Is ovulation possible after Ovitrelle? Development of ovulation - how many hours after the Ovitrel injection does it occur? How long does it take for Ovitrel to ovulate reviews?

Instructions for use:

Ovitrel is a luteinizing drug of recombinant choriogonadotropin alpha, an analogue of human chorionic gonadotropin (hCG).

Release form and composition

• Solution for subcutaneous administration: clear or slightly opalescent liquid, colorless or light yellow (0.5 ml in a clear glass syringe complete with an injection needle, 1 set in a plastic container, 1 container in a cardboard box);
• Lyophilisate for preparing a solution for subcutaneous administration: powder or porous mass of almost white or white color (0.25 mg in bottles, 1, 2 or 10 bottles complete with an ampoule of solvent (1, 2 or 10 ampoules, respectively) in plastic containers, 1 container in a cardboard box).

1 0.5 ml syringe contains:

• Active ingredient: choriogonadotropin alpha – 0.25 mg (6500 International Units (IU));
• Auxiliary components: methionine, mannitol, poloxamer 188, sodium hydroxide, phosphoric acid, water for injection.

1 bottle contains:

• Active ingredient: choriogonadotropin alpha – 0.25 mg (6500 IU);
• Auxiliary components: phosphoric acid, sucrose, sodium hydroxide in the amount necessary to maintain the pH level.

Solvent: water for injection.

Indications for use

Ovitrel is used in an ovulation induction protocol with multiple maturation of follicles (superovulation) during ART (assisted reproductive technologies), including in vitro fertilization, to induce the final maturation of follicles and the formation of the corpus luteum after stimulation with gonadotropin preparations.

Also, indications for the use of the drug are anovulatory or oligoovulatory infertility, in which Ovitrel is used to stimulate the ovaries in order to obtain mature follicles and luteinization at the end of the process of stimulating follicular growth.

Contraindications

• Vaginal bleeding of unknown origin;
• Ectopic pregnancy within the previous 3 months;
• Uterine fibroids incompatible with pregnancy;
• Tumors in the pituitary gland and hypothalamus;
• Ovarian tumors not associated with polycystic ovarian cysts;
• Primary egg failure;
• Cancer of the breast, uterus or ovary;
• Thromboembolism;
• Congenital defects in the development of the genital organs that are incompatible with pregnancy;
• Postmenopause;
• Hypersensitivity to the components of the drug.

Ovitrel is used with caution in patients with serious systemic diseases, the exacerbation of which can be provoked by pregnancy.

Directions for use and dosage

Solution for subcutaneous administration
The drug is administered subcutaneously. Each syringe is used for single use only.

• Use in the ovulation induction protocol: the contents of the syringe (0.25 mg) are administered once 24-48 hours after the last injection of follicle-stimulating hormone (FSH) or luteinizing hormone (LH), provided that the optimal level of follicle development is achieved;
• Anovulatory or oligoovulatory infertility: the contents of the syringe (0.25 mg) are administered once 24-48 hours after reaching the optimal level of follicle development. On the day of drug injection and the next day, sexual intercourse is recommended.

Lyophilisate for the preparation of solution for subcutaneous administration
The solution prepared from the lyophilisate is administered subcutaneously.

To use Ovitrel independently, patients need to study the instructions and act in accordance with the instructions:

1. The injection must be carried out observing the rules of asepsis and antisepsis;
2. To carry out the injection, you should prepare by laying out on a clean surface two swabs soaked in alcohol and a pre-filled or ready-to-use syringe;
3. The injection must be carried out in an area of ​​the body selected on the recommendation of the attending physician (the front of the thigh or abdominal area). The injection site should be wiped with a swab with alcohol, the disinfected area of ​​skin should be pulled together with your fingers, a needle should be inserted into the skin fold at an angle of 45-90°, gently pressing the piston, slowly inject the entire volume of the solution, carefully remove the needle, then wipe the injection site with a second swab with circular movements. alcohol. It is necessary to avoid getting the solution into a vein;
4. After the procedure, the used syringe should be placed in a container for disposal of sharps; the unused volume of the drug must be destroyed.

When administering an increased dose of Ovitrel or if an injection is missed, the patient should seek advice from her doctor.

Side effects

• Reproductive system: often – OHSS (ovarian hyperstimulation syndrome); rarely - tenderness of the mammary glands, severe OHSS;
• Digestive system: often – abdominal pain, nausea, vomiting; rarely - diarrhea;
• Central nervous system: often – headache; rarely - anxiety, irritability, fatigue, depression;
• Local reactions: often - pain and hyperemia in the injection area;
• Skin: very rarely - mild reversible skin rash;
• Other: often – fatigue; very rarely – mild hypersensitivity reactions.

special instructions

Before starting therapy with Ovitrel, it is necessary to establish the causes of infertility in a woman and her sexual partner and assess possible risk factors in the event of pregnancy. It is necessary to take into account the presence of tumors of the hypothalamus and pituitary gland, adrenal insufficiency, clinically pronounced hypothyroidism, hyperprolactinemia, as well as the specific treatment methods used.

Due to the large number of follicles maturing simultaneously during ovarian stimulation, women are at risk of developing OHSS. Clinical studies have shown that OHSS (moderate to mild in most episodes) occurred in approximately 4% of cases. Severe OHSS can become a serious complication of stimulation. Rarely, the following complications are possible due to severe OHSS: acute respiratory distress syndrome, hemoperitoneum, thromboembolism, ovarian torsion. The protocol for stimulating follicular growth to reduce the risk of OHSS recommends careful monitoring of the ovarian response using ultrasound and determining the level of estradiol in the blood before and during the course of therapy.

During stimulation, the risk of multiple pregnancy increases compared to the natural process of fertilization; Most induced pregnancies result in twins. When using assisted reproduction methods, the number of children born corresponds to the number of embryos transferred into the uterine cavity.

After treatment for anovulatory infertility (including the use of assisted reproductive technologies), according to statistics, the number of miscarriages exceeds the population average, but is comparable to other types of infertility.

Administration of the drug may affect the immunological picture of hCG levels in urine and blood serum for 10 days and give a false positive reaction in the case of a pregnancy test.

Ovitrel may slightly stimulate thyroid function.

It is necessary to inform your doctor about cases of increased side effects and about all adverse reactions not described in the instructions.

Drug interactions

There are no data on the interaction of Ovitrel with other medicinal substances/drugs. Despite this, the patient should inform the attending physician about all medications, including over-the-counter medications, currently or recently taken.

Analogues

There is no information on analogues of the drug Ovitrel.

Terms and conditions of storage

The drug must be stored in its original packaging, out of reach of children, at a temperature of 2-8 °C, do not freeze.

The drug can be stored at temperatures up to 25 °C (outside the refrigerator) for 30 days, within the expiration date. After this period, unused solution should be destroyed.

Shelf life – 2 years.

Infertility is a problem for many married couples these days, often due to ovulation problems.

When carrying out assisted reproductive technologies, the method of stimulating ovulation is used. Ovitrel is one of the most effective drugs used for these purposes.

About the medicine

Ovitrel is a drug that promotes accelerated maturation of the follicle, the development of ovulation and the formation of the corpus luteum.

The main active ingredient of the drug is choriogonadotropin alpha. This is a synthetic analogue of human chorionic gonadotropin, identical in structure and properties, obtained through recombinant technologies. Excipients include purified water, mannitol, sodium hydroxide and phosphoric acid.

Indications

Ovitrel is used during assisted reproductive procedures (including IVF) in an ovulation induction protocol with multiple maturation of follicles, as an initiator of the final maturation of follicles and the formation of the luteal body after the use of gonadotropins.

The drug is also prescribed for infertility, which is caused by the absence or abnormally rare ovulation. In this case, Ovitrel stimulates the ovaries to mature follicles and form the corpus luteum.

Contraindications

There is a list of conditions for which Ovitrel cannot be used:

• benign and malignant neoplasms of the pituitary gland and hypothalamus;
• hypersensitivity to the active substance or to any of the additional components that are included in the composition;
• various formations in the ovaries, including cysts (with the exception of polycystic ovary syndrome);
• bleeding of unknown etiology;
• malignant neoplasms of the mammary glands, uterus or ovaries;
• ectopic (ectopic) pregnancy in the last 3 months;
• thromboembolism;
• primary ovarian failure;
• developmental anomalies of the female genital organs that are incompatible with pregnancy;
• uterine fibroids, in which pregnancy is contraindicated;
• postmenopausal period;
• pregnancy and lactation.

Ovitrel should be used with extreme caution in the presence of systemic diseases, since pregnancy can cause their exacerbation.

Release form and cost of the drug

The drug is available as a pre-filled syringe with a hypodermic needle., which contains 0.5 ml of clear liquid (250 mcg of choriogonadotropin alpha). Another form of release is powder for preparing a solution in a bottle.

The cost of Ovitrel packaging depends on the form of release and the manufacturer, on average it is in the range of 2000-2800 rubles.

Analyzes and examinations

Before starting to use the drug, the doctor must determine whether infertility is really due to insufficient maturation of the follicle and lack of ovulation, and not to the pathology of other organs. It is also necessary to identify the presence of other diseases that are contraindications to the drug. To do this, a comprehensive comprehensive medical examination of both the woman herself and her partner is carried out.

Basic indications are determined through ultrasound of the ovaries and hormonal studies. It is especially important to identify signs of hypothyroidism, adrenal insufficiency, hyperprolactinemia, neoplasms of the pituitary gland and hypothalamus using special laboratory and instrumental methods. When the functioning of these organs is restored, ovulation can occur independently, without additional stimulation.

Infertility can be caused by pathology on the part of the partner, so it is important to obtain spermogram data. Normally, for successful fertilization, the number of motile, active sperm should be at least 50% of the total number. This indicator is negatively affected by several factors:

• elderly age;
• infectious processes;
• frequent consumption of spicy foods;
• regular hot baths.

Another possible cause of sperm death is varicocele, which leads to an increase in temperature in the testicles. Also it is important to exclude sexually transmitted infections - gonorrhea and trichomoniasis.

How to use?

If the drug is used at home, then you must follow a certain sequence of actions:

After the manipulation, the empty syringe must be disposed of in a special container, and the remaining contents must be destroyed and not used for reuse.

Side effects

When using Ovitrel, a woman may experience some side effects, which are most often associated with an incorrectly selected or administered dose:

• ovarian hyperstimulation syndrome, breast tenderness;
• nausea, vomiting, abdominal pain, diarrhea, abdominal discomfort;
• headache, depression, fatigue, irritability, anxiety, weakness;
• pain and redness at the injection site;
• slight skin rash;
• hypersensitivity reactions from minor symptoms to anaphylactic shock;
• thromboembolism.

How many hours after the injection does the follicle mature?

Determined that follicle maturation occurs within 24-36 hours after the injection. Since sperm can remain viable in a woman’s body for up to 1 week, sexual intercourse can be planned immediately after the injection, as well as the next day. Fertilization of the egg will occur as soon as ovulation occurs.

The effectiveness of the drug cannot be determined using an ovulation test, since the structure of hCG is very similar to the structure of luteinizing hormone (LH), namely, an increase in the concentration of LH is reflected in the form of a positive result on the test.

A positive test will only indicate the presence of a drug substance, and not the process of ovulation. This reaction may continue for 10 days, so The first pregnancy test is carried out approximately 2 weeks after the expected day of ovulation.

Objective confirmation of the onset of ovulation can only be obtained using ultrasound.

How does it develop normally?

Ovulation normally develops due to a sharp increase in the concentration of LH; hCG has the same property. The active substance of Ovitrel, choriogonadotropin alpha, is similar in structure to a woman’s hCG, obtained from urine.

HCG binds to membrane receptors for LH on oocyte and ovarian granulosa cells, promotes the process of meiosis in eggs, ovulation and the formation of the luteal body.

Another important property of Ovitrel is the ability to increase the level of estradiol and progesterone in the concentration necessary for ovulation.

Why does it sometimes not happen?

In the vast majority of cases, Ovitrel injection leads to the development of ovulation within 24 hours. There are a number of reasons that prevent ovulation from occurring:

• improperly performed stimulation of follicle maturation;
• absence of a dominant follicle;
• health problems of the partner that were not detected by the spermogram;
• hormonal disorders;
• the woman has other diseases and pathological conditions that affect the development of ovulation.

Ovitrel is a drug that cannot be used independently, without medical supervision. Only the attending physician can prescribe the drug and select an individual dosage, taking into account the complex of laboratory and instrumental data. The patient is required to follow as accurately as possible the days of the Ovitrel injection, sexual intercourse, and ultrasound monitoring.

You should know that there are many reasons for the lack of ovulation, and not every form of anovulation is corrected with the help of hCG. It is necessary to understand that this method of stimulation does not provide a 100% guarantee of ovulation and pregnancy.

When using ovulation stimulants, the risk of developing multiple pregnancies increases significantly compared to natural conception (most women have twins).

Before using Ovitrel, it is extremely important to make sure that the problem of infertility lies precisely in women’s health, and not in the quality of the partner’s sperm. A spermogram should be obtained immediately before treatment, which will prevent the couple from wasting money and time in the future.

Ovitrel is one of the most popular and effective drugs for stimulating ovulation. Before use, both partners must undergo a comprehensive medical examination, and after medical consultation, follow all recommendations and instructions.

Video on the topic

We invite you to watch a video about the drug Ovitrel:

During pregnancy, after implantation of the embryo, the amount of a special hormone in the blood increases - human chorionic gonadotropin. Choriogonadotropin alpha, which is the basis of the drug Ovitrel, is produced using recombinant DNA technology and resembles natural gonadotropin in its amino acid sequence.

Thus, the effect of choriogonadotropin alpha on the body is identical to the effect of hCG. This allows you to prescribe Ovitrel before IVF puncture for:

• stimulation of the final stage in follicle maturation;
• the formation of the corpus luteum, which is responsible for the secretion of progesterone and estradiol.

Before prescribing the drug, the patient undergoes a full examination to exclude the following pathology:

• bleeding from the genital tract of unspecified cause;
• benign and malignant formations in the ovaries, uterus and mammary glands;
• tumor of the hypothalamus or pituitary gland;
• recent or currently existing thromboembolic diseases;
• hypersensitivity to the components of the drug;
• used with caution in cases of identified chronic diseases of various organs and systems (for example, disruption of the thyroid gland, adrenal glands, etc.), when pregnancy, regardless of the “method” of onset, can provoke a severe exacerbation.

Important! Ovitrel is not prescribed during postmenopause, pregnancy and lactation.

Ovitrel for IVF in a natural cycle

The IVF program includes several stages. Treatment regimens in different clinics may differ, but the basis is the same.

At the first stage, superovulation is stimulated to obtain a large number of eggs. For this purpose, from the 3-5th day of the menstrual cycle, drugs are used that affect the concentration of FSH and LH, which activates changes in the ovarian follicular apparatus (gonadotropins, GnRH agonists and antagonists, clomiphene). The protocol is selected by the doctor individually.

When choosing, this group of drugs is not used. Basically, this regimen is selected for patients with infertility with preserved normal ovulatory cycles. Of course, this method has the advantages of low cost, simplicity and the possibility of repeated repetition, but there is a risk of premature ovulation or empty follicles during puncture.

During the entire period, ultrasound monitoring is carried out, the number, diameter, growth of follicles and thickness of the endometrium of the uterus are determined.

At the second stage, when the follicle reaches 18-20 mm and the thickness of the endometrium is about 10 mm, Ovitrel is administered to support IVF for the final maturation of the eggs. The main condition for prescribing the drug is the presence of mature follicles in an amount of at least 3. 35-36 hours after choriogonadotropin, follicle puncture is performed. If you do not puncture, then ovulation will occur in 42-48 hours.

The next step is fertilization of the eggs and cultivation of the embryo.

On days 3-5 after puncture, the embryo is transferred to the uterus with the administration of hormonal drugs.

The final stage is confirmation of pregnancy (after replantation, determination of hCG in the blood on the 12th day, and on the 14th day in the urine; ultrasound).

Note! During the administration of Ovitrel, there will be a false-positive reaction in the blood serum and urine for the presence of pregnancy during the first 10 days.

How and where to inject Ovitrel during IVF?

The drug is a clear or light yellow solution of 0.5 ml, which contains 250 mcg of choriogonadotropin alpha. Available in ready-made form, in syringes with a needle for single use.

Before the procedure, the anterior surface of the thigh or abdomen is disinfected, the skin is folded and the needle is directed at an angle of 45°, avoiding the vein. The medicine is administered slowly, and after removing the needle, the injection site is treated with alcohol.

The medication should be stored in the refrigerator; if stored at room temperature, Ovitrel should be used within 30 days.

Ovarian pain after Ovitrelle: reasons

When using the drug, you may experience discomfort in the lower abdomen on the left or right in the area of ​​projection of the ovaries where ovulation occurred.

But severe pain can be the result of the development of (OHSS), which is a serious complication when many follicles are formed in the ovary, reaching the size of large cysts, followed by rupture and a pronounced clinical picture.

To avoid such consequences, dynamic ultrasound and blood tests for estradiol are performed throughout the entire period of stimulation, including before the start of injections.

Note! If you have any complaints, be sure to see a doctor.

What is better for IVF: Ovitrel or Pregnil?

The therapeutic effect when using these drugs is identical, but there is a difference in the active substance and dosage. The composition of the drug Pregnil includes human chorionic gonadotropin, 1 ampoule of which contains 500, 1500, 5000 IU in powder form, which must be mixed with 1 ml of solvent. Each box contains 3 sets.

Ovitrel contains an analogue of human chorionic gonadotropin (hCG) - recombinant chorionic gonadotropin alpha with a dosage of 6500 IU per 0.5 ml syringe.

Both drugs are used in IVF protocols, but the use of Ovitrel ensures final maturation of oocytes with a reduced risk of developing severe ovarian hyperstimulation syndrome.

Application details.

One bottle of Ovitrel contains 250 mcg Choriogonadotropin alpha (6500 IU).

Additional substances: phosphoric acid, sucrose, sodium hydroxide . Solvent: distilled water.

One 0.5 ml syringe of Ovitrel contains 250 mcg Choriogonadotropin alpha (6500 IU).

Additional substances: sodium hydroxide, phosphoric acid, methionine, poloxamer 188 , water.

Release form

Lyophilisate for making a solution in the form of a white powder. 1, 2 or 10 bottles of powder and solvent in a plastic container; one container in a cardboard box.

Clear, colorless or pale yellow solution for injection; slight opalescence is allowed. 0.5 ml of this solution in a syringe with needles; one syringe in a plastic container; one container in a cardboard box.

pharmachologic effect

Gonadotropic, luteinizing action.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Recombinant alpha choriogonadotropin , possessing identical to human natural human chorionic gonadotropin amino acid sequence. Reacts with transmembrane receptors luteinizing on the walls of ovarian cells. Initiates acceleration oocyte meiosis , development of the corpus luteum, ovulation , synthesis by the corpus luteum and.

Pharmacokinetics

After intravenous administration, it is distributed into the extracellular space with a half-life of approximately 4.5 hours. With the subcutaneous route of administration, bioavailability approaches 40%, and the half-life is approximately 30 hours. and drug release are similar to those of natural human chorionic gonadatropin .

Indications for use

• Used in a complex of reproductive technologies to induce final maturation of follicles and luteinization after activation gonadotropic drugs .
• At anovulatory or oligoovulatory type for process induction ovulation And luteinization during the completion of stimulation of follicular development.

Contraindications

• Tumors of the hypothalamus or pituitary gland.
• Hypersensitivity to the components of the drug.
• Ovarian tumors or cysts not associated with polycystic ovary syndrome.
• Malignant tumors of the mammary glands, ovaries or uterus.
• Vaginal bleeding of idiopathic origin.
• (last three months).
• Ovarian failure.
• Thromboembolism .
• Developmental defects incompatible with.
• Postmenopause .

Side effects

• Digestive reactions: nausea, abdominal pain, vomiting.
• Reactions from the genitourinary area: , pain in the mammary glands.
• Reactions from nervous activity: irritability, fatigue, anxiety.
• Local reactions: pain or hyperemia in the injection area.
• Dermatological reactions: rash.
• Other reactions: feeling tired, mild.

Instructions for use (Method and dosage)

The instructions for Ovitrel advise using the subcutaneous route of administration of the drug. Each syringe or vial is intended for single use.

Ovitrel for infertility

At oligoovulatory infertility or anovulatory type for process induction ovulation And luteinization during the completion of stimulation of follicle development, 250 mcg of the drug is administered 1-2 days once after the last injection follicle-stimulating or luteinizing hormone and achieving the required level of follicle maturation. Sexual intercourse is recommended on the day of administration and the next day.

Ovitrel before puncture with assisted reproductive technologies

When used to induce follicle maturation and luteinization after activation gonadotropic drugs 250 mcg of Ovitrel is administered once 1-2 days after the last injection follicle-stimulating or luteinizing hormone and achieving the required level of follicle maturation.

Rules for self-use of the drug

• You need to wash your hands.
• Place 1 syringe with medicine and 2 swabs soaked in alcohol on a clean surface.
• Next, you should immediately inject subcutaneously (in the abdominal wall or anterior thigh area): wipe the area of ​​skin with an alcohol swab, pull it tightly with your fingers and inject by inserting the needle at an angle of 45° into the skin fold. It is necessary to avoid getting the medicine into a vein. The drug should be administered slowly. After finishing the injection, it is recommended to wipe the injection site with an alcohol swab in a circular motion.
• After the injection, it is recommended to place the used syringe in a special container. Any unused amount of medication should be destroyed.

Video on how to inject Ovitrel:

In details:

Overdose

Signs of overdose: ovarian overstimulation syndrome , manifested by the formation of large ovarian cysts with a high probability of their rupture, the appearance of circulatory disorders and ascites .

Treatment of overdose: at high risk of occurrence it is recommended to stop administration human chorionic gonadatropin , and also avoid sexual contact for at least 4 days or use barrier methods of contraception.

Interaction

There are no data on interactions with other drugs.

The patient should inform the doctor about all medications that she is currently using or has taken in the recent past.

Terms of sale

Only by prescription.

Storage conditions

Keep away from children. Do not freeze. Store at a temperature of 2-8 degrees.

Best before date

special instructions

Before starting treatment, the causes need to be investigated infertility in the patient and her partner, as well as assess risk factors for possible pregnancy. It is recommended to take into account the presence of pronounced , hyperprolactinemia, adrenal insufficiency, tumors of the hypothalamus or pituitary gland, specific treatment methods used.

During ovarian stimulation there is a risk of developing ovarian hyperstimulation syndrome due to the simultaneous development of a large number of follicles. In rare cases of severe forms of this condition, complications may include ovarian torsion, acute distress syndrome, hemoperitoneum, thromboembolism . To reduce risk ovarian hyperstimulation syndrome careful monitoring of the condition of the ovaries (ultrasound) and determination of the number estradiol before and during treatment.

When performing stimulation, the likelihood of multiple pregnancy increases compared to conventional fertilization.
Quantity after therapy anovulatory infertility exceeds the population average, but is comparable to other types of infertility.

Administration of the drug for 10 days can influence the immunological picture of the content human chorionic gonadotropin in plasma and urine and lead to the detection of a false-positive pregnancy test.

5 minutes to read.

In a healthy woman, ovulation occurs monthly. This process is characterized by the maturation of the follicle in the ovaries, subsequently one of them bursts, releasing an egg ready for fertilization. It is possible to conceive a child only during the period of ovulation. However, some women never ovulate. Then they resort to stimulating it in various ways. These include the drug Ovitrel.

Description of the drug

The drug is presented in the form of recombinant human chorionic gonadotropin. The synthetic compound is absolutely identical to the natural one. The drug belongs to the group of hormonal medications.

It was developed for use in the field of gynecology and reproductive medicine. Ovitrel is a development of foreign specialists (the drug is manufactured in Italy).

You can purchase medication at a pharmacy only with a prescription from a doctor. Under no circumstances should you engage in hormonal therapy without consulting a specialist. Before prescribing, the doctor is obliged to conduct a comprehensive examination and only then prescribe a course of treatment. Moreover, both partners must come for the examination.

Ovitrel is aimed at stimulating ovulation, after which the egg will be released from the follicle. This process significantly increases the chances of conception. In addition to stimulating ovulation, the production of progesterone and estrogen increases.

Mechanism of action

The pharmacological action of this drug is fully described in the instructions. The administered medication promotes egg division, rupture of the follicle, followed by the onset of ovulation. At the same time, the corpus luteum is formed, and the active production of hormones that are necessary to maintain pregnancy - estradiol and progesterone - occurs.

All these properties of Ovitrel not only contribute to conception itself, but also to the consolidation of the egg in the uterus, as well as to the full development of the fetus.

When does ovulation occur after the injection?

After the drug has been introduced into the woman’s body, sexual intercourse should occur on the same day and the next. This is necessary because it is impossible to say with certainty when exactly the egg will be released. But this period ranges from 24 to 36 hours. Three days after the injection of the drug, the woman needs to have an ultrasound, which will show whether ovulation has occurred.

How to inject the drug correctly?

The drug must be injected under the skin in the abdomen or thigh. The volume of the medication is 250 mcg. This should be done 24-48 hours after the last injection of follicle-stimulating hormone.
The injection of the drug is a regular injection. Therefore, those women who know how to give injections do not have to go to a medical facility. For those who have not learned how to give injections, it is best to carry out the procedure with professionals.

In any case, it is important to follow the basic rules:

1. Use disinfectants.
2. First you need to prepare cotton swabs and a syringe with the finished product. Be sure to treat the injection site with alcohol.
3. Then the injection itself is carried out (injected into the stomach or thigh - it doesn’t matter, it’s the woman’s choice). During the injection, the skin should be tightened as much as possible. The needle is inserted at an angle of 45 or 90 degrees. You must be extremely careful and ensure that the medication does not enter the vein. You need to empty the syringe slowly, without sudden jerks. After removing the needle, the injection site should be wiped again with alcohol and a cotton swab should be used to massage the area in a circle.
4. After the procedure, the syringe must be thrown away. Sometimes a small amount of the drug remains in it, but its use is strictly prohibited.

When excreted from the body

Ovitrel begins to be excreted from the body 30 hours after injection. The time for complete removal of the product ranges from 4-7 days. In some cases, the period may take up to ten days. Basically, it all depends on the amount of fluid you drink and the functioning of your kidneys.

Contraindications

A complete list of restrictions for use is indicated in the instructions for the drug:

1. individual intolerance to the components of the drug;
2. tumors (and it does not matter whether they are malignant or benign) of the internal genital organs, hypothalamus and pituitary gland;
3. formations or cysts on the ovaries;
4. vaginal bleeding, the cause of which cannot be determined;
5. mammary cancer;
6. ectopic pregnancy, which was no later than three months before stimulation;
7. lactation period;
8. thromboembolism of any vessels;
9. primary ovarian failure;
10. uterine fibroids;
11. the onset of menopause;
12. congenital pathologies of the reproductive system organs that block the process of conception or gestation.

Important! When planning a pregnancy, it is important to consider every moment. This is especially true for serious illnesses, which during the period of bearing a baby can go into the stage of exacerbation.

Side effects

In some cases, after the administration of Ovitrel, the following side effects may be observed:

1. pain in the abdomen, nausea, vomiting, less often - diarrhea;
2. chest pain, ovarian hyperstimulation syndrome;
3. the woman becomes more irritable, sensitivity increases, migraines are observed;
4. the level of performance decreases;
5. nervous tension and anxiety;
6. barely noticeable rashes on the skin;
7. the injection site may swell, the woman may feel pain in this place;
8. mild symptoms of allergies and feelings of fatigue.

As you can see, most side effects are not very pronounced and therefore do not cause any discomfort to the patient. However, special attention should be paid to ovarian hyperstimulation. In this case, you should consult a doctor and possibly stop taking Ovitrel.

When to take a pregnancy test

It is better not to rush to take a pregnancy test after injecting the drug. You need to wait at least one week. And even in this case, the test result may be erroneous. Experts recommend conducting several tests at intervals of 2-3 days, starting from the seventh day after the administration of Ovitrel. For a 100% result, a woman will need to be tested for the presence of hCG, this is a hormone that is secreted in the placenta from the moment of conception. He is the one who talks about pregnancy.

Price

Let's consider the pricing policy in Russia and Ukraine.

In the Russian Federation, you can purchase powder, which is enough for one injection, for about 2,300 rubles. In the capital region, this price may be 150-200 rubles higher.

For a syringe with an already diluted one you will have to pay a little more - 2600 rubles.

In Ukraine, the injection solution is more expensive compared to Russia - 1900 hryvnia. You can buy undiluted powder - it will cost 1300 hryvnia.

Conclusion

Most patients respond positively to the drug Ovitrel, noting its effectiveness. However, women during therapy need to monitor the condition of the thyroid gland, as it receives additional stress. Also, do not forget that the day before the injection of the medicine and in the next two weeks after the procedure, drinking alcohol is strictly prohibited.