Nise tablets indications for use. Nise tablets, instructions for use Nise for injection instructions for use

NSAIDs, the structure of which contains a sulfonylide group.
Drug: NIZE®
Active substance of the drug: nimesulide
ATX encoding: M01AX17
KFG: NSAIDs. Selective COX-2 inhibitor
Registration number: P No. 010513
Registration date: 02/26/06
Owner reg. cred.: DR. REDDY`S LABORATORIES LTD. (India)

Nise release form, drug packaging and composition.

The suspension for oral administration is yellow in color, with a pleasant odor and characteristic taste, redisperses when shaken.

5 ml
nimesulide
50 mg

Excipients: sucrose, sorbitol, methylparaben, propylparaben, xanthan gum, citric acid, quinoline yellow dye WS, pineapple flavor, polysorbate 80, glycerol, purified water.

60 ml - dark glass bottles (1) complete with dosage cap - cardboard packs.
Dispersible tablets
1 tab.
nimesulide
50 mg

Excipients: microcrystalline cellulose, calcium phosphate, corn starch, sodium carboxymethyl starch, magnesium stearate, talc, colloidal silicon dioxide, aspartame, pineapple flavor.

The tablets are almost white, with a yellowish tint, round, biconvex, with a smooth surface.

1 tab.
nimesulide
100 mg

Excipients: microcrystalline cellulose, corn starch, calcium hydrogen phosphate, sodium starch glycolate, purified talc, magnesium stearate, colloidal anhydrous silicon.

10 pieces. - blisters (1) - cardboard packs.
10 pieces. - blisters (2) - cardboard packs.
10 pieces. - blisters (10) - cardboard packs.

DESCRIPTION OF THE ACTIVE SUBSTANCE.
All information provided is provided for information only about the drug; you should consult your doctor about the possibility of use.

Pharmacological action of Nise

NSAIDs, the structure of which contains a sulfonylide group. It is believed that nimesulide is a selective COX-2 inhibitor. It has a pronounced anti-inflammatory, as well as analgesic and, to a lesser extent, antipyretic effect. The mechanism of action is associated with inhibition of prostaglandin synthesis. Suppresses the synthesis of prostaglandins in the area of ​​inflammation to a greater extent than in the gastric mucosa or kidneys, which is due to inhibition primarily of COX-2.

In addition, in the mechanism of the anti-inflammatory action of nimesulide, its ability to suppress the formation of free oxygen radicals (without affecting hemostasis and phagocytosis) and inhibit the release of the enzyme myeloperoxidase is important.

Pharmacokinetics of the drug.

After oral administration, nimesulide is well absorbed from the gastrointestinal tract, Cmax in blood plasma is reached after 1-2 hours.

Protein binding is 99%. After oral administration of a single dose of 100 mg, nimesulide is present in the tissues of the female genital organs in a concentration of 40% of the concentration in plasma.

Metabolized in the liver, the main metabolite hydroxynimesulide has pharmacological activity.

T1/2 from plasma is 2-3 hours

It is excreted from the body mainly through urine, about 98% of the dose is excreted within 24 hours. With prolonged therapy, accumulation of nimesulide is not observed.

Indications for use:

Osteoarthritis, extra-articular rheumatic diseases, pain and inflammation after surgery, pain and fever during acute inflammatory processes in the upper respiratory tract, pain associated with dysmenorrhea.

Dosage and method of administration of the drug.

Orally for adults 100-200 mg 2 times a day, for children - 1.5 mg/kg 2-3 times a day.

Maximum dose: for children - 5 mg/kg/day in 2-3 doses.

Side effects of Nise:

From the digestive system: heartburn, nausea, stomach pain; in some cases - tarry stools, melena (associated with bleeding and erosive and ulcerative lesions of the gastrointestinal tract).

From the side of the central nervous system: rarely - headaches, dizziness, drowsiness.

Allergic reactions: skin rash, erythema, urticaria.

Other: rarely - oliguria, fluid retention in the body, local or systemic edema; in some cases - thrombocytopenic purpura.

Contraindications to the drug:

Peptic ulcer of the stomach and duodenum in the acute phase, acute bleeding from the gastrointestinal tract, moderate and severe liver failure, renal failure (creatinine clearance less than 30 ml/min), pregnancy, lactation; hypersensitivity to nimesulide and other NSAIDs (including acetylsalicylic acid).

Use during pregnancy and lactation.

Nimesulide is contraindicated for use during pregnancy and lactation.

There are no direct indications of the embryotoxic and tocolytic effects of nimesulide.

Special instructions for use of Nise.

Caution should be used internally in patients with impaired renal function, arterial hypertension, cardiac dysfunction, and visual impairment.

When used externally, a doctor's monitoring of the condition of elderly patients with impaired renal function, liver function, and congestive heart failure is required.

When used in pediatrics, dosage forms intended for children should be used. In children under 6 years of age, when using nimesulide externally, medical supervision is required.

Impact on the ability to drive vehicles and operate machinery

Due to the fact that nimesulide, when taken orally, can cause dizziness and drowsiness, it should be used with caution in patients engaged in potentially hazardous activities that require increased concentration and rapid psychomotor reactions.

DRUG INTERACTIONS
Manifestations of drug interactions are possible when nimesulide is ingested simultaneously with digoxin, phenytoin, lithium preparations, diuretics, antihypertensive drugs, other NSAIDs, anticoagulants, cyclosporine, methotrexate, and oral hypoglycemic agents.

Do you know what Nise (tablets) helps with? If you do not have such information, we will present it in the materials of this article.

Packaging of the drug and its composition

We will talk about what Nise (tablets) can help with below. The active ingredient of this medicine is nimesulide. It also includes components such as microcrystalline cellulose, aspartame, calcium phosphate, colloidal silicon dioxide, corn starch, magnesium stearate, sodium carboxymethyl starch, pineapple flavor and talc.

The medication in question goes on sale in blisters of 10 tablets, packed in cardboard packs.

The principle of action of the drug

Before answering the question of what Nise (tablets) helps with, you should tell us how this drug works.

According to the instructions, this is an NSAID that selectively inhibits COX-2, that is, an enzyme involved in the synthesis of prostaglandins - mediators of pain, inflammation and swelling. In addition to anti-inflammatory properties, the drug in question exhibits antipyretic and analgesic effects.

It should also be said that this medication inhibits (reversibly) the formation of prostaglandin E2 in the ascending pathways of the nociceptive system and the source of inflammation, as well as in the pathways of impulses (pain) in the spinal cord.

The drug "Nise", analogs of which are listed below, reduces the concentration of prostaglandin H2 (short-lived), from which, under the influence of prostaglandin isomerase, prostaglandin E2 arises. A decrease in the concentration of the latter leads to a decrease in the degree of activation of EP-type receptors (prostanoid), which is expressed in anti-inflammatory and analgesic effects.

It should also be noted that the drug in question affects COX-1 to a small extent. Under physiological conditions, it almost does not prevent the formation of prostaglandin E2 from arachidonic acid. Due to this, the number of side effects of the drug is reduced.

Basic properties of the drug (NSAIDs)

The drug "Nise" is capable of suppressing this by inhibiting the synthesis of thromboxane A2 and endoperoxides. In addition, it suppresses the release of histamine and also reduces the degree of bronchospasm that was caused by exposure to acetaldehyde and histamine.

Experts have proven that nimesulide effectively suppresses the synthesis of urokinase and interleukin-6, preventing the destruction of cartilage tissue. In addition, it inhibits the synthesis of metalloproteases, preventing the destruction of collagen and proteoglycans.

According to the instructions, by reducing the activity of myeloperoxidase, the drug in question exhibits antioxidant properties and slows down the formation of (toxic) O2 breakdown products. It interacts with glucocorticoid receptors and activates them, which enhances the anti-inflammatory effect.

Drug kinetics

After oral administration, the painkiller "Nise" is absorbed from the intestines. Eating reduces the rate of absorption of the drug, but does not affect its extent.

The peak concentration of nimesulide in the blood is reached after 2.6 hours. Its binding to proteins reaches 95%.

This drug penetrates into all tissues of the woman’s genital organs. In addition, it is found in the acidic environment of the inflammation site and synovial fluid.

Metabolism of nimesulide occurs in the liver. Its half-life is 5 hours. It is excreted mainly by the kidneys, as well as with bile.

Indications for taking tablets

What does Nise (tablets) help with? The drug in question is prescribed for:

• radiculitis, rheumatoid arthritis, sciatica;
• lumbago, osteoarthritis, articular syndrome in rheumatic disease and exacerbation of gout;
• arthralgia, ankylosing spondylitis;
• arthritis of various origins, osteochondrosis with radicular syndrome;
• inflammation of the ligaments, myalgia of non-rheumatic and rheumatic origin, bursitis, inflammation of the tendons;

  

• pain syndrome of various origins (including injuries, in the postoperative period, toothache, algodismenorrhea, headache);
• inflammation of the musculoskeletal system, as well as soft tissues.

It should also be noted that “Nise” helps well with temperature. This drug is used for fever of various origins, including inflammatory and infectious diseases.

Contraindications for NSAIDs

The drug "Nise" should not be prescribed during pregnancy. It should also not be used for:

• “aspirin triad”;
• erosive and ulcerative lesions of the gastrointestinal tract (with exacerbation);
• breastfeeding;
• bleeding from the gastrointestinal tract;
• impaired liver function;
• in children under two years of age;
• severe renal failure;
• hypersensitivity.

This drug is prescribed with extreme caution for type 2 diabetes mellitus, arterial hypertension and heart failure.

How to take Nise?

The medication in question in tablet form is prescribed only orally. Adult patients are recommended to take 100 mg twice a day. The maximum dosage of the drug per day is 400 mg.



As for dispersible tablets, before taking such a medicine, it should first be dissolved in 5 ml of plain water (in 1 dessert spoon). This remedy should be taken at the end of a meal or after a meal.

The drug in tablet form is not prescribed to children. For them, there is another form of medication - a suspension. It is recommended to take it from the age of two years.

Side effects

The drug "Nise", the dosage of which was presented above, can cause such undesirable reactions as:




Cases of overdose

What symptoms occur when taking a large number of Nise tablets? The dosage of this medication must be determined by your doctor. If the drug is accidentally ingested (in large quantities), the patient may develop the following symptoms: convulsions, increased blood pressure, irritation of the gastrointestinal mucosa, impaired renal function, liver failure and respiratory depression.

To eliminate such conditions, the patient's stomach is washed, activated charcoal is prescribed and symptomatic therapy is carried out.

Drug interactions

With simultaneous oral administration of the drug "Nise" with diuretics, "Digoxin", "Phenytoin", antihypertensive drugs and lithium drugs, as well as with other NSAIDs, cyclosporine, anticoagulants, methotrexate, hypoglycemic medications (orally), the patient may experience drug interactions (from - due to competition of these agents for binding to proteins).

The drug "Nise": analogues and reviews

You can replace the drug in question with such medications as “Nimulid”, “Aponil”, “Arcoxia”, “Mesulide”, “Meloxicam”, “Nimesil”, “Movalis”, “Nimesulide”, “Denebol”, “Nimica”.



Most consumer reviews about the drug in question are positive. According to them, Nise quickly relieves pain, and the drug is also used as highly effective. Although some patients claim that this medication has one significant drawback. It very often causes side effects such as dizziness, weakness and problems with the digestive system. In this case, doctors recommend replacing the drug with a similar remedy.

Nise is an excellent drug that belongs to the anti-inflammatory group. Easily relieves fever, has an analgesic and antiplatelet effect. Nise reduces inflammation and is recommended for many diseases of the musculo-ligamentous system and joint pain.

Composition, release form, packaging

The main component of the drug is nimesulide. It has good absorption, its maximum amount appears in the blood after 1-2 hours. It is eliminated from the body almost completely through bile and kidneys.

The drug also includes additional elements:

• calcium phosphate;
• cellulose;
• starch (usually corn);
• talc;
• magnesium stearate;
• flavoring additives;
• aspartame;
• sodium glycolate;
• silicon dioxide (colloidal).

Nise is a convex tablet, round on both sides, containing 100 mg of the main element. One blister consists of 10 pieces. It can also be produced in the form of granules for suspension, ointment or gel. All types of medicines are packaged in cardboard packaging.

The photo shows the release form of the drug Nise

Manufacturer

Nise is an Indian drug manufactured by Dr. Reddy's Laboratories Limited. It is recognized by medical professionals as one of the best drugs for treating inflammation and relieving pain.

Indications

The drug is prescribed for many diseases associated with the musculoskeletal system. It could be:

• rheumatic pains;
• arthritis and spondyloarthritis;
• radiculitis, myalgia;
• inflammation of muscle tissue and tendons;
• bruises and other soft tissue damage;
• different course;
• fever in any disease.

Indications for use of the drug Nise in our video:

Contraindications

Like other medications, Nise is contraindicated for certain diseases. It is strictly forbidden to take it during exacerbations of the existing duodenum, stomach, etc. Do not use this drug during pregnancy or breastfeeding. Contraindications also include:

• , hepatic, ;
• children under 12 years of age;
• diabetes;
• individual intolerance to components.

When using the gel, additional contraindications include skin irritation, open wounds and areas of infection. It is unacceptable for the gel to come into contact with mucous membranes and eyes.

Mechanism of action

Nise should also be prescribed to patients engaged in hazardous activities (drivers, machinists, etc.) with extreme caution, since the drug can cause drowsiness and. When using the drug in elderly patients, dosage adjustment is not required.

Drug interactions

When taking Nise together with medications that can reduce blood clotting, the effect of the latter may be enhanced. The drug also reduces the effect and can several times increase the possibility of unpleasant side effects when taken. Use with corticosteroids may significantly increase the risk of gastric bleeding.

During treatment with this drug, it is necessary to avoid the simultaneous use of drugs that have a hepatotoxic effect. Categorically, it also increases the risk of adverse reactions.

Instructions for use of the drug Nise:

Nise is a widely known drug from the NSAID group with powerful analgesic, anti-inflammatory and antipyretic effects. Instructions for use of Nise tablets and gel indicate that the main area of ​​application of the drug is the relief of pain of various etiologies and localizations (joint pain, dental pain, headaches, menstrual pain). In addition, the medication is used as part of the complex treatment of many diseases of the joints and spine and other conditions accompanied by an inflammatory process.

Nise - description and principle of operation

The mechanism of action of Nise is based on the fact that its active substance, nimesulide, inhibits a special enzyme (COX-2), which is responsible for the production of inflammatory mediators (prostaglandins). As a result, the severity of the inflammatory process decreases, fever, pain and swelling disappear. The active component, nimesulide, additionally exhibits antioxidant properties, preventing the formation of toxic oxygen breakdown products.

Local forms of Nise quickly relieve pain in the area of ​​application, reduce swelling and morning stiffness of the joints and provide freedom of movement. When taken orally, the active substance is absorbed from the gastrointestinal tract for a short time and penetrates into the synoval fluid and the acidic environment in areas of inflammation. The drug is metabolized by the liver and excreted in urine and bile.

Release forms

For ease of use, the anti-inflammatory drug is available in different dosage forms:

• Nise tablets contain 100 mg of the active ingredient nimesulide.
• Dispersed tablets contain 50 mg of nimesulide. Before taking, they should be dissolved in a small amount of water. Both options are packaged in 10 tablets per blister. Each cardboard box containing the drug contains 2 blisters of tablets.
• Nise suspension - 5 ml of the drug contains 50 mg of active substance. The suspension is packaged in 60 ml bottles equipped with a dosage cap.
• Gel Nise (1%) - 1 g of gel contains 10 mg of active substance. The gel is produced in aluminum tubes of 20 and 50 g.

When is Nise used?

Indications for use of the drug are the following conditions:

• inflammatory - degenerative diseases of muscles, joints and bones. This list includes many pathologies - arthritis of various etiologies, osteoarthritis, radiculitis, rheumatism, lumbago, atralgia and myalgia.
• with radicular syndrome;
• ankylosing spondylitis;
• , inflammatory process in ligaments and tendons.

Nise is widely used to eliminate inflammation and pain in traumatic injuries of the musculoskeletal system and soft tissue bruises. Another area of ​​application is pain in the postoperative period and for pain of a wide variety of origins (for example, dental, headache, menstrual). In addition, Nise for pain can be used as part of a complex treatment of infectious diseases, since the drug exhibits antipyretic, analgesic properties and helps cope with a feverish state.

Contraindications

Since the drug belongs to the group of non-steroidal anti-inflammatory drugs, it has the same contraindications as most other NSAIDs. Nise should not be used to relieve fever and pain in the following conditions:

• peptic ulcer and erosive lesions of the gastrointestinal tract;
• pregnancy, lactation;
• gastrointestinal bleeding;
• liver or kidney failure;
• children's age (up to 2 years);
• individual intolerance to nimesulide.

With extreme caution, the drug in tablets is prescribed to patients suffering from diabetes, hypertension, autoimmune diseases (systemic lupus erythematosus), and heart failure.

During pregnancy and lactation, taking a drug from the NSAID group is prohibited, since the active substance negatively affects the course of pregnancy and fetal development. Medicines containing nimesudide are prohibited for use even at the stage of pregnancy planning. Nise should not be taken during breastfeeding, as the active substance can pass into breast milk.

Instructions for use

Instructions for use Nise instructs adults to take 1 tablet twice a day, preferably before meals. The maximum permissible daily dose of the drug should not exceed 400 mg (4 tablets).

The dispersible tablet should be dissolved in 1 tsp before use. water and drink it afterwards. In this case, it is recommended to take the drug after meals.

The suspension can be drunk before meals or after meals if it causes discomfort in the stomach.

Before using Nise gel, the affected area should be washed and dried. The drug is applied in a thin layer to clean skin. The amount of gel varies depending on the area being treated. Frequency of use - no more than 4 times a day. The maximum period of use of the external product is 10 days.

The instructions for use indicate that when applying the gel should not be rubbed into the skin, otherwise you may get burned. The substance capsaicin, which is part of the gel, can provoke redness of the skin and a feeling of heat and burning. If severe irritation appears in the area where the drug is applied, stop using the gel. Sometimes pain may remain in the treatment area even after stopping use of the drug.

The external agent should be used with caution, avoiding contact with mucous membranes and eyes. After the procedure, the tube with the gel should be tightly capped and be sure to wash your hands with soap.

How many days can you drink Nise? The answer to this question is within the competence of the attending physician. It all depends on the severity of the condition, the severity of the pain syndrome and the inflammatory process, as well as the presence of concomitant diseases and possible contraindications. Since the active ingredient of the drug, nimesulide, has a negative effect on the gastric mucosa and can provoke the development of an ulcerative process, they try to prescribe drugs from the PVA group in short courses. On average, the duration of treatment with Nise is 7-10 days.

Is Nise okay for children?

The use of the drug in children is suitable taking into account age restrictions. Any form of Nise should not be used in young children. From 2 years of age and older, it is allowed to prescribe the drug in the form of a suspension for oral administration. The pediatrician calculates the required dose individually, taking into account the child’s body weight and general condition. Children over 3 years old can be prescribed dispersible tablets; children aged 12 years and older are prescribed the drug in the same dosage as adults.

Adverse reactions

The use of a drug from the NSAID group can cause a number of adverse reactions from various organs and systems of the body:

On the part of the digestive system, when taking the drug orally, manifestations such as pain in the abdominal area, stool disorders (diarrhea) are possible. With long-term use of Nise, the development of ulcerative and erosive lesions of the gastrointestinal tract is possible.

From the nervous system, judging by the reviews of patients, headaches, dizziness, and weakness often occur. On the part of the respiratory system, bronchospasm and shortness of breath are noted. It is possible to develop disorders of the hematopoietic system (anemia, thrombocytopenia, leukopenia). The cardiovascular system may respond to taking the drug with hot flashes, heart rhythm disturbances, and palpitations.

In case of individual intolerance to nimesulide, allergic reactions develop, which are manifested by skin symptoms (rash, hyperemia). In severe cases, the rapid development of an allergic reaction leads to anaphylactic shock, requiring emergency medical care.

When applying the gel, reactions such as itching, peeling, urticaria-type rashes, and a temporary change in skin color are observed. But such manifestations do not require discontinuation of the drug and go away on their own with further use of the gel.

Drug overdose

An overdose of Nise can lead to serious consequences and be accompanied by impaired renal function, liver failure, convulsions, increased blood pressure, respiratory depression, drowsiness and apathy. Sometimes the patient's situation is aggravated by the development of gastrointestinal bleeding. In case of overdose, the patient is sent to the hospital, where the stomach is washed, sorbents (Polysorb, Polypefan) and osmotic laxatives are prescribed.

To prevent an overdose, you should strictly follow the instructions for the drug and not exceed the maximum permissible daily doses. The dose of medication for a child should be calculated by the attending physician, taking into account body weight, age, severity of symptoms and other individual characteristics.

The drug Nise should be used with extreme caution in patients suffering from cardiovascular pathologies, liver and kidney diseases, and dehydration. It is not recommended to use this remedy if there are pathologies of the organs of vision, metabolic disorders, diseases of the digestive tract, or asthenic conditions.

For kidney pathologies, the drug is approved for use only under the supervision of a physician. If the course of treatment lasts more than 7 days, it is necessary to monitor kidney and liver functions. If there are malfunctions in their work, Nise must be discontinued and drugs containing nimesulide should not be used in the future during therapy.

One of the side effects of Nise is a decrease in blood clotting, so it should not be prescribed to patients taking anticoagulants and who have a tendency to bleed. This remedy cannot be used for diseases such as hemorrhagic diathesis.

If, while taking the tablets, symptoms such as vomiting, abdominal pain, darkening of urine, yellowing of the skin, increased fatigue, changes in blood counts occur, the use of the drug should be discontinued, since such symptoms indicate toxic damage to the liver.

When treating Nise, you should completely avoid drinking alcohol, since methanol increases the toxic effect of the drug on the liver and significantly increases the risk of developing drug-induced hepatitis.

Interaction with other drugs

Concomitant use of Nise with aspirin and other NSAIDs increases the risk of bleeding, as these drugs reduce blood viscosity. The same effect is observed when Nise is combined with glucocorticosteroids. In addition, it is not recommended to prescribe Nise simultaneously with cyclosporines, which increase its nephrotoxic effect, and Methotrexate.

Analogues

Structural analogues of Nise containing the same active substance (nimesulide) are the following drugs:

• Actasulide;
• Aponil;
• Mesulide;
• Nimesulide;
• Prolid;
• Flolide.

Analogues of Nise gel are external agents Diclofenac, Nimulid, Voltaren.

Price

In the pharmacy chain, any dosage form of Nise can be purchased without a doctor’s prescription. But before using it, it is better to consult with a specialist in order to promptly identify possible contraindications and avoid unwanted complications. Here are the average prices for the drug.

• Nise gel 1% (20g) - from 180 rubles;
• Nise tablets (20 pieces) - from 200 rubles;
• Nise dispersible tablets (20 pieces) - from 190 rubles;
• Nise suspension (60ml) - from 230 rubles.

Instructions

The drug Nise 100 is used to prevent and eliminate inflammation and pain of various origins. Considering that its active ingredient is safe for the body, the medication can be given not only to adults, but also to children over 3 years old.

Name

Tradename

International nonproprietary name

Nimesulide (Nimesulide).

Latin name

Pharmacological group

COX-2 inhibitors. NSAIDs (non-steroidal anti-inflammatory drugs).

Release forms and composition

The anti-inflammatory drug is produced in tablet form. Each tablet contains 100 mg of nimesulide, which is the active ingredient of the medicine. Additionally it contains:

• 3 mg magnesium stearate;
• 2 mg colloidal silicon dioxide;
• 1 mg talc;
• 35 mg sodium carboxymethyl starch;
• 54 mg corn starch;
• 40 mg microcrystalline cellulose;
• 75 mg calcium hydrogen phosphate.

Mechanism of action

Pharmacodynamics

The drug belongs to the group of sulfonanilides. Suppresses the production of prostaglandins in the inflammatory focus. The medication has antipyretic, analgesic and anti-inflammatory effects.

The drug has a high level of absorption after oral administration. Food inhibits this process, but does not affect its severity.

The maximum concentration of nimesulide in blood plasma is achieved in 1.5-3 hours. It binds 95% to plasma proteins, up to 1% to lipoproteins, and 2% to erythrocytes.

Pharmacokinetics

The half-life is from 1.5 to 5 hours. Excreted in bile and urine. In elderly patients, children and people with kidney failure, the pharmacokinetic properties of the drug change slightly.

What are Nise 100 tablets for?

NSAIDs are used by patients with the following pathologies and conditions:

• rheumatic and non-rheumatic forms of myalgia;
• osteoarthritis;
• osteochondrosis accompanied by radicular syndrome;
• spondylitis of ankylosing type;
• arthritis (psoriatic);
• acute stage of gout, accompanied by inflammation of the joints;
• bursitis, inflammation of tendons, ligaments;
• pain of various origins.

Contraindications

The main restrictions on taking NSAIDs:

• age under 3 years;
• severe liver disorders and renal failure;
• gastrointestinal bleeding;
• exacerbation of peptic ulcer disease;
• skin damage;
• individual intolerance to nimesulide and additional ingredients of the anti-inflammatory drug.

The medicine is prescribed with caution to persons with a history of peptic ulcers, ulcerative colitis and Crohn's disease.

Directions for use and dosage Nise 100

Adults are prescribed dosages of 100 mg twice a day. The maximum amount of medication per day is 400 mg.

Considering that food intake slows down the absorption of the active substance, it is better to use the drug 30-50 minutes after eating. The tablets can be dissolved in a teaspoon of clean and warm water.

For children from 3 to 12 years old, the drug is prescribed in an amount of 3-5 mg per 1 kg of weight, twice or thrice a day. The maximum daily dose is 5 mg per 1 kg of body weight in 2-3 doses.

For adolescents whose body weight exceeds 40 kg, the medicine is prescribed in the same dosage as for adults.

Does Nise 100 cause side effects?

NSAIDs sometimes cause the following negative effects:

• digestive system: abdominal pain, diarrhea, increased activity of transaminases in the liver, toxic form of hepatitis, heartburn, nausea;
• nervous system: dizziness, migraine;
• hematopoietic system: anemia, thrombocytopenia, agranulocytosis;
• CVS: increased blood pressure;
• immunity: Quincke's edema, itching and rashes on the skin, bronchial spasms;
• others: prolongation of bleeding, fluid retention in the body, hematuria.

Overdose

May manifest as vomiting, fatigue and apathy. Negative symptoms are eliminated with supportive treatment measures. There is a risk of respiratory depression, exacerbation of kidney failure, development of arterial hypertension and bleeding in the intestines.

Therapy is supportive and symptomatic. The medicine does not have an antidote substance. Hemodialysis and forced diuresis do not have the desired effect.

special instructions

In cases of visual and renal impairment, NSAIDs are prescribed with caution.

Long-term drug therapy requires regular monitoring of the condition of the kidneys and liver.

During pregnancy and lactation

The use of NSAIDs is contraindicated during pregnancy. If there is a need to take it during lactation, then breastfeeding should be abandoned.

In childhood

NSAIDs are prescribed to children from 3 years of age.

In old age

For impaired renal function

Prescribed with caution.

For liver dysfunction

In such patients, NSAIDs are used with caution.

Effect on concentration

Considering that NSAIDs can cause dizziness and fatigue, you need to be vigilant when operating vehicles and other machinery.

Drug interactions

With other drugs

A mutual enhancement of the pharmacotherapeutic effect is possible when NSAIDs are combined with anticoagulants, antihypertensive drugs, diuretics, Digoxin, lithium drugs, Phenytoin, Methotrexate, Cyclosporine, oral hypoglycemics and other non-inflammatory anti-inflammatory drugs.

Alcohol compatibility

The drug is incompatible with alcohol, so you should refrain from drinking such drinks during the treatment period.

Storage conditions and periods

Tablets should be stored at room temperature, away from moisture and light. Their shelf life is 2 years.

Conditions for dispensing from pharmacies

Is it sold without a prescription?

A prescription is required to purchase NSAIDs.

What is the price?

From 196 rub. for 20 tablets.

Analogues

In Russian pharmacies you can find the following anti-inflammatory drug substitutes:

• Nise nimesulide;
• Nimesan;
• Nemulex;
• Nimika;
• Nimulid;
• Nimesil.