Can Trimedat cause a worsening of the condition? "Trimedat": reviews of the drug and comparison with analogues. Drugs with similar effects

Dysfunction of the gastrointestinal tract is a fairly common phenomenon, not always associated with serious diseases. , being an antispasmodic, helps normalize intestinal motility functions. It is aimed at relieving unpleasant phenomena such as cramps, flatulence, constipation, nausea and vomiting.

In the case where the listed phenomena are symptoms of a serious disease, and not just a temporary disruption of intestinal function, the use of the product must be agreed with a specialist. Trimedat is available in several forms, has a certain effect on the patient’s body and has several.

Trimedat is an antispasmodic drug.

Trimedat is an antispasmodic drug available in two white forms. The first - with a 100-milligram dosage - has the appearance of a flat cylinder.

A characteristic feature of these tablets is the “TM” symbol embossed on one side and two intersecting lines on the other. The 200-milligram tablets are also cylindrical, but convex on both sides. A line is extruded on one side, and on the other there are two elements shaped like drops.

The main active ingredient of the drug is trimebutine maleate, the amount of which depends on the drug. In addition to it, the tablets contain various excipients that promote normal absorption of the drug by the body.

Pharmacodynamics. Trimebutine restores intestinal motility, affecting its enkephalinergic system. In the case of a hypokinetic state of intestinal smooth muscles, Trimedat stimulates their work, and in a hyperkinetic state, it has an antispasmodic effect on them. This dual effect occurs due to the fact that trimebutine is able to act on excitatory and suppressive receptors.

The medicinal effect of Trimedat extends throughout the entire period, due to which there is a decrease in the pressure of the esophageal sphincter, the process of emptying the stomach from food improves, and intestinal motor functions return to normal. In addition, the product has a beneficial effect on the functioning of smooth muscle receptors, as a result of which they respond better to incoming food. The main purpose of trimebutine is to normalize the functioning of intestinal smooth muscles in cases of abnormalities caused by motility disorders.

Pharmacokinetics. The absorption of the drug occurs quickly - already 1-2 hours after it enters the bloodstream, the maximum concentration of the active substance in the blood plasma is noted. Up to 6% of the substance enters the blood. Distribution volume - 88 l. The active component practically does not bind to plasma proteins and is able to overcome the placental barrier to a small extent.

After the drug is processed by the liver, it is mostly excreted in the urine. After a day, the body gets rid of approximately two-thirds of trimebutine. Trimedat is an antispasmodic drug whose active ingredient is trimebutine. The main effect of the drug is associated with the restoration of normal.

Indications and contraindications for use

Trimedat is intended for children aged three years and older.

The drug has two main effects. Depending on the state of the smooth muscles of the intestine, the drug can both stimulate motility and have an antispasmodic effect on it.

Therefore, Trimedat is effective for a wide variety of gastrointestinal motility disorders. In particular, the disorders that Trimedat can cope with include:

• and its symptoms
• increased gastrointestinal irritability
• dyspepsia
• postoperative intestinal obstruction
• diseases of various digestive organs
• pain, colic
• diseases of the stomach and intestines, the symptoms of which are unclear

• Children 3-5 years old can be given 25 milligrams per dose, not exceeding the daily allowance of 75 milligrams
• Children 5-12 years old are allowed to take the drug 50 milligrams. Daily norm - 150 milligrams
• for children over 12 years of age, as well as adults, the permissible dosage is 100-200 milligrams per dose. In this case, care should be taken not to exceed the daily dose of the drug - 600 milligrams.

The main course of treatment in adults lasts one month. In order to prevent a possible relapse, it is advisable to conduct a repeat course, which lasts three months. The daily rate for a repeated course is 300 milligrams. In case of overdose of the drug, increased manifestation of its side effects may be observed. Depending on the consequences of an overdose, in particular, on their severity, therapy is carried out in order to overcome specific negative manifestations.

Pregnant and breastfeeding women should consult a doctor before taking the drug. Although clinical studies have not revealed embryotoxic and teratogenic consequences of taking Trimedat, its use is contraindicated in the first four months. In addition, taking the drug is not recommended during lactation, since there is no reliable data on its safety during this period.

The dosage of the drug depends on the age of the patient. Women during pregnancy or lactation should first consult a doctor before taking Trimedat.

Trimedat is an antispasmodic drug indicated for use by people suffering from various intestinal motility disorders. When using the product, you must remember that it has certain indications and contraindications. It is also important to monitor the dosage of the drug in order to avoid possible unpleasant consequences from its overdose.

But the video will tell you why flatulence, which is an indication for the use of Trimedat, is terrible:

Trimedat is a potent antispasmodic drug. Its active component is trimebutine maleate. The pharmacological effect of this drug is to regulate the motor function and sensitivity of the digestive tract by contracting and relaxing the smooth muscles of the intestine, which makes Trimedat promote faster gastric emptying. This medication weakens the pressure of the esophageal sphincter, thereby restoring the full physiological activity of the intestinal muscles. Moreover, it ensures a timely response of the smooth muscles of the large intestine to food that is difficult to digest.

Trimedate is productively absorbed from the gastrointestinal tract. Approximately 2 hours after entering the human body, its concentration in the blood plasma reaches its maximum. The breakdown of this medicine occurs in the liver. It is excreted in the urine in the form of unchanged metabolites.

What are Trimedat tablets prescribed for?

1. This medication is prescribed for dyspeptic disorders and symptoms, as well as for nausea and vomiting.
2. It is used in the treatment of gastroduodenal disorders - painful sensations in the abdomen and stomach, in eliminating the feeling of oversaturation with food and digestive disorders, etc.
3. Trimedat is often used in the treatment of irritable bowel syndrome, which is manifested by colic, abdominal pain, diarrhea or constipation, as well as intestinal spasms.
4. Doctors recommend this medication for the treatment of gastroesophageal reflux disease.
5. This drug is also used as part of a comprehensive preparation for x-ray or endoscopic examination of the intestines and stomach.
6. The use of this drug is indicated in the treatment of dyspeptic disorders and disorders in children that were caused by or associated with impaired motility of the stomach and intestines.

Among the contraindications to the use of this drug are the following conditions:

• pregnancy and lactation;
• hypersensitivity to substances present in this medication;
• children up to 3 years old.

The rules for using this medicine depend on the patient’s well-being, the type of disease, his age and other characteristics of his body. Tablets should be taken orally with sufficient liquid.

• Children over the age of 12 and adults should drink 100–200 mg. drug 3 times a day. If we are talking about preventing a relapse of irritable bowel syndrome, then after a course of treatment during a period of remission, medical experts recommend continuing to use the medicine at a daily dosage of 300 mg. Such treatment should be carried out for 12 weeks.
• Children aged 5 to 12 years should take 50 mg. drug 3 times a day.
• Children whose age ranges from 3 to 5 years need to drink 25 mg. medications 3 times a day.

This medication should be taken with caution, carefully following the recommendations of a medical specialist and the above instructions, since if treated incorrectly, you may experience various adverse reactions, including nausea and loss of consciousness.

Storage conditions for Trimedat

This medicine, like all other medicines, should be kept out of the reach of children. It is advisable that the place where you are going to store this drug is protected from sunlight and heat.
Trimedat is an effective antispasmodic drug. It differs from similar analogue drugs in that it acts very quickly, eliminating pain and spasms. If you do not know what Trimedat is prescribed for, and in what cases doctors strongly recommend that you stop using this medication, carefully read this instructional article. It provides reliable information about the rules of treatment with this drug.

How to take Trimedat correctly?

Trimedat is a South Korean drug that normalizes the motor function of the gastrointestinal tract and biliary system. The active ingredient is Trimebutin; in addition to it, the medication contains additional auxiliary components. Available in tablet form, 100 and 200 mg, in foil, plastic packaging in quantities of 10/20/30 pieces. What are the indications and contraindications for Trimedat according to the instructions for use, how much does the product cost and what analogues can be replaced - we will analyze in detail in this article.

What does the drug and its substitutes affect?

Normal motility is peristaltic movements of the intestines, promoting the uniform movement of food gruel from the esophagus to the rectum.

Most intestinal motility disorders have many causes, and the gastroenterologist's arsenal must include medications that can normalize intestinal motility, both increased and decreased.

Trimedat has a positive effect on both spastic disorders and conditions associated with decreased motor activity of the intestines and biliary system.

In adults and children, motor dysfunction is distinguished by hypo- or hyperkinetic type. In order to make a diagnosis, it is necessary to conduct diagnostics to exclude acute surgical pathology and oncological processes.

The drug is a universal modulator, the use of which is justified in the early stages of the disease without specifying the type of disorder of intestinal motor function.

The active substance was synthesized in the 70s of the last century in France and was successfully used abroad under the name Debridat. In our country, this medicine with its real trade name appeared in 2007.

There are other analogues:

• Trimedat Valenta of domestic production;
• Trimpsa;
• Neobutin;
• Neobutin retard.

Why does stomach pain occur (reasons)

Abdominal pain is a symptom that occurs in many pathological conditions in abdominal surgery.

• cramping or dull;
• there are no clear boundaries;
• a connection is established with food or the act of defecation;
• weakness, hyperhidrosis, lack of air may accompany pain;
• palpation in the projection of localization is painful.

For somatic pain, abdominal surgeons exclude acute pathology, since most patients require surgery. Treatment with this drug in these cases is not effective and even dangerous. This type of pain is characterized by an acute onset, lack of connection with anything, pronounced intensity, and poor effect of drug treatment.

Abdominal pain of psychogenic origin is typical for people with emotional and mental instability and disappears during therapy with psychotropic medications. Trimedat is not the drug of choice for psychogenic pain.

When to see a doctor urgently

Patients with acute pain do not put off visiting a specialist; According to statistics, more than 80% are delivered to the hospital by an emergency team.

Note that all diseases for which the drug is prescribed do not exclude the development of other pathologies that may exist against the background of impaired intestinal motility.

Here is a list of symptoms associated with pain in the abdomen, which are dangerous in terms of the development of oncological processes:

• causeless weight loss;
• the first signs of the disease appeared after 45–50 years;
• enlarged lymph nodes;
• dense formation in the abdominal cavity;
• low-grade fever;
• pain in the projection of the liver;
• blood in the stool;
• yellowness, itching and dry skin.

Mechanism of action of the drug

The drug belongs to the group of opioid peptides. Trimedat acts on peripheral opiate receptors, which are present in all parts of the gastrointestinal tract. They are located in the submucosal and intermuscular nerve fibers of the intestine. Scientists know mu-, delta and kappa receptors. Mu and delta are responsible for motor excitation, and kappa is responsible for inhibition.

The medication affects all three subtypes, without being specific to any one. The working substance can have a sufficient effect: both inhibit peristalsis and enhance it.

According to the official instructions, the drug has antispasmodic/prokinetic properties. In addition, the medication helps normalize humoral regulation:

• increases the synthesis of motilin;
• reduces the production of gastrin, glucagon, the hormone insulin, pancreatin and intestinal peptide.

The following happens:

• food evacuation accelerates;
• motor activity of the large intestine is normalized;
• pain syndrome decreases.

What does Trimedat help with? Indications for use

There are a number of pathological conditions in gastroenterology when the use of medication is effective:

These include:

• motility disorders in gastrointestinal pathologies (dyspepsia of any origin, gastroesophageal reflux, MS with all its symptoms: abdominal pain, bloating, loose stools/constipation);
• after surgical interventions complicated by intestinal paresis;
• as preparation of the intestine for instrumental diagnostics (fluoroscopy and endoscopy).

It can be used as symptomatic therapy after dietary errors.

The medication has found application in pediatrics: all disorders associated with impaired motor skills are successfully corrected with the use of the drug.

Contraindications

1. Age up to 3 years for the domestic form of the drug, up to 12 years from the Valenta company;
2. Pregnancy in the first trimester;
3. Individual hypersensitivity reactions;
4. Conditions associated with lactase deficiency.

During breastfeeding, it is better for the mother to refrain from taking the medication, since today there is no specific data on the effect of its individual components on breast milk.

The official instructions do not contain information about drug overdose and the interaction of its individual components with other drugs.

There are no obstacles to driving during therapy.

How to take Trimedat? Instructions for use

Treatment regimens, dosage and course duration are as follows:

The medicine is taken orally on an empty stomach; it is optimal to take the tablet with water in the amount of 150-200 mg. If dyspeptic disorders are acute, you can take the drug regardless of the fullness of the stomach.

In pediatric practice, tablets are allowed to be taken when a small patient reaches 3 years of age. Children from 3 to 5 years old are prescribed 25 mg 3 times a day.

From 5 years of age, the dosage is increased to 50 mg 3 times a day.

The duration of treatment and the required dosage are determined individually in each case.

Here are some commonly used treatment regimens:

Irritable bowel syndrome.

During the period of exacerbation, 200 mg 3 times a day for 1 month, then the dosage is reduced, and for maintenance and preventive purposes, 100 mg is taken orally for 3 months.

Cholecystitis, gastritis, pancreatitis, gastric and duodenal ulcers, gastroesophageal reflux, etc.

They are used for a long time, 2-3 months, since short courses are ineffective. Reception is resumed every 3 months.

Dyspepsia due to poor nutrition.

In these cases, in adults and children, use as an emergency measure is justified.

The medicine is taken in a dosage appropriate for age for 5-7 days, until the state of health returns to normal.

Instrumental examination of the gastrointestinal tract.

It is enough to drink the drug 1-2 times on the eve of the diagnostic procedure.

Postoperative intestinal paresis

The course of treatment is 30 days, the dosage corresponds to age.

If intestinal motility does not return to normal, therapy should be continued.

Constipation.

Prescribed in an age-specific dosage until stool normalization.

The medication in question must be taken in accordance with the official instructions for use, which are supplied in the package along with the drug.

What side effects may occur in children and adults?

The list of undesirable effects is quite impressive, but according to most patient reviews, the product is perceived well.

Side effects from taking the medication

• change in taste sensations;
• dyspeptic disorders;
• headache;
• emotional arousal;
• skin manifestations such as urticaria;
• urinary retention;
• disruption of the menstrual cycle;
• engorgement of the mammary glands.

Regulator of gastrointestinal motility.
Drug: TRIMEDAT®

Active substance of the drug: trimebutine
ATX encoding: A03AA05
KFG: A drug that regulates the motor function of the gastrointestinal tract
Registration number: LSR-005534/07
Registration date: 12/28/07
Owner reg. credential: Shchelkovo Vitamin Plant OJSC (Russia)

Trimedat release form, drug packaging and composition.

The tablets are white, round, biconvex, with a symbol in the form of two drop-shaped elements extruded on one side and a line on the other side.
1 tab.
trimebutine maleate
200 mg

Excipients: lactose, colloidal silicon dioxide, talc, corn starch, magnesium stearate.

10 pieces. — cellular contour packages (3) — cardboard packs.

The description of the drug is based on the officially approved instructions for use.

Pharmacological action of Trimedat

Regulator of gastrointestinal motility. Trimebutine, acting on the enkephalinergic system of the intestine, is a regulator of its peristalsis. Having an affinity for excitation and suppression receptors, it has a stimulating effect in hypokinetic conditions of intestinal smooth muscles and an antispasmodic effect in hyperkinetic conditions.

The drug acts throughout the gastrointestinal tract, reduces the pressure of the esophageal sphincter, promotes gastric emptying and increased intestinal motility, and also promotes the response of the smooth muscles of the colon to food irritants.

Trimebutine restores the normal physiological activity of the intestinal muscles in various gastrointestinal diseases associated with motility disorders.

Pharmacokinetics of the drug.

Suction

After oral administration, trimebutine is rapidly absorbed from the gastrointestinal tract. Cmax in blood plasma is achieved after 1-2 hours. Bioavailability is 4-6%.

Distribution

The degree of binding to plasma proteins is low - about 5%. Vd - 88 l. Trimebutine penetrates the placental barrier to a small extent.

Metabolism

Trimebutine is biotransformed in the liver.

Removal

Trimebutine is excreted in the urine mainly in the form of metabolites (approximately 70% during the first 24 hours). T1/2 - about 12 hours.

Indications for use:

Gastrointestinal motility disorders in the following diseases and conditions:

Gastroesophageal reflux disease;

Dyspeptic disorders in gastroduodenal diseases (abdominal pain, indigestion, nausea, vomiting);

Irritable bowel syndrome (manifested by pain, abdominal colic, intestinal cramps, flatulence, diarrhea and/or constipation);

Postoperative paralytic ileus;

Preparation for X-ray/endoscopic examination of the gastrointestinal tract;

Dyspeptic disorders in children.

Dosage and method of administration of the drug.

Adults and children over 12 years of age should take the drug orally at 100-200 mg 3 times a day.

Side effects of Trimedat:

Rarely: skin reactions.

Contraindications to the drug:

Children under 12 years of age (for this dosage form);

Hypersensitivity to the components of the drug.

Use during pregnancy and lactation.

The use of the drug Trimedat is contraindicated in the first trimester of pregnancy.

The use of the drug Trimedat is contraindicated during breastfeeding due to the lack of reliable clinical data confirming the safety of the drug.

Experimental studies have not revealed any evidence of teratogenicity or embryotoxicity of the drug.

Special instructions for the use of Trimedat.

No data provided.

Drug overdose:

To date, no cases of overdose of Trimedat have been reported.

Interaction of Trimedat with other drugs.

Data on drug interactions with Trimedat are not provided.

Terms of sale in pharmacies.

The drug is approved for use as a means of OTC.

Terms of storage conditions for the drug Trimedat.

The drug should be stored out of the reach of children at a temperature not exceeding 25°C. Shelf life: 3 years.

And excipients: corn starch, colloidal silicon dioxide, lactose, talc, magnesium stearate.

Release form

The medication is available in tablet form, in packages of 10, 20, 30 pieces.

pharmachologic effect

Myotropic antispasmodic regulating motor skills digestive system . The active substance acts on the enkephalinergic system of the intestine, regulates peristalsis . Trimebutine has an antispasmodic effect in hyperkinesis of smooth muscle tissue of the digestive tract, and in hypokinetic conditions it stimulates intestinal function.

The drug enhances peristalsis and promotes emptying stomach , reduces pressure on esophageal sphincter , acts throughout the intestine, enhances the response of the smooth muscle tissue of the large intestine to various food stimuli.