Trichopolum: indications for use in gynecology. What does Trichopolum treat? Instructions, reviews and prices Does trichopolum affect

Trichopolum is an antibacterial drug, a nitroimidazole derivative, which is used in the treatment of a variety of infectious diseases. Its therapeutic effect is based on slowing down the growth and reproduction of protozoa and bacteria. Despite the fact that Trichopolum is known as one of the most effective medicines, after its use, patients can develop a number of negative reactions from many systems: digestive, nervous, as well as sensory and hematopoietic organs. What the drug Trichopolum is and what side effects it causes will be discussed in this article.

Information about the drug

Trichopolum is prescribed for the following diseases: liver amoebiasis, giardiasis, vaginitis, amoebic dysentery, ulcerative gingivitis, trichomoniasis and other infections.

The drug has an antimicrobial and antiprotozoal effect due to its active ingredient - metronidazole.

It is active against a number of bacteria and protozoa belonging to the anaerobic and aerobic groups:

• Giardia;
• Trichomonas;
• fusobacteria;
• balantidam;
• clostridia;
• Helicobacter pylori;
• amoeba;
• bacteroids.

The action of the antibiotic Trichopolum in the body of patients is based on damage to the DNA of these pathogenic microorganisms that cause the corresponding infectious diseases.

Action of Trichopolum in the body

The drug penetrates quite quickly into the blood from the digestive tract and reaches its highest concentration 1.5 - 3 hours after each dose. You need to take tablets or capsules on an empty stomach; any food consumed with it, especially fatty and rich foods, can reduce the rate of its absorption and multiply the total time required to achieve its maximum level of concentration in the blood plasma.

The medicine easily passes through the blood-brain and placental barriers, spreads quickly and evenly throughout the body, entering various organs, tissues and biological fluids:

• saliva;
• seminal fluid and vaginal secretions;
• bile;
• liver;
• brain and spinal cord.

Trichopolum is processed by the liver and excreted by the kidneys; its half-life takes about 6-8 hours.

At this time, in patients, the urine may turn red or even dark red-brown due to the presence of pigments (coloring substances) in it, which are formed as a result of metabolism.

How the digestive and genitourinary systems can react to Trichopolum

Side effects when using the drug Trichopolum may have different intensity of manifestation. When mild, they do not threaten human health at all and go away on their own, after the patient’s body adapts to the new substance. But, if over time they not only do not disappear, but become more noticeable, you must immediately see a doctor to adjust the dose and subsequent regimen of use.

From the gastrointestinal tract and genitourinary system, the weakest negative reactions to the antibiotic Trichopolum can be as follows:

• loss of appetite;
• metallic taste in the mouth;
• loss of taste;
• dry mouth.

If the patient’s body reacts more strongly to the substances included in the drug, they develop:

• stomatitis;
• jaundice;
• dyspepsia;
• polyuria;
• frequent or, conversely, decreased urination;
• epigastric pain;
• prolonged diarrhea or constipation;
• polyuria;
• urinary incontinence;
• burning when urinating;
• vaginal pain;
• cystitis;
• candidiasis;
• blood in urine and stool;
• nausea and vomiting;
• intestinal colic;
• glossitis.

The most serious, although rare, complications are considered to be anorexia, pancreatitis and cholestatic hepatitis.

How the nervous and skeletal system can react to Trichopolum

The human nervous system may also react negatively to this medicine.

In sick people, it can cause, with the mildest manifestations:

• visual impairment;
• weakness;
• drowsiness;
• insomnia;
• rise in temperature;
• headache;
• convulsions;
• dizziness.

In more serious cases, the central nervous system reacts by developing:

• diplopia;
• cerebellar syndrome;
• peripheral neuropathy;
• ataxia;
• myopia;
• depression;
• encephalopathy;
• ataxia;
• hallucinations;
• disturbances in motor coordination,
• increased excitability and confusion.

After taking this medication, patients may experience bone and muscle pain, another common negative effect of the drug.

Allergic reactions

Trichopolum can cause allergic reactions of varying severity:

• skin rash;
• angioedema;
• heaviness in the chest;
• dry skin;
• peeling;
• difficulty breathing due to nasal congestion;
• swelling of the entire face or just part of it;
• anaphylactic shock.

The latter condition, although it occurs rarely, poses an immediate threat to the lives of patients. If it occurs, you should immediately call an ambulance, as the patient can die very quickly. In the circulatory system, Trichopolum can cause: agranulocytosis, thrombocytopenia, thrombophlebitis, anemia (decrease in the normal level of red blood cells) and exudative erythema multiforme.

Restrictions and contraindications

During treatment with Trichopolum, it is strictly prohibited to drink any alcohol. It is contraindicated for patients with central nervous system pathologies, women in the first trimester of pregnancy and breastfeeding women, since it can be transmitted to the child and children under 6 years of age along with milk. For patients diagnosed with liver failure, it is prescribed only on the special instructions of the attending physician and under his constant supervision, since it is quite possible that taking Trichopolum can sharply worsen their condition, up to the occurrence of hepatic coma.

If, while taking this drug, patients develop pathological changes in the circulatory system, then the further course of Metronidazole therapy is adjusted taking into account the hemogram data.

If, during therapy with Trichopolum, candidiasis of the mucous surfaces of the mouth, gastrointestinal tract and genitals develops, then antifungal drugs must be prescribed along with it. While taking Metranidazole, patients should refrain from driving any type of vehicle or working with complex equipment and mechanisms due to the likely development of severe dizziness, confusion or loss of consciousness, and convulsions.

Interaction with other medications

Trichopolum increases the effect of the use of coumarin derivatives, therefore, if they are prescribed together, the dose of the anticoagulant is adjusted. Medicines that affect microsomal liver enzymes (inducers and inhibitors) reduce or, conversely, enhance the effect of Trichopolum. When using Metronidazole together with high doses of lithium preparations, you should carefully check the level of this microelement in the blood, since it is quite possible that its toxic effect on the kidneys will greatly increase.

Trichopolum can also several times increase the effect on cardiac function of Astemizole and Terfenadine, increasing the possibility of prolonged arrhythmias, which can be fatal, and fainting. In case of an overdose of the drug, patients may experience nausea, vomiting, ataxia, and severe convulsions. Hemodialysis is used to remove it from the body.

The fact is that this drug tends to have an inhibitory effect on almost all protozoan microorganisms. These are Giardia, and Amoebas, and Trichomonas, and so on and so forth. In addition, this drug copes very effectively with anaerobic microorganisms, while providing a fairly strong antimicrobial effect. It should also be noted that Trichopolum is very easily and quickly absorbed from the gastrointestinal tract and also quickly “takes over” such tissues and organs of the human body as: saliva, kidneys, liver, breast milk, seminal fluid, lungs, skin and many other. The drug leaves the body only after twelve to twenty-four hours. This drug is excreted through both urine and feces.

Trichopolum is a fairly well-known drug that has found its wide use in the fight against giardiasis, trichomoniasis, amoebic dysentery, and various bacterial infections. A distinctive feature of this medication is that it can be taken not only by women, but also by men. Moreover, it is extremely important that both sexual partners undergo the course of therapy.

Due to the fact that metronidazole (Trichopolum) has been in medical practice for more than 50 years, some bacteria may become resistant to it. This is important in the treatment of vaginal infections caused by gardnerella (bacterial vaginosis) and E. coli. These bacteria are able to unite and produce protective substances that prevent the destructive action of the antibiotic.

Despite the fact that this drug belongs to the category of one of the best, it, like many other drugs of the same effect, can cause a number of side effects. We immediately draw the attention of all readers to the fact that these side effects can make themselves felt both from the digestive system and from the nervous system, sensory organs and hematopoiesis. So, for example, the following side effects may occur from the digestive system: stomatitis, hepatitis, pancreatitis, dyspepsia, dry mouth, metallic taste and some others.

The nervous system may react to this drug by causing headache, nearsightedness, dizziness, diplopia, neuropathy, ataxia or cerebellar syndrome. From the hematopoietic system, the following may be noted: agranulocytosis, anemia or thrombocytopenia. Other side effects that may be caused by trichopolum include various allergic reactions, as well as changes in the color of urine. To reduce the risk of side effects to a minimum, it is worth remembering special dietary supplements (dietary supplements).

If trichomoniasis is detected, only a doctor should prescribe treatment, since self-treatment can lead to serious and unpredictable consequences.

Trichomoniasis is usually treated with anti-trichomoniasis drugs, for example, Trichopolum, which are used both generally and locally. This is due to the fact that when applied topically, this drug eliminates redness, itching, inflammation of the genital organs, and in general, it fights bacteria inside the patient’s body.

Treatment with trichopolum, like other antibiotics, is carried out over a course that usually lasts 10 days. However, if the disease is advanced, longer therapy may be required.

During treatment with this drug, it is necessary to avoid sexual intercourse and adhere to a diet, limiting spicy and fried foods, as well as salty foods and alcohol. Alcohol is especially contraindicated and should not be taken even within one day after the last dose of the drug.

To reduce the side effects of Trichopolum, like any other antibiotics, it is necessary to consume a sufficient amount of fermented milk products containing lacto- or bifidobacteria. This drug kills not only pathogenic bacteria, but also beneficial ones, which leads to intestinal dysbiosis, and yogurt or kefir prevents this.

In addition to Trichopolum, for trichomoniasis it is also important to take immunostimulating drugs to strengthen the body's immune system. After completing the course of treatment, it is necessary to take tests a week after the end of treatment.

The patient is considered cured of trichomoniasis if no trichomonas are detected in the analysis for 2 months.

During the treatment of vaginitis caused by Trichomonas in women and Trichomonas urethritis in men, it is required to abstain from sexual intercourse; simultaneous therapy of both sexual partners is mandatory.
Patients who have a medical history indicating side effects from the central nervous system and the hematopoietic system during therapy with metronidazole, if necessary, should be under the strict supervision of their attending physician.
When prescribing Trichopolum to patients with severe liver failure, it is recommended to adjust the dosage of the drug due to the potential accumulation of metronidazole in the body.
The drug should be used with caution in patients who are predisposed to edema or in patients receiving glucocorticosteroids due to the high concentration of sodium in the solution.
During drug therapy, a darker coloration of the urine is observed.
When using this drug, false results may be observed in the analysis of liver transaminase activity, triglyceride levels and the presence of sugar in the blood plasma.

The drug Trichopolum is indicated for:
- trichomoniasis (including chronic, acute);
- giardiasis;
- amebiasis and amoebic liver abscesses;
- infectious diseases caused by anaerobic microorganisms (including peritonitis, suppuration of the abdominal cavity and liver; endometritis, infectious inflammation of the ovaries and fallopian tubes, postoperative pain syndromes; pneumonia, pleural empyema, meningitis, brain abscesses; skin infections);
- prevention of complications during surgical operations on the colon, during appendectomy, as well as during surgical interventions in the field of gynecology.
- for peptic ulcers of the duodenum or stomach, prescribed together with a bismuth preparation and an antibiotic (amoxicillin);
- local therapy of vaginitis caused by Trichomonas and other pathogens.

The drug is contraindicated:
- during the first 3 months of pregnancy;
- in case of hypersensitivity to the drug component metronidazole or other nitroimidazole derivatives.

The drug is not recommended for use in the first three months of pregnancy. Therapy with this drug during the remaining 6 months of pregnancy is permitted only when the likely benefit to the mother outweighs the possible risk to the fetus.
The use of intravaginal tablets is not recommended during the entire period of pregnancy.
If drug therapy is necessary during lactation, it is recommended to stop breastfeeding.

Trichopolum is an antiprotozoal drug with an antimicrobial effect, a derivative of 5-nitroimidazole. The action of the drug occurs through biochemical regeneration of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic bacteria. The reduced 5-nitro group of metronidazole acts on the DNA of the bacterial cell, inhibiting the synthesis of their nucleic acids, which leads to the destruction of bacteria.
This drug is effective against such microorganisms as: Gardnerella vaginalis, Giardia intestinalis, obligate anaerobic bacteria: Bacteroides spp. (including Bacteroides distasonis, Bacteroides thetaiotaomicron), Veillonela spp.; some gram-positive microorganisms: Eubacterium spp., peptococci, peptostreptococci, etc.

Pharmacodynamics of the drug:
When used internally, it is well absorbed by the gastrointestinal mucosa.
The drug component metronidazole penetrates into most tissues and biological fluids of the body (saliva, bile, vaginal secretions, peritoneal fluid, cerebrospinal fluid, bone tissue, liver, red blood cells). The drug binds to plasma proteins by approximately 20%. Metronidazole penetrates the blood-brain and placental barrier and is excreted in breast milk.
The half-life lasts approximately 8 hours. Excreted in urine (60-80%) and feces (6-15%).

Trichopolum is one of the most effective modern drugs. It was originally used to treat trichomonas infections, but today the range of uses has expanded. Treatment with Trichopolum is recommended for men and women with various infectious diseases. You can learn more about the recommendations in this article and at an appointment with a specialist doctor.

What is Trichopolum taken for?

Today the list of indications is wider; the medicine is used for:

• trichomoniasis, chronic and acute;
• vaginitis;
• stomach and intestinal ulcers (taken together with Amoxicillin);
• giardiasis;
• liver abscesses caused by amoebic organisms;
• infectious pathologies;
• peritonitis;
• inflammations of a gynecological nature;
• purulent diseases of the abdominal cavity;
• meningitis;
• brain abscesses;
• skin infections;
• pneumonia;
• sore throat;
• gonorrhea;
• demodicosis.

Separately, it is worth noting the use after gynecological operations and procedures on the colon. The drug reduces the risk of postoperative complications and protects the patient from the development of infection.

Some specialists use the drug in the treatment of alcoholism: when taken simultaneously with alcohol, a general deterioration in well-being and allergic reactions are possible. This contributes to the development of a persistent aversion to strong drinks.

Action diagram

The action of Trichopolum is biochemical. The nitro group of the drug molecule is integrated into the respiratory chain of anaerobic and protozoan organisms, thereby disrupting their ability to breathe and causing death. In some varieties, Trichopolum also causes DNA degradation.

After administration, the medicine enters the gastrointestinal tract, where it is quickly absorbed. The efficiency is about 80%. The main substance (metronidazole) easily penetrates the tissues and fluids of the body, gradually concentrating in them. It accumulates, in particular, in breast milk, so taking the medicine is not recommended for nursing mothers: you should wait until the end of lactation or interrupt it prematurely.

Treatment of women with Trichopolum

The drug is most often used in gynecology. Its purpose is to treat inflammatory processes caused by bacteria.

Here is an approximate list of diseases for which Trichopolum is treated:

• vaginitis;
• cystitis;
• endometritis;
• colpitis;
• chlamydia;
• gonorrhea.

The drug is also actively used during surgical operations, before or immediately after them.

Is Trichopolum harmful during pregnancy?

This question worries all pregnant patients. Indeed, this drug is not recommended for expectant mothers. It is strictly contraindicated in the first trimester, due to the good absorption of metronidazole. The substance easily penetrates the membrane of the placenta. The component is harmful to the developing fetus and in the early stages can cause various disorders or lead to intrauterine death. Treatment is also prohibited during breastfeeding; the milk of a woman undergoing therapy is not suitable for feeding the baby.

In the second and third trimesters, taking Trichopolum is allowed, but with prior agreement with a specialist.

Situations where a woman took the drug without knowing about pregnancy require special consideration. In this case, the doctor may recommend an abortion for medical reasons: in the first three months, the baby’s body is formed, and drug intervention in the process often results in serious complications in the fetus. But expectant mothers should not despair: full formation begins approximately 20 days after fertilization. Usually by this time a woman notices a delay in menstruation and manages to stop taking medications.

Trichopolum for men

In addition to diseases characteristic of both sexes, indications for use are:

• chlamydia;
• trichomonas urethritis;
• gonorrhea;
• giardiasis;
• licheniasis;
• amoebiasis;
• balantidiasis.

Trichopolum and children

The instructions for the drug clearly indicate that it can be taken by persons aged six years and older. The drug is categorically not recommended for young children, and it is better to give the medicine to those who have reached the specified age after prior agreement with a medical specialist.

Children drink Trichopolum when:

• infectious diseases of a protozoal nature;
• oncological diseases with simultaneous infection;
• acne in adolescents caused by demodicosis.

In the latter case, the drug is usually combined with external agents. Metronidazole ointment is effective.

Release forms

Trichopolum can be purchased in the form of:

• tablets for oral use;
• vaginal tablets/suppositories;
• solution for infusion.

They differ from each other in excipients. Thus, ordinary tablets contain starch, gelatin, and molasses, which simplify the swallowing of the medicine and its absorption through the gastrointestinal tract.

Vaginal tablets are based on stearic acid, silicon dioxide, povidone, etc. This composition is categorically not suitable for oral administration. It is easy to distinguish between medications: products for vaginal therapy are much larger in size, which simplifies their administration.

The optimal release form is selected by the doctor according to the patient’s gender and the problem. Thus, suppositories are used exclusively by women, the solution and tablets are recommended for both sexes.

How to take Trichopolum correctly

The dosage of the drug depends on the type of disease, the age of the patient and the form of the drug. Calculations are made exclusively by the attending physician. The course may also vary. For example, in the presence of trichomonas infections, therapy requires at least 10 days, taking two tablets per day.

For bacterial vaginitis, the daily dose is one and a half grams, for those suffering from ulcerative formations - half a gram per day in two doses. And vaginal suppositories are used exclusively one per day.

For intravenous infusion, the maximum dose for an adult patient is four grams. When administered to children, the medicine is calculated as follows: 7.5 ml per 1 kg of weight.

List of contraindications and side effects

The drug is strictly prohibited for children under six years of age and women in early pregnancy or breastfeeding.

Also clear contraindications are:

• CNS lesions;
• leukopenia;
• epileptic seizures;
• liver failure;
• hypersensitivity.

If the dosage is not followed or the recommendations are ignored, side effects may occur. The main one is a gastrointestinal disorder: diarrhea, pain, nausea or vomiting, loss of appetite.

Stomatitis may occur. Also common side effects include:

• damage to the circulatory system;
• disorders of the genitourinary system;
• problems with the central nervous system;
• diseases of the musculoskeletal system;
• skin rashes.

A complete list of side effects can be found in the instructions included with the drug. If you follow the recommendations, the likelihood of negative consequences is reduced.

is a well-known drug that has been used for decades to combat various infections. The article will help you understand why Trichopolum tablets are needed, how to use them correctly and what precautions should be taken during treatment.

Trichopolum is an antibacterial and antiprotozoal medicine containing metronidazole. This is a generic version of metronidazole produced in Poland.

The drug contains a low-active compound that is metabolized in the body to form active substances that act on microorganisms, providing a wide spectrum of action. The most common and widely known reason for using Trichopolum is trichomonas, which affected the name of the medicine.

The drug is used locally and systemically: orally and in the form of infusions. The oral form is available in the form of tablets containing 250 mg of metronidazole.

The package contains 20 tablets and is protected from counterfeiting by special printing elements.

The box features invisible ink writing and black and white elements that change color from white to black when viewed from different angles.

Indications for use

Trichopolum tablets are intended to combat infections caused by bacteria and protozoa susceptible to metronidazole:

• anaerobic microbes
• leishmania
• amoebas
• Trichomonas

The drug is used in the complex therapy of gastric ulcers, the treatment of infectious diseases, trichomoniasis, giardiasis, surgical infections, infections of the oral cavity and ENT organs (chronic sinusitis, Simanovsky-Vincent angina).

Trichopol tablets are also used for step therapy after using the infusion form of metronidazole.

Dosage and rules of use

The dose and regimen of taking the medicine is determined by the doctor. The duration of treatment depends on what Trichopolum tablets are used for; a short course lasts 5-10 days. The half-life of metronidazole is 10 hours.

Rules for taking pills:

• Amoebic dysentery is treated with Trichopolum for 7 days, using 2 tablets three times. For children, 30–40 mg/kg per day is used, taken three times. With the development of a liver abscess and surgical intervention, Trichopolum therapy does not stop.
• For giardiasis, Trichopolum tablets are prescribed for 5 days. Daily dose: adults – 750–1000 mg, children are given up to 500 mg.
• Trichomoniasis is treated with Trichopolum for 10 days, prescribing 1 tablet 2 times a day. The dose can be increased to 4 Trichopolum tablets per day. All sexual partners need to be treated, even in the absence of signs of the disease or with negative test results for the presence of the causative agent of the disease. In addition to tablets, women are advised to use vaginal suppositories.
• For nonspecific colpitis, the use of Trichopolum is required, 1 tablet 2 times a day. It is taken for a week while treating the partner. It is better to supplement treatment with a dosage form for topical use.
• In the treatment of infections caused by anaerobic flora, 4-6 tablets of Trichopolum are prescribed per day in 2-3 doses, for children over 6 years old - at a daily dosage of 20-30 mg/kg.
• To eradicate Helicobacter in the treatment of gastric ulcers, Trichopolum is used in combination with proton pump inhibitors and other antibiotics.

Metronidazole is fast and complete, so the time of use of the medicine is not related to food intake. But to reduce the severity of adverse reactions, it is better to take Trichopolum tablets after meals.

Trichopolum treatment cannot be combined with alcohol consumption due to the high likelihood of developing an Antabuse-like reaction, manifested by a number of unpleasant symptoms: nausea, vomiting, facial flushing, palpitations, feeling of heat and lack of air. Similar reactions are possible when even small amounts of ethyl alcohol enter the body - for example, as part of alcohol-containing medications.

Contraindications and side effects

There are several contraindications for the use of Trichopolum tablets, which include:

1. allergic and other reactions to metronidazole or imidazole-based drugs and to other components of the drug
2. age less than 6 years
3. treatment with disulfiram (teturam)
4. recent alcohol use

In some medical reference books you can find contraindications for the first trimester of pregnancy, but in modern instructions in most countries there is no such contraindication. The instructions for the original metronidazole drug do not contain such a contraindication.

During therapy with Trichopolum, the development of allergic manifestations and adverse reactions from the skin, digestive and excretory, nervous systems and sensory organs is possible. Most reactions do not require discontinuation of the medication.

More often observed:

• a feeling of bitterness in the mouth and an unpleasant aftertaste, often described as “metallic”
• pain in the epigastric region
• nausea
• change in urine color to red-brown
• dizziness and headache
• skin redness

Allergic phenomena may occur in the form of urticaria and Quincke's edema, skin itching, frequent loose stools, vomiting, discoloration of the tongue, stomatitis, damage to peripheral nerves and convulsions, drowsiness, loss of consciousness, depressed mood. Color vision may be impaired and its acuity may decrease. Such manifestations are usually reversible and disappear after discontinuation of the drug.

Rare adverse events include blood changes, mental disorders, fever, aseptic meningitis, hepatitis with liver failure.

If any expected or unexpected adverse reactions occur, you should immediately notify your doctor about them in order to make a decision on continuing or stopping treatment and possible therapeutic correction of the patient’s condition. If fainting or confusion occurs, treatment is stopped.

More information about Trichopolum can be found in the video:

Can it be used during pregnancy and breastfeeding?

Metronidazole is able to pass through the placental barrier, and it can also be secreted into breast milk. Although animal studies have not revealed a teratogenic effect of metronidazole, further studies are not sufficient to exclude a risk to humans.

Therefore, during pregnancy, Trichopolum is prescribed only if it is impossible to achieve an effect without its use and only in situations where the expected positive result outweighs the possible risk, especially in the first trimester of pregnancy.

Trichopolum is not used during breastfeeding. Its use requires stopping feeding the child for the duration of treatment; resumption of breastfeeding is possible two days after the end of taking the drug.

Drug interactions and special instructions

Products that should not be used with Trichopolum:

• preparations containing ethyl alcohol
• disulfiram (Antabuse, Teturam)
• Busulfan

The use of Trichopolum with indirect anticoagulants due to the risk of bleeding, lithium salts, cimetidine, 5-fluorouracil, cyclosporine, and phenobarbital requires caution and constant monitoring.

Some concomitant diseases require enhanced medical and laboratory monitoring during treatment with Trichopolum: chronic disorders of the nervous system, blood diseases, renal failure using hemodialysis, liver failure.

When using Trichopolum, you should not drive vehicles or work with dangerous machinery and animals due to the possible effect on the reaction rate.

Under the influence of Trichopolum, it is possible to distort the results of laboratory biochemical studies: liver enzymes, indicators of fat metabolism and glycemia.

After treatment with metronidazole, candidiasis of the oral cavity and genital organs may develop, so prophylactic use of antifungal agents will be required.

Sometimes you need to replace a medicine because the prescribed one is unavailable or find an inexpensive equivalent. Trichopolum is a relatively inexpensive, high-quality drug made in Europe, with counterfeit-proof packaging. Therefore, it makes sense to look for a replacement if it is unavailable, because cheap generics cannot always provide the desired therapeutic effect.

The most common analogues of Trichopolum tablets are domestically produced unbranded metronidazole preparations and Indian Metrogyl. You can find an original product on sale - French Flagyl.

Trichopolum tablets are a reliable antibacterial and antiprotozoal agent, the effectiveness and safety of which has been confirmed by experience of use.

Quality and price ensured the popularity and fame of this medicine. Correct use of the drug and compliance with a number of precautions during its use can avoid unwanted reactions and improve the quality of treatment.

Trichopolum is an antimicrobial, antiprotozoal drug.

Trichopolum is used for the effective treatment of a variety of bacterial infections of various etiologies. The medicine is white flat tablets. The active ingredient of the drug is metronidazole, which has an active effect on various protozoa, aerobes and anaerobes.

Metronidazole damages bacterial DNA and restores the nitro group.

Clinical and pharmacological group

A drug with antiprotozoal and antibacterial effects for topical use in gynecology.

Terms of sale from pharmacies

Can buy according to a doctor's prescription.

Price

How much does Trichopolum cost in pharmacies? The average price is 190 rubles.

Composition and release form

Trichopolum has three release formats: oral and vaginal tablets (erroneously called suppositories) and a solution for infusion. Detailed composition of each medicine:

1. Oral tablets contain metronidazole + excipients: magnesium stearate, starch, molasses, gelatin.
2. Trichopolum vaginal tablets contain the active ingredient metronidazole + excipients: cellulose, povidone, crospovidone, silicon dioxide and stearic acid.
3. The infusion solution contains metronidazole + excipients: citric acid monohydrate, sodium chloride, sodium hydrogen phosphate and water.

Is this an antibiotic or not?

Inhibition of DNA replication leads to cell death. Trichopolum is effective against protozoa, anaerobic bacteria, a number of gram-negative and gram-positive organisms (giardia, balantidia, gardenella, trichomonas, clostridia, fusobacteria, bacteroides, peptococci, etc.).

Pharmacological effect

The action of Trichopolum is based on the biochemical reduction of the nitro group. The substance metronidazole inhibits the synthesis of nucleic acids and directly interacts with the DNA of microorganism cells. This process leads to the immediate death of negative bacteria.

The following are sensitive to the drug:

• Trichomonas;
• Giardia;
• fusobacteria;
• bacteroides;
• and amoebas.

Absorbed into the patient’s gastrointestinal tract, the drug reaches maximum concentration in the patient’s body after 1.5-3 hours. The rate of concentration of metronidazole in the blood plasma also depends on the dosage of the drug taken. The substance metronidazole does not interact with viruses, facultative anaerobes, and fungi.

The drug penetrates the placental barrier and the blood-brain barrier. The medicine enters the bile, saliva, cerebrospinal fluid and other tissues of the sick person’s body. Metronidazole is distributed fairly evenly in the body. Metabolism of the substance occurs in the liver. The half-life of the drug is 6-8 hours. It may be longer if the sick patient has any special liver pathologies.

When you take this drug, you may experience a change in the color of your urine. The drug is eliminated by the kidneys.

Indications for use

What does it treat? The oral form of the antifungal drug Trichopolum is effective for protozoal and sexually transmitted infections of the genitourinary tract:

• therapy for trichomoniasis;
• treatment of giardiasis, amoebiasis;
• stomach ulcer;
• helicobacter infection;
• cystitis (complex therapy);
• balantidiasis, leishmaniasis;
• trichomonas urethritis in men and vaginitis in women;
• bacterial infections of joints, heart;
• bacterial endocarditis, pulmonary pneumonia;
• ovarian abscess, endometritis.

Trichopolum suppositories, erroneously called vaginal suppositories, vaginal tablets, according to the instructions for use, have the following indications for which they are prescribed by doctors for the local treatment of gynecological problems:

• bacterial vaginosis;
• nonspecific vaginitis;
• trichomonas vaginitis;
• as part of complex treatment with Nystatin, the chronic form of thrush is treated.

Solution for infusion administration Trichopolum is used for the following indications:

• chronic complicated trichomoniasis;
• giardiasis;
• meningitis;
• skin infections;
• peritonitis, abscess of the abdominal cavity and liver, ovaries and fallopian tubes, lung, brain;
• endometritis;
• complications after surgery;
• pneumonia, empyema of the pleura of the lungs;
• prevention of complications during operations on the colon, removal of the appendix;
• in combination with bismuth and Amoxicillin for peptic ulcers.

Contraindications

There is a group of people who cannot use Trichopolum for treatment. Taking the medication is contraindicated in the following cases:

1. Blood diseases;
2. Severe abnormalities in the central nervous system;
3. Liver damage;
4. Children under 3 years of age;
5. Individual intolerance to the drug;
6. The first half of pregnancy, since the drug can be introduced through the placenta;
7. During lactation. Metronidazole can accumulate in the milk of a nursing woman and threaten the well-being of the baby, so only if absolutely necessary, the mother can take metronidazole, but at this point she will have to stop feeding milk.

In case of liver failure, the concentration of metronidazole in plasma increases to dangerous levels. Use metronidazole with caution in patients with kidney disease. If, during treatment with it, dizziness or problems with the gastrointestinal tract occur, therapy should be stopped.

Prescription during pregnancy and lactation

It is not recommended to use the drug during pregnancy, especially not in the first trimester. Further, the drug is used only when the potential benefit to the mother is higher than the expected risk to the fetus.

It is also impossible to feed the baby with breast milk, since the active substance is transferred along with it. It is possible to continue feeding only 2 days after the last use of the drug.

Dosage and method of administration

As indicated in the instructions for use, Trichopolum tablets are used orally, without chewing, during or after meals. The dosage of the drug depends on age and disease, namely:

• When treating trichomoniasis with tablets, the adult and child dosage (from 10 years old) is 1 tablet three times a day, or 4 tablets should be taken over the course of a week, divided into two doses. The course of treatment with medication can be repeated after a month if necessary;
• The same dosage is used in the treatment of bacterial vaginosis. In this case, a single dose of eight tablets is also possible;
• When treating amebiasis, the dosage of Trichopolum is 3 tablets three times a day for children over 10 years of age and adults. Children under 10 years of age are usually prescribed reduced dosages. Regardless of age, the duration of the treatment course is five days;
• When treating amoebic liver abscess and other forms of extraintestinal amebiasis, a halved dosage is usually prescribed, which is 1.5 tablets three times a day. The treatment course lasts five days. The same dosage is usually used in the treatment of asymptomatic cyst carriage, but the duration of treatment can be 10 days;
• Children over 10 years of age and adults take one Trichopolum tablet three times a day for the treatment of periodontal infections and acute odontogenic infections. The duration of treatment is determined by the doctor and can vary from three to seven days.

Treatment of infections caused by anaerobic bacteria usually begins with intravenous infusions of Trichopolum, which are then replaced with tablets. The dosage of the medication for children over 10 years of age and adults is 2 tablets 3-4 times a day for a course of no more than 7 days.

According to indications, Trichopolum is administered intravenously in cases of severe infections, or when it is impossible to take the medication orally. The adult dosage of Trichopolum according to the instructions for intravenous administration is 500 mg at an injection rate of 5 ml per minute, with an 8-hour administration interval. The maximum dose is no more than 4 g per day. For children under 12 years of age, the dosage of Trichopolum infusions is 7.5 mg of medication per 1 kg of body weight in 3 divided doses at an injection rate of 5 ml per minute.

According to indications, Trichopolum in the form of a solution for infusion is not recommended for use with other medications.

Adverse reactions

• from the urinary system - pain during urination, inflammation of the bladder, polyuria, predominance of nighttime diuresis over daytime, change in urine color;
• allergic reactions - skin rash, itching, urticaria, erythema, swelling of the nose, rhinorrhea, fever, dermatitis;
• muscle pain and joint pain;
• from the digestive canal - lack of appetite, the appearance of a metallic taste in the mouth, stomach pain, nausea, vomiting, intestinal colic, bloating, increased gas formation, diarrhea, increased activity of liver transminases, reactive pancreatitis;
• from the nervous system - headaches, dizziness, ataxia, confusion, neuropathy, increased excitability, impaired coordination of movements, convulsions, drowsiness, in rare cases, hallucinations;
• leukopenia, neutropenia, thrombocytopenia, agranulocytosis.

If one or more of the listed side effects occurs, treatment with Trichopolum tablets should be stopped and consult a doctor for advice.

Overdose

There is no data on overdose with vaginal tablets. Symptoms of overdose with oral tablets and Trichopolum solution include seizures, peripheral neuropathy, and neurological symptoms. When taking more than 15 g of the drug at a time, nausea and vomiting were observed, and the patient lost coordination of movements. Treatment methods for drug overdose include symptomatic therapy.

special instructions

Metronidazole may cause immobilization of treponemes, resulting in false-positive Nelson test results (TPI).

If there are indications in the anamnesis of changes in the composition of peripheral blood, as well as when using the drug in high doses and/or during long-term treatment, monitoring of a general blood test is necessary.

Interaction with other drugs

When using the drug, it is necessary to take into account interactions with other medications:

1. It is not recommended to use metronidazole in combination with non-depolarizing muscle relaxants (vecuronium bromide).
2. Under the influence of barbiturates, the effectiveness of metronidazole may decrease due to acceleration of its metabolism in the liver.
3. Cimetidine inhibits the metabolism of metronidazole, which can lead to an increase in its concentration in the blood plasma and an increased risk of adverse reactions.
4. The drug is compatible with sulfonamides and antibiotics.
5. Metronidazole causes ethanol intolerance, so alcohol should be avoided during treatment.
6. You should not combine metronidazole with disulfiram, since the interaction of these drugs may cause depression of consciousness and the development of mental disorders.
7. When used simultaneously with indirect anticoagulants (including warfarin), metronidazole enhances their effect, which leads to an increase in prothrombin time.
8. When taken simultaneously with lithium preparations, it is possible to increase its concentration in the blood plasma.