Coldact for flu. Koldakt: brief instructions, analogues. Drug group, INN, scope of application

Name:

Coldact Flu Plus

Pharmacological
action:

Combination drug prolonged action.
Chlorphenamine has an antiallergic effect, eliminates lacrimation, itching in the eyes and nose.
Paracetamol has an antipyretic and analgesic effect: it reduces the pain syndrome observed during colds - sore throat, headache, muscle and joint pain, and reduces high fever.
Phenylephrine has a vasoconstrictor effect - reduces swelling and hyperemia of the mucous membranes of the upper respiratory tract and paranasal sinuses.

Indications for
application:

Symptomatic treatment of colds, flu, acute respiratory viral infections (fever, pain, rhinorrhea).

Mode of application:

Inside.
Capsules
Adults and children over 12 years old, 1 capsule. every 12 hours for 3–5 days.
Suspension
Shake before use.
For adults and children over 12 years old - 10 ml (2 teaspoons) 3-4 times a day, for children 6-12 years old - 5 ml (1 teaspoon) 3-4 times a day.
Duration of use as an antipyretic is no more than 3 days; as a pain reliever - no more than 5 days.

Side effects:

Increased blood pressure, tachycardia;
- drowsiness, difficulty falling asleep;
- dizziness;
- increased excitability;
- dry mucous membranes;
- mydriasis;
- accommodation paresis;
- increased intraocular pressure;
- loss of appetite, nausea;
- epigastric pain, anemia.
Very rarely: urinary retention, allergic reactions (skin rash, itching, urticaria, angioedema).
Rarely: anemia, thrombocytopenia, leukemia, agranulocytosis.
With long-term use in high doses possible hepatotoxic and nephrotic effects.

Contraindications:

Common to both dosage forms:
- hypersensitivity to any of the components included in the composition;
- severe atherosclerosis of the coronary arteries;
- arterial hypertension;
- diabetes;
- angle-closure glaucoma;
- peptic ulcer of the stomach and duodenum;
- diseases of the pancreas;
- difficulty urinating with prostate adenoma;
- deficiency of the enzyme glucose-6-phosphate dehydrogenase;
- thyrotoxicosis;
- severe diseases of the liver, kidneys, heart, bladder;
- diseases of the blood system;
- pregnancy;
- lactation period.

Additional for capsules:
- children's age up to 12 years.
Additionally for suspension:
- children under 6 years of age.
Carefully: congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), bronchial asthma and COPD.

Without a doctor's instructions, the drug should not be used by patients undergoing treatment with other medications, in particular MAO inhibitors.
If, despite taking the drug, the disease is accompanied by ongoing fever or repeated increases in temperature are observed, you should consult a doctor.
Cannot be taken with alcohol and combine with other drugs containing paracetamol.
When using Coldact Flu Plus, it is not advisable to use sleeping pills, tranquilizers and other psychotropic drugs.
Distorts laboratory test results in the quantitative determination of glucose and uric acid in plasma. In case of long-term treatment, peripheral blood parameters and the functional state of the liver are monitored.
Impact on the ability to drive vehicles and operate machinery
During the treatment period, it is necessary to refrain from driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Interaction
other medicinal
by other means:

The risk of developing hematotoxic effects of paracetamol increases with simultaneous use of barbiturates, diphenine, carbamazepine, rifampicin, zidovudine and other inducers of microsomal liver enzymes.
Enhances the effects of sedative medications, ethanol, MAO inhibitors.
Antidepressants, phenothiazine derivatives, antiparkinsonian and antipsychotic drugs increase the risk of developing urinary retention, dry mouth, and constipation.

GCS increase the risk of developing glaucoma.
Paracetamol reduces the effectiveness of uricosuric drugs.
Chlorphenamine combined with furazolidone can lead to hypertensive crisis, agitation, and hyperrexia.
Tricyclic antidepressants enhance the adrenomimetic effect of phenylephrine, simultaneous administration of halothane increases the risk of developing ventricular arrhythmia.
Reduces the hypotensive effect of guanethidine, which in turn enhances the alpha-adrenergic stimulating activity of phenylephrine.

Pregnancy:

Overdose:

Symptoms caused by paracetamol, appear after taking more than 10-15 g: pallor of the skin, decreased appetite, nausea, vomiting, hepatonecrosis, increased activity of liver transaminases, increased prothrombin time.
Treatment: gastric lavage in the first 6 hours, administration of SH-group donors and precursors for the synthesis of glutathione-methionine 8-9 hours after an overdose and N-acetylcysteine ​​after 12 hours.
In case of accidental overdose, consult a doctor immediately, regardless of whether any symptoms of overdose are noted or not.

Release form:

Capsules Coldact Flu Plus prolonged action - hard gelatin, with a red cap and a transparent body, size “0”, containing white or almost white, yellow and orange to red pellets - 10 pcs. in a blister.
Suspension Coldact Flu Plus orange in color with a characteristic odor - in a 60 ml bottle complete with a dosed spoon.

Storage conditions:

Store in a dry place at a temperature not exceeding 25°C.
Keep out of the reach of children.
Best before date- 2 years.
Do not use after expiration date.

1 capsule of Coldact Flu Plus extended release contains:
- active ingredients: chlorphenamine maleate - 8 mg, paracetamol - 200 mg, phenylephrine hydrochloride - 25 mg;
- excipients: talc; hypromellose; ethylcellulose; diethyl phthalate; MCC; povidone; purified water*; isopropanol*; sodium disulfite; disodium edetate; crimson dye (Ponceau 4 R); sunset yellow dye; quinoline yellow dye; Non Pariel Seeds18/22 granules (sugar granules: sucrose, starch syrup);
- capsule shell: gelatin; purified water; methyl parahydroxybenzoate; propyl parahydroxybenzoate; Azorubine dye; crimson dye (Ponceau 4R).

5 ml Coldakta Flu Plus suspension for oral administration contains:
- active ingredients: chlorphenamine maleate - 2 mg, paracetamol - 125 mg, phenylephrine hydrochloride - 5 mg;
- excipients: methyl parahydroxybenzoate; propyl parahydroxybenzoate; sodium saccharinate; disodium edetate; sodium chloride; sucrose; MCC; carmellose sodium; xanthan gum; glycerol; colloidal silicon dioxide; polysorbate 20; lemon acid; sodium citrate; sunset yellow dye; orange flavor (051941CS2); raspberry flavor (502700C); pineapple flavor (503092C); purified water.

Coldact Flu Plus is a combination drug characterized by a prolonged action. It has a powerful anti-allergic and anti-inflammatory effect. Instructions for use of Coldact Flu Plus will describe in detail when you can take this medicine.

With this drug you can quickly get rid of a runny nose, sore throat, and watery eyes. Coldact Flu Plus is also intended to eliminate pain. The use of this medicine allows you to reduce body temperature, as well as get rid of swelling and hyperemia of the upper respiratory tract.

Coldact Flu Plus is a medicine designed to relieve symptoms of influenza and ARVI. It also has an analgesic effect. It is prescribed against:

• Sore throat;
• runny nose;
• swelling of the mucous membrane;
• sinusitis, tracheitis, pharyngitis;
• hay fever;
• lacrimation;
• high temperature;
• fever and pain syndrome;
• allergic rhinitis.

The effectiveness of Coldact Flu Plus is due to its specific composition. It is completely safe and, when used correctly, cannot cause serious harm to the body. The basis of the drug is:

• Chlorphenamine – relieves itching in the eyes and nose, fights lacrimation, has an antiallergic effect;
• paracetamol is an antipyretic and anti-inflammatory drug that helps get rid of pain in the throat, muscles and joints;
• phenylephrine – relieves swelling and hyperemia of the mucous membranes of the upper respiratory tract.

Coldact Flu Plus is slowly absorbed from the gastrointestinal tract. Already 2-6 hours after consumption, its maximum concentration in the blood reaches.

45% of the components are bound by blood proteins. The active substance is completely eliminated from the body after 30 hours along with urine.

Release forms

Instructions for use

Coldact Flu Plus is intended for internal use. It should be consumed only after meals so as not to irritate the gastric mucosa. For acute respiratory viral infections and influenza, capsules should be taken once every 12 hours, and the duration of therapy should not exceed 3 days.

To treat rhinitis, capsules are also prescribed, which must be taken 3 times a day for 6-12 days. If you use Coldact Flu Plus as an antipyretic, you can do this for no more than 5 days.

For allergic rhinitis, Coldact Flu Plus capsules are taken for 3-6 days, 1 piece every 8 hours. When treating chronic rhinitis, the duration of treatment should be at least a month. Coldact Flu Plus can be used as a pain reliever for no more than 5 days.

Coldact Flu Plus can also be used in the form of a suspension. Before use, it must be shaken thoroughly so that the settled active ingredients dissolve. You should take the medicine as follows:

• 2 teaspoons - children over 12 years old and adults;
• 1 teaspoon – for children from 6 to 13 years old.

Contraindications

• Severe arterial hypertension;
• difficulty urinating;
• atherosclerosis of the coronary arteries;
• diabetes mellitus;
• recent myocardial infarction;
• allergies and hypersensitivity to the components of the drug;
• angle-closure glaucoma;
• aortic aneurysm;
• unstable angina;
• thyrotoxicosis;
• pregnancy and lactation.

Also, doctors do not prescribe Coldact Flu Plus to children under 12 years of age, the elderly, or during concurrent therapy with tricyclic antidepressants or MAO inhibitors.

People with renal or liver failure, congenital hyperbilirubinemia, Rotor, Dubin or Gilbert syndrome, chronic obstructive pulmonary disease or bronchial asthma may take the medicine with extreme caution.

Dosage

Coldact Flu Plus in all produced dosage forms has only one dosage.

• Capsules – contains 200 mg of paracetamol, 25 mg of phenylephrine and 8 mg of chlorphenamine. Additionally, the composition of the drug includes granulated sugar, sucrose and starch syrup.
• Suspension (5 ml) – contains 125 mg of paracetamol, 5 mg of phenylephrine, 2 mg of chlorphenamine. Additionally, sodium citrate, citric acid, glycerin and sucrose are present.

Side effects

Coldact Flu Plus rarely causes side effects. Sometimes patients experience:

• Hives, skin rash, itching and peeling;
• angioedema;
• nausea and vomiting;
• stomach ache;
• agranulocytosis;
• increased blood pressure;
• insomnia;
• dizziness and headache;
• increased excitability;
• dry mouth and urinary retention;
• iron deficiency anemia, agranulocytosis, thrombocytopenia;
• accommodation paresis;
• increased pressure inside the eye.

With long-term use of Coldact Flu Plus in people who have hypersensitivity to the components of the drug, hemolytic or aplastic anemia, nephrotoxicity, papillary necrosis, renal colic, interstitial nephritis, glycosuria, methemoglobinemia or pancytopenia may occur.

Price

Coldact Flu Plus can be easily purchased at any pharmacy. The average cost of capsules is 150-290 Russian rubles, one bottle of suspension is 100-180.

Analogs

Analogs for the active substance (paracetamol, phenylephrine, chlorphenamine):

• Anacold;
• TheraFlu Extratab;
• Lorraine;
• AntiFlu;
• Lorraine plus;

Cheap analogues of Coldact Flu Plus:

• Vicks active symptomax– intended for the treatment of cold and flu symptoms. The approximate cost at the pharmacy is from 30 to 60 Russian rubles.
• Brustan– relieves inflammatory processes in the body, relieves pain. Can be used as symptomatic therapy for myositis, fibrositis, fractures and other lesions. The approximate cost at the pharmacy is from 50 to 90 Russian rubles.
• Gripgo– fights symptoms of influenza and other viral diseases. Reduces body temperature and relieves pain. The approximate cost at the pharmacy is from 12 to 55 Russian rubles.
• Gripout– intended for the treatment of acute and respiratory viral diseases. Effectively fights high fever and runny nose. The approximate cost at the pharmacy is from 40 to 90 Russian rubles.
• Gripflu– intended for the treatment of infectious diseases of the upper respiratory tract. Also helps reduce body temperature. The approximate cost in pharmacies is 15 to 40 Russian rubles.

Overdose

If you take Coldact Flu Plus according to the instructions, the risk of overdose is minimal. It occurs only when taking 10 grams of medication or more at the same time. This phenomenon can be recognized by pale skin, nausea and vomiting, decreased appetite, dizziness, apathy, excessive transaminase activity and an increase in antithrombin time.

To minimize the negative consequences of a drug overdose, it is necessary to perform gastric lavage. After this, donors of SH groups and methionine precursors are introduced. In case of overdose, you must immediately call a doctor, regardless of whether there are signs of it or not.

Thank you

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!

What kind of drug is Coldact? Composition, mechanism of action, types, analogues

Coldact is a combination drug that is used to treat symptoms of acute respiratory viral infections ( ARVI), influenza and some bacterial respiratory tract infections. The drug under this brand name is being developed by the Indian pharmaceutical concern Ranbaxy Laboratories Limited. This plant is one of the largest plants in India in terms of sales.

Composition and pharmacological group of the drug Coldact

Coldact preparations differ in composition and release form. These drugs are multicomponent and are intended to improve the patient's condition during colds, flu and others, which are accompanied by fever, headache, runny nose, sore throat, cough, muscle pain, joint pain and other symptoms.

The composition of Coldact to eliminate the symptoms of ARVI and influenza includes paracetamol, phenylephrine hydrochloride and chlorphenamine maleate.
Other forms of the drug may also contain ambroxol hydrochloride, guaifenesin, amylmetacresol and 2,4-dichlorobenzyl alcohol. These drugs have a non-narcotic analgesic effect, antipyretic effect, vasoconstrictor, expectorant, antiseptic and antiallergic effects.

Coldact flu plus in the form of capsules and suspensions

The drug coldact flu plus is currently available in the form of extended-release capsules ( long-term) actions and suspensions for oral administration.

One Coldact capsule contains paracetamol ( 200 mg), phenylephrine hydrochloride ( 25 mg), chlorphenamine maleate ( 8 mg).

Excipients in the capsules are:

• talc;
• hypromellose;
• ethylcellulose;
• diethyl phthalate;
• sodium disulfite;
• crimson dye;
• sunset yellow dye;
• sucrose and others.

Coldact flu plus are hard gelatin capsules with a red cap and a transparent body. These capsules contain white or almost white, yellow or orange to red pellets ( type of capsules). This dosage form is available in an aluminum blister of 10 capsules. The cardboard box, which contains one blister, must also contain instructions for use.

Coldact flu plus suspension for oral administration contains 125 mg of paracetamol, 5 mg of phenylephrine hydrochloride and 5 mg of chlorphenamine maleate. This form is available in a bottle ( 60 ml) made of dark glass, complete with dosing spoon.

Coldact broncho in the form of syrup

The drug coldact broncho is a syrup that contains ambroxol hydrochloride ( 15 mg), chlorphenamine maleate ( 2 mg), guaifenesin ( 100 mg), phenylephrine hydrochloride ( 5 mg). This form of release of the drug has mucolytic, expectorant, antiallergic and vasoconstrictor effects.

The syrup is transparent, orange in color, and has a characteristic taste and smell. It comes in a cardboard package containing a dark glass bottle ( 60 or 100 ml) and instructions for use.

Coldact lorpils in the form of lozenges

This dosage form is an antiseptic for topical use in ENT practice and dentistry. This drug is used for infectious diseases of the mouth and throat - pharyngitis, laryngitis, tonsillitis, gingivitis, stomatitis and others.

This drug is available in the form of round lozenges, orange in color, with lemon or orange flavor. One lozenge contains 2,4-dichlorobenzyl alcohol ( 1.56 mg) and amylmetacresol ( 780 mcg).

Excipients of lozenges are:

• levomenthol;
• sucrose;
• liquid glucose;
• purified water;
• anhydrous citric acid;
• orange or lemon oil.

Currently, you can find cardboard packs on sale containing 5 cell-free contour packs of 4 tablets each ( only 20 tablets) and instructions for use.

Mechanism of action of the drug

Koldakt is a combination drug that is most often used in the form of extended-release capsules ( long-term) actions. These capsules contain three main active ingredients - paracetamol, pheniramine maleate and phenylephrine hydrochloride.

Paracetamol is an analgesic ( painkiller) is a non-narcotic drug that has a central effect. It has an antipyretic, analgesic effect for sore throat, headache, joint and muscle pain, and reduces high body temperature. The mechanism of action of this substance is associated with the suppression of prostaglandin synthesis, mainly in the center of thermoregulation, which is located in the hypothalamus. One of the functions of prostaglandins is to participate in the development of inflammation. Paracetamol provides pain relief by increasing the pain threshold. It also plays an important role in reducing body temperature due to its effect on the hypothalamic thermoregulation center. Paracetamol has virtually no anti-inflammatory effect. It also does not cause irritation to the mucous membrane of the stomach and intestines and does not affect water-salt metabolism.

Chlorphenamine has an antiallergic effect. This substance suppresses brain receptors that are responsible for the development of an allergic reaction. When using this substance, itching of the eyes, nose, swelling and hyperemia is eliminated ( congestion of blood vessels with blood) mucous membranes of the nasal cavity, nasopharynx and paranasal sinuses, and exudative manifestations are reduced ( discharge from small blood vessels due to inflammation).

Phenylephrine hydrochloride is an adrenergic agonist and vasoconstrictor. Mainly, this substance has a stimulating effect on alpha-adrenergic receptors. Stimulation of these receptors, which are located on the blood vessels of the nasal mucosa, leads to their narrowing, a decrease in the volume of incoming blood and a decrease in the volume of the mucosa itself. Thus, vasoconstriction leads to a reduction in the flow of fluid into the nose, throat and sinus lining. Phenylephrine, mainly due to vasoconstriction, reduces nasal congestion and facilitates nasal breathing.

Ambroxol hydrochloride ( bromhexine derivative), which is part of Coldact syrup, reduces the viscosity of sputum, facilitates the release of bronchial secretions and stimulates local immunity.

Guaifenesin is a mucolytic agent that stimulates the secretory cells of the bronchial mucosa. This substance reduces the viscosity and increases the volume of sputum, promotes its discharge and the transition of unproductive ( dry) cough into productive ( ) cough.

Analogues of the drug

Koldakt is an imported drug intended to treat colds. It successfully combines several active substances that reduce the symptoms of ARVI and influenza. The most common and convenient form of Coldact release is long-acting capsules. If this drug is not available in pharmacies in Russian cities, the pharmacist may instead offer another drug that has a similar effect.

Analogs of Coldact Flu Plus in capsules are the following drugs:

• adjicold;
• Theraflu extratab;
• flu;
• combiflu;
• maxigrip;
• antiflu and others.

The listed drugs have a similar composition, but differ in the dosage of active ingredients. Also, all these drugs are available in various forms ( tablets, powder).

Also, for colds, for the fastest possible cure, it is recommended to use lozenges. These tablets have analgesic, softening and antibacterial effects.

If necessary, Coldact Lorpils can be replaced by:

• ajisept;
• rinzoy lorcept;
• astrasept;
• gorpilsom;
• strepsils and others.

Which is better – coldakt or rinza?

Rinza is also a multicomponent drug, with a composition similar to Coldact. Along with paracetamol, chlorphenamine and phenylephrine, Rinza also contains caffeine. Caffeine has a stimulating effect on the central nervous system, which leads to a decrease in the patient's drowsiness and fatigue, as well as an increase in mental and physical performance. Rinza and Coldact have antipyretic, analgesic, decongestant, antitussive, and antiallergic effects. Both drugs can be effective in treatment. In any case, before using any of these drugs, you should consult a specialist.

Which is better – Coldact or antiviral drugs ( rimantadine, ingavirin)?

Antiviral drugs are drugs that have an inhibitory effect on various stages of virus reproduction in the human body. Creating these tools is one of the most difficult tasks. Remantadine and ingavirin, for example, have anti-influenza activity.

Remantadine has antiviral activity and inhibits the penetration of the virus into cells. This drug is used to prevent and treat influenza. Undesirable side effects when treated with this drug are insomnia, difficulty concentrating, nervousness, and others. Remantadine is also teratogenic ( disruption of embryonic development under the influence of various factors) and embryotoxic ( negative impact in the first three weeks after fertilization) action.

Ingavirin is a drug that has antiviral and anti-inflammatory activity. This drug helps reduce the duration of the disease and reduce the risk of complications. The drug does not have embryotoxic and teratogenic effects, as well as mutagenic ( change in the hereditary properties of an organism, manifested in offspring), immunotoxic and carcinogenic effects.

Thus, Coldact is not an antiviral drug; it does not have activity against the influenza virus in the human body. It is a drug that alleviates the symptoms of the disease and the course of the disease.

Indications for the use of coldact drugs

These drugs provide a reduction in several manifestations of colds at once. The effect of various forms of coldact release can be both general and local.

Coldact is used for the very first symptoms of ARVI and influenza, namely, elevated body temperature, headache, aches, chills, muscle and joint pain, itchy nose, nasal congestion, runny nose and other manifestations.

Does Coldact help with cough?

Coughing is a protective reaction of the body, the purpose of which is to clear the airways of substances that have entered from the outside or as a result of illness. The cough reflex occurs in response to irritation of the respiratory tract with the participation of the cough center, which is located in the medulla oblongata. There are unproductive ( dry) cough and productive ( accompanied by sputum production) cough. Cough occurs due to inflammation of the respiratory tract and lungs, allergic reactions and other conditions. Antitussive therapy is necessary for non-productive cough, as well as for thick sputum, debilitating cough and other types of cough.

Coldact broncho is a combination drug that contains the substances guaifenesin and ambroxol. These drugs reduce the viscosity of bronchial secretions and facilitate expectoration. They are used in the complex treatment of respiratory tract diseases and bronchial obstruction syndrome ( obstruction).

This drug is used for the symptomatic treatment of colds and flu, accompanied by a cough with difficult-to-discharge viscous sputum.

If after 5 days of taking the drug the cough persists or fever, headache, sore throat and other symptoms are noted along with the cough, you should consult your doctor.

Is it possible to take Coldact if there is no fever?

Adults are recommended to take antipyretic drugs at a temperature of 38.5 degrees or higher, and children - at a temperature of 38 degrees or more. In the drug Koldakt, paracetamol has an antipyretic effect. Also, this substance in different doses also has analgesic properties. If there is severe pain, this drug can be used even in the absence of fever ( for example, at a temperature of 37.5 degrees).

This drug alleviates the symptoms of an acute respiratory viral infection or influenza, and does not treat the disease itself. It is important to follow the instructions and adhere to the principles of taking the drug and the prescribed dosage.

Instructions for use of the drug

In order for the treatment to be effective, you should carefully study the instructions for use before use. These instructions always indicate how to take the drug correctly, how many times a day, in what dosage and other information. Each form of Coldact release has its own recommendations for use.

Use of coldact in the form of suspension and syrup

Coldact flu plus suspension is intended for oral administration. The single dose taken depends on the age of the patient. The package along with the bottle contains a dosage spoon ( 5 ml). The interval between doses should be 4 hours. Children over 6 years of age are recommended to take one dose no more than 5 times a day. If you have an elevated body temperature that lasts more than 3 days and the presence of pain for more than 5 days, you should consult a specialist.

Coldact broncho syrup is also taken orally. Before use, shake the bottle with its contents. Recommended dose for children over 12 years of age and adults 20 ml ( 4 teaspoons) 3 times a day. Children from 6 to 12 years old can take 10 ml ( 2 teaspoons) 2 or 3 times a day. This drug should be taken evenly throughout the day. It is not recommended to take the syrup for more than 7 days without a doctor's prescription.

Using coldact in the form of capsules and lozenges

Coldact flu plus in the form of long-acting capsules is taken orally. Children over 12 years of age and adults should take 1 capsule every 12 hours for 3 to 5 days.

Coldact lorcept lozenges are recommended to be taken every 2 hours, 1 tablet. The maximum daily dose for an adult patient is 8 tablets. Children over 5 years of age can also take 1 tablet every 4 hours.

If symptoms worsen or persist after 5 days of using the medicine, you should stop taking it and consult your doctor.

Should Coldact be taken before or after meals?

This drug is usually recommended to be taken after meals. 1 or 2 hours should pass between using the drug and eating. Coldact flu plus in long-acting capsules is recommended to be taken with a small amount of water.

How long does it take for cold act to take effect?

Koldakt begins to act in the human body 20 – 30 minutes after taking it. The duration of action of capsules is 12 hours, and the suspension or syrup is 4 – 4.5 hours.

Paracetamol is absorbed quite quickly and completely from the gastrointestinal tract ( Gastrointestinal tract). It is also distributed in most tissues of the body. Phenylephrine is also absorbed from the gastrointestinal tract quite quickly. Its maximum concentration in blood plasma is reached after 1 – 2 hours. Chlorphenamine after oral administration is relatively slowly absorbed from the gastrointestinal tract. All these substances are metabolized in the liver and excreted in the urine.

How to store cold product?

The drug should be stored at a temperature of no more than 25 degrees, in a dry place protected from light. It is also necessary to store Koldakt in places inaccessible to children to avoid the development of unwanted side reactions if the medicine is used carelessly.

Shelf life of the drug

Medicines retain their beneficial properties only if properly stored. The shelf life of Coldact is 2 years from the date of production, and it is prohibited to use it after this period. If the expiration date is exceeded, as well as if the drug is stored incorrectly, adverse reactions may occur.

If the drug has become unusable or the expiration date has expired, do not throw it into wastewater or onto the street. In this case, the product must be placed in a bag and placed in a trash container. Thus, these actions will help protect the environment.

Side effects of the drug

If you take medications according to the recommendations specified in the instructions for use, you can avoid or reduce the risk of side effects. Before using Coldact, you must carefully study the instructions supplied by the manufacturer.
Side effects when using Coldact flu plus

Body system	Side effects
Blood system
Liver	Rarely there is an increase in the activity of liver transaminases ( enzymes).
Skin and subcutaneous tissues
Mental disorders	Nervousness and insomnia are rarely observed.
Allergic reactions	Rarely - hypersensitivity, urticaria, angioedema ( Quincke's edema). Very rarely, an anaphylactic reaction, Stevens-Johnson syndrome, and toxic epidermal necrolysis may occur.

Is Coldact compatible with alcohol?

You should not take alcoholic beverages at the same time as Coldact, as this may increase the risk of adverse reactions. Alcohol is hepatotoxic. The use of medications also negatively affects the functioning of the liver - they load it. It is worth noting that when the drug and alcohol are used together, the risk of gastrointestinal bleeding increases, blood pressure rises, and a severe allergic reaction may develop. Also, when the concentration of alcohol in the blood increases, it depresses the central nervous system.

Interaction with other drugs

Koldakt is a multicomponent drug, and when used simultaneously with other drugs, the possibility of developing both undesirable reactions and weakening or enhancing the beneficial properties of the substances included in the drug should be taken into account.

Thus, it is highly undesirable to take Coldact together with other medicines containing paracetamol or other non-steroidal anti-inflammatory drugs ( ibuprofen, aspirin and others), hypnotics and anxiolytics ( tranquilizers) medicinal substances.

When taking coldact and antidepressants, antiparkinsonian and antipsychotic drugs at the same time, the risk of developing urinary retention in the body, dry mouth, and constipation increases. When using glucocorticosteroids, the risk of developing glaucoma increases.

Paracetamol may reduce the effectiveness of uricosuric drugs ( drugs that increase the excretion of uric acid in gout), as well as when administered simultaneously with barbiturates, carbamazepine, isoniazid and others, the risk of developing the hepatotoxic effect of paracetamol increases. With prolonged and regular use, paracetamol enhances the effect of warfarin and other indirect anticoagulants, and this increases the risk of bleeding.
Chlorphenamine simultaneously with furazolidone, monoamine oxidase inhibitors ( MAO) may lead to hyperpyrexia ( a condition in which the body temperature is above 41 degrees), agitation, hypertensive crisis ( excessive increase in blood pressure).

Phenylephrine concomitantly with MAO inhibitors can lead to an increase in blood pressure, and it also reduces the effectiveness of beta-blockers and antihypertensive drugs. When taking phenylephrine and digoxin and other cardiac glycosides simultaneously, the risk of arrhythmia and myocardial infarction increases.

How does an overdose manifest when taking Coldact?

In case of overdose, you should immediately contact a specialist, as it is very important to provide timely medical assistance in this case.

After taking more than 10 g of paracetamol, overdose symptoms are pronounced, which are manifested by pallor of the skin, decreased appetite, nausea, vomiting, pain in the epigastric region, and acute liver failure. Acute liver failure can lead to encephalopathy ( brain damage), metabolic acidosis ( decrease in blood concentration of bases), cerebral edema and death. Rarely, liver failure can develop suddenly and be complicated by renal failure.

In case of an overdose of phenylephrine, the patient experiences nausea, vomiting, agitation, irritability, psychosis, insomnia, convulsions, as well as tachycardia, increased blood pressure, reflex bradycardia ( decreased heart rate due to illness).

Symptoms of chlorphenamine overdose include central nervous system depression ( central nervous system), hyperthermia, mydriasis ( dilated pupils), dry mouth, flushing, urinary retention, intestinal paresis. Nausea, vomiting, disorientation, hallucinations, psychosis, convulsions, and arrhythmias are also observed.

Contraindications to the use of Coldact

Before starting treatment with these drugs, you must familiarize yourself with the contraindications that are indicated in the instructions for use. If the drug is prescribed by a doctor, you should draw his attention to the patient’s concomitant diseases.
hyperbilirubinemia, epilepsy, cardiovascular diseases, alcohol dependence.

Bronchocoldact

Intolerance to components, simultaneous use of antidepressants and beta-blockers, convulsions, arterial hypertension, diabetes mellitus, thyrotoxicosis, pheochromocytoma, prostate adenoma, gastric and duodenal ulcers, angle-closure glaucoma, children under 6 years of age.

Use with caution in case of renal and/or liver failure.

Koldakt lorpils

Hypersensitivity to the components of the drug, children under 5 years of age.

Koldakt during pregnancy and breastfeeding

According to the instructions for use of the drug, it is prohibited to use it in the form of capsules, suspension and syrup for oral administration to pregnant women and during breastfeeding. It is known that paracetamol is one of the safe non-steroidal anti-inflammatory drugs, and this drug does not have a negative effect on the health of a pregnant woman, as well as during breastfeeding. But, in addition to paracetamol, the drug contains phenylephrine and pheniramine, which can adversely affect the course of pregnancy and the health of the child who receives breast milk. In this case, the baby must be transferred to artificial feeding.

Considering the fact that there are no clinical data on the safety of lozenges during pregnancy and breastfeeding, taking Coldact Lorpils is also contraindicated.

Is there any restriction in taking Coldact related to driving a vehicle and operating other machinery?

During the period of use of capsules, suspension and syrup, Coldact is not recommended to drive a car or engage in potentially hazardous activities. These actions require increased concentration and speed of psychomotor reactions, and cold act can weaken them.

Can children take Coldact?

Koldakt is a multicomponent drug that must be used in children strictly following the instructions for use. Thus, long-acting capsules to eliminate the symptoms of colds and flu can be used by children from 12 years of age. Coldact broncho syrup and coldact flu plus suspension for oral administration can be used in children over 6 years of age. Coldact Lorpils lozenges can be taken by children from 5 years of age. However, we should not forget that treatment of children should be carried out strictly under the supervision of the attending physician.

Price ( price) koldakta in Russian cities

The cost of Coldact may vary depending on its type and country of origin, as well as on the city in which the pharmacy is located, since the cost of transporting the drug to remote parts of the country significantly increases its price.
Considering that the most common form of Coldact release is extended-release capsules, they are most often found on sale. For more detailed information about other forms of coldact release, you should contact the pharmacies of the city in which the patient lives.

Cost of koldakt in various cities of Russia

Do I need a prescription to purchase the drug?

Koldakt drugs are sold in pharmacies without a doctor's prescription. These medications alleviate the symptoms of the disease in the early stages of its development. You should be careful when self-medicating and take into account all contraindications. If symptoms worsen or persist after 5 days of using the medicine, you should consult your doctor immediately.

Coldact Flu Plus is a drug for the symptomatic treatment of acute respiratory diseases, which has antipyretic, alpha-adrenergic, vasoconstrictor and antihistamine effects, and eliminates the symptoms of “colds”.

Combined drug with prolonged action. The therapeutic effect is due to the active ingredients included in the composition:

• Chlorphenamine maleate is an H1 receptor blocker. Helps reduce vascular permeability of the mucous membrane of the upper respiratory tract, eliminates lacrimation and rhinorrhea.
• Paracetamol has analgesic, antipyretic and anti-inflammatory effects.
• Phenylephrine hydrochloride reduces the severity of hyperemia and swelling of the mucous membrane of the upper respiratory tract and paranasal sinuses.

Coldact Flu Plus capsules have a solid consistency and a red cap, they are packaged in a blister of 10 pieces, a cardboard pack contains 1 or 10 blisters and instructions.

The suspension has an orange color and a characteristic odor; it is contained in a 60 ml bottle. The cardboard box contains one bottle, a measuring spoon and instructions.

Indications for use

What does Coldact Flu Plus help with? According to the instructions, the drug is prescribed in the following cases:

• symptomatic treatment of colds, flu, acute respiratory viral infections (fever, pain, rhinorrhea).

Instructions for use of Coldact Flu Plus, dosage

Capsules and suspension are taken orally; the suspension must be shaken before use.

Capsules are intended for adults and children over 12 years of age. Standard dosages of Coldact Flu Plus according to the instructions for use - 1 capsule every 12 hours.

Suspension dosages:

• Adults and children over 12 years old – 10 ml (2 teaspoons) 3-4 times a day,
• Children aged 6 to 12 years – 5 ml (1 teaspoon) 3-4 times a day

Do not take the drug for more than 5 days without consulting a doctor.

Side effects

The instructions warn about the possibility of developing the following side effects when prescribing Coldact Flu Plus:

• Increased blood pressure, tachycardia, drowsiness, difficulty falling asleep, dizziness, increased excitability, dry mucous membranes, mydriasis, accommodation paresis, increased intraocular pressure, loss of appetite, nausea, epigastric pain, anemia.
• Very rare: urinary retention, allergic reactions (skin rash, itching, urticaria, angioedema).
• Rarely: anemia, thrombocytopenia, leukemia, agranulocytosis.
• With long-term use in high doses, hepatotoxic and nephrotic effects are possible.

Contraindications

It is contraindicated to prescribe Coldact Flu Plus in the following cases:

• hypersensitivity to any of the components of the drug,
• severe atherosclerosis of the coronary arteries,
• unstable angina,
• aortic aneurysm,
• recent (within the last 6 months) myocardial infarction,
• severe hypertension,
• thyrotoxicosis,
• angle-closure glaucoma,
• difficulty urinating,
• age up to 12 years,
• During pregnancy and breastfeeding,
• simultaneous use of MAO inhibitors or tricyclic antidepressants.

No dose adjustment is required in elderly patients.

For patients with severe hepatic or renal insufficiency, Coldact Flu Plus is prescribed with caution.

Overdose

Treatment of overdose consists of washing the stomach, intestines, and taking intestinal sorbents (activated carbon). SH-group donor compounds, N-acetylcysteine ​​and methionine are also used, which reduce the negative effects of high doses of paracetamol.

Analogues of Coldakt Flu Plus, price in pharmacies

If necessary, you can replace Coldact Flu Plus with an analogue of the active substance - these are the following drugs:

1. AntiFlu,

Similar in action:

• Decathylene,
• Cameflu,
• Flu effect,
• Coldfree,
• Theraflu,
• Pharmacitron,

When choosing analogues, it is important to understand that the instructions for use of Coldact Flu Plus, the price and reviews of drugs with similar effects do not apply. It is important to consult a doctor and not change the drug yourself.

Price in Russian pharmacies: Coldact Flu Plus capsules 10 pcs. – from 199 to 275 rubles, according to 794 pharmacies.

The shelf life of tablets and suspension is 2 years from the date of manufacture. The drug must be stored in a dry place, out of reach of children, at an air temperature no higher than +25º C.

special instructions

Without a doctor's instructions, the drug should not be used by patients undergoing treatment with other medications, in particular MAO inhibitors. If, despite taking the drug, the disease is accompanied by ongoing fever or repeated increases in temperature are observed, you should consult a doctor.

Do not take with alcohol or combine with other drugs containing paracetamol.

When using Coldact Flu Plus, it is not advisable to use sleeping pills, tranquilizers and other psychotropic drugs.

Distorts laboratory test results in the quantitative determination of glucose and uric acid in plasma. In case of long-term treatment, peripheral blood parameters and the functional state of the liver are monitored.

During the treatment period, it is necessary to refrain from driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Interaction with other drugs

Concomitant use with psychotropic and hypnotics may lead to increased sedation.

Concomitant use with MAO inhibitors, tricyclic antidepressants, ganglion blockers, adrenoreceptor blockers, rauwolfia alkaloids, methyldopa can lead to an increase in blood pressure.

Coldact Flu Plus should not be taken with medications containing paracetamol.