How to take the second package of Yarina. Yarina: instructions for use. Contraindications to the use of Yarina

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Ease of use. Single-phase tablets have constant doses of estrogens and gestagens throughout the entire cycle, which means they cannot be confused. The drug should be taken at the same time, but delaying it for up to 12 hours will not cause a decrease in effectiveness.

Reliability. The tablets are effective as sterilization, but their effect is easily reversible. And if conception occurred while taking Yarin tablets, the instructions do not insist on terminating the pregnancy, because this drug does not cause deviations in the development of the child.

Cosmetic effect. The tablets can be taken by women of any age who have no contraindications, but they are intended primarily for adult women of the gestagenic type who have given birth. The peculiarity of this type is a tendency to acne, oily skin and hair, depression and lower back pain before the onset of menstruation. The gestagen drospirenone contained in Yarina has an antiandrogenic effect, as a result of which acne appears much less frequently and the oiliness of the skin and hair is reduced. It also fights fluid retention in the body, due to which hidden swelling disappears and weight decreases.

Unexpressed side effect. The instructions describe Yarina's birth control pills as a low-dose drug. This means that the contraceptive effect is achieved using a minimum dose of active ingredients.

Yarina: composition of the drug.

The oral contraceptive Yarina is a monophasic combination drug, it contains two main active components in a constant dose: estrogen ethinyl estradiol 30 mcg and gestagen drospirenone at a dose of 3 mg.

In addition, in pharmacies you can find the drug "Yarina Plus". In addition to the active ingredients, it contains calcium levomefolate, an active version of folic acid (vitamin B9).

Folates enter the body with food, and the need for them increases sharply during pregnancy and lactation. It is during this period that a lack of vitamin B9 manifests itself - from increased fatigue and decreased appetite to folate deficiency anemia. "Yarina Plus" is suitable for those who have experienced such symptoms in the past, and for those who are planning a pregnancy in the foreseeable future.

Otherwise, the instructions do not describe any significant differences between the drugs “Yarina” and “Yarina Plus”. It is indicated that levomefolate can reduce the effect of some anticonvulsants (phenytoin) and cytostatics (methotrexate), which must be taken into account when prescribing the latter.

Yarina, instructions for use.

Like any contraceptives, Yarina’s drug has contraindications and restrictions for use, so they are prescribed by a gynecologist, who then must examine the woman annually to decide on the possibility of further taking this particular contraceptive.

Birth control pills begin to be taken simultaneously with the onset of menstruation, or from days 2 to 5, then the contraceptive effect is not guaranteed within a week from the start of use. After taking 21 tablets from the blister, you should take a break for a week, after which the drug is resumed.

According to the instructions, Yarina should be taken daily, at the same time. The maximum delay is 12 hours, and if counting from the last pill taken, then 36 hours.

If for some reason the time for taking it was missed, the next dose should be taken as soon as the woman remembered it, and the next one at the usual time.

If the failure occurred from days 1 to 7 of the cycle, then for a week you will have to remember about barrier methods of protection.

If the tablet was missed from days 8 to 14, and there were no violations before that, there is no risk of pregnancy, and additional protective measures are not needed.

If you missed 15-21 tablets, then you will have to skip the seven-day break and immediately move on to the next package.

Vomiting that occurs within 4 hours after the next dose is equivalent to missing a pill. It is believed that during this time the drug did not have time to be absorbed, so you must follow the instructions described above and take the missing tablet from another package.

With the help of combined contraceptives, you can skip your next menstruation. This is possible if you immediately start taking the next course of pills without interruption.

Yarina: price in pharmacies (Moscow).

In different pharmacy chains, the price of the drug Yarina can vary significantly.

For a package of 21 tablets of Yarina, the price can range from 535 to 1058 rubles, for 63 tablets (for three cycles) - from 1595 to 2858 rubles, for the drug Yarina plus the price fluctuates within the same range.

In general, the price for Yarina birth control pills is approximately the same as the prices for other monophasic combined contraceptives with an antiandrogenic effect (Zhannin, Diane 35).

Film-coated tablets in blister packs, two types:

Active tablets are orange, round, biconvex, on one side with “Y+” embossed in a regular hexagon (21 pieces in a blister). Active ingredient: 1 tablet contains ethinyl estradiol (micronized, in the form of betadex clathrate) - 30 mcg, drospirenone (micronized) - 3 mg, calcium levomefolate (micronized) - 451 mcg. Excipients: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, hyprolose, magnesium stearate.
Auxiliary (vitamin) tablets are light orange in color, round, biconvex, on one side with “M+” embossed in a regular hexagon (7 pieces in a blister). Active ingredient: 1 tablet contains calcium levomefolate (micronized) - 451 mg. Excipients: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, hyprolose, magnesium stearate.

Pharmacological action

Yarina Plus is a low-dose monophasic oral combined estrogen-progestogen contraceptive drug, including active tablets and auxiliary vitamin tablets containing calcium levomefolate. The contraceptive effect of Yarina Plus is mainly achieved by suppressing ovulation and increasing the viscosity of cervical mucus.

In women taking combined oral contraceptives (COCs), the cycle becomes more regular, the pain, intensity and duration of menstrual bleeding decrease, resulting in a reduced risk of iron deficiency anemia. There is also evidence of a reduced risk of endometrial and ovarian cancer.

Drospirenone, contained in Yarina Plus, has an antimineralocorticoid effect and helps prevent hormone-dependent fluid retention, which can manifest itself in weight loss and a reduction in the likelihood of peripheral edema. Drospirenone also has antiandrogenic activity and helps reduce acne (blackheads), oily skin and hair. This effect of drospirenone is similar to the effect of natural progesterone produced in the female body. This should be taken into account when choosing a contraceptive, especially for women with hormone-dependent fluid retention, as well as women with acne and seborrhea. When used correctly, the Pearl index (an indicator reflecting the number of pregnancies in 100 women using a contraceptive during the year) is less than 1. If pills are missed or used incorrectly, the Pearl index may increase.

The acid form of calcium levomefolate is structurally identical to naturally occurring L-5-methyltetrahydrofolate (L-5-methyl-THF), the main folate form found in food. The average concentration in the blood plasma of people who do not consume foods fortified with folic acid is about 15 nmol/l. Levomefolate, unlike folic acid, is a biologically active form of folate. Thanks to this, it is absorbed better than folic acid. Levomefolate is indicated to meet the increased need and ensure the necessary folate content in a woman’s body during pregnancy and lactation. The addition of levomefolate calcium to an oral contraceptive reduces the risk of developing a neural tube defect if a woman becomes unexpectedly pregnant immediately after stopping contraception (or, in very rare cases, when using oral contraception).

Indications for use

contraception (primarily for women with symptoms of hormone-dependent fluid retention in the body);
contraception and treatment of moderate acne (acne vulgaris);
contraception in women with folate deficiency.

Directions for use and doses

Take the tablets at approximately the same time every day, with water if necessary. Follow the direction of the arrows until you have taken all 28 tablets. As a rule, menstruation begins 2-3 days after taking the last active tablet of Yarina Plus (i.e. during the period when you take the last 7 tablets from the last row of the package). Do not take a break between packs, i.e. Start taking pills from a new pack the day after you finish your current pack, even if you have not yet finished your menstrual-like bleeding (withdrawal bleeding). This means that you will always start a new pack on the same day of the week, and that the withdrawal bleed will occur around the same dates each month.

Start taking the drug

When no hormonal contraceptive was used in the previous month
Start taking Yarin Plus on the first day of the cycle, that is, on the first day of menstrual bleeding. Take the pill that is marked with the appropriate day of the week. Then take the tablets in order. Yarina Plus begins to act immediately, so there is no need to use additional barrier methods of contraception. Consult your doctor if you are not sure when exactly to start taking the drug.
When switching from other combined oral contraceptives
You can start taking Yarin Plus the next day after you take the last pill from the current package of hormonal contraceptives (this means that there will be no break in taking the pills). If your previous contraceptive also contains tablets without active substances, you can start taking Yarin Plus the day after taking the last active tablet (if you have doubts, ask your doctor about this). You can start taking it later, but no later than the day that follows the planned 7-day break in taking the contraceptives you are currently using (or no later than the next day after taking the last inactive pill from the package of the contraceptives you are using).
When switching from a vaginal ring or contraceptive patch
If you have previously used a vaginal ring or transdermal patch, it is preferable to start taking it on the day the ring/patch was removed, but no later than the day on which the ring/patch was scheduled to be replaced. If you follow these rules, additional contraception is not necessary.
When switching from oral contraceptives containing only gestagen (mini-pills)
You can stop taking the mini-pill on any day and start taking Yarin Plus the next day at the same time. During the first 7 days of taking the pills, you must also use an additional barrier method of contraception (for example, a condom).
When switching from an injectable contraceptive, an implant, or from a progestogen-releasing intrauterine contraceptive (Mirena)
Start taking Yarin Plus on the day when the next injection is due or on the day the implant or intrauterine contraceptive is removed. During the first 7 days of taking the pills, you must also use an additional barrier method of contraception.
After childbirth
If you have just given birth, your doctor may recommend that you wait until the end of your first normal menstrual cycle before starting to take Yarina Plus. Sometimes, on the recommendation of a doctor, it is possible to start taking the drug earlier.
After spontaneous miscarriage or abortion in the first trimester of pregnancy
Consult your doctor. It is usually recommended to start taking it immediately.

Stop taking Yarina Plus

You can stop taking Yarina Plus at any time. If you are not planning a pregnancy, ask your doctor about other methods of contraception. If you want to become pregnant, stop taking Yarina Plus and wait until your menstrual bleeding occurs naturally before trying to become pregnant. This will help you calculate your baby's expected due date.

Taking missed pills

If the delay in taking the next pill is less than 12 hours, the contraceptive effect of Yarina Plus is maintained. Take the pill as soon as you remember. Take the next tablet at your usual time. If the delay in taking the pills is more than 12 hours, contraceptive protection may be reduced. The more pills in a row are missed, and the closer this missed dose is to the start or end of the dose, the higher the risk of pregnancy. In this case, you can be guided by the following rules:

More than one tablet from the package was forgotten
Consult your doctor.

One tablet missed in the first week of taking the drug
Take the missed tablet as soon as you remember (even if this means taking two tablets at the same time). Take the next tablet at your usual time. Additionally, use a barrier method of contraception for the next 7 days. If sexual intercourse took place within a week before missing the pill, the possibility of pregnancy must be taken into account. Consult your doctor immediately (see also Regimen for taking missed pills).

One tablet was missed in the second week of taking the drug
Take the missed tablet as soon as you remember (even if this means taking two tablets at the same time). Take the next tablet at your usual time. If you have taken your pills correctly during the 7 days preceding the first missed pill, the contraceptive effect of Yarina Plus is maintained and you do not need to use additional contraceptive measures. Otherwise, as well as if you miss two or more tablets, you must additionally use barrier methods of contraception for 7 days.

One tablet was missed in the third week of taking the drug
If all tablets have been taken correctly in the 7 days preceding the first missed pill, there is no need to use additional contraceptive methods. You can follow either of the following two options without the need for additional contraceptive measures.

Take the missed tablet as soon as you remember (even if this means taking two tablets at the same time). Take the next tablet at your usual time. Start the next pack immediately after finishing the current pack, so there is no break between packs. Withdrawal bleeding is unlikely until the second pack of tablets is gone, but spotting or breakthrough bleeding may occur on the days you take the drug.
Stop taking the pills in your current pack, take a break of 7 days or less (including the day you missed the pills), and then start a new pack. Using this regimen, you can always start taking the next pack on the day of the week when you usually do it. If after a break in taking the pills there is no expected menstrual bleeding, you may be pregnant. Consult your doctor before starting a new pack.

In severe gastrointestinal disorders, absorption may be incomplete, so additional contraceptive measures should be taken. If vomiting or diarrhea occurs within 4 hours after taking an active tablet, the recommendations regarding missed tablets apply, which are listed in the section “Taking missed tablets.” If you do not want to change your usual dosing regimen, you will need to take additional tablet(s) from a different package.

Delay in the onset of menstrual bleeding

You can delay the onset of menstrual bleeding if you start taking the next package of Yarina Plus immediately after finishing the current package. You can continue taking the tablets from this pack for as long as you wish or until the pack runs out. If you want menstrual-like bleeding to begin, stop taking the pills. While taking Yarina from the second package, spotting or bleeding may occur on the days of taking the pills. Start the next pack after the usual 7-day break.

Changing the day of the onset of menstrual bleeding

If you take the tablets as recommended, you will have menstrual bleeding on about the same day every 4 weeks. If you want to change it, shorten (but do not lengthen) the period of time you are free from taking pills. For example, if your cycle usually starts on Friday, but in the future you want it to start on Tuesday (3 days earlier), the next pack should start 3 days earlier than usual. If your pill-free break is very short (for example, 3 days or less), menstrual-like bleeding may not occur during the break. In this case, bleeding or spotting may occur while taking the tablets from the next package.

Side effect

When taking the drug Yarina Plus, like any other medicines, adverse reactions may occur, although their occurrence is not necessary in all patients. See sections "With caution" and "Special instructions". Please read these sections carefully and if you experience any adverse reactions, including serious ones, consult your doctor.

Below is the frequency of adverse reactions reported during clinical trials of Yarina. These adverse reactions can also be attributed to the drug Yarina Plus.

Frequent adverse reactions (more than 1/100 and less than 1/10):

depressed mood
headache
migraine
nausea
pain in the mammary glands
vaginal candidiasis
cycle disorder
acyclic bleeding

Uncommon adverse reactions (more than 1/1000 and less than 1/100):

change in body weight
fluid retention
libido change
increased blood pressure (BP)
decrease in blood pressure
vomit
eczema
vaginitis

Rare adverse reactions (more than 1/10000 and less than 1/1000):

hypoacusis
thromboembolism
bronchial asthma
discharge from the mammary glands

Adverse reactions that were reported during use of Yarina Plus, but the frequency of which could not be assessed: hypersensitivity reaction, mood swings, contact lens intolerance, abdominal pain, diarrhea, rash, urticaria, erythema nodosum, erythema multiforme, breast enlargement iron

In women with hereditary forms of angioedema, exogenous estrogens may cause or worsen symptoms of angioedema. If any of the side effects become serious or if you notice any side effects not listed in the instructions, please tell your doctor.

Contraindications for use

Yarina Plus is contraindicated in the presence of any of the conditions/diseases listed below. If any of these conditions/diseases develop for the first time while taking the drug, the drug should be discontinued immediately.

Thrombosis (venous and arterial) and thromboembolism currently or in history (including deep vein thrombosis, pulmonary embolism, myocardial infarction, stroke), cerebrovascular disorders.
Conditions preceding thrombosis (including transient ischemic attacks, angina) currently or in history.
The presence of multiple or severe risk factors for venous or arterial thrombosis.
Migraine with focal neurological symptoms currently or in history.
Diabetes mellitus with vascular complications.
Liver failure and severe liver diseases (until liver tests normalize).
Severe and/or acute renal failure.
Liver tumors (benign or malignant) currently or in history.
Detected hormone-dependent malignant neoplasms (including genitals or mammary glands) or suspicion of them.
Bleeding from the vagina of unknown origin.
Pregnancy or suspicion of it.
Breastfeeding period.
Hypersensitivity or intolerance to any of the components of the drug Yarina Plus.
Yarina Plus contains lactose and is therefore contraindicated in patients with rare hereditary lactose intolerance, lactase deficiency or glucose-galactose malabsorption.

Carefully

The potential risk and expected benefit of using the drug Yarina Plus should be assessed in each individual case in the presence of the following diseases/conditions and risk factors:

Risk factors for the development of thrombosis and thromboembolism: smoking, obesity, dyslipoproteinemia, controlled arterial hypertension, migraine without focal neurological symptoms, uncomplicated valvular heart disease, hereditary predisposition to thrombosis (thrombosis, myocardial infarction or cerebrovascular accident at a young age in someone close to relatives);
Other diseases in which peripheral circulatory disorders may occur: diabetes mellitus without vascular complications, systemic lupus erythematosus, hemolytic-uremic syndrome, Crohn's disease and ulcerative colitis, sickle cell anemia, phlebitis of the superficial veins;
Hereditary angioedema;
Hypertriglyceridemia;
Liver diseases that are not contraindications (see “Contraindications”);
Diseases that first appeared or worsened during pregnancy or against the background of previous use of sex hormones (for example, jaundice and/or itching associated with cholestasis, cholelithiasis, otosclerosis with hearing impairment, porphyria, pregnancy herpes, Sydenham's chorea);
Postpartum period.

Use of the drug Yarina during pregnancy and breastfeeding

The drug is contraindicated during pregnancy. If pregnancy is detected while taking Yarina Plus, the drug should be discontinued immediately. Data on the results of taking the drug Yarina Plus during pregnancy are limited and do not allow us to draw any conclusions about the negative impact of the drug on pregnancy, the health of the fetus and newborn child. At the same time, extensive epidemiological studies have not revealed an increased risk of developmental defects in children born to women who took COCs before pregnancy or teratogenic effects in cases of inadvertent use of COCs in early pregnancy. Specific epidemiological studies have not been conducted on the drug Yarina Plus.

The drug is contraindicated during breastfeeding. Taking COCs can reduce the amount of breast milk and change its composition, so their use is not recommended until breastfeeding is stopped. Small amounts of sex hormones and/or their metabolites may be excreted in milk, but there is no evidence of their negative effects on the health of the child.

Use for liver and kidney dysfunctions

The use of the drug is contraindicated in the presence or history of severe forms of liver disease (until the liver test results are normalized), the current presence or history of benign or malignant liver tumors;
The drug is contraindicated for use in women with severe renal impairment and acute renal failure.

special instructions

If any of the conditions, diseases and risk factors listed below currently exist, the potential risks and expected benefits of using Yarina Plus should be carefully weighed in each individual case and discussed with the woman before she decides to start taking this drug. drug.

For disorders of the cardiovascular system

There is epidemiological evidence of an increased incidence of venous and arterial thrombosis and thromboembolism (such as deep vein thrombosis, pulmonary embolism, myocardial infarction, stroke) when taking COCs. These diseases are rarely observed. The risk of developing venous thromboembolism (VTE) is greatest in the first year of taking such drugs. An increased risk is present after initial use of combined oral contraceptives or resumption of use of the same or different combined oral contraceptives (after a dosing interval of 4 weeks or more). Data from a large prospective study involving 3 groups of patients suggest that this increased risk is predominantly present during the first 3 months.

Overall risk of VTE in patients taking low-dose combined oral contraceptives (Data from a large prospective study of 3 patient groups shows that in women with or without risk factors for VTE using ethinyl estradiol/drospirenone containing contraceptives at a dosage of 0.03 mg/3 mg, respectively , the incidence of VTE is the same as with the use of levonorgestrel-containing oral contraceptives.VTE can be fatal (in 1-2% of cases).

VTE, manifested as deep vein thrombosis or pulmonary embolism, can occur with the use of any combined oral contraceptives.

It is extremely rare that when using combined oral contraceptives, thrombosis of other blood vessels occurs, for example, hepatic, mesenteric, renal, cerebral veins and arteries or retinal vessels. There is no consensus regarding the relationship between the occurrence of these events and the use of combined oral contraceptives.

Symptoms of deep vein thrombosis (DVT) include the following: unilateral swelling of the lower extremity or along a vein in the leg, pain or discomfort in the leg only when standing up or when walking, localized warmth in the affected leg, redness or discoloration of the skin on the leg.

Symptoms of pulmonary embolism (PE) include: difficulty or rapid breathing; sudden cough, including with hemoptysis; sharp pain in the chest, which may intensify with deep inspiration; sense of anxiety; severe dizziness; fast or irregular heartbeat. Some of these symptoms (eg, shortness of breath, cough) are nonspecific and may be misinterpreted as signs of other more or less severe events (eg, respiratory tract infection).

Arterial thromboembolism can lead to stroke, vascular occlusion, or myocardial infarction. Symptoms of a stroke include: sudden weakness or loss of feeling in the face, arm or leg, especially on one side of the body, sudden confusion, problems with speech and comprehension; sudden unilateral or bilateral vision loss; sudden disturbance in gait, dizziness, loss of balance or coordination; sudden, severe or prolonged headache for no apparent reason; loss of consciousness or fainting with or without an epileptic seizure. Other signs of vascular occlusion: sudden pain, swelling and slight blue discoloration of the extremities, acute abdomen.

Symptoms of myocardial infarction include: pain, discomfort, pressure, heaviness, a feeling of squeezing or fullness in the chest, arm, or chest; discomfort radiating to the back, cheekbone, larynx, arm, stomach; cold sweat, nausea, vomiting or dizziness, severe weakness, anxiety or shortness of breath; fast or irregular heartbeat.

Arterial thromboembolism can be fatal.

The risk of developing thrombosis (venous and/or arterial) and thromboembolism increases in the presence of:

obesity (body mass index more than 30 kg/m2);
family history (for example, venous or arterial thromboembolism ever in close relatives or parents at a relatively young age). In the case of a hereditary or acquired predisposition, the woman should be examined by an appropriate specialist to decide on the possibility of taking the drug Yarina Plus;
prolonged immobilization, major surgery, any leg surgery or major trauma. In these situations, it is advisable to stop using the drug Yarina Plus (in the case of a planned operation, at least four weeks before it) and not resume taking it for two weeks after the end of immobilization;
dyslipoproteinemia;
arterial hypertension;
migraine;
heart valve diseases;
atrial fibrillation;
with age;
in smokers (with increasing number of cigarettes or increasing age, the risk increases, especially in women over 35 years of age);

The possible role of varicose veins and superficial thrombophlebitis in the development of venous thromboembolism remains controversial.

The increased risk of thromboembolism in the postpartum period should be taken into account.

Peripheral circulatory disorders may also occur in diabetes mellitus, systemic lupus erythematosus, hemolytic uremic syndrome, chronic inflammatory bowel disease (Crohn's disease or ulcerative colitis) and sickle cell anemia.

An increase in the frequency and severity of migraines during use of Yarina Plus (which may precede cerebrovascular events) may be grounds for immediate discontinuation of this drug.

Biochemical indicators indicating a hereditary or acquired predisposition to venous or arterial thrombosis include the following: resistance to activated protein C, hyperhomocysteinemia, antithrombin-III deficiency, protein C deficiency, protein S deficiency, antiphospholipid antibodies (anticardiolipin antibodies, lupus anticoagulant).

When assessing the risk-benefit ratio, it should be taken into account that adequate treatment of the relevant condition may reduce the associated risk of thrombosis. It should also be taken into account that the risk of thrombosis and thromboembolism during pregnancy is higher than when taking low-dose oral contraceptives ( Tumors

The most significant risk factor for developing cervical cancer is persistent human papillomavirus infection. There are reports of a slight increase in the risk of developing cervical cancer with long-term use of COCs. However, the connection with taking COCs has not been proven. The possibility of the relationship of these data with screening for cervical diseases and with characteristics of sexual behavior (less frequent use of barrier methods of contraception) is discussed. A meta-analysis of 54 epidemiological studies showed that there is a slightly increased relative risk of developing breast cancer diagnosed in women currently taking COCs (relative risk 1.24).

The increased risk gradually disappears within 10 years of stopping these drugs. Because breast cancer is rare in women under 40 years of age, the increase in breast cancer diagnoses in current or recent COC users is small relative to the overall risk of breast cancer. Its connection with COC use has not been proven. The observed increased risk may be a consequence of careful monitoring and earlier diagnosis of breast cancer in women using COCs. Women who have ever used COCs are diagnosed with earlier stages of breast cancer than women who have never used them.

In rare cases, during the use of COCs, the development of benign, and in extremely rare cases, malignant liver tumors was observed, which in some patients led to life-threatening intra-abdominal bleeding. If severe abdominal pain, liver enlargement, or signs of intra-abdominal bleeding occur, this should be taken into account when making a differential diagnosis

Other states

Clinical studies have shown no effect of drospirenone on plasma potassium concentrations in patients with mild to moderate renal failure. However, in patients with impaired renal function and an initial potassium concentration at the upper limit of normal, the risk of developing hyperkalemia cannot be excluded while taking medications that lead to potassium retention in the body.

Women with hypertriglyceridemia (or a family history of this condition) may have an increased risk of developing pancreatitis while taking COCs. Although slight increases in blood pressure have been described in many women taking COCs, clinically significant increases have rarely been observed. However, if a persistent, clinically significant increase in blood pressure develops while taking Yarina Plus, this drug should be discontinued and treatment of arterial hypertension should be started. The drug can be continued if normal blood pressure values are achieved with the help of antihypertensive therapy.

The following conditions have been reported to develop or worsen both during pregnancy and while taking COCs, but their relationship with COC use has not been proven: jaundice and/or pruritus associated with cholestasis; formation of gallstones; porphyria; systemic lupus erythematosus; hemolytic-uremic syndrome; chorea; herpes during pregnancy; hearing loss associated with otosclerosis. Cases of Crohn's disease and ulcerative colitis have also been described with the use of COCs.

In women with hereditary forms of angioedema, exogenous estrogens may cause or worsen symptoms of angioedema.

Acute or chronic liver dysfunction may require discontinuation of Yarina Plus until liver function tests return to normal. Recurrent cholestatic jaundice, which develops for the first time during pregnancy or previous use of sex hormones, requires discontinuation of the drug Yarina Plus.

Although COCs may have an effect on insulin resistance and glucose tolerance, there is no need to change the therapeutic regimen in diabetic patients using Yarina Plus. However, women with diabetes should be closely monitored while taking this drug.

Chloasma can sometimes develop, especially in women with a history of chloasma during pregnancy. Women with a tendency to chloasma while taking Yarina Plus should avoid prolonged exposure to the sun and exposure to ultraviolet radiation.

Folates may mask vitamin B12 deficiency.

Laboratory tests

Taking Yarina Plus may affect the results of some laboratory tests, including indicators of liver, kidney, thyroid, adrenal function, the concentration of transport proteins in plasma, indicators of carbohydrate metabolism, parameters of blood coagulation and fibrinolysis. Changes usually do not go beyond normal values. Drospirenone increases plasma renin activity and aldosterone concentrations, which is associated with its antimineralocorticoid effect.

There is a theoretical possibility of increasing the concentration of potassium in the blood plasma in women receiving Yarina Plus simultaneously with other drugs that can increase the content of potassium in the blood plasma. These drugs include angiotensin II receptor antagonists, potassium-sparing diuretics, and aldosterone antagonists. However, in studies evaluating the interaction of drospirenone with angiotensin-converting enzyme (ACE) inhibitors or indomethacin, there was no significant difference in plasma potassium concentrations compared with placebo.

Reduced efficiency

The effectiveness of Yarina Plus may be reduced in the following cases: if tablets are missed, with vomiting and diarrhea, or as a result of drug interactions.

Frequency and severity of menstrual-like bleeding

While taking the drug Yarina Plus, during the first few months, irregular (acyclic) bleeding from the vagina (spotting or “breakthrough” uterine bleeding) may be observed. Use hygiene products and continue taking your pills as usual. Irregular bleeding usually stops as your body adapts to the drug (usually after 3 cycles of taking the tablets). If they continue, increase in intensity, or return after stopping, consult a doctor.

No regular menstrual bleeding

If you took all the pills correctly and did not vomit while taking the pills or taking other medications at the same time, then the likelihood of pregnancy is low. Continue taking Yarina Plus as usual. If there are no 2 menstrual bleeding in a row, consult a doctor immediately. Do not start taking the next package until your doctor rules out pregnancy.

When to consult a doctor

Regular checkups

If you are taking Yarina Plus, your doctor will tell you about the need for regular examinations, at least once every 6 months.

Consult your doctor as soon as possible

If there are any changes in your health, especially any of the conditions listed in these instructions (see also “Contraindications” and “Use with caution”);
With local compaction in the mammary gland;
If you are going to use other medications (see also “Interactions with other medications”);
If prolonged immobility is expected (for example, the leg is in a cast), hospitalization or surgery is planned (consult with your doctor at least 3-4 weeks before the proposed surgery);
If you experience unusually heavy bleeding from the vagina;
If you forgot to take a pill in the first week of taking the pack and had sexual intercourse seven days or less before;
You have not had regular menstrual bleeding twice in a row or you suspect that you are pregnant (do not start taking the next package until you have consulted your doctor).

Stop taking the tablets and consult your doctor immediately if you notice possible signs of thrombosis, myocardial infarction or stroke: unusual cough; unusually severe pain behind the sternum, radiating to the left arm; unexpected shortness of breath, unusual, severe and prolonged headache or migraine attack; partial or complete loss of vision or double vision; slurred speech; sudden changes in hearing, smell, or taste; dizziness or fainting; weakness or loss of sensation in any part of the body; severe abdominal pain; severe leg pain or sudden swelling of either leg.

Yarina Plus does not protect against HIV infection (AIDS) or any other sexually transmitted disease.

Impact on the ability to drive vehicles and machinery

There have been no reported cases of adverse effects of the drug Yarina Plus on the speed of psychomotor reactions; No studies have been conducted to study the effect of the drug on the speed of psychomotor reactions.

Overdose

There have been no reported cases of overdose of Yarina Plus. Symptoms that may occur in case of overdose: nausea, vomiting, spotting vaginal discharge or metrorrhagia (more often in young women). There is no specific antidote; symptomatic treatment should be carried out.

Calcium levomefolate and its metabolites are identical to folates found in food products, the daily consumption of which does not harm the body. Taking levomefolate calcium at a dose of 17 mg/day (a dose 37 times higher than that contained in 1 tablet of Yarina Plus) for 12 weeks was well tolerated.

Drug interactions

Interaction of oral contraceptives with other drugs may lead to breakthrough uterine bleeding and/or decreased contraceptive reliability.

Interactions leading to a decrease in the effectiveness of the drug Yarina Plus

Effect on hepatic metabolism: the use of drugs that induce liver microsomal enzymes can lead to an increase in the clearance of sex hormones. Such drugs include: phenytoin, barbiturates, primidone, carbamazepine, rifampicin, possibly also oxcarbazepine, topiramate, felbamate, griseofulvin and preparations containing St. John's wort. HIV protease inhibitors (eg, ritonavir) and non-nucleoside reverse transcriptase inhibitors (eg, nevirapine) and combinations thereof also have the potential to affect hepatic metabolism.

Effect on enterohepatic recirculation: According to individual studies, some antibiotics (for example, penicillins and tetracyclines) may reduce the enterohepatic recirculation of estrogens, thereby reducing the concentration of ethinyl estradiol.

While taking medications that affect liver microsomal enzymes, and for 28 days after their discontinuation, a barrier method of contraception should be additionally used.

While taking antibiotics (except for rifampicin and griseofulvin) and for 7 days after their discontinuation, a barrier method of contraception should be additionally used. If the period of use of the barrier method of contraception ends later than the hormone-containing orange tablets in the package, you should skip taking the remaining auxiliary light orange tablets and start taking Yarina Plus from a new package without interruption in taking the tablets.

Interactions that reduce the effectiveness of calcium levomefolate

Effect on folate metabolism: Some drugs reduce blood folate concentrations or reduce the effectiveness of levomefolate calcium by inhibiting the enzyme dihydrofolate reductase (eg, methotrexate, trimethoprim, sulfasalazine, and triamterene) or by reducing folate absorption (eg, cholestyramine) or through unknown mechanisms ( for example, antiepileptic drugs: carbamazepine, phenytoin, phenobarbital, primidone and valproic acid).

Effect on metabolism of COCs (enzyme inhibitors)

The main metabolites of drospirenone are formed in plasma without the participation of the cytochrome P450 system. Therefore, the effect of inhibitors of the cytochrome P450 system on the metabolism of drospirenone is unlikely.

Effect of COCs or calcium levomefolate on the activity of other drugs

COCs may affect the metabolism of other drugs, leading to an increase (for example, cyclosporine) or a decrease (for example, lamotrigine) in their plasma and tissue concentrations.

Based on interaction studies, as well as studies in female volunteers taking omeprazole, simvastatin and midazolam as test substrates, it can be concluded that the effect of drospirenone 3 mg on the metabolism of other drugs is unlikely.

Folates may alter the pharmacokinetics or pharmacodynamics of some drugs that affect folate metabolism, such as antiepileptic drugs (phenytoin), methotrexate or pyrimethamine, which may be accompanied by a decrease (mostly reversible, provided the dose of the drug affecting folate metabolism is increased) of their therapeutic effect. The administration of folate during treatment with such drugs is recommended mainly to reduce the toxicity of the latter.

The drug Yarina, produced by the German company Bayer, is a hormonal contraceptive intended for women. It effectively prevents pregnancy. However, to achieve the desired result with minimal side effects, the product should be taken strictly following the instructions.

Main characteristics

The contraceptive is available in the form of light yellow tablets, each of which has a special film coating and an engraved image in the form of a hexagon with the letters “DO” in the center.

The drug is supplied to pharmacies in special cardboard packages containing 1 or 3 blisters. Each such plate contains 21 tablets (this is how many days you need to take the product before taking a break).

Compound

The active ingredients of the drug Yarina are:

drospirenone (3 mg);
ethinyl estradiol (30 mcg).

But there are also additional components:

macrogol 6000;
pregelatinized starch;
titanium dioxide;
magnesium stearate;
lactose monohydrate;
hypromellose;
povidone K25;
iron oxide;
corn starch.

This contraceptive is low-dose, containing a small amount of hormones, and monophasic (the medicine has the same composition).

Admission rules

Yarina begins to act from the first tablet, which can be taken on the day of the start of menstruation or a day after stopping the use of other contraceptives. The full course is designed for three calendar weeks, during which you should drink the dose prescribed by your doctor at the same time. After this, the woman needs a break of 7 days.. During a week-long rest, the body independently provokes the onset of menstruation. After the break is completed, you can begin the next course of taking the drug.

Since the tablets begin to act in full force only on the seventh day, during the initial period of using Yarina it is recommended to use barrier means of protection against unwanted pregnancy.

Action

The contraceptive has a suppressive effect on the ovulation process and stimulates abundant secretion of cervical fluid, which prevents sperm from penetrating into the uterine cavity. In addition, the menstrual cycle is regulated: bleeding becomes less profuse and painful.

Features of drug interactions

If Yarina is taken together with drugs that activate the production of liver microsomal enzymes, this can lead to intensive removal of sex hormones from the body.

As a result, the woman experiences breakthrough bleeding and oral contraception becomes less effective. Therefore, it is necessary to resort to barrier-type contraceptives. The same should be done when using Tetracycline or Penicillin.

Side effects

Women taking Yarina may experience the following side effects:

thromboembolism;
scanty brown vaginal discharge;
attacks of nausea and vomiting;
abdominal pain, diarrhea;
mood swings;
migraine;
thrombosis;
increase or decrease in libido levels;
rash, urticaria;
weight gain;
swelling;
discharge from the mammary glands (in some cases, the girl’s breasts hurt and become enlarged);
allergy.

There are other unpleasant manifestations from the drug Yarina, for example, thrush. It occurs quite often, as with other contraceptives. Usually the development of candidiasis is a consequence of a period of addiction, so over time it disappears on its own.

The presence of bloody discharge when taking Yarina in some cases indicates serious pathologies. If, after starting to use the product, your period does not end for a long time, it is recommended to check your blood clotting system.

Use in old age

Yarina’s instructions state that during menopause, birth control pills should not be used, since after menopause a woman can no longer become pregnant.

However, in some cases, menopause lasts several years, and the work of the reproductive system still continues (even the restoration of the menstrual cycle is observed after a long pause). In such cases, the need and methods of contraception should be discussed with your doctor.

Yarina Plus

The drug Yarina has a variation called Yarina Plus, which differs in active and auxiliary tablets. Both types of drugs are interchangeable. At the same time, this remedy is able to compensate for the lack of folates, which contributes to the rapid normalization of hormonal levels in case of discontinuation of the contraceptive.

Price

Yarin tablets are provided only with a prescription written by a doctor. Ordering from online pharmacies is also carried out based on the relevant recommendations of the gynecologist.

The exact cost of the ordered drug will directly depend on the size of the trade markup and the region in which the purchase is made. However, approximate values can be determined.

Rules for stopping pills

If you need to stop taking the drug right in the middle of the cycle, it is recommended to take a week-long break, after which you can simply stop taking the drug.

In cases where, after a single use of a contraceptive, nausea, apathy or other side symptoms occur, it is necessary to clarify what exactly caused the poor health. This may not be the result of the pill, but may be due to other factors.

In addition, it is necessary to take into account the specific action of hormonal substances, which significantly restructure the functioning of the entire body. The period of adaptation to contraceptives can last up to several months, after which all unpleasant manifestations disappear.

If side effects are too pronounced and incompatible with further use of the drug, the course should be discontinued. To avoid withdrawal syndrome, you need to use another contraceptive instead of Yarina.

The best option to discontinue the drug, in case of long-term use, is to gradually reduce the dosage (the woman starts taking ½, ¼ tablets, etc.).

Reason for missed period after cancellation

Provided that the rules for taking Yarina were fully followed (without skipping or re-using tablets in case of diarrhea or vomiting), then the likelihood of conception and the associated delay in menstruation immediately after stopping the drug is almost zero. Although this possibility should not be completely ignored.

Much more often, women do not have periods after discontinuing Yarina due to changes in the body’s functioning associated with the loss of an external source of hormones. Then you just need to wait until the state of the reproductive system normalizes.

If menstruation does not appear for two full cycles, you should definitely contact a gynecologist. Until the results of the examination are received, contraceptive use is not resumed.

Effect on ovulation

Yarina is indicated for women who have no gynecological problems and whose menstrual cycle is regular. This drug, like other drugs of similar action, causes the body to work as if ovulation has already occurred.

At the same time, certain components of the tablets interfere with the maturation of the egg. As a result, its separation does not occur, and conception becomes impossible. In addition, when using Yarina, painful menstruation disappears, the volume of blood released decreases, which reduces the likelihood of developing iron deficiency anemia and other complications.

In women who have not previously used the drug, slight or spotting bleeding may also be detected during the intermenstrual period. Ovulation after stopping taking Yarina often occurs almost immediately, although there are exceptions when the process of egg maturation requires additional stimulation.

Yarina's birth control pills have a special composition, which arouses increased interest in them among gynecologists and their patients. This is a modern, high-quality hormonal contraceptive that does not have many of the side effects of other combined oral contraceptives (COCs). It is produced in Germany by the large company Bayer Pharma.

Effect of the drug

Yarin contains two components for hormonal contraception - ethinyl estradiol (estrogenic) and drospirenone (gestagenic) in low dosages (30 mcg and 3 mg, respectively). The medicine is a monophasic contraceptive, that is, in all tablets of the package the ratio of these active ingredients does not change.

While taking it, the likelihood of pregnancy is the same as when using other low-dose COCs. The number of unplanned pregnancies during a year among 100 women does not exceed 1. If the patient follows all the rules for using the drug, the probability of conception approaches 1:500.

Yarina hormonal tablets prevent pregnancy by a combination of the following effects:

suppression;
increased viscosity of the mucus of the cervical canal, which makes it difficult for sperm to enter the uterus;
inhibition of cyclic processes occurring during the cycle in the endometrium; in this case, conditions are created that are unfavorable for the implantation of the egg, even if fertilization has occurred.

Thus, the drug affects many processes necessary for conception, so it effectively prevents pregnancy.

Additional medicinal effects:

restoration of regular menstruation;
decrease ;
reducing the amount of blood lost during menstrual or intermenstrual bleeding;
prevention of iron deficiency anemia in women;
reducing the risk of ovarian and uterine cancer.

Features and indications

There is nothing unusual about Yarina’s estrogenic component, ethinyl estradiol. It is necessary to regulate the functioning of the ovaries. Its presence in the drug causes some typical side effects of COCs, for example, a tendency to vein thrombosis.

The peculiarity of the product is its gestagen component. Drospirenone, unlike levonorgestrel and other similar substances, has additional activity:

has an effect similar to the drug spironolactone; that is, it is a weak diuretic that preserves potassium in the body, but at the same time prevents the appearance of edema and other signs;
does not cause weight gain with long-term use;
has an antiandrogenic effect: prevents or treats acne, excess oily skin and hair, hirsutism (appearance of facial hair).

These features determine the group of patients for whom Yarina is most suitable. They have the following symptoms:

swelling, irritability, migraine and other signs of premenstrual syndrome;
phenomena of hirsutism - acne, excess oiliness of hair and skin, the appearance of unwanted hairs on the face, seborrhea.

Indications for taking Yarina are a necessity. It can be prescribed even to young girls who have started their menstrual cycle, without changing the dose or regimen. After menopause, when there are no cycles, there is no need to use Yarina.

How to drink Yarina?

To simulate the natural menstrual cycle, the drug is taken 21 days in a row, 1 tablet. It is advisable to do this at the same time of day, regardless of meals. After 3 weeks of use, a break of 7 days is required.

On what day do menstruation begin when taking Yarin?

Menstruation begins after 2-3 days. Even if they did not stop by the end of the week's break, they begin the 3-week course again. In this case, it is not necessary to open a new package, since the hormone content in all tablets is the same. However, it is more convenient to start using the drug from the next package, so as not to get confused and prevent missing tablets.

If your period does not end within 2 days after resuming the course of pills, you should consult a doctor.

Effect on the menstrual cycle

In the first months of using the drug, some women experience irregular bleeding. Adaptation occurs within 3 months of use. If after this the regular cycle has not been restored, you need to contact a gynecologist.

It is especially important to consult a doctor in time if, after several normal cycles, irregular discharge appears again. In such a situation, it is necessary to exclude pregnancy and malignant tumors of the genital organs.

Pregnancy after Yarina can occur in the next cycle after the next menstruation.

Start of reception

The doctor who prescribed it should tell you how to take Yarina for the first time. There are also detailed instructions in the instructions for use.

You can end your appointment at any time. If pregnancy is not planned, you should start using others.

Missing an appointment

If the patient forgets to take a pill, resuming use of the medicine depends on how much time has passed since the required but missed dose.

The rules for resuming contraception are determined by the week in which the unplanned break occurred.

1st week

Take the pill as early as possible. If the patient forgot to use the drug on the previous day, then she will need to take 2 tablets at once (“forgotten” and the next one).
Take subsequent tablets as usual.
For a week after this, you must use condoms during sexual intercourse.
It must be taken into account that pregnancy can also occur if sexual intercourse took place during the previous week before missing the pill.

2nd week

The basic rules are the same as for skipping the 1st week.
If the patient took the drug correctly for a week before the unplanned break, additional contraception is not needed.
If during the week before skipping the drug was taken in violation of the regimen, or if more than one tablet was missed, you must resume your usual daily intake and use condoms over the next week.

3rd week

At this time, the likelihood of an unplanned pregnancy increases. However, if there were no violations in the dosage regimen during the week before skipping, additional contraception is not needed. Otherwise, the patient chooses one of two options:

Start taking the medication as soon as possible, one tablet per day. In this case, do not take a break between packages. In this case, menstruation will not occur. There may only be a slight spotting discharge. After completing the next pack, take the usual one-week break.
Do not take pills for a week, including the “missed” day. This will cause menstruation. After 7 days, start using the medicine from a new package. If you don’t have your period after stopping Yarina, you should consult a doctor; you may be pregnant.

Vomiting or diarrhea in the first 4 hours after taking the pill is considered to be missed. In this case, you need to follow the above rules depending on the week in which this happened.

Changing the start date of menstruation

With the help of the drug, you can shift the onset of your next period. This property can be used in exceptional cases, for example, when traveling to the seaside or before an important sports performance.

To prevent menstruation from starting this month, Yarina should not be discontinued after taking the entire package. Immediately, without a week's break, the medication from the next package begins. It can be continued for the required number of days, up to 21. Menstruation will begin 1-2 days after finishing using the medicine. In addition, spotting or short-term menstrual-like bleeding are possible while using the second package. The contraceptive effect is not reduced.
To reschedule your period a few days earlier, you should reduce the interval between packs by the required number of days in advance. After completing the second package, menstruation will begin, that is, menstruation will come as many days earlier as the “free” interval between packages was shorter.

Side effects

6 out of 100 women taking Yarina experience nausea. With the same frequency, patients have chest pain. If such symptoms appear, you should consult a doctor. You may need to select a different contraceptive.

The most dangerous side effects are thrombosis, that is, blockage of arteries or veins.

In 1-10% of cases the following side effects are observed:

unstable mood, depression, weakened libido;
migraine headache;
irregular bleeding from the vagina.

The development of thrombosis occurs in one in 10,000 women and less frequently. In this case, the following pathological conditions may appear:

thrombosis of the veins of the extremities;
pulmonary embolism;
myocardial infarction;
ischemic stroke.

In large studies and in practice, conditions have been identified that may be somehow related to taking Yarina, but occur extremely rarely when using this drug:

slight increase in risk (for patients over 40 years of age);
increased likelihood of benign or malignant liver tumors;
the appearance of erythema nodosum - rounded nodes, usually located on the anterior surfaces of the legs;
pancreatitis with simultaneous elevated levels of triglycerides in the blood;
arterial hypertension;
increased symptoms with hereditary angioedema;
liver dysfunction;
worsening diabetes;
ulcerative colitis and Crohn's disease (intestinal damage);
chloasma (dark spots on the skin);
manifestations of intolerance, for example, allergic skin rash.

No negative effects on the fetus were detected during early pregnancy. However, if this condition is suspected, the medication should be stopped.

Contraindications

The drug Yarina has the following contraindications:

previous vascular thrombosis, including deep vein thrombosis, pulmonary embolism, myocardial infarction, ischemic stroke;
previous transient ischemic attack;
IHD, including angina pectoris;
migraine with the appearance of focal neurological symptoms (impaired movements, sensitivity, smell, speech, etc.);
diabetes complicated by micro- or macroangiopathy (vascular damage);
factors that increase the risk of vascular thrombosis: atrial fibrillation, valvular heart disease, high blood pressure, previous surgery with prolonged bed rest or limb immobility, and smoking in women over 35 years of age;
pancreatitis, accompanied by an increase in triglyceride levels in the blood;
liver diseases with altered liver tests (ALT, AST, alkaline phosphatase, bilirubin);
liver tumors;
liver or kidney failure;
malignant tumor of the genital organs or mammary gland, or suspicion of them;
vaginal bleeding of unknown origin;
suspicion of pregnancy;
breast-feeding;
individual intolerance.

If the listed conditions appear while taking Yarina, it should be stopped immediately.

This COC can be taken for fibroids, endometriosis, ovarian cysts and other non-tumor diseases of the genital organs.

Interaction with other drugs

Some medications may reduce the contraceptive effectiveness of the drug.

phenytoin;
drugs from the group of barbiturates;
carbamazepine, oxcarbazepine;
rifampicin and rifabutin;
topiramate or felbamate;
griseofulvin;
products based on St. John's wort;
some medications for the treatment of HIV infection.

Special rules must be observed when taking antibiotics such as penicillins (Amoxiclav, Oxacillin, Ampicillin and others) and tetracyclines (Doxycycline and others). During treatment with these drugs, as well as for a week after completing the course, you must additionally use condoms.

If during this week, when additional barrier contraception is needed, the pills from the package run out, immediately start the next one, without the usual one-week break.

Yarina and other hormonal contraceptives

The Bayer company, in addition to this drug, produces a similar one - Yarina Plus.

What is the difference between Yarina and Yarina plus?

Yarina plus contains another component - calcium levomefolate, which is the active form of folic acid. Its purpose is to reduce the risk of defects in the fetal nervous system if pregnancy occurs while taking COCs.

This medicine is prescribed to patients who receive insufficient amounts of folic acid.

Which is better: Yarina or other COCs (Jess, Janine, Klaira, Regulon, Belara)?

It is better to get the answer from the gynecologist who is observing you, since all these drugs have differences in properties and are prescribed in different clinical situations:

Complete analogues in composition, cheaper than Yarina:

Anabella (Czech Republic) - 1400 rubles for 84 tablets;
Midiana (Hungary) – 740 rubles for 21 tablets;
Vidora (Spain) – 625 rubles for 21 tablets;
Modell Pro (Israel) – 691 rubles for 21 tablets;
Yamera (India).

Preparations Jess and Dimia are practically no different from Yarina, except for the amount of ethinyl estradiol in them - not 30, but 20 mcg.

Yarina is a fairly expensive drug, so you need to ensure its authenticity. To do this, you should take a good look at the tablets from the package. It may contain 1 or 3 blisters of 21 tablets. Each of them has an even light yellow color and is covered with a film shell. On one of the sides there is a hexagon embossed, in which the letters DO are located. You should not take the drug if its external characteristics do not correspond to those indicated, and also if it was sold at a price significantly lower than the average (about 1000 rubles for 21 tablets).

Yarina is a monophasic oral contraceptive. This means that all tablets in the package contain the same dose of hormones. One tablet of Yarina contains 30 mcg (0.03 mg) of ethinyl estradiol and 3 mg of Drospirenone.

One package contains one blister (plate) of Yarina for use for one month.

ATTENTION: The drug has contraindications. Do not start using this drug without first consulting your doctor.

Analogues

Preparations Midiana and Yarina Plus contain the same dose of hormones as Yarina.

Advantages of Yarina

Oral contraceptives (OC) Yarina have an antiandrogenic effect. This means that they block the action of male sex hormones (androgens) in a woman’s body. It is known that androgens are a common cause of oily facial skin and acne. Therefore, Yarina can have a cosmetic effect - eliminate or at least weaken acne (blackheads).

In addition, Yarina helps relieve pain during menstruation, as well as reduce the manifestations of premenstrual syndrome (PMS). Yarin tablets do not retain water in the body, so taking them does not increase a woman’s weight.

Yarina can be used as a treatment for endometriosis, adenomyosis, uterine fibroids, polycystic ovary syndrome and some other gynecological diseases.

Rules for receiving Yarina

If you are taking Yarina for the first time: the first tablet should be taken on the first day of menstruation (this day is considered the first day of the menstrual cycle). Your period may stop when you start taking the pills due to the effects of hormones. It's not scary.
You can start taking the pills on the 3-5th day of your period, but in this case you need to use additional contraception (for example, a condom) for another week after starting to take the pills.
It is advisable to take the tablets at approximately the same hour every day.
It is recommended to take the tablets in the order indicated on the blister. But, if you mixed something up and started taking the tablets out of order, then nothing bad will happen, since all Yarin tablets contain the same dose of hormones.
After finishing the blister (when you have finished 21 tablets), you should take a 7-day break, during which you do not need to take tablets. During the 7-day break, you may begin to menstruate.
Taking the first tablet from the next blister should be started on the 8th day after a 7-day break, regardless of menstruation (even if it has not yet begun or has not yet ended).

Do I need to use protection during the 7-day break?

During the week-long break between packs, there is no need to use additional contraceptives, since the contraceptive effect remains at a high level.

But this is only true for those cases when the woman took the pills from the previous package without skipping and according to the rules. If you missed one or more tablets in the third week of taking Yarina, or if the effect of the tablets could be reduced for another reason (vomiting, diarrhea, taking medications, etc.), then it is recommended not to take a 7-day break at all.

How to switch to Yarina from other birth control pills?

If you have been taking other birth control pills and now want to switch to Yarina, follow these rules:

If the blister of previous birth control pills contained 28 tablets, then taking the first Yarin tablet should be started the day after the end of 28 tablets of the previous OC.
If the package of previous OCs contained 21 tablets, then taking the first Yarin tablet can be started the day after the blister of previous birth control pills ends, or on the 8th day after a seven-day break.

How to switch to OK Yarina from a vaginal ring or hormonal patch?

The first tablet of Yarin should be taken on the day when you remove the vaginal ring or remove the hormonal patch, or on the day when you need to attach a new patch, or put the vaginal ring back on.

How to switch to Yarin from an intrauterine device (IUD)?

When switching to Yarina birth control pills from an intrauterine device, take the first pill on the day the device is removed. For 7 days after starting to take Yarin, use additional contraception (for example, condoms).

How to start taking Yarin after an abortion?

If the pregnancy was terminated at less than 12 weeks, the first Yarin tablet can be taken on the day of the abortion.

If you are more than 12 weeks pregnant, then you can start taking Yarina 21-28 days after the abortion. To avoid unwanted pregnancy, in this case, use a condom for another week after you start taking birth control pills. If you had unprotected sexual intercourse before starting to take OK, then you should not take Yarina until you are sure that you are not pregnant.

How to start taking Yarina after childbirth?

You can start taking Yarina 21 or 28 days after birth. If you start taking the pills later, you need to take additional protection for another 7 days. If you had unprotected sex before starting to take birth control pills, you can start taking the pills only after you have ruled out a possible pregnancy.

Can I take Yarina if I am breastfeeding?

What should I do if I missed Yarina’s pill?

If the delay in taking the Yarin tablet is less than 12 hours (that is, less than 36 hours have passed since taking the last tablet), then the contraceptive effect of the tablets is not reduced. Take the missed pill as soon as you remember. In this case, there is no need to take additional protection.

If the delay in taking the dose was more than 12 hours, then look at which tablet was missed:

From 1 to 7 tablets: you need to take the missed tablet as soon as you remember, even if this means taking 2 tablets at the same time. Use additional contraception (such as a condom) for the next 7 days.
From 8 to 14 tablets: you need to take the missed tablet as soon as you remember, even if this means taking 2 tablets at the same time. If you took the pills according to the rules for the previous 7 days (before skipping), you don’t have to use additional contraception. In any other case, it is recommended to take additional protection for another week after release.
From 15 to 21 tablets: take the missed Yarina tablet as soon as you remember, even if this means taking 2 tablets at the same time. After this, continue taking the tablets as usual, and after finishing the blister, immediately start the next blister (without taking a 7-day break). If you took all your pills on time for the previous 7 days before missing the pill, then there is no need for additional contraception. Otherwise, use protection for another 7 days after missing it.

What should I do if I missed several Yarina tablets?

If you missed 2 Yarina tablets in a row, pay attention to which tablets you missed. If these are tablets of the first or second week of taking (from 1 to 14), then take 2 tablets as soon as you remember about the omission and 2 more tablets the next day. Then take one tablet per day as usual until the pack runs out. Use additional contraception for another 7 days after resuming taking the pills.

If you missed two tablets in a row in the 3rd week of taking it (from 15 to 21), then there are two options: 1. continue taking Yarina, one tablet per day until the package runs out and then, without taking a 7-day break, start new packaging. At the same time, use additional contraception for another 7 days after the missed period. 2. throw away the current (unfinished) package and start taking a new package with the first tablet (one tablet per day, as usual). In this case, you need to use additional contraception for another 7 days after the missed date.

If you miss 3 Yarina tablets in a row, throw away the current pack of tablets and start a new pack with the first tablet. Use additional contraception for another 7 days. You will have an increased risk of pregnancy, so if your period does not come during the next break, contact your gynecologist.

If you are not sure what to do in your situation, use additional contraception until you talk to your doctor. In any case, if you miss two or more tablets, be sure to use additional protection (using condoms) for at least 7 days.

1-2 days after missing the pills, you may experience spotting or breakthrough bleeding, similar to your period. This is not dangerous and is associated with Yarina’s passes. Continue taking the pills according to the instructions and the discharge will stop.

Bloody discharge when taking Yarina

Some women experience spotting brown discharge while taking Yarina. Such discharge is normal if you started taking Yarina several months ago, if the discharge appears in the middle of the package or continues for several days after the end of menstrual-like bleeding.

However, in some situations, spotting may indicate a decrease in the effect of Yarina and even some diseases. You can read more about this in the article: About spotting while taking OK.

What reduces the contraceptive effect of Yarina?

The contraceptive effect of Yarina can be reduced by vomiting, diarrhea, taking large doses of alcohol, or taking certain medications. Read more about this here:

How to delay menstruation with the help of Yarin?

If you need to delay your period, then after finishing one package of Yarin, start a new blister the next day without taking a 7-day break. In this case, menstruation will be delayed by 2-4 weeks, but slight spotting may appear approximately in the middle of the next package.

Please note: you can postpone your period only if you took Yarin at least one month before unwanted menstruation.

Do I need to take long breaks from taking Yarina?

If you have been taking Yarina for more than 6-12 months, you may be wondering if you should take a break for a few months. You can read about how useful such breaks are by following the link: Is it necessary to take long breaks from taking birth control pills?

What to do if you don’t have your period during a 7-day break from taking Yarin?

Carefully remember whether you took all the pills correctly last month.

If you followed the basic rules for taking Yarin tablets, did not skip or were more than 12 hours late in taking them, then do not worry. After completing the 7-day break, you can start taking a new blister. If you don’t have your period during the next 7-day break, then contact your gynecologist to rule out a possible pregnancy. For other possible reasons for a delay, read the article 10 reasons for a delay in menstruation.

If in the past month you had errors in taking pills (missing, being late), then stop taking Yarina pills until you are sure that you are not pregnant.

What should I do if I become pregnant while taking Yarina?

Pregnancy when taking Yarin tablets correctly is extremely rare. It is more likely that pregnancy occurred as a result of mistakes that you made in the previous month.

So, what to do if the test unexpectedly shows 2 stripes? First of all, stop taking the pills and contact your gynecologist.

Taking Yarina in the early stages of pregnancy cannot harm the health of your unborn child, so you can leave the pregnancy without fear. In this case, start taking folic acid as soon as possible.

Yarina's appointment before surgery

If you are undergoing a planned operation, then taking Yarin tablets should be stopped a month (4 weeks) before surgery. This will reduce the risk of blood clots in the vessels. If the operation is required urgently, be sure to tell the surgeon that you are taking birth control pills. In this case, the doctor will take additional measures to prevent blood clots (with the help of medications).

You will be able to start taking Yarin 2 weeks after you are able to walk independently after surgery.

How often should you visit a gynecologist while taking Yarin?

Even if nothing bothers you, you need to visit a gynecologist for preventative care at least once a year.

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РЇСЂРёРЅР°: РёРЅСЃС‚СЂСѓРєС†РёСЏ Rє RїСЂРёРјРµРЅРµРЅРёСЋ

РЇСЂРёРЅР° СЌС‚Рѕ РјРѕРЅРѕС„Р°Р·РЅС‹Р№ РѕСЂР°Р»СЊРЅС‹Р№ РєРѕРЅС‚СЂР°С†РµРїС‚РёРІ. Р'СЃРµ С‚Р°Р±Р»РµС‚РєРё РІ СѓРїР°РєРѕРІРєРµ СЃРѕРґРµСЂР¶Р°С‚ РѕРґРЅСѓ Рё С‚Сѓ Р¶Рµ РґРѕР·Сѓ РіР ѕСЂРјРѕРЅРѕРІ: СЌС‚РёРЅРёР»СЌСЃС‚СЂР°РґРёРѕР» 30 RјРєРі Рё РґСЂРѕСЃРїРµСЂРёРЅРѕРЅРѕРЅ 3 РјРі. РћРґРЅР° СѓРїР°РєРѕРІРєР° СЂР°СЃСЃС‡РёС‚Р°РЅР° РЅР° 1 РјРµРЅСЃС‚СЂСѓР°Р»СЊРЅС‹Р№ С†РёРєР». РњРёРґРёР°РЅР° Рё РЇСЂРеРЅР° РїР»СЋСЃ – СЌС‚Рѕ RїРѕР»РЅС‹Рµ Р°РЅР°Р»РѕРіРё RїСЂРµРїР°СЂР°С‚Р° РЇСЂРё PSP°. РџСЂРµРёРјСѓС‰РµСЃС‚РІР° РїСЂРµРїР°СЂР°С‚Р° РЇСЂРёРЅР°:

RђРЅС‚РёР°РСРґСЂРѕРіРµРЅРЅС‹Р№ СЌС„С„РµРєС‚
РЈР»СѓС‡С€Р°РµС‚ СЃРѕСЃС‚РѕСЏРЅРёРµ РєРѕР¶Рё
РЎРЅРёР¶Р°РµС‚ Р±РѕР»Рё РІРѕ РІСЂРµРјСЏ РјРµРЅСЃС‚СЂСѓР°С†РёРё
РќРµ Р·Р°РґРµСЂР¶РёРІР°СЋС‚ Р¶РёРґРєРѕСЃС‚СЊ І РЕСЂРіР°РЅРёР·РјРµ
РќРµ РѕР±Р»Р°РґР°СЋС‚ Р°РЅР°Р±РѕР»РёС‡РµСЃРєРёРј SЌС„С„РµРєС‚РѕРј
РџСЂРёРјРµРЅСЏРµС‚СЃСЏ РєР°Рє Р»РµС‡РµР±РЅРѕРµ SЃСЂРµРґСЃС‚РІРѕ РїСЂРё R°РґРµРЅРѕРјРёРѕР·Р µ, RјРёРѕРјРµ RјР°С‚РєРё, R°РґРµРЅРѕРјРёРѕР·Рµ, RїРѕР»РёРєРёСЃС‚РѕР·Рµ

RљР°Рє РїСЂРёРЅРјР°С‚СЊ РЇСЂРёРЅСѓ?

Р СЃР»Рё РїСЂРµРґСЃС‚РѕРёС‚ РїСЂРёРµРј РЇСЂРёРЅС‹ РІРїРµСЂРІС‹Рµ, С‚Рѕ RїРµСЂРІСѓСЋ S‚Р°Р±Р »РµС‚РєСѓ РЅР°С‡РеРЅР°СЋС‚ РїСЂРёРЅРёРјР°С‚СЊ СЃ РїРµСЂРІРѕРіРѕ РґРЅСЏ РЅР°С‡ Р°Р»Р° РјРµРЅСЃС‚СЂСѓР°С†РёРё. РњРѕР¶РЅРѕ РЅР°С‡Р°С‚СЊ РїСЂРёРµРј С‚Р°Р±Р»РµС‚РѕРє РґРѕ 5-РіРѕ РґРЅСЏ RјРµРЅСЃС‚СЂСѓР°Р»С ЊРЅРѕРіРѕ С†РеРєР»Р°, РЅРѕ С‚РѕРіРґР° РЅРµРѕР± S…РѕРґРёРјРѕ РІ С‚РµС‡РµРЅРµ RїРѕСЃР»РµРґСѓСЋС‰РµР№ РЅРµРґРµР»Рё РґРѕРїРѕР»РЅРёС‚РµР»СЊР ЅРѕ РїСЂРµРґРѕС…СЂР°РЅСЏС‚СЊСЃСЏ Р±Р°СЂСЊРµСЂРЅРѕР№ РєРѕРЅС‚СЂР°С†РµРїС†РеРµР№. РўР°Р±Р»РµС‚РєРё РѕР±СЏР·Р°С‚РµР»СЊРЅРѕ RїСЂРёРЅРёРјР°С‚СЊ RµР¶РµРґРЅРµРІРЅРѕ РІ РѕРґРЅРѕ Ryo S ‚Рѕ Р¶Рµ РІСЂРµРјСЏ СЃСѓС‚РѕРє. RR»РёС‚РµР»СЊРЅРѕСЃС‚СЊ РїСЂРёРµРјР° 21 РґРµРЅСЊ, Р·Р°С‚РµРј РґРµР»Р°РµС‚СЃСЏ 7-РґРЅРµРІРЅС ‹Р№ РїРµСЂРµСЂС‹РІ Рё РЅР° 8-Рµ СЃСѓС‚РєРё РЅР° S‡РёРЅР°СЋС‚ РїСЂРёРµРј РЅРѕРІРѕР№ РєРѕРЅРІР°Р»СЋС‚С‹. R' SЌS‚РѕС‚ 7-РґРЅРµРІРЅС‹Р№ РїРµСЂРёРѕРґ RїСЂРѕР№РґРµС‚ RјРµРЅСЃС‚СЂСѓР°С†РёСЏ. РџСЂРёРµРј РЅРѕРІРѕР№ РєРѕРЅРІР°Р»СЋС‚С‹ РЅРµРѕР±С…РѕРґРёРјРѕ RїСЂРёРЅРёРјР°С‚СЊ СЃС‚СЂРѕР іРѕ СЃ 8 РґРЅСЏ РїРѕСЃР»Рµ 7-РґРЅРµРІРЅРѕРіРѕ РїРµСЂРµСЂС‹РІР°, РґР°Р¶Рµ РµСЃР»Рё РјРµРЅСЃС‚С ЂСѓР° S†РёСЏ РµС‰С' РЅРµ Р·Р°РєРѕРЅС‡РеР»Р°СЃСЊ.

Р СЃС‚СЊ Р»Рё РЅРµРѕР±С…РѕРґРёРјРѕСЃС‚СЊ РІ РєРѕРЅС‚СЂР°С†РµРїС†РёРё РІРѕ РІСЂРµРјСЏ 7-РґРЅР µРІРЅРѕРіРѕ РїРµСЂРµСЂС‹РІР°?

РџСЂРѕС‚РёРІРѕР·Р°С‡Р°С‚РѕС‡РЅС‹Р№ СЌС„С„РµРєС‚ РїСЂРµРїР°СЂР°С‚Р° СЂР°СЃРїСЂРѕСЃС‚С ЂР°РЅСЏРµС‚СЃСЏ Рё РЅР° 7-РґРЅРµРІРЅС‹Р№ РїРµСЂРµСЂС‹РІ, РїРѕСЌС‚РѕРјСѓ РґРѕРїРѕР»РЅРёС‚РµР»СЊРЅР°СЏ RєРѕРЅС‚СЂР°С†РµРїС†РёСЏ R І СЌС‚РѕС‚ РїРµСЂРеРѕРґ РЅРµ РЅСѓР¶РЅР°. RћРґРЅР°РєРѕ РґР°РЅРЅРѕРµ SѓS‚РІРµСЂР¶РґРµРЅРёРµ SЃРїСЂР°РІРµРґР»РёРІРѕ S‚РѕР»СЊРєРѕ РІ С‚ РѕРј СЃР»СѓС‡Р°Рµ, РµСЃР»Рё РїСЂРµРґС‹РґСѓС‰Р°СЏ SѓРїР°РєРѕРІРєР° РїСЂРёРЅРёРјР°Р »Р°СЃСЊ Р±РµР· РїРѕРіСЂРµС€РЅРѕСЃС‚РµР№. Р СЃР»Рё Р±С‹Р»Р° РїСЂРѕРїСѓС‰РµРЅР° 1 РеР»Рё Р±РѕР»РµРµ S‚Р°Р±Р»РµС‚РѕРє, Р±С‹Р»Р° СЂРІРѕС‚Р° РёР »Рё РґРёР°СЂРµСЏ, С‚Рѕ РїРµСЂРµСЂС‹РІ РґРµР»Р°С‚СЊ РЅРµ РЅСѓР¶РЅРѕ, РЅСѓР¶РЅРѕ РїСЂРѕСЃС‚Р * РЅР°С‡Р°С‚СЊ РїСЂРёРµРј РЅРѕРІРѕР№ РєРѕРЅРІР°Р»СЋС‚С‹ .

РџРµСЂРµС…РѕРґ СЃ РґСЂСѓРіРіРє… РїСЂРѕС‚РеРІРѕР·Р°С‡Р°С‚РѕС‡РЅС‹С… С‚Р°Р±Р»РµС‚РѕРє

РџСЂРё РїРµСЂРµС…РѕРґРµ SЃ РґСЂСѓРіРѕРіРѕ РІРІРґР° РїСЂРѕС‚РёРІРѕР·Р°С‡Р°С‚РѕС‡РЅС‹С… С‚Р° Р±Р»РµС‚РѕРє РЅР° РљРћРљ РЇСЂРеРЅР° РЅРµРѕР±С…РѕРґРјРјРѕ RїСЂРёРґРµСЂР¶РёРІР °С‚СЊСЃСЏ СЃР»РµРґСѓСЋС‰РёС… РїСЂР°РІРёР»:

Р СЃР»Рё РІС‹ РїСЂРеРЅРёРјР°Р»Рё РїСЂРѕС‚РёРІРѕР·Р°С‡Р°С‚РѕС‡РЅС‹Рµ S‚Р°Р±Р»РµС‚РєРё, РіРґРµ Р ±С‹Р»Рѕ 28 С ‚Р°Р±Р»РµС‚РѕРє, С‚Рѕ РІ СЌС‚РѕРј SЃР»СѓС‡Р°Рµ РЇСЂРеРЅСѓ РЅР°РґРѕ РЅР°С‡РёРЅР°С‚СЊ РїСЂРёР SРёРјР°С‚СЊ, РЅРµ РґРµР»Р°СЏ РїРµСЂРµСЂС‹РІ, С‚Рѕ РµСЃС‚СЊ СЃСЂР°Р·Сѓ РїРѕСЃР»Рµ 28 С‚Р°Р±Р»РµС‚РєРё.
Р СЃР»Рё Сѓ РїСЂРµРґС‹РґСѓС‰РµРіРѕ РїСЂРµРїР°СЂР°С‚Р° Р±С‹Р»Р° 21 С‚Р°Р±Р»РµС‚РєР° РІ РєРѕРЅРІР °Р»СЋС‚Рµ, С‚ Рѕ РЅСѓР¶РЅРѕ РЅР°С‡Р°С‚СЊ РїСЂРёРµРј РЇСЂРёРЅС‹ РїРѕСЃР»Рµ 7-РґРЅРµРІРЅРѕРіРѕ РїРµСЂРµСЂС ‹РІР°.

РџРµСЂРµС…РѕРґ Рє РчСЂРеРЅР° РїРѕСЃР»Рµ РїСЂРёРјРµРЅРµРЅРЅРІР°РіРіРёРЅР°Р»СЊРЅРѕРіРѕ РєРѕР»СЊС †Р° РёР»Рё РїР»Р°СЃС‚С‹СЂСЏ

РќР°С‡Р°Р»Рѕ РїСЂРеРµРјР° РЇСЂРёРЅР° СЃРѕРІРїР°РґР°РµС‚ СЃ РґРЅРµРј СѓРґР°Р»РµРЅРёСЏ РєРѕР»СЊС† Р° РёР»Рё СЃРЅСЏС‚РёСЏ РїР»Р°СЃС‚С‹СЂСЏ.

РџРµСЂРµС…РѕРґ Рє РЇСЂРёРЅР° СЃ Р’РњРЎ

РџРµСЂРІР°СЏ С‚Р°Р±Р»РµС‚РєР° РЇСЂРёРЅР° СЃРѕРІРїР°РґР°РµС‚ СЃ СѓРґР°Р»РµРЅРёРµРј Р’РњРЎ. РџСЂРё СЌС‚РѕРј РІ РїРµСЂРІС‹Рµ 7 РґРЅРµР№ РЅРµРѕР±С…РѕРґРёРјР° РґРѕРїРѕР»РЅРёС‚РµР»СЊРЅР°СЏ R єРѕРЅС‚СЂР°С†РµРїС†РёСЏ.

РџСЂРёРµРј РЇСЂРёРЅР° РїРѕСЃР»Рµ Р°Р±РѕСЂС‚Р°

РќР°С‡Р°Р»Рѕ РїСЂРёРµРјР° РЇСЂРёРЅР° СЃРѕРІРїР°РґР°РµС‚ СЃ РґРЅРµРј Р°Р±РѕСЂС‚Р°. Р' СЃР»СѓС‡Р°Рµ, РµСЃР»Рё СЃСЂРѕРє Р±РµСЂРµРјРµРЅРЅРѕСЃС‚Рё Р±С‹Р» Р±РѕР»РµРµ 12 РЅРµРґРµР»СЊ, C ‚Рѕ РѕЃРїРѕР»СЊР·РѕРІР°РЅРёРµ РїСЂРµРїР°СЂР°С ‚Р° РјРѕР¶РЅРѕ РЅР°С‡Р°С‚СЊ S‡РµСЂРµР· 3-4 РЅРµРґРµР»Рё РїРѕСЃР»Рµ Р°Р±РѕСЂС‚Р°.

RџСЂРёРјРµРЅРµРЅРёРµ RЇСЂРёРЅС‹ RїРѕСЃР»Рµ SЂРѕРґРѕРІ

RџСЂРёРµРј RїСЂРµРїР°СЂР°С‚Р° RїРѕСЃР»Рµ SЂРѕРґРѕРІ RјРѕР¶РЅРѕ RЅР°С‡Р°С‚СЊ S‡РµСЂРµР· 21-28 РґРЅРµР№, РµСЃР»Рё РІС‹ РЅРµ РєРѕСЂРјРёС‚Рµ РіСЂСѓРґСЊСЋ. Р СЃР»Рё РїСЂРёРµРј РЇСЂРеРЅС‹ РЅР°С‡Р°С‚ РїРѕР·Р¶Рµ 28 РґРЅРµР№, С‚Рѕ РЅРµРѕР±С…РѕРґРёРјР° РґРѕР їРѕР»РЅРёС‚РµР»СЊРЅР°СЏ Р±Р°СЂСЊРµСЂРЅР°СЏ РєРѕРЅС ‚СЂР°С†РµРїС†РёСЏ РІ С‚РµС‡РµРЅРёРµ 1 РЅРµРґРµР»Рё. RќР°С‡РёРЅР°С‚СЊ RїСЂРеРµРј RЇСЂРёРЅС‹ RјРѕР¶РЅРѕ S‚РѕР»СЊРєРѕ RІ S‚РѕРј SЃР»СѓС‡Р°Рµ, РєРѕ РіРґР° Р¶РµРЅС‰РёРЅР° СѓРІРµСЂРµРЅР° РІ РѕС‚СЃСѓС‚СЃС‚РІРёРё Р±РµСЂРµРјРµРЅРЅРѕСЃС‚Рё. R”R”SЏ RєRѕSЂRјSЏS‰РёС… R¶РµРЅС‰РёРЅ RљРћРљ RSRµ RїРѕРґС…РѕРґСЏС‚ РІ RєР°С‡РµСЃС‚РІРµ RєРѕR ЅС‚СЂР°С†РµРїС†РеРё, С‚Р°Рє РєР°Рє СОССЃС‚СЂРѕРіРµРЅС‹ ... R”R”SЏ RєRѕSЂRјSЏS‰РёС… СЃСѓС‰РµСЃС‚РІСѓСЋС‚ S‡РёСЃС‚РѕРїСЂРѕРіРµСЃС‚РёРЅРѕРІС‹Рµ Rї СЂРµРїР°СЂР°С‚С‹.

Р§С‚Рѕ РїСЂРµРґРїСЂРёРЅСЏС‚СЊ РІ СЃР»СѓС‡Р°Рµ РїСЂРѕРїСѓСЃРєР° РЇСЂРёРЅС‹?

РљРѕРЅС‚СЂР°С†РµРїС‚РёРІРЅС‹Р№ СЌС„С„РµРєС‚ РїСЂРµРїР°СЂР°С‚Р° РЅРµ SЃРЅРёР¶Р°РµС‚СЃС Џ РµСЃР»Рё РїСЂРѕРёР·РѕС€Р»Р° Р·Р°РґРµСЂР ¶РєР° РІ РїСЂРёРµРјРµ РїСЂРµРїР°СЂР°С‚Р° РЅРµ Р±РѕР»РµРµ 12 С‡Р°СЃРѕРІ. РќСѓР¶РЅРѕ РІС‹РїРёС‚СЊ РїСЂРѕРїСѓС‰РµРЅРЅСѓСЋ S‚Р°Р±Р»РµС‚РєСѓ. RћS‡РµСЂРµРґРЅСѓСЋ S‚Р°Р±Р»РµС‚РєСѓ РІС‹РїРёС‚СЊ RїРѕ RїР»Р°РЅСѓ. R' RґР°РЅРЅРѕРј SЃР»СѓС‡Р°Рµ РґРѕРїРѕР»РЅРЕС‚РµР»СЊРЅР°СЏ RєРѕРЅС‚СЂР°С†РµРїС†РёСЏ РЅРµ РЅС ѓР¶РЅР°. Р СЃР»Рё РїСЂРѕРїСѓСЃРє СЃРѕСЃС‚Р°РІРёР» Р±РѕР»РµРµ 12 С‡Р°СЃРѕРІ, С‚Рѕ РґР°Р»СЊРЅРµР№С€Р°СЏ С‚Р°Р єС‚РёРєР° Р·Р°РІРІРёСЃРёС ‚ РѕС‚ С‚РѕРіРѕ РєР°РєР°СЏ РѕјРµРЅРЅРѕ S‚Р°Р±Р»РµС‚РєР° РїРѕ СЃС‡РµС‚Сѓ Р±С‹Р»Р° РїСЂРѕРїS ѓС‰РµРЅР°. Р СЃР»Рё СЌС‚Рѕ СЃ 1 РїРѕ 7 С‚Р°Р±Р»РµС‚РєРё, С‚Рѕ РЅСѓР¶РЅРѕ РІС‹РїРёС‚СЊ S‚Р°Р±Р»РµС‚РєСѓ, Рє Р°Рє С ‚РѕР»СЊРєРѕ РІСЃРїРѕРјРЅРёР»Рё Рѕ РїСЂРѕРїСѓСЃРєРµ Рё РґР°Р»РµРµ RїРѕ RѕР±С‹С‡РЅРѕР№ СЃС…РµРј Рµ. R' SЌS‚РѕРј SЃР»СѓС‡Р°Рµ РЅРµРѕР±С…РѕРґРёРјР° РґРѕРїРѕР»РЅРёС‚РµР»СЊРЅР°СЏ РєРѕРЅС‚СЂР°С†Рµ РїС†РёСЏ 7 РґРЅРµР№. Р СЃР»Рё СЌС‚Рѕ СЃ 8 РїРѕ 14 С‚Р°Р±Р»РµС‚РєРё, СЃС…РµРјР° РґРµР№СЃС‚РІРёР№ РєР°Рє РІ РїСЂРµРґС‹РґС ѓС‰РµРј СЃР»СѓС‡Р°Рµ, РЅРѕ РІ РґРѕРїРѕР»РЅРёС‚РµР»СЊРЅРѕР№ РєРѕРЅС‚СЂР°С†РµРїС†РеРё РЅРµС‚ РЅРµРѕР±С…РѕРґРёРјРѕS ЃС‚Рё, РµСЃР»Рё РґРѕ СЌС‚РѕРіРѕ РЅРµ Р±С‹Р»Рѕ РїСЂРѕРїСѓСЃРєРѕРІ РІ РїСЂРёРµРјРµ. R' RїSЂRѕS‚РёРІРЅРѕРј SЃР»СѓС‡Р°Рµ РЅСѓР¶РЅР° РґРѕРїРѕР»РЅРёС‚РµР»СЊРЅР°СЏ RєРѕРЅС‚СЂР°С†Р µРїС†РёСЏ 7 РґРЅРµР№. Р СЃР»Рё СЌС‚Рѕ СЃ 15 РїРѕ 21 С‚Р°Р±Р»РµС‚РєРё, С‚Рѕ РЅСѓР¶РЅРѕ РІС‹РїРёС‚СЊ РїСЂРѕїСѓС‰РµРЅ РЅСѓСЋ С‚Р°Р±Р»РµС‚РєСѓ, РєР °Рє С‚РѕР»СЊРєРѕ РІСЃРїРѕРјРЅРёР»Рѕ РїСЂРѕРїСѓСЃРєРµ, РґР°Р»РµРµ RїРѕ РѕР±С‹С‡РЅРѕР№ СЃС…Рµ РјРµ, РїРѕ РѕРєРѕРЅС‡Р°РЅРёРё РєРѕРЅРІР°Р»СЋС‚С‹ РЅСѓР¶РЅРѕ РЅР° S‡Р°С‚СЊ РЅРѕРІСѓСЋ Р±РµР· 7-РґРЅРµРІРЅРѕРіРѕ РїРµСЂРµСЂС‹РІР°. Р СЃР»Рё РґРѕ СЌС‚РѕРіРѕ РїСЂРѕРїСѓСЃРєР° РІ С‚РµС‡РµРЅРёРµ 7 РґРЅРµР№ РїРѕРіСЂРµС€РЅРѕСЃС‚Р е РІ РїСЂРёРµРјРµ РїСЂРµРїР°СЂР°С‚Р° РЅРµ Р±С‹Р»Рѕ, С‚Рѕ РЅРµС‚ РЅРµРѕР± S…РѕРґРёРјРѕСЃС‚РІ РґРѕРїРѕР»РЅРёС‚РµР»СЊРЅРѕР№ РєРѕРЅС‚СЂР°С†РµРїС†РеРё, РІ РїСЂРѕС‚Рё RІРЅРѕРј SЃР»СѓС‡Р°Рµ – 7 РґРЅРµР№ РїСЃРїРѕР»СЊР·РѕРІР°С‚СЊ РїСЂРµР· РµСЂРІР°С‚РёРІ.

R SЃР»Рё РїСЂРѕРїСѓС‰РµРЅРѕ RЅРµСЃРєРѕР»СЊРєРѕ S‚Р°Р±Р»РµС‚РѕРє

R SЃР»Рё РїСЂРѕРїСѓС‰РµРЅРѕ 2 S‚Р°Р±Р»РµС‚РєРё RїРѕРґСЂСЏРґ, S‚Рѕ РЅСѓР¶РЅРѕ RїРѕСЃС‚СѓРїРё S‚СЊ SЃР»РµРґСѓСЋС‰РёРј РѕР±СЂР°Р·РѕРј: Р СЃР»Рё СЌС ‚Рѕ СЃ 1 РїРѕ 14 РґРЅРё, С‚Рѕ РЅСѓР¶РЅРѕ РїСЂРёРЅСЏС‚СЊ 2 С‚Р°Р±Р»РµС‚РєРё Рё РµС‰С' 2 С‚Р°Р±Р»Р µС‚РєРё РЅР° СЃР» РµРґСѓСЋС‰РёР№ РґРµРЅСЊ. Р”Р°Р”РµРµ РїРѕ РѕР±С‹С‡РЅРѕР№ СЃС…РµРјРµ. РџСЂРё СЌС‚РѕРј РЅСѓР¶РЅРѕ РџСЃРїРѕР»СЊР·РѕРІР°С‚СЊ 7 РґРЅРµР№ Р±Р°СЂСЊРµСЂРЅСѓСЋ РєРѕРЅС‚С ЂР°С†РµРїС†РёСЋ. Р СЃР»Рё РїСЂРѕРїСѓСЃРє РІС‹РїР°Р» РЅР° 15-21 РґРЅРё, С‚Рѕ РµСЃС‚СЊ 2 РІР°СЂРеР°РЅС‚Р°: 1) РґРѕРїРёС ‚СЊ РЇСЂРёРЅСѓ РґРѕ РєРѕРЅС†Р° РїРѕ 1 С‚Р °Р±Р»РµС‚РєРµ 1 СЂР°Р· РІ РґРµРЅСЊ Рё, РЅРµ РґРµР»Р°СЏ 7-РґРЅРµРІРЅС‹Р№ РїРµСЂРµСЂС‹РІ‡, РЅР°С‡Р° S‚СЊ РЅРѕРІСѓСЋ SѓРїР°РєРѕРІРєСѓ, РёСЃРїРѕР»СЊР ·СѓСЏ РґРѕРїРѕР»РЅРёС‚РµР»СЊРЅСѓСЋ РєРѕРЅС‚СЂР°С†РµРїС†РёСЋ 7 РґРЅРµР№; 2). * РѕР±С‹С‡РЅРѕР№ СЃС… РµРјРµ, РїСЂРµРґРѕС…СЂР°РЅСЏСЏСЃСЊ РґРѕРїРѕР»РЅРёС‚РµР»СЊРЅРѕ. R SЃР»Рё РїСЂРѕРїСѓС‰РµРЅРѕ 3 С‚Р°Р±Р»РµС‚РєРё, РЅР°С‡РЅРёС‚Рµ RЅРѕРІСѓСЋ SѓRїР°РєРѕРІРєСѓ R їРѕ РѕР±С‹С‡РЅРѕР№ СЃС…РµРјРµ, РёСЃРїРѕР»СЊР·СѓСЏ 7 РґРЅРµР№ Р±Р°СЂСЊРµСЂРЅСѓСЋ RєРѕРЅС‚СЂР°С†РµРїС†РёСЋ. РџРѕСЃР»Рµ РїСЂРѕРїСѓСЃРєР° С‚Р°Р±Р»РµС‚РѕРє С‡РµСЂРµР· 1-2 РґРЅСЏ РјРѕРіСѓС‚ РїРѕСЏРІРІРёС‚ СЊСЃСЏ РјР°Р¶СѓС‰РёРµ РІС‹РґРµР»РµРЅРёСЏ. RS‚Рѕ РЅРѕСЂРјР°Р»СЊРЅРѕ Рё РЅРµ РѕРїР°СЃРЅРѕ.

Р§С‚Рѕ РјРѕР¶РµС‚ СЃРЅРёР·РёС‚СЊ СЌС„С„РµРєС‚РёРІРЅРѕСЃС‚СЊ РЇСЂРёРЅС‹?

R'РѕР»СЊС€РеРµ РґРѕР·С‹ Р°Р»РєРѕРіРѕР»СЏ
Р”РёР°СЂРµСЏ
Р РІРѕС‚Р°
РџСЂРёРµРј РЅРµРєРѕС‚РѕСЂС‹С… Р»РµРєР°СЂСЃС‚РІРµРЅРЅС‹С… РїСЂРµРїР°СЂР°С‚РѕРІ

RљР°Рє РѕС‚СЃСЂРѕС‡РёС‚СЊ RјРµРЅСЃС‚СЂСѓР°С†РёСЋ СЃ RїRѕRјРѕС‰СЊСЋ РљРјРёРЅС‹?

РќР°С‡РЅРёС‚Рµ РїСЂРеРµРј РѕС‡РµСЂРµРґРЅРѕРіРѕ Р±Р»РёСЃС‚РµСЂР° Р±РµР · 7-РґРЅРµРІРЅРѕРіРѕ R їРµСЂРµСЂС‹РІР°. РћС‚СЃСЂРѕС‡РёС‚СЊ РјРµРЅСЃС‚СЂСѓР°С†РёСЋ СЃ RїРѕРјРѕС‰СЊСЋ РїСЂРёРµРјР° РґР°РхРЅРѕРіР ѕ РїСЂРµРїР°СЂР°С‚Р° РјРѕР¶РЅРѕ S‚РѕР»СЊРєРѕ РІ СЃР»СѓС‡Р°Рµ, РµСЃР» Рё РІС‹ РїСЂРёРЅРёРјР°Р»Рё РЇСЂРёРЅСѓ РІ РїСЂРµРґС‹РґСѓС‰РµРј S†РёРєР»Рµ.

R'РµСЂРµРјРµРЅРЅРѕСЃС‚СЊ РЅР° С„РѕРЅРµ РЇСЂРёРЅС‹

РЇСЂРёРЅР° – СЌС‚Рѕ РїСЂРµРїР°СЂР°С‚ СЃ РІС‹СЃРѕРєРѕР№ СЌС„С„РµРєС‚РёРІРЅРѕСЃС‚СЊСЋ, РѕР ґРЅР°РєРѕ Р±РµСЂРµРјРµРЅРЅРѕСЃС‚СЊ РІСЃРµ Р¶Рµ РјРѕР¶РµС‚ РЅР°СЃС‚СѓРїРёС‚СЊ РїСЂРё РїРѕРіСЂРµС€РЅРѕСЃС‚СЏС… РІ РїСЂРјРјРµРЅРµРЅРёРё. Р СЃР»Рё Р±РµСЂРµРјРµРЅРЅРѕСЃС‚СЊ РЅР°СЃС‚СѓРїРёР»Р°, СЃР»РµРґСѓРµС‚ РїСЂРµРєСЂР°С‚РёС‚СЊ R їСЂРёРµРј S‚Р°Р±Р»РµС‚РѕРє. РІРѕРєР°Р·Р°РЅРѕ, С‡С‚Рѕ РїСЂРµРїР°СЂР°С‚ РЅРµ РѕРєР°Р·С‹РІР°РµС‚ РЅРµРіР°С‚РёРІРЅРѕРіРѕ РІ R»РёСЏРЅРёРµ РЅР° РїР»РѕРґ Рё S‚РµС‡ РµРЅРёРµ Р±РµСЂРµРјРµРЅРЅРѕСЃС‚Рё, RїРѕСЌС‚РѕРјСѓ RїСЂРё R¶РµР»Р°РЅРёРё RјРѕР¶РЅРѕ СЃРѕС…СЂР° РЅСЏС‚СЊ Р±РµСЂРµРјРµРЅРЅРѕСЃС‚СЊ.

R SЃР»Рё РїСЂРµРґСЃС‚РѕРёС‚ RїR»Р°РЅРѕРІРѕРµ RѕРїРµСЂР°С‚РёРІРЅРѕРµ R»РµС‡РµРЅРёРµ

R SЃР»Рё РїСЂРµРґСЃС‚РѕРёС‚ RїR»Р°РЅРѕРІРѕРµ RѕРїРµСЂР°С‚РёРІРЅРѕРµ R»РµС‡РµРЅРёРµ, СЃР»РµРґ СѓРµС‚ РїСЂРµРєСЂР°С‚РёС‚СЊ РїСЂРёРµРј РЇСЂРёРЅС‹ Р·Р° 4 РЅРµРґРµР»Рё РґРѕ РѕРїРµСЂР°С †RyoRyo. RS‚Рѕ РЅСѓР¶РЅРѕ РґР»СЏ СЃРЅРёР¶РµРЅРёСЏ СЂРёСЃРєР° РѕСЃР»РѕР¶РЅРµРЅРёР№ РІ РІРІрґРµ С‚СЂРѕРјР± РѕР·Р° СЃРѕСЃСѓРґРѕРІ. R' SЃР»СѓС‡Р°Рµ SЃСЂРѕС‡РЅРѕР№ РѕРїРµСЂР°С†РеРё РЅРµРѕР±С…РѕРґРјРѕ RїСЂРµРґСѓРїСЂРµРґРёС‚ SЊ S…РёСЂСѓСЂРіР° Рѕ РїСЂРёРµРјРµ RљРћРљ.

Р§Р°СЃС‚РѕС‚Р° РїРѕСЃРµС‰РµРЅРёСЏ RіРёРЅРµРєРѕР»РѕРіР° РїСЂРё РїСЂРёРµРјРµ РЇСЂРёРЅС‹

РџРѕСЃРµС‰Р°С‚СЊ РіРѕРЅРµРєРѕР»РѕРіР° РЅРµРѕР±С…РѕРґРјРјРѕ 1 СЂР°Р· РІ РіРѕРґ, РґР°Р¶Рµ РµСЃР»Рё РЅРµС‚ РЅРеРєР°РєРёС… Р¶Р°Р»РѕР±.

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Yarina: instructions for use

Each yarina tablet contains: □ Active substances ethinyl estradiol 0.03 mg drospirenon 3 mg □ excipients of lactose monohydrate, corn starch, corn -bonded corn, magnium K25, magnesium stearate, gydro -mopylmethyl cellulose), macrogol 6000, talco (macrogol ( Magnesium hydrosilate), titanium dioxide (E 171), iron (II) oxide (E 172).

The tablets are film-coated, round, biconvex, light yellow in color, with a hexagon engraved on one side with the letters “DO” inside.

pharmachologic effect

Yarina is a low-dose monophasic oral combined estrogen-progestogen contraceptive drug.

Yarina's contraceptive effect is carried out through complementary mechanisms, the most important of which include suppression of ovulation and changes in the properties of cervical secretion, as a result of which it becomes impenetrable to sperm.

When used correctly, the Pearl index (an indicator reflecting the number of pregnancies in 100 women using a contraceptive during the year) is less than 1. If pills are missed or used incorrectly, the Pearl index may increase.

In women taking combined oral contraceptives, the cycle becomes more regular, painful menstrual-like bleeding is less common, the intensity and duration of bleeding decreases, resulting in a reduced risk of iron deficiency anemia. There is also evidence of a reduced risk of endometrial and ovarian cancer.

Drospirenone contained in Yarin has an antimineralocorticoid effect and is able to prevent weight gain and the appearance of other symptoms (for example, edema) associated with estrogen-dependent fluid retention.

Drospirenone also has antiandrogenic activity and helps reduce acne (blackheads), oily skin and hair. This effect of drospirenone is similar to the effect of natural progesterone produced by the female body. This should be taken into account when choosing a contraceptive, especially for women with hormone-dependent fluid retention, as well as women with acne and seborrhea.

Indications for use

Contraception (prevention of unwanted pregnancy).

Contraindications

Yarina should not be used if you have any of the conditions/diseases listed below.

Thrombosis (venous and arterial) and thromboembolism currently or in history (including deep vein thrombosis, pulmonary embolism, myocardial infarction, stroke), cerebrovascular disorders.

Conditions preceding thrombosis (including transient ischemic attacks, angina) currently or in history.

Hereditary or acquired predispositions to venous or arterial thrombosis, such as APC resistance, antithrombin III deficiency, protein C deficiency, protein S deficiency, hyperhomocysteinemia and antiphospholipid antibodies (anticardiolipin antibodies, lupus anticoagulant).

Migraine with focal neurological symptoms, current or history

Diabetes mellitus with vascular complications.

Multiple or severe risk factors for venous or arterial thrombosis, including complicated lesions of the heart valve apparatus, atrial fibrillation, cerebrovascular disease or coronary artery disease; uncontrolled arterial hypertension, major surgery with prolonged immobilization, smoking over the age of 35 years.

Pancreatitis with severe hypertriglyceridemia, currently or in history.

Liver failure and severe liver disease (until liver tests normalize)

Liver tumors (benign or malignant) currently or in history.

Severe and/or acute renal failure.

Identified hormone-dependent malignant diseases (including genital organs or mammary glands) or suspicion of them.

Bleeding from the vagina of unknown origin.

Pregnancy or suspicion of it.

Breastfeeding period.

Hypersensitivity to any of the components of the drug Yarina

If any of these conditions appear for the first time while taking Yarina, stop taking this drug immediately and consult your doctor. In the meantime, use non-hormonal birth control. See also “Special Instructions”.

Pregnancy and lactation

Yarina should not be used during pregnancy and breastfeeding. If pregnancy is detected while taking Yarina, the drug should be discontinued immediately and consult a doctor. However, extensive epidemiological studies have not found an increased risk of developmental defects in children born to women who received sex hormones before pregnancy, or when taking sex hormones inadvertently in early pregnancy.

Taking combined oral contraceptives may reduce the amount of breast milk and change its composition, so their use is not recommended until you stop breastfeeding.

Directions for use and doses

The calendar pack contains 21 tablets. In the package, each tablet is marked with the day of the week on which it should be taken. Take the tablets orally at the same time every day with a small amount of water. Follow the direction of the arrow until all 21 tablets have been taken. You do not take the drug for the next 7 days. Menstruation (withdrawal bleeding) should begin within these 7 days. It usually starts 2-3 days after taking the last pill.

Yarina. After a 7-day break, start taking the next tablets from the pack, even if the bleeding has not stopped yet. This means that you will always start a new pack of pills on the same day of the week, and that your withdrawal bleed will occur on approximately the same day of the week each month.

Taking pills from Yarina’s first package

When no hormonal contraceptive was used in the previous month

Start taking Yarina on the first day of the cycle, that is, on the first day of menstrual bleeding. Take the pill that is marked with the appropriate day of the week. Then take the tablets in order. You can also start taking it on days 2-5 of the menstrual cycle, but in this case you must use an additional barrier method of contraception (condom) during the first 7 days of taking the pills from the first package.

When switching from other combined oral contraceptives, vaginal ring or contraceptive patch

You can start taking Yarina the day after you take the last tablet of the current package of combined oral contraceptives (i.e., without interruption). If the current package contains 28 tablets, you can start taking Yarina the next day after taking the last active tablet. If you are not sure which pill it is, ask your doctor. You can also start taking it later, but in no case later than the next day after the usual break in taking (for drugs containing 21 tablets) or after taking the last inactive tablet (for drugs containing 28 tablets in a package).

Taking Yarina should begin on the day the vaginal ring or patch is removed, but no later than the day when a new ring is to be inserted or a new patch is applied.

When switching from oral contraceptives containing only gestagen (mini-pills)

You can stop taking the mini-pill on any day and start taking Yarina the next day at the same time. During the first 7 days of taking the pills, you must also use an additional barrier method of contraception.

When switching from an injectable contraceptive, an implant, or from a progestogen-releasing intrauterine contraceptive (Mirena)

Start taking Yarina on the day your next injection is due or on the day your implant or intrauterine device is removed. During the first 7 days of taking the pills, you must also use an additional barrier method of contraception.

After childbirth

If you have just given birth, your doctor may recommend that you wait until the end of your first normal menstrual cycle before starting to take Yarina. Sometimes, on the recommendation of a doctor, it is possible to start taking the drug earlier.

After spontaneous or medical abortion in the first trimester

pregnancy

Taking missed pills

If the delay in taking the next pill is less than 12 hours,

Yarina's contraceptive effect remains. Take the tablet as soon as

remember this. Take the next tablet at your usual time.

If the delay in taking the pills is more than 12 hours, contraceptive protection may be reduced. The more pills in a row are missed, and the closer this missed dose is to the start or end of the dose, the higher the risk of pregnancy.

In this case, you can be guided by the following rules:

More than one tablet is forgotten from the pack. Consult your doctor.

One tablet missed in the first week of taking the drug

Take the missed tablet as soon as you remember (even if this means taking two tablets at the same time). Take the next tablet at your usual time. Additionally, use a barrier method of contraception for the next 7 days. If sexual intercourse took place within a week before missing the pill, the possibility of pregnancy must be taken into account. Consult your doctor immediately.

One tablet was missed in the second week of taking the drug

Take the missed tablet as soon as you remember (even if this means taking two tablets at the same time). Take the next tablet at your usual time. If you took the pills correctly during the 7 days preceding the first missed pill, the contraceptive effect of Yarina is maintained and you do not need to use additional contraceptive measures. “Otherwise, as well as if you miss two or more pills, you must additionally use barrier methods of contraception for 7 days.

One tablet was missed in the third week of taking the drug

If all tablets have been taken correctly in the 7 days preceding the first missed pill, there is no need to use additional contraceptive methods. You can follow either of the following two options without the need for additional contraceptive measures.

1. Take the missed pill as soon as you remember (even if this means taking two pills at the same time). Take the next tablet at your usual time. Start taking the tablets from the next pack immediately after you finish taking the tablets from the current pack, so there is no break between packs. Withdrawal bleeding is unlikely until the second pack of tablets is gone, but spotting or breakthrough bleeding may occur on the days you take the drug.

2. Stop taking the pills from the current pack, take a break of 7 days or less (including the day you missed the pills), and then start taking the pills from the new pack.

Using this regimen, you can always start taking the next pack of tablets on the day of the week that you usually do.

If you do not get your expected period after taking the pills, you may be pregnant. Consult your doctor before starting a new pack.

If you have had vomiting or diarrhea (stomach upset) within 4 hours of taking Yarina tablets, the active ingredients may not have been completely absorbed. This situation is similar to skipping a drug dose. Therefore, follow the instructions for missed pills.

Delaying the onset of menstruation

You can delay the onset of menstruation if you start taking the tablets from the next package of Yarina immediately after finishing the current package. You can continue taking the tablets in this pack for as long as you wish, or until the tablets in this pack run out. If you want your period to start, stop taking the pills. While taking Yarina from the second package, spotting or bleeding may occur on the days of taking the pills. Start taking the tablets from the next package after the usual 7-day break.

Changing the day your period starts

If you take the pills as recommended, you will have your period on about the same day every 4 weeks. If you want to change it, shorten (but do not lengthen) the period of time you are free from taking pills. For example, if your menstrual cycle usually starts on Friday, but in the future you want it to start on Tuesday (3 days earlier), you should start taking the pills in the next pack 3 days earlier than usual. If your pill-free break is very short (for example, 3 days or less), menstruation may not occur during the break. In this case, bleeding or spotting may occur while taking the tablets from the next package. Additional information for special populations Children and adolescents

The drug Yarina is indicated only after the onset of menarche. Available data do not suggest dose adjustment in this group of patients.

Elderly patients

Not applicable. Yarina is not indicated after menopause.

Patients with liver disorders

Yarina is contraindicated in women with severe liver disease until liver function tests return to normal. See also section "Contraindications".

Patients with kidney problems

Yarina is contraindicated in women with severe renal failure or acute renal failure. See also section "Contraindications".

Side effect

When taking Yarina, like any other medicine, adverse reactions may occur, although their occurrence is not necessary in all patients. If any adverse reaction becomes serious or you notice an adverse reaction not listed in this leaflet, please tell your doctor or pharmacist.

Serious unwanted effects:

In case of undesirable effects, including serious reactions associated with the use of the drug, see the sections “Precautions”, “Special Instructions” and “Contraindications”. Please read these sections carefully and consult your doctor if necessary. The following adverse reactions have been reported in women using Yarina:

Common undesirable effects (more than 1/100 and less than 1/10):

□ mood swings, depression/low mood

□ decrease or loss of libido (decreased or loss of sexual desire)

□ migraine

□ nausea

□ pain in the mammary glands, irregular uterine bleeding (“breakthrough” bleeding), bleeding from the genital tract (bleeding from the vagina) of unspecified origin

Rare undesirable effects (more than 1/10000 and less than 1/1000):

□ venous or arterial thromboembolism*

□ *Approximate frequency based on the results of epidemiological studies covering the group of combined oral contraceptives. The frequency bordered on very rare.

□ “Venous or arterial thromboembolism” includes the following nosological units: occlusion of peripheral deep veins, thrombosis and

embolism/pulmonary vascular occlusion, thrombosis, embolism and infarction/myocardial infarction/cerebral infarction and stroke not defined as hemorrhagic.

Side effects that have been reported during use of Yarina, but the incidence of which could not be assessed: erythrema multiforme (a skin condition characterized by itchy red rashes or local swelling of the skin).

Additional Information:

Listed below are adverse reactions with a very rare incidence or with delayed symptoms, which are believed to be associated with taking drugs from the group of oral combined contraceptives (see also “Contraindications” and “Special instructions”).

□ The incidence of breast cancer diagnosis in women taking combined oral contraceptives is slightly increased. Because breast cancer is rare in women under 40 years of age, the increase in breast cancer diagnoses in women taking combined oral contraceptives is small relative to the overall risk of breast cancer.

Other states

□ Erythema nodosum.

□ Women with hypertriglyceridemia (increased risk of pancreatitis while taking combined oral contraceptives).

□ Increased blood pressure.

□ Conditions that develop or worsen while taking combined oral contraceptives, but their relationship has not been proven: jaundice and/or itching associated with cholestasis; formation of gallstones; porphyria; systemic lupus erythematosus; hemolytic-uremic syndrome; chorea; herpes during pregnancy; hearing loss associated with otosclerosis.

□ In women with hereditary angioedema, estrogen may cause or worsen symptoms.

□ Liver dysfunction.

□ Impaired glucose tolerance or effects on insulin resistance.

□ Crohn's disease, ulcerative colitis.

□ Chloasma.

□ Hypersensitivity (including symptoms such as rash, urticaria). Interaction

Interaction of oral contraceptives with other drugs

agents (inducers of microsomal liver enzymes, some antibiotics)

can lead to

breakthrough bleeding and/or decreased contraceptive effectiveness (see “Interaction with other drugs”).

Overdose

No serious adverse events have been reported following overdose. Based on cumulative experience with combined oral contraceptives, symptoms that may occur with an overdose of active tablets: nausea, vomiting, spotting or metrorrhagia.

In case of overdose, consult a doctor.

Interaction with other drugs

Some medications may reduce the effectiveness of Yarina. These include drugs used to treat epilepsy (eg, primidone, phenytoin, barbiturates, carbamazepine, oxcarbazepine, topiramate, felbamate), tuberculosis (eg, rifampicin, rifabutin), and HIV infection (eg, ritonavir, nevirapine); antibiotics to treat certain other infectious diseases (eg penicillin, tetracyclines, griseofulvin); and St. John's wort medicines (used mainly to treat low mood). Oral combination contraceptives may affect the metabolism of other drugs (eg, cyclosporine and lamotrigine).

There is a theoretical possibility of increased serum potassium levels in women receiving Yarina concomitantly with other drugs that may increase serum potassium levels. These drugs include angiotensin II receptor antagonists, some anti-inflammatory drugs (eg, indomethacin), potassium-sparing diuretics, and aldosterone antagonists. However, in a study evaluating the interaction of drospirenone with ACE inhibitors or indomethacin, there was no significant difference between serum potassium concentrations compared with placebo.

Always tell the doctor prescribing Yarina what medications you are already taking. Also tell any doctor or dentist who prescribes other drugs, or the pharmacist who sells drugs to you at the pharmacy, that you are taking Yarina.

Features of application

The following warnings regarding the use of other combined oral contraceptives should also be taken into account when using Yarina.

□ Thrombosis

Thrombosis is the formation of a blood clot (thrombus) that can block a blood vessel. When a blood clot breaks off, thromboembolism develops. Sometimes thrombosis develops in the deep veins of the legs (deep vein thrombosis), vessels of the heart (myocardial infarction), brain (stroke), and very rarely in the vessels of other organs.

The results of epidemiological studies indicate a relationship between the use of combined oral

contraceptives and an increased incidence of venous and arterial thrombosis and thromboembolism (such as deep vein thrombosis, pulmonary embolism, myocardial infarction, cerebrovascular disorders) when taking combined oral contraceptives. These diseases are rare.

The risk of developing venous thromboembolism (VTE) is greatest in the first year of taking such drugs. An increased risk is present after initial use of combined oral contraceptives or resumption of use of the same or different combined oral contraceptives (after a dosing interval of 4 weeks or more). Data from a large study suggest that the increased risk is predominantly present during the first 3 months.

The overall risk of VTE in patients taking low-dose combined oral contraceptives (

In very rare cases, venous or arterial thromboembolism can cause serious functional impairment, be life-threatening, or be fatal.

VTE, manifested as deep vein thrombosis or pulmonary embolism, can occur with the use of any combined oral contraceptives.

Very rarely, when using combined oral contraceptives, thrombosis of other blood vessels occurs, for example, hepatic, mesenteric, renal, cerebral veins and arteries or retinal vessels.

The risk of developing thrombosis (venous and/or arterial) and thromboembolism increases:

□ with age;

□ in smokers (with increasing number of cigarettes or increasing age, the risk increases, especially in women over 35 years old);

in the presence of:

□ family history (for example, venous or arterial thromboembolism ever in close relatives or parents at a relatively young age). In the case of a hereditary or acquired predisposition, the woman should be examined by an appropriate specialist to decide on the possibility of taking the drug;

□ obesity (body mass index more than 30 kg/m2);

□ dislipoproteinemia;

□ arterial hypertension;

□ migraine;

□ heart valve diseases;

□ atrial fibrillation;

□ prolonged immobilization, major surgery, any leg surgery or major trauma. In these situations, it is advisable to stop using the drug Yarina (in the case of a planned operation, at least four weeks before it) and not to resume taking it for a period of time.

two weeks after the end of immobilization.

□ Tumors

The connection between taking combined oral contraceptives and breast cancer has not been proven, although it is detected slightly more often in women taking combined oral contraceptives than in women of the same age who are not using them. This difference may be due to the fact that women are screened more often when taking the drug and therefore breast cancer is detected at an early stage.

In rare cases, during the use of sex steroids, the development of benign, and in extremely rare cases, malignant liver tumors, which can lead to life-threatening intra-abdominal bleeding, has been observed. The connection with the use of drugs has not been proven. If you suddenly experience severe abdominal pain, consult your doctor immediately.

The most significant risk factor for developing cervical cancer is persistent human papillomavirus infection. Cervical cancer was detected slightly more often in women using combined oral contraceptives for a long period of time. The connection with the use of combined oral contraceptives has not been proven. This may be due to more frequent gynecological examinations to detect cervical diseases or to characteristics of sexual behavior (less frequent use of barrier methods of contraception).

The above mentioned tumors can be life threatening or fatal.

□ Reduced efficiency

The effectiveness of Yarina may be reduced in the following cases: if you miss pills, with vomiting and diarrhea, or as a result of drug interactions.

□ Women with a tendency to chloasma should avoid prolonged exposure to the sun and exposure to ultraviolet radiation while taking the drug.

□ In women with hereditary forms of angioedema, exogenous estrogens may cause or worsen symptoms of angioedema

□ During the use of combined oral contraceptives, cases of Crohn's disease and ulcerative colitis, as well as worsening of endogenous depression and epilepsy, have been described.

Insufficient control of the menstrual cycle

As with other combined oral contraceptives, when taking Yarina, irregular vaginal bleeding (spotting or breakthrough bleeding) may be observed during the first few months. Use hygiene products and continue taking your tablets as usual. Irregular menstrual-like bleeding usually stops as your body adapts to Yarina (usually after 3 cycles of taking the pills). If they continue, become severe, or return after stopping, consult your doctor. No regular menstrual bleeding If you took all the pills correctly and did not have vomiting or diarrhea

while taking pills or not taking other medications at the same time, then the likelihood of pregnancy is low. Continue taking Yarina as usual.

If there are no two menstrual bleeding in a row, consult a doctor immediately. Do not start taking the next pack until your doctor has ruled out pregnancy.

Impact on the ability to drive a car and operate machinery

Not found.

When to Consult a Doctor Regular Checkups

If you are taking Yarina, your doctor will tell you about the need for regular check-ups, at least once every 6 months.

Consult your doctor as soon as possible:

□ if you have any health changes, especially any of the conditions listed in this leaflet (see also “Contraindications” and “Use with caution”);

□ with local compaction in the mammary gland;

□ if you are going to use other medications (see also “Interactions with other medications”);

□ if prolonged immobility is expected (for example, a leg is in a cast), hospitalization or surgery is planned (consult your doctor at least 4 - 6 weeks in advance);

□ if unusual heavy vaginal bleeding occurs;

□ if you forgot to take a pill in the first week of taking the pack and had sexual intercourse seven days or less before;

□ you have not had your regular menstruation twice in a row or you suspect that

that you are pregnant (do not start taking the next pack until you have consulted your doctor).

Stop taking the tablets and consult your doctor immediately if you notice possible signs of thrombosis, myocardial infarction or stroke: unusual cough; unusually severe pain behind the sternum, radiating to the left arm; unexpected shortness of breath; unusual, severe or prolonged headache or migraine attack; partial or complete loss of vision or double vision; slurred speech; sudden changes in hearing, smell, or taste; dizziness or fainting; weakness or loss of sensation in any part of the body; severe abdominal pain; severe leg pain or sudden swelling of either leg.

Yarina does not protect against HIV infection (AIDS) or any other sexually transmitted disease.

Precautionary measures

If you are using combined oral contraceptives if you have any of the diseases/conditions listed below, you may need to be closely monitored for reasons why. Before you start taking Yarina, tell your doctor if you have any of the following conditions and diseases.

Risk factors for the development of thrombosis and thromboembolism: smoking; thrombosis, myocardial infarction or cerebrovascular accident at a young age in one of the immediate family; obesity; dyslipoproteinemia (for example, high blood cholesterol); arterial hypertension; migraine; heart valve defects; prolonged immobilization, major surgery, major trauma

Other diseases in which peripheral circulatory disorders may occur (diabetes mellitus; systemic lupus erythematosus; hemolytic uremic syndrome; Crohn's disease and ulcerative colitis; sickle cell anemia), phlebitis of the superficial veins

Hereditary angioedema

Hypertriglyceride emia

Liver diseases

Diseases that first appeared or worsened during pregnancy or during previous use of sex hormones (for example, jaundice and/or itching associated with cholestasis, cholelithiasis, otosclerosis with hearing impairment, porphyria, herpes of pregnancy, Sydenham's chorea)

Postpartum period

Release form

Film-coated tablets. 21 tablets are placed in a blister made of aluminum foil and polyvinyl chloride film. 1 or 3 blisters, along with a pocket for carrying the blister and instructions for use, are placed in a cardboard box.

Storage conditions

Store at a temperature not exceeding 25 °C.

Keep out of the reach of children.

Best before date

3 years. Do not use after the expiration date!

Conditions for dispensing from pharmacies

On prescription.

Yarina analogues, synonyms and group drugs

Midiana
Dimia
Janine
Novinet
Rigevidon 21 + 7
Lindinet 20
Lindinet 30

Self-medication may be harmful to your health. You should consult your doctor and also read the instructions before use.

apteka.103.by

Yarina

Composition and release form Yarina is available in the form of film-coated tablets. The active substances included in the drug are ethinyl estradiol in a dosage of 30 mg. and Drospirenone at a dosage of 3 mg. One package of the drug contains 21 tablets. How does Yarina work? Yarina's contraceptive is a combined drug, as it contains two sex hormones - estrogen and gestagen. In addition, the product is low-dose (low doses of hormones) and monophasic (all tablets contain the same amount of hormones). Yarina’s ability to protect against pregnancy is based on two mechanisms - suppression of ovulation (ovum maturation) and a change in the properties of the secretion (mucus) located in the cervix. Thick cervical mucus becomes an obstacle to sperm penetration. In addition, taking Yarina helps to regulate the menstrual cycle (if it is irregular). Pain during menstruation decreases, bleeding becomes less intense (this fact reduces the risk of developing iron deficiency anemia). Other beneficial effects of Yarina are antimineralocorticoid and antiandrogenic effects. The hormone Drospirenone has this effect - it reduces fluid retention in the body, reduces swelling, so that body weight does not increase. The antiandrogenic effect is the ability of the drug to reduce the symptoms of acne (acne) and regulate the production of sebum in the skin and hair (reduces seborrhea). Indications for use

The main indication for the use of tablets is to prevent unwanted pregnancy.

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