muscle resistance to oxygen starvation. The maximum concentration of the active substance in the blood after oral administration is achieved after 1-3 hours. The drug is completely metabolized by microsomal liver enzymes. The half-life of cinnarizine is 2-4 hours. It is excreted by the intestines (most of it) and by the kidneys.

Cinnarizine is available in tablets. The drug should be taken after meals. For cerebral circulation disorders - 25-50 mg three times a day, for circulatory disorders in peripheral vessels - 50-75 mg three times a day, for labyrinthine-vestibular dysfunctions - 25 mg three times a day, for kinetosis, adults take before a planned trip 25 mg each with the possibility of taking an additional dose after 6 hours; children take half of the indicated dose.

The maximum daily dose of cinnarizine is 225 mg. In case of hypersensitivity to the drug, the drug course begins with half the dose, gradually increasing it until an optimal therapeutic response is obtained. The duration of pharmacotherapy varies from 2-3 weeks to several months. At the initial stage of treatment, you should stop taking ethanol in any form. Due to the presence of antihistamine activity in cinnarizine, the drug can give a positive result in a doping test in athletes, as well as mask positive reactions in diagnostic skin tests (in this regard, treatment should be interrupted 4 days before the test). During long-term drug courses, it is recommended to periodically monitor the functional parameters of the liver and kidneys, as well as the picture of peripheral blood. Patients suffering from Parkinson's disease should be prescribed cinnarizine with extreme caution. The drug potentiates the effect of ethanol, sedatives and antidepressants. When used together with nootropics, vasodilators and antihypertensive drugs, cinnarizine enhances their effect. The drug plays a particularly important role in geriatric practice. Cerebrovascular insufficiency, which progresses with age, interferes with the normal blood supply to brain tissue, resulting in the gradual death of brain neurons. One of the reasons on which the severity of brain function disorders depends is atherosclerotic vascular changes. In some cases, this factor begins to play a decisive role, as, for example, in senile dementia. The goal of treatment in older patients is to slow age-related structural and functional changes. Considering the direct effect of cinnarizine on the blood vessels of the brain, it is one of the most prescribed drugs for patients of this profile.

Pharmacology

Cinnarizine is a selective blocker of “slow” calcium channels, reduces the entry of calcium ions into cells and reduces their concentration in the plasma membrane depot, reduces the tone of the smooth muscles of arterioles, and enhances the vasodilating effect of carbon dioxide. Directly affecting the smooth muscles of blood vessels, it reduces their response to biogenic vasoconstrictors (adrenaline and norepinephrine). It has a vasodilating effect (especially in relation to cerebral vessels), without having a significant effect on blood pressure. It exhibits moderate antihistamine activity, reduces the excitability of the vestibular apparatus, and lowers the tone of the sympathetic nervous system. Effective in patients with latent cerebral circulatory failure, initial cerebral atherosclerosis and chronic cerebral vascular diseases with post-stroke focal symptoms. In patients with impaired peripheral circulation, it improves blood supply to organs and tissues (including the myocardium), and enhances post-ischemic vasodilation. Increases the elasticity of red blood cell membranes, their ability to deform, and reduces blood viscosity. Increases muscle resistance to hypoxia.

Pharmacokinetics

Cmax in blood plasma is achieved after oral administration in 1-3 hours. Plasma protein binding is about 91%. Completely metabolized in the liver through dealkylation. T 1/2 - 4 hours. Excreted in the form of metabolites: 1/3 - by the kidneys, 2/3 - by the intestines.

Release form

Tablets are white or white with a creamy tint, flat-cylindrical, with a bevel.

	1 tab.
cinnarizine	25 mg

Excipients: aerosil, calcium stearate, potato starch, lactose, low molecular weight medical polyvinylpyrrolidone.

50 pcs. - cans (1) - cardboard packs.
10 pieces. - contour cell packaging (5) - cardboard packs.

Dosage

Inside, after eating. For cerebrovascular accidents - 25-50 mg 3 times a day; for peripheral circulation disorders - 50-75 mg 3 times a day; for labyrinthine disorders - 25 mg 3 times a day; for sea and air sickness, before an upcoming trip for adults - 25 mg, if necessary, repeat the dose after 6 hours. Children are prescribed half the dose for adults. The maximum daily dose should not exceed 225 mg.

In case of high sensitivity to the drug, treatment begins with 1/2 dose, increasing it gradually. The course of treatment ranges from several weeks to several months.

Overdose

Symptoms: vomiting, drowsiness, tremor, excessive decrease in blood pressure, coma. In case of overdose, there is no specific antidote; it is necessary to perform gastric lavage and take activated charcoal.

Treatment: symptomatic.

Interaction

Pharmaceutical: No chemical incompatibility known.

Pharmacodynamic: Strengthens the effect of alcohol, sedatives and antidepressants. When used simultaneously with nootropic, antihypertensive and vasodilator drugs, it enhances their effect, and when used simultaneously with drugs prescribed for arterial hypotension, it reduces their effect.

Pharmacokinetic: no data.

Side effects

From the nervous system: drowsiness, increased fatigue, headache, extrapyramidal disorders (tremor of the limbs and increased muscle tone, hypokinesia), depression.

From the digestive system: dry mouth, pain in the epigastric region, dyspepsia, cholestatic jaundice.

From the skin: increased sweating, lichen planus (extremely rare).

Allergic reactions: skin rash.

Other: decreased blood pressure, increased body weight, development of lupus-like syndrome.

Indications

• the period of convalescence after suffering an ischemic and hemorrhagic stroke, traumatic brain injury;
• encephalopathy;
• labyrinthine disorders (including for maintenance therapy for dizziness, tinnitus, nystagmus, nausea, vomiting of labyrinthine origin);
• migraine (prevention of attacks);
• Meniere's disease;
• sea ​​and air sickness (prevention);
• peripheral circulatory disorders (prevention and treatment) - obliterating endarteritis, thromboangiitis obliterans, Raynaud's disease, diabetic angiopathy, thrombophlebitis, trophic disorders, trophic and varicose ulcers, pre-gangrenous conditions, paresthesia, night cramps and coldness in the extremities.

Contraindications

• pregnancy,
• lactation period,
• children under 12 years of age;
• hypersensitivity to the drug.

With caution: Parkinson's disease.

Features of application

Use during pregnancy and breastfeeding

Contraindicated during pregnancy and lactation.

Use for liver dysfunction

With long-term use, a control examination of liver function is recommended.

Use for renal impairment

With long-term use, a follow-up examination of renal function is recommended.

Use in children

Contraindicated in children under 12 years of age.

special instructions

At the beginning of treatment, you should refrain from taking ethanol.

Due to the presence of an antihistamine effect, cinnarizine can affect the test result during anti-doping control of athletes (false-positive result), as well as neutralize positive reactions during skin diagnostic tests (treatment should be discontinued 4 days before the test).

Influence on the ability to drive vehicles and operate machinery.

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

The drug Cinnarizine is an effective calcium channel blocker and is intended for the treatment of a variety of cerebrovascular disorders.

This therapeutic agent has a pronounced vasodilating effect, helps reduce blood viscosity and increase the resistance of body tissues to hypoxia.

In this article we will look at why doctors prescribe Cinnarizine, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Cinnarizine can be read in the comments.

Composition and release form

Release form: 25 mg tablets. The blister contains 50 tablets. The composition of the Cinnarizine 0.025 g tablet includes:

• active ingredient cinnarizine – 25 mg;
• starch;
• milk sugar monohydrate;
• Excipients: PVP 25, Aerosil 200, and magnesium stearate.

Clinical and pharmacological group: calcium channel blocker with a predominant effect on cerebral vessels.

What is Cinnarizine used for?

Indications for taking the drug Cinnarizine are the following diseases and pathological conditions:

• vestibular disorders;
• stroke (ischemic);
• post-stroke condition (rehabilitation period);
• consequences of TBI;
• migraine;
• encephalopathy due to circulatory failure;
• intellectual-mnestic disorders;
• thrombophlebitis;
• obliterating angiosclerosis;
• angiopathy due to diabetes mellitus;
• other peripheral circulatory disorders.

For diagnosed kinetoses (“road sickness”), Cinnarizine can be prescribed as a prophylactic agent.

pharmachologic effect

The drug has a positive effect on cerebral and cardiac circulation due to blocking calcium channels on cell membranes. In addition, Cinnarizine increases the ability of tissues to withstand the effects of oxygen starvation, improves blood microcirculation processes and increases the ability of red blood cells to change their shape without losing their properties.

During the use of the drug, there is a relief of spasms of vascular smooth muscles and a decrease in their susceptibility to drugs, as well as other substances that have vasoconstrictor effects. There is also a slight blocking of histamine receptors (located mainly in the central nervous system).

Instructions for use

The dosage regimen is determined by the indications. The maximum dose is 225 mg per day.

1. Seasickness and air sickness (before an upcoming trip): adults – 25 mg (if necessary, I take the dose again after 6 hours); children - half the adult dose.
2. Cerebrovascular accidents: 3 times a day, 25-50 mg.
3. Peripheral circulation disorders: 3 times a day, 50-75 mg.
4. Labyrinthine disorders: 3 times a day, 25 mg.

With high sensitivity to Cinnarizine, therapy begins with 1/2 dose, gradually increasing it. The duration of the therapeutic course can vary from several weeks to several months.

Contraindications

Cinnarizine has been used in medical practice for a long time, therefore it is a studied and fairly safe drug when used and prescribed correctly. Contraindications to the prescription of the drug are pregnancy and breastfeeding, allergic reactions.

One should remember about the likely increase in manifestations in patients with Parkinson's disease, up to an akinetic crisis. You should also remember about the possible hepatotoxicity, so you should limit the use simultaneously with drugs that affect the cytochrome system or are simply metabolized by the liver, especially in cases of liver failure. Such drugs include statins, antidepressants, paracetamol and other analgesics, etc.

Side effects

Following the instructions for use, the following side effects occur:

• dermatological rashes;
• various allergic reactions;
• increased drowsiness and fatigue;
• headache;
• depression;
• cholestatic jaundice appears;
• dyspeptic disorders - diarrhea, pain, heartburn, impaired peristalsis;
• the appearance of excess weight;
• extrapyramidal type disorders;
• thirst;
• inhibited state;
• heaviness in the epigastric region, as well as painful spasms;
• tremor.

If you experience any side effects from taking the medication, you should definitely consult with your doctor who prescribed the drug. It is possible that the doctor will simply reduce the dosage of the medicine or cancel it completely and replace Cinnarizine with another effective medicine with a similar therapeutic effect on the body.

Analogs

Structural analogues of Cinnarizine according to the active substance:

• Vertizin;
• Vertisin Forte;
• Combitropil;
• NooKam;
• Omaron;
• Pyracesin;
• Stugeron;
• Tsinedil;
• Cinnarizine Sopharma;
• Cinnarone;
• Cinnasan;
• Phezam.

Attention: the use of analogues must be agreed with the attending physician.

The vessels of the brain form a special part of the body's circulatory system. Our brain depends on the functioning of this part of the circulatory system. If there are problems with blood circulation in a given part of the body, this can lead to various disorders of the motor functions of the body, intelligence, speech, memory and attention. To restore normal blood supply to the patient, doctors often prescribe Cinnarizine, a vasodilator that is characterized by high activity specifically in relation to the blood vessels of the brain.

Description

Cinnarizine is a drug that has been used for several decades. It was developed by specialists from the Belgian company Janssen. However, it was produced by domestic pharmacology back in Soviet times, so it is widely believed that it is a domestically developed drug, although in fact this is not the case. Nevertheless, in our country the drug is perhaps the most popular.

Cinnarizine always contains the active substance of the same name. Cinnarizine belongs to the class of drugs called slow calcium channel blockers. Most drugs in this class have a hypotensive effect. However, cinnarizine contained in the drug does not seriously affect blood pressure levels. However, thanks to its biochemical action, it helps to relax the smooth muscles of the walls of blood vessels and reduce their tone. This is achieved due to the fact that the drug blocks the flow of calcium ions into vascular smooth muscle cells. It also makes tissues insensitive to substances that contribute to the narrowing of the lumen of blood vessels, such as angiotensin and vasopressin. In addition, the drug has moderate antihistamine activity, reduces the excitability of the vestibular apparatus, suppresses nystagmus, and reduces the tone of the sympathetic nervous system.

First of all, the vasodilating effect concerns the vessels of the circulatory system that supplies the brain with blood. This effect of the drug allows it to successfully combat disorders of the blood supply to the brain, but only if they were associated with insufficient functionality of the circulatory system. Improving the blood supply to brain tissue ultimately affects the cognitive, speech and motor functions of the nervous system and improves the patient’s well-being.

The drug also has an effect on peripheral vessels in other parts of the body, improves blood supply to peripheral tissues, limbs, and myocardium. In addition, cinnarizine improves the physical properties of cells in the blood, making them more elastic, reduces blood viscosity, and increases muscle resistance to lack of oxygen. It is also important to note that the vasodilating properties of the drug appear mainly only in small vessels; the drug has almost no effect on large vessels. It does not have a teratogenic effect.

Pharmacokinetics

After oral administration, the active substance contained in the medication quickly enters the systemic circulation. The time to reach the maximum concentration of the drug in the blood after administration is 1-3 hours. Cinnarizine actively binds to blood plasma proteins. The percentage of the drug bound to proteins is 91%.

Completely metabolized in the liver. A third of the drug is excreted from the body by the kidneys, the rest by the intestines. The half-life is 4 hours.

Indications

The scope of application of the drug includes acute circulatory disorders of the brain and peripheral vessels. Situations in which the product can be used:

• recovery period after acute cerebrovascular accident (ischemic stroke),
• recovery period after hemorrhagic stroke (bleeding in brain tissue),
• recovery from traumatic brain injury,
• spasms of cerebral vessels,
• encephalopathy of vascular origin,
• atherosclerosis of cerebral vessels (initial stages),
• senile vascular (decrease in intelligence),
• migraine prevention,
• Meniere's disease
• coronary heart disease (as part of complex therapy),
• climacteric syndrome,
• dizziness and headaches of vascular etiology.

The wide range of application of the drug is the prevention and treatment of peripheral circulatory disorders. This list includes the following diseases:

• obliterating endarteritis;
• thromboangiitis obliterans;
• Raynaud's disease;
• diabetic angiopathy (circulatory disorders caused by diabetes mellitus);
• thrombophlebitis;
• varicose and trophic ulcers;
• pregangregous conditions during trophic processes;
• paresthesia;
• night cramps and coldness in the extremities, intermittent claudication, nonspecific aortoarteritis;
• Lelish syndrome;
• acrocyanosis.

Cinnarizine can also be prescribed as part of complex therapy for:

• nervous disorders,
• worsening mood,
• irritability,
• stress,
• rapid psychological and mental fatigue,
• decreased ability to remember information and concentrate.

When the cognitive functions of the brain deteriorate, it is effective to use the drug together with nootropic drugs, especially those that contain piracetam. The drug can also be used for allergies, of course, as part of complex therapy. The reason for this is its antihistamine properties.

Sometimes Cinnarizine is prescribed to people suffering from vegetative-vascular dystonia, changes in well-being and blood pressure depending on meteorological conditions.

Cinnarizine is also often used for motion sickness or so-called motion sickness. In this case, it can be used as a prophylactic agent before long trips by car, sea transport or airplane flights.
Another area of ​​application of the drug is labyrinthine disorders associated with impaired functioning of the inner ear. Symptoms of labyrinthine disorders include dizziness, tinnitus, nystagmus, nausea and vomiting.

It should be noted that many foreign experts doubt the effectiveness of the drug for disorders of cerebral and peripheral circulation. According to WHO recommendations, Cinnarizine should be used only for vestibular disorders, motion sickness, dizziness and for the prevention of migraine attacks.

Contraindications

It is not recommended to use Cinnarizine for women who are breastfeeding. Or, when using the drug, mothers need to stop breastfeeding the child and switch to artificial feeding. Also, Cinnarizine is not prescribed for low blood pressure.

Cinnarizine is prescribed with caution for Parkinson's disease. Treatment of elderly patients (over 65 years of age) suffering from extrapyramidal disorders or having a history of them should only be carried out under the supervision of a physician.

Contraindication is hypersensitivity to the main and auxiliary substances contained in the tablets. This is one of the few disadvantages of the drug. In particular, it is not recommended for people with lactose intolerance to take cinnarizine.

Use of the drug during pregnancy

According to the instructions, the manufacturer does not recommend the use of the drug during pregnancy. Thus, pregnancy is among the contraindications. Cinnarizine has not been tested in pregnant women, so its use in this case may be unsafe. Therefore, if a woman expecting a child needs to use drugs to treat cerebrovascular and vestibular disorders, she needs to find a replacement drug with the help of a doctor. Of course, if the expected benefit to the mother outweighs the potential risk to the fetus, then the doctor may prescribe this remedy.

Can young children be treated with Cinnarizine?

As indicated in the description of the drug, it can be used to treat patients starting from 12 years of age and cannot be used in young children. However, in practice, pediatricians often prescribe Cinnarizine for acute or chronic disorders of the nervous system in the younger age group, sometimes even in infants and newborns suffering from brain hypoxia as a result of birth injuries, prematurity, and hydrocephalus. In this case, therapy cannot be delayed, and any remedy that will help cope with this problem will be most welcome. After all, the baby’s nervous tissue must actively develop from the first days of life, and the slightest deviation from the norm can result in problems with the nervous and mental functions of the body in adulthood. Therefore, many pediatric neurologists prescribe Cinnarizine to infants in a dosage of 1/6 or 1/4 tablets per day, advising them to dissolve them in milk or water.

However, it should be noted that many experts consider treatment with Cinnarizine at this age unacceptable, and set the lower age limit at which the drug can be taken at 5 years. Of course, Cinnarizine is a remedy familiar to many doctors since Soviet times, has a positive reputation and seems completely safe. But it is also necessary to keep in mind that Cinnarizine does not have pediatric dosage forms, such as suspension, solution or syrup, or solution for parenteral administration, and tablets are not intended for use by young children. Also, the tablets are not easily divided into small parts so that the dosage corresponds to the age of the child. True, the product has a neutral taste, so giving a child a powdered tablet is not difficult. However, crushing the tablet itself cannot be considered the optimal method of administration, because this destroys the tablet shell and, as a result, disrupts the natural process of absorption of the active substance. And this can entail not only an insufficient supply of it in the blood and a decrease in the therapeutic effect, but also a negative effect on the gastrointestinal tract. Therefore, if possible, you should still choose an alternative to Cinnarizine for the treatment of infants.

Use in school-age children

However, when using the drug in children of older preschool and school age, many factors should be taken into account. It must be borne in mind that Cinnarizine is not a nootropic drug; it does not affect the concentration of neurotransmitters, biochemical processes and metabolism in the brain. One should not think that Cinnarizine has miraculous powers and can make a normal child a genius. And it’s not worth using the product just so that the child does better at school and gets straight A’s, it can only harm his health. To use the drug there must be serious reasons - these are disorders of the nervous system pathology confirmed using diagnostic methods that have arisen as a result of insufficient blood circulation.

Release form

Cinnarizine is available only in tablet form. There are no other dosage forms, such as capsules, syrup, drops or ampoules with a solution for parenteral administration. Each tablet contains 25 mg of Cinnarizine. The tablets are white and biconvex in shape.

Also in the tablets you can find several excipients:

• Aerosil-200,
• microcrystalline cellulose,
• lactose monohydrate,
• polyvinylpyrrolidone,
• wheat starch,
• Magnesium stearate.

However, it should be borne in mind that a medicine called Cinnarizine is produced by various pharmaceutical companies (Bulgarian and several Russian enterprises). Therefore, for each version of the product, the list of auxiliary components contained in them may be slightly different. Therefore, before use, you must carefully read the instructions for use.

Tablets should be stored in a dry place out of reach of children at a temperature of +25°C. Shelf life – 5 years. Cinnarizine is available in pharmacies with a prescription.

Analogs

There are several structural analogues on the market, both domestic and imported:

• Stugeron,
• Vertizin,
• Tsinedil,
• Cinnarone,
• Cinnasan.

These medications also contain Cinnarizine as an active ingredient. However, naturally, the price and quality are not the same from different manufacturers.

Also very popular are medications that contain the nootropic drugs Piracetam and Cinnarizine in various dosages:

• Fezam,
• Combitropil,
• Nookam,
• Omaron,
• Pyracesin.

In these medications, Cinnarizine and Piracetam mutually enhance the therapeutic effect of each other, due to which the scope of application of these drugs exceeds the scope of use of Cinnarizine and Piracetam separately.

There are also other medications with similar indications. This category includes:

• nootropic medications,
• medications for the treatment of cerebrovascular insufficiency,
• motion sickness remedies,
• medications for the treatment of vestibular disorders,
• medications for dizziness.

However, not in all cases they can replace Cinnarizine. You should not try to replace Cinnarizine on your own if it was prescribed by a doctor, because contraindications, side effects and use of drugs with different compositions, although they seem to belong to the same category, may differ significantly. Particular care must be taken when selecting medications for treating children.

Reviews

Most reviews about the medication are positive. Many patients or their relatives note a noticeable effect in cases of cerebral and peripheral circulation disorders, problems with the vestibular apparatus, and an increase in intellectual performance. Another attractive quality of Cinnarizine for many is its low price. However, some note side effects from taking it as disadvantages - drowsiness, hypotension, stomach pain, allergic reactions, and with long-term use - weight gain.

Instructions

The dosage of Cinnarizine depends on the disease. For cerebrovascular insufficiency and for the prevention of migraine, the dosage is 1-2 tablets (25-50 mg) three times a day.

For peripheral circulatory disorders, the dosage is 2-3 tablets (50-75 mg) 3 times a day.

For labyrinthine disorders (vestibular disorders), the dosage is one tablet (25 mg) three times a day.

The maximum daily dosage is 225 mg (9 tablets).

For children 6-12 years old, the dosage should be halved. That is, if one tablet is indicated for a corresponding disease, then you need to take half a tablet, if two, then one tablet. And the number of doses remains the same - three times a day. The maximum daily dosage for children 6-12 years old is 4-5 tablets (100-125 mg).

For motion sickness syndrome, before an upcoming trip (or plane flight), about half an hour before it starts, you should take one tablet (25 mg) as a preventive measure. If necessary, you can take a tablet every 6 hours during the trip.

Cinnarizine is recommended to be taken after meals, although this is not a strict recommendation, since the absorption of the active substance is not dependent on food. However, the tablets may cause irritation to the lining of the stomach, and to minimize such side effects it is recommended to take them with a full stomach. The tablets should be swallowed without chewing and with plenty of water.

If you do not take into account the use for the prevention of motion sickness syndrome, Cinnarizine must be taken in long courses, the duration of which ranges from 2-3 weeks to several months. It is recommended to take a break of a month between courses.

Side effects

The drug does not have many side effects. It is distinguished by a high degree of security. However, when taking it, some side effects associated with the central nervous system, gastrointestinal tract or allergic reactions may occur.

Reactions associated with the central nervous system:

• drowsiness;
• increased fatigue;
• extrapyramidal disorders (tremor, tics, hypokinesia, increased tone of striated skeletal muscles, chorea);
• depression;
• irritability;
• headache, mainly in the back of the head;
• Parkinson's syndrome;
• decreased motor activity (hypokinesia).

Parkinson's syndrome and extrapyramidal disorders can usually only appear with long-term use of the medication.

Reactions associated with the digestive tract:

• dryness or unpleasant taste in the mouth,
• pain in the epigastric region,
• dyspepsia,
• cholestatic jaundice (stagnation of bile in the hollow structures of the hepatobiliary system),
• and bloating
• belching.

Skin reactions when taking the medicine are possible - rash, urticaria. Lichen planus and lupus erythematosus are rare. Some patients also report increased sweating (hyperhidrosis) as a side effect. Systemic allergic reactions, such as Quincke's edema, may also occur.

From the cardiovascular system, the most common side effect should be considered a decrease in blood pressure.

Weight gain may also occur with long-term use of the medication.

If side effects occur, you must inform your doctor. In some cases, side effects disappear after adjusting the dose, while in other cases complete discontinuation of the medication is required.

Drug interactions

The drug enhances the effect of antidepressants, hypnotics, nootropics, sedatives, vasoconstrictors and antihypertensive medications of various types. For other medications, for example, for blood pressure medications, it reduces their effectiveness. Do not take Phenylpropanolamine at the same time as Cinnarizine. When used simultaneously with Cinnarizine, it reduces its activity. In general, a large number of negative drug interactions between the drug and others were not recorded.

The ability of Cinnarizine and Piracetam to enhance each other's effects is the reason why this combination is used in many medications.

Interaction with alcohol

The drug also enhances the inhibitory effect of ethyl alcohol on the central nervous system. Alcohol and Cinnarizine do not mix well together. Therefore, when taking, especially at the beginning of the course of treatment, you should refrain from drinking alcohol.

special instructions

Since the drug has antihistamine activity, it may interfere with the results of skin allergy tests. Thus, the drug must be discontinued at least 4 days before testing.

During the treatment period, it is not recommended to drive vehicles or perform work that requires concentration, since one of the side effects is drowsiness. This phenomenon is especially typical for the initial period of treatment.

Patients prone to hypotension should monitor their blood pressure throughout the course of therapy. Also, once every 1-2 weeks, all patients are recommended to monitor the condition of the kidneys and liver by taking blood tests. The following parameters must be determined:

• aLaT,
• аСаТ,
• alkaline phosphatase,
• urea concentration,
• creatinine,
• leukocyte formula.

Overdose

An overdose occurs when taking a medication in a dose exceeding the maximum single dose (75 mg) or daily dose (225 mg). For children, these indicators must be divided by two. In case of overdose, various negative phenomena can be observed:

• vomit,
• drowsiness,
• low blood pressure.

Coma and even death may occur. There is no specific antidote. In case of overdose, it is recommended to lavage the stomach and take enterosorbents, for example, activated carbon, Polysorb, Enterosgel. Symptomatic therapy is also provided.

In this article you can read the instructions for use of the drug Cinnarizine. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Cinnarizine in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Cinnarizine in the presence of existing structural analogues. Use for the treatment of vascular disorders (stroke and encephalopathy) in adults, children (including infants and newborns), as well as during pregnancy and lactation.

Cinnarizine- a selective blocker of “slow” calcium channels, reduces the entry of calcium ions into cells and reduces their concentration in the plasma membrane depot, reduces the tone of the smooth muscles of arterioles, and enhances the vasodilating effect of carbon dioxide. Directly affecting the smooth muscles of blood vessels, it reduces their response to biogenic vasoconstrictors (adrenaline and norepinephrine). It has a vasodilating effect (especially in relation to cerebral vessels), without having a significant effect on blood pressure. It exhibits moderate antihistamine activity, reduces the excitability of the vestibular apparatus, and lowers the tone of the sympathetic nervous system.

Effective in patients with latent cerebral circulatory failure, initial cerebral atherosclerosis and chronic cerebral vascular diseases with post-stroke focal symptoms. In patients with impaired peripheral circulation, it improves blood supply to organs and tissues (including the myocardium), and enhances post-ischemic vasodilation. Increases the elasticity of red blood cell membranes, their ability to deform, and reduces blood viscosity. Increases muscle resistance to hypoxia.

Pharmacokinetics

Excreted in the form of metabolites: 1/3 - by the kidneys, 2/3 - by the intestines.

Indications

• the period of convalescence after suffering an ischemic and hemorrhagic stroke, traumatic brain injury;
• encephalopathy;
• labyrinthine disorders (including for maintenance therapy for dizziness, tinnitus, nystagmus, nausea, vomiting of labyrinthine origin);
• migraine (prevention of attacks);
• Meniere's disease;
• sea ​​and air sickness (prevention);
• peripheral circulatory disorders (prevention and treatment) - obliterating endarteritis, thromboangiitis obliterans, Raynaud's disease, diabetic angiopathy, thrombophlebitis, trophic disorders, trophic and varicose ulcers, pre-gangrenous conditions, paresthesia, night cramps and coldness in the extremities.

Release forms

Tablets 25 mg.

Other forms of the pure drug Cinnarizine, be it injections in ampoules, capsules, etc. does not occur, it is possible that these medications are counterfeits.

Instructions for use and dosage

Inside, after eating. For cerebrovascular accidents - 25-50 mg 3 times a day; for peripheral circulation disorders - 50-75 mg 3 times a day; for labyrinthine disorders - 25 mg 3 times a day; for sea and air sickness, before an upcoming trip for adults - 25 mg, if necessary, repeat the dose after 6 hours. Children are prescribed half the dose for adults. The maximum daily dose should not exceed 225 mg.

In case of high sensitivity to the drug, treatment begins with 1/2 dose, increasing it gradually. The course of treatment ranges from several weeks to several months.

Side effect

• drowsiness;
• increased fatigue;
• headache;
• extrapyramidal disorders (tremor of the limbs and increased muscle tone, hypokinesia);
• depression;
• dry mouth;
• pain in the epigastric region;
• dyspepsia;
• cholestatic jaundice;
• increased sweating;
• lichen planus (extremely rare);
• skin rash;
• decrease in blood pressure;
• increase in body weight.

Contraindications

• pregnancy;
• lactation period;
• children under 12 years of age (use of the drug in infants and newborns is contraindicated);
• hypersensitivity to the drug.

Use during pregnancy and breastfeeding

Contraindicated during pregnancy and lactation.

Use in children

Contraindicated in children under 12 years of age.

special instructions

At the beginning of treatment, you should refrain from taking ethanol (alcohol).

Due to the presence of an antihistamine effect, cinnarizine can affect the test result during anti-doping control of athletes (false-positive result), as well as neutralize positive reactions during skin diagnostic tests (treatment should be discontinued 4 days before the test).

Impact on the ability to drive vehicles and operate machinery

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Drug interactions

Pharmaceutical: No chemical incompatibility known.

Pharmacodynamic: Strengthens the effect of alcohol, sedatives and antidepressants. When used simultaneously with nootropic, antihypertensive and vasodilator drugs, it enhances their effect, and when used simultaneously with drugs prescribed for arterial hypotension, it reduces their effect.

Analogues of the drug Cinnarizine

Structural analogues of the active substance:

• Vertizin;
• Vertisin Forte;
• Stugeron;
• Tsinedil;
• Cinnarizine Sopharma;
• Cinnarone;
• Cinnasan.

In combinations with Piracetam (increased nootropic effect):

• Combitropil;
• NooKam;
• Omaron;
• Pyracesin;
• Phezam.

Analogs in terms of effect (nootropic effect):

• Amylonosar;
• Aminalon;
• Ampasse;
• Anvifen;
• Bilobil;
• Gammalon;
• Gleatser;
• Gliatilin;
• Glycine;
• Gopantam;
• Hopantenic acid;
• Delecite;
• Demanol;
• Idebenone;
• Intellan;
• Cortexin;
• Lutsetam;
• Mexipridol;
• Memotropil;
• Minisem;
• Nootropil;
• Noocetam;
• Pantogam;
• Pirabene;
• Piracetam;
• Semax;
• Tenoten;
• Phenibut;
• Phenotropil;
• Cerebrolysate;
• Cerebrolysin;
• Encephabol.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

One tablet contains: active ingredient - cinnarizine - 25 mg; excipients: lactose monohydrate, potato starch, povidone, colloidal anhydrous silicon dioxide, magnesium stearate.

Description

Tablets are white or almost white, flat-cylindrical, with a bevel.

Indications for use

Chronic cerebrovascular insufficiency, incl. for residual effects after a stroke (dizziness, tinnitus, headache, memory and attention disorders).

Vestibular disorders (including Meniere's disease, dizziness, tinnitus, nystagmus, nausea and vomiting of labyrinthine origin).

Prevention of kinetosis (“road sickness” - sea and air sickness).

Migraine (prevention of attacks).

Peripheral circulation disorders (“intermittent” claudication, Raynaud’s disease, diabetic angiopathy, thrombophlebitis, trophic disorders, including trophic and varicose ulcers).

Contraindications

Hypersensitivity, pregnancy, lactation, children under 5 years of age.

Carefully

Parkinson's disease.

Directions for use and doses

Inside, after eating.

For chronic cerebrovascular insufficiency - 25 mg 3 times a day.

If peripheral circulation is impaired - 50 - 75 mg 3 times a day.

For the prevention of sea and air sickness - 25 mg 30 minutes before the upcoming trip, if necessary, repeat the dose after 6 hours; for children over 5 years old - ½ dose for adults.

For vestibular disorders - 25 mg 3 times a day. For children, the dose is reduced by 2 times.

The maximum daily dose should not exceed 225 mg. In case of high sensitivity to cinnarizine, treatment begins with 1/2 dose, increasing it gradually. To achieve an optimal therapeutic effect, the drug should be taken continuously, for a long time - from several weeks to several months.

Side effect

From the nervous system: drowsiness, increased fatigue, headache, extrapyramidal disorders (tremor of the limbs and increased muscle tone, hypokinesia), depression.

From the digestive system: dryness of the oral mucosa, pain in the epigastric region, dyspepsia, cholestatic jaundice.

From the skin: increased sweating, lichen planus (extremely rare).

Allergic reactions: skin rash.

Others: decreased blood pressure, increased body weight, lupus-like syndrome.

Overdose

Symptoms: vomiting, drowsiness, tremor, excessive decrease in blood pressure, coma.

Treatment: there is no specific antidote, gastric lavage, activated charcoal, symptomatic therapy

Interaction with other drugs

When used simultaneously with tricyclic antidepressants, hypnotics and sedatives, ethanol, ethanol-containing drugs, the effect on the central nervous system is enhanced.

When used simultaneously with antihypertensive drugs, the hypotensive effect is enhanced; with nootropic drugs, vasodilators - the effect of nootropic and vasodilator drugs is enhanced.

Features of application

At the beginning of treatment you should refrain from drinking alcohol.

Due to the presence of an antihistamine effect, cinnarizine can affect the results of anti-doping control of athletes (false-positive results), as well as neutralize positive reactions during skin diagnostic tests (treatment should be discontinued 4 days before the test).