Ovitrel with IVF is a drug for stimulating ovulation. Is it possible to ovulate after Ovitrel? Ovitrel how long does it take

Many women do not know what are the drugs that are important if sexual function is impaired. It is important to know how to inject Ovitrel and when ovulation occurs after an injection.

Indications

The advantage of the drug is that it is produced in a convenient form. The package contains a medicine and a syringe for it. That the procedure went well, detailed instructions are attached. Ovitrel is used for IVF in almost all cases. The drug has already proven itself, as evidenced by the positive feedback from women who have already become mothers.

Ovitrel acts on the body, increasing the chances of pregnancy. Before carrying out the fertilization process, the preparation stage is important. In the body of a woman, there should not be hormonal disruptions in order for the embryo to take root.

Ovitrel before puncture necessary for assisted reproductive technologies. It is administered two days after the injection is given to stimulate the follicles. This will allow you to reach the optimal level of their maturation.

Ovitrel before insemination will help ensure the meeting of the egg and sperm. That is, it affects the increase in the chances of getting pregnant as soon as possible. Ovitrel after insemination can show the presence of pregnancy. However, this does not confirm it, but only means that hCG is present in the body.

When does ovulation occur after an Ovitrel injection? This happens from a day to one and a half, that is, in the next 36 hours after the administration of the drug. As a rule, this is confirmed by ultrasound.

To stimulate a successful pregnancy, it is required to continue to inject Ovitrel after embryo transfer.

This remedy stimulates the rupture of the dominant follicle, if it develops normally, grows to the desired size, but does not burst on its own.

Where to inject Ovitrelle? The drug is administered subcutaneously. Do it in the stomach or in the thigh. It is better if the issue is dealt with by a specialist. Although, if a woman knows how to give ordinary injections, she will cope with this task. The package comes with a step-by-step instruction manual.

Why inject Ovitrel during IVF:

1. helps follicles mature faster;
2. stimulates ovulation and maturation of the corpus luteum;
3. affects the fact that the bubble bursts and the cell comes out.

When to inject Ovitrel (cycle day)? Doctors, in compliance with all the rules, do this on the 12th day of the cycle.

How to inject Ovitrel in the stomach:

• wash and disinfect hands;
• prepare a syringe with medicine, moisten two swabs in alcohol;
• inject into the abdomen or anterior thigh area. To do this, the skin is wiped with alcohol. It is necessary to put Ovitrel at an angle of 45 degrees;
• it is important not to get into a vein, but to administer the drug slowly;
• wipe the injection site with a swab;
• the syringe is removed into the container, the medicine is disposed of.

Many patients complain that their stomach hurts after Ovitrel. This occurs in case of accumulation of fluid in the abdominal cavity and circulatory disorders. As a rule, this happens with an overdose of the drug. So, it is required to be protected from conception.

How much does Ovitrelle cost? The price will depend on the number of syringes and powder bags in the package. In Russia, you can buy medicine at a cost of 2 to 3 thousand rubles.

It is necessary to stimulate ovulation with the help of the drug after studying all the pros and cons. It is important to read the instructions and side effects. Ovitrel can be used after full confirmation that there is no threat to health.

Infertility is a problem for many couples these days, often due to ovulation problems.

When carrying out assisted reproductive technologies, the method of ovulation stimulation is used. Ovitrel is one of the most effective drugs used for this purpose.

About the drug

Ovitrel is a drug that promotes the accelerated maturation of the follicle, the development of ovulation and the formation of the corpus luteum.

The main active ingredient of the drug is choriogonadotropin alfa. This is a synthetic analogue of human chorionic gonadotropin, identical in structure and properties, obtained through recombinant technologies. Excipients include purified water, mannitol, sodium hydroxide and phosphoric acid.

Indications

Ovitrel is used during assisted reproductive measures (including IVF) in the ovulation induction protocol with multiple maturation of follicles, as an initiator of the final maturation of follicles and the formation of the luteal body after the use of gonadotropins.

Also, the drug is prescribed for infertility, the cause of which is the absence or abnormally rare ovulation. In this case, Ovitrelle stimulates the ovaries to mature follicles and form a corpus luteum.

Contraindications

There is a list of conditions under which Ovitrel should not be used.:

• benign and malignant neoplasms of the pituitary and hypothalamus;
• hypersensitivity to the active substance or to any of the additional components that make up the composition;
• various formations in the ovaries, including cysts (with the exception of polycystic ovaries);
• bleeding with unknown etiology;
• malignant neoplasms of the mammary glands, uterus or ovaries;
• ectopic (ectopic) pregnancy in the last 3 months;
• thromboembolism;
• primary ovarian insufficiency;
• anomalies in the development of female genital organs that are incompatible with pregnancy;
• uterine fibroids, in which pregnancy is contraindicated;
• postmenopausal period;
• pregnancy and lactation.

Ovitrel should be used with extreme caution in the presence of systemic diseases, since pregnancy can cause their exacerbation.

Release form and cost of the drug

The drug is available as a pre-filled syringe with a hypodermic needle., which contains 0.5 ml of a clear liquid (250 mcg of hCG alfa). Another form of release is a powder for preparing a solution in a vial.

The cost of packing Ovitrel depends on the form of release and the manufacturer, on average it is in the range of 2000-2800 rubles.

Analyzes and examinations

Before starting the use of the drug, the doctor must establish whether infertility is really associated with insufficient maturation of the follicle and with the absence of ovulation, and not with the pathology of other organs. It is also necessary to identify the presence of other diseases that are contraindications to the appointment of the drug. For this, a comprehensive comprehensive medical examination of both the woman herself and her partner is carried out.

Main indications are determined by ultrasound of the ovaries and the study of hormonal levels. It is especially important to identify signs of hypothyroidism, adrenal insufficiency, hyperprolactinemia, neoplasms of the pituitary gland and hypothalamus using special laboratory and instrumental methods. When the functioning of these organs is restored, ovulation can occur on its own, without additional stimulation.

Infertility can be caused by pathology on the part of the partner, so it is important to obtain spermogram data. Normally, for successful fertilization, the number of mobile, active spermatozoa should be from 50% of the total. This indicator is negatively affected by several factors:

• elderly age;
• infectious processes;
• frequent consumption of spicy food;
• regular hot baths.

Another possible cause of sperm death is varicocele, which leads to an increase in temperature in the testicles. Also it is important to exclude sexual infections - gonorrhea and trichomoniasis.

How to apply?

If the drug is used at home, then it is necessary to adhere to a certain sequence of actions:

After the manipulation, the empty syringe must be disposed of in a special container, and the remains of its contents must be destroyed and not used for reuse.

Side effects

When using Ovitrel, a woman may experience some side effects, which are most often associated with an incorrectly selected or administered dose:

• ovarian hyperstimulation syndrome, breast tenderness;
• nausea, vomiting, abdominal pain, diarrhea, abdominal discomfort;
• headache, depression, fatigue, irritability, anxiety, weakness;
• pain and redness at the injection site;
• small skin rash;
• hypersensitivity reactions from minor symptoms to anaphylactic shock;
• thromboembolism.

How many hours after the injection does the follicle mature?

Determined that follicle maturation occurs within 24-36 hours after the injection. Since spermatozoa can remain viable in a woman's body for up to 1 week, sexual intercourse can be planned immediately after the injection, as well as the next day. Fertilization of the egg will occur as soon as ovulation occurs.

The effectiveness of the drug cannot be determined using an ovulation test, since the structure of hCG is very similar to the structure of luteinizing hormone (LH), namely, an increase in the concentration of LH is reflected in the form of a positive result on the test.

A positive test will only mean the presence of a drug substance, and not the process of ovulation. This reaction can last up to 10 days, so the first pregnancy test is carried out approximately 2 weeks after the expected day of ovulation.

Objective confirmation of the onset of ovulation can only be obtained with the help of ultrasound.

How does it develop normally?

Ovulation normally develops due to a sharp increase in the concentration of LH, hCG has the same property. The active substance of Ovitrel, hCG alfa, is similar in structure to a woman's hCG, obtained from urine.

HCG binds to membrane receptors for LH on the cells of oocytes and ovarian granulosa, promotes the process of meiosis in eggs, ovulation and the formation of the luteal body.

Another important property of Ovitrel is the ability to increase the level of estradiol and progesterone in the concentration necessary for ovulation.

Why doesn't it come sometimes?

In the vast majority of cases, an injection of Ovitrel leads to the development of ovulation during the day. There are a number of reasons that prevent ovulation from occurring:

• improperly performed stimulation of follicle maturation;
• absence of a dominant follicle;
• violations of the health of the partner, which were not detected by the spermogram;
• hormonal disorders;
• the presence of other diseases and pathological conditions in a woman that affect the development of ovulation.

Ovitrel is a drug that cannot be used alone without medical supervision. Only the attending physician can prescribe the remedy and select an individual dosage, taking into account the complex of laboratory and instrumental data. The patient is required to follow the days of the Ovitrel injection, sexual intercourse, and ultrasound monitoring as accurately as possible.

You should be aware that there are many reasons for the lack of ovulation, and not every form of anovulation is corrected with hCG. It must be understood that this method of stimulation does not give a 100% guarantee of ovulation and pregnancy.

When using ovulation stimulants, the risk of developing multiple pregnancies is significantly increased compared to natural conception (most women have twins).

Before using Ovitrel, it is extremely important to make sure that the problem of infertility lies precisely in women's health, and not in the quality of the partner's sperm. A spermogram should be obtained immediately before treatment, which will prevent the couple from wasting money and time in the future.

Ovitrel is one of the most popular and effective drugs for ovulation stimulation. Before use, both partners must undergo a comprehensive medical examination, and after a medical consultation, follow all recommendations and instructions.

Related videos

We offer you to watch a video about the drug Ovitrel:

An ovitrel injection is given to women as part of reproductive technologies who want to get pregnant, as they cannot recover from infertility for a long time. - a synthetic analogue of human gonadotropin, which is available in injectable form. Many women are concerned about the question - how soon after ovitrel can pregnancy occur, and who helped ovitrel?

Pharmacological properties of the drug

An injection of the drug exhibits gonadotropic and luteinizing properties. The synthetic analogue has the same efficiency as the natural component and is in no way inferior in its properties. Ovitrel stimulates ovulation, after which the egg is released from the follicle, which creates high chances for conception. In addition to stimulating ovulation, there is an increased production of progesterone and estrogen by the corpus luteum.

How LS works

If a woman has anovulatory type infertility, then treatment involves an integrated approach. First, stimulation occurs with the help of follicle-stimulating hormone and luteotropic hormone, so that the dominant follicle can mature normally with a developed egg. When stimulation with luteotropin and follitropin is completed, after 1-2 days, ovitrel is administered in an amount of 250 μg subcutaneously. You need to have sex on the day of the injection or the very next day, because the egg is released into the uterine cavity 1-1.5 days after the injection. All ongoing processes are regularly monitored using an ultrasound machine.

How well does ovitrel help?

According to medical statistics, many women have become pregnant by this method and have given birth to healthy children. Anovulatory infertility, although not the most common, but occurring disease of the female reproductive system. Drugs like ovitrel and its analogues have helped many to conceive a child. True, there is always a risk of negative side effects, the most unpleasant of which is ovarian hyperstimulation. It occurs in about 4 cases out of 100. Such situations depend more on the competence of the doctor than on the individual reaction to the drug or side effects.

Contraindications for use

It is impossible to stimulate the ovaries with chorionic gonadotropin if there is a history of pituitary tumors and oncology of the hypothalamus. The medication is not used for increased hypersensitivity reactions and intolerance of an individual order. You can not use the remedy for any cystic formations, ectopic pregnancy, breast cancer and bleeding from the uterus of unknown origin, thromboembolism, ovarian insufficiency.

Possible side effects

From the gastrointestinal tract: diarrhea, stomach pain, nausea and vomiting.

Reproductive system: Ovarian overstimulation or painful breast engorgement.

Nervous system: depression, mood swings, migraines, decreased performance, anxiety.

Local: redness at the injection site, which disappears on its own.

Other side effects: skin itching, urticaria, any other allergic reactions, dermatitis, chronic fatigue.

If ovulation is disturbed, it is impossible to plan a child. Pathology is corrected with medications, one of which is Ovitrel. It is necessary to consider the method of application of the drug and how Ovitrel works during ovulation.

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What is an ovitrel?

Ovitrel is a drug containing an analogue of female chorionic gonadotropin. Available in the form of injections or powder. The synthetic analogue of hCG does not differ from the natural one in properties.

The main purpose of taking the drug is to stimulate ovulation, after which the mature germ cell leaves the follicle. In addition, the drug accelerates the production of progesterone in the female body.

The composition of the drug includes auxiliary components:

• purified water;
• mannitol;
• phosphoric acid;
• methionine.

The distribution of the solution in the body occurs 4.5 hours after its administration. The half-life of the drug is 30 hours.

Use of the drug during ovulation

With an anovular cycle, treatment with Ovitrel is carried out in a complex manner. Initially, therapy is carried out with the help of luteotropic and follicle-stimulating hormone. It is necessary for the normal growth and maturation of the egg. A few days after hormonal therapy, Ovitrel injections are performed.

The drug greatly increases the chances of pregnancy, but preparatory measures are necessary before using it. A woman should not suffer from hormonal disruptions, otherwise a fertilized egg will not be able to attach to the endometrium of the uterus.

It is forbidden to independently select the dosage of Ovitrel. This can lead to deterioration or death. The use of the drug is possible only under the supervision of a gynecologist. The doctor monitors the development of the follicle and the effect of the drug on the egg.

If a woman injects Ovitrel at home, then it is important for her to follow some rules:

1. Wash your hands with soap before the procedure.
2. Prepare several swabs soaked in alcohol.
3. Draw up the medicine in the syringe at the dosage recommended by the doctor.
4. Wipe the area of ​​\u200b\u200bthe body where the drug will be injected with a swab. Gynecologists recommend performing an injection in the abdomen or front of the thigh.
5. Position the needle at a 45 degree angle. This rule must be observed to prevent the drug from entering the vein.
6. Do not use the remaining solution for a second injection.

In case of accidental violation of the dosage, you should consult a doctor. The same applies to cases where one or more injections were missed.

The daily dosage of Ovitrel is 250 mcg. To stimulate ovulation, you need 5000 IU hCG, and for the maturation of the egg - 10000 IU hCG.

How fast will ovulation occur?

How long does it take to ovulate after Ovitrel? It is believed that after the administration of the drug, the maturation of the female germ cell occurs within 36 hours. In practice, there have been cases when ovulation occurred on the first day after the injection.

After injections of Ovitrel, you can immediately start planning a child. Spermatozoa that enter a woman during intercourse remain viable for up to 1 week. 36 hours will be enough for them to fertilize an egg that has left the follicle.

The medicine is injected before IVF. The drug allows:

• accelerate the maturation of follicles;
• stimulate the maturation of the corpus luteum;
• contribute to the rupture of the capsule in which the egg is located.

Injections are prohibited in the following cases:

• in the presence of neoplasms in the ovaries;
• with inflammation of the organs of the reproductive system;
• with intolerance to the components of the drug.

Side effects of injections include:

• symptoms of intoxication;
• headache;
• feeling tired;
• allergic rashes;
• change of mood.

Before starting treatment, both partners are examined. After all, the conception of a child depends not only on the lady.

Ultrasound should be performed 2-3 days after the start of treatment.

How does ovulation occur after Ovitrel?

In the second phase of the cycle, the drug helps to increase the production of hormones involved in the process of ovulation - estradiol and progesterone. The course of treatment is prescribed after taking medications that stimulate the growth of the follicle.

The process of ovulation becomes impossible with insufficient levels of sex hormones in the female body. Ovitrel contains all the necessary substances to stimulate the maturation of the egg.

Why does pregnancy not occur?

A long-awaited pregnancy does not always occur even in the presence of ovulation. For this reason, Ovitrel does not guarantee a 100% chance of conceiving a child.

Among the negative factors that adversely affect the possibility of conception, it should be noted:

1. Failure of the hormonal background. Occurs with emotional exhaustion or after viral diseases.
2. endocrine disorders.
3. Incompatibility of woman and man. The immune cells of a lady can react negatively to spermatozoa, producing antibodies against them.
4. Inflammation of the organs of the reproductive system.
5. Illiterate douching.
6. Polycystic ovaries.
7. Obstruction of the fallopian tubes.
8. Endometriosis of the uterus is a disease in which the endometrium grows relative to the mucous membranes. As a result, neoplasms of a benign nature are formed in the genital organ, preventing the implantation of the fetal egg.

In the initial stages of the listed pathologies, a woman does not observe characteristic symptoms in herself. In this case, it is possible to identify the reason for the impossibility of conceiving a child only after a complete examination of the body.

Pregnancy may not occur due to deviations in the health of a man. This happens due to:

1. Insufficient activity of spermatozoa. This indicator is determined using a spermogram. Normally, a man should have from 50% of mobile “tadpoles”. The following factors negatively affect sperm activity: advanced age, past infectious diseases, eating spicy food, being in a hot bath.
2. Diseases of the varicocele. Manifested by the expansion of the seminiferous tubules. Spermatozoa in pathology die due to an increase in temperature in the testicles.
3. Sexual infections - trichomoniasis, gonorrhea.

The cost of the drug

Ovitrel can be purchased at any pharmacy or ordered online. The average cost of the drug is from 2200-2800 rubles per pack.

About the drug Ovitrel women leave positive feedback. Thanks to the medicine, it became possible for them to successfully conceive a child with an anovular cycle. Among the side effects of the drug, ovarian hyperstimulation is noted. A consequence is observed quite rarely - in 5 cases out of 100. Adverse reactions are observed due to an incorrectly drawn up regimen of therapy or if the female body is intolerant to the components of the drug.

After treatment, pregnancy is determined by a test or blood test. If conception has occurred, then doctors prescribe additional therapy for the normal functioning of the corpus luteum and the preservation of the life of the embryo.

Ovitrel is a drug for stimulating the maturation of eggs. Injection with medicine is a serious hormonal effect on the female body. For this reason, self-medication with the use of medication is unacceptable.

A successful IVF protocol depends on many factors, the most important part of the procedure is the preparation of the woman. To obtain several high-quality embryos, ovulation stimulation with hormonal drugs is used, one of them is Ovitrel.

With the help of stimulation, it is possible to provoke the maturation of not a single egg, as occurs in the natural cycle, but from 8 to 20. But it is very important to use the drug under the supervision of a doctor, otherwise everything will be in vain.

Ovulation is a determining factor for pregnancy. If ovulation does not occur, but the egg will not enter the fallopian tube and the sperm will not be able to fertilize it. The hormonal background of a woman affects this process, therefore, ovulation is stimulated with hormonal drugs.

Source: eco-pharm.ru

The active ingredient in Ovitrel is hCG, a hormone produced by the pituitary gland. He is responsible for the process of ovulation.

The drug is indicated for infertility in the event that there is no ovulation and menstruation, or to stimulate superovulation for a successful IVF protocol. It is prescribed after taking follicle-stimulating hormones instead of hCG preparations. Ovitrel helps the follicle break through and release a mature egg, and also stimulates the formation of the corpus luteum.

Contraindications

Ovitrel has a number of contraindications:

• allergic reactions to the components of the drug;
• tendency to uterine bleeding;
• tendency to thrombosis;
• in oncological diseases.

In addition, Ovitrel can provoke the following side effects:

• violations of the digestive tract;
• ovarian hyperstimulation;
• weakness;
• allergic rash;
• headache.

To avoid side effects, it is recommended to use the drug under the supervision of a reproductologist.

Application

Ovitrel is applied subcutaneously. It is supplied as a powder, complete with water for injection. Before use, the powder is dissolved in water, and then an injection is made in the abdomen, 2-3 centimeters from the navel. The injection is made one day after the end of taking the follicle-stimulating hormone.

Within 24-48 hours, it is necessary to perform an ovarian puncture during IVF, otherwise ovulation will occur and it will no longer be possible to remove the eggs. With insemination, the introduction of sperm into the uterus is performed on the day of ovulation. The doctor controls the process of maturation of the follicles with the help of ultrasound.

Injection rules:

• Hands and ampoules are treated with alcohol;
• Ampoules are opened, the powder is diluted with water;
• The finished solution is taken into the syringe, air is released;
• The abdomen is treated with alcohol;
• The fold of the abdomen is clamped into the hand and a needle is inserted into it;
• The drug is injected and the needle is removed;
• The injection site is treated with alcohol.

It is best if the injection is given by a doctor. It is very important to observe the prescribed dosage and timing of the injection, otherwise the procedure may fail.